• 대한족부족관절학회지
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• 제23권1호
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• pp.18-23
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• 2019

Purpose: This study compared and analyzed the risk factors that affect a wound healing group and healing failure group. Materials and Methods: From 2010 to 2018, 39 patients who had suffered a single toe amputation were evaluated retrospectively. The patients were divided into two groups (wound healing group and healing failure group - within at least 3 months following the amputation). Regarding the possible risk factors, age, gender, Wagner and Brodsky classifications, duration of diabetes mellitus, whether the patient had peripheral arterial occlusive disease (PAOD) or cardiovascular disease, body mass index, HbA1c, total cholesterol, estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), smoking, and alcohol were investigated. Results: The mean duration of diabetes mellitus was 140 months in the healing group and 227 months in the healing failure group, and the duration of diabetes was significantly longer in the failure group (p=0.009). A significant difference in eGFR was observed between the two groups ($59.17mL/min/1.73m^2$ in the healing group and $31.1mL/min/1.73m^2$ in the failure group) (p=0.022). Sixteen patients with PAOD were found, all 10 patients in the healing failure group were PAOD patients. Conclusion: To reduce the additional complications in single toe amputation patients, the underlying disease and appropriate treatment are the most important factors. In addition, a more proximal level of amputation also should be considered in cases of patients with PAOD, high BUN and low eGFR, and patients with long-term diabetes.

• 대한족부족관절학회지
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• 제28권2호
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• pp.75-79
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• 2024

Ankle arthrodesis was performed on a 55-year-old male patient with an active lifestyle who developed severe arthritis in the left ankle. Over the follow-up period, high tibial valgization osteotomy was conducted for painful medial knee joint arthritis with genu varum deformity to correct overall lower limb alignment from varus to valgus with respect to the fused ankle. This study was conducted to investigate how hindfoot alignment would change when the overall alignment of the lower limb shifted from varus to valgus with the ipsilateral ankle in a fused state. Conclusively, while no intrinsic changes in the hindfoot alignment were observed following the alteration of lower limb alignment, the hindfoot naturally adjusted to valgus deviation in response to limb valgus realignment. Moreover, symptoms changed in line with this adjustment. Given the absence of similar case studies or reports, a review of relevant literature is included to contribute to knowledge of this subject.

• 대한영상의학회지
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• 제84권6호
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• pp.1397-1402
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• 2023

결절성 근막염은 양성 섬유모세포 증식으로 유방에는 드물게 보고된다. 저자들은 악성 영상 소견을 보인 55세 여자 환자의 증례를 보고한다. 유방촬영술에서 오른쪽 유방에 유방조직과 비슷한 밀도를 보인 부분적으로 경계가 불명확한 결절이 보였고 인공지능 점수는 75%였다. 초음파에서 미세 소엽상 경계, 주변부 고에코를 가진 타원형의 저에코 결절이 보였고 증가된 혈류와 부드러운 탄성도를 보였다. 조직검사와 수술 후 결절성 근막염으로 진단되었다. 결절성 근막염은 유방에서 드물지만, 악성과 비슷하게 보일 수 있다. 따라서 불필요한 중재시술을 막기 위해 감별진단으로 고려되어야 한다.

• 생명과학회지
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• 제33권11호
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• pp.868-875
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• 2023

Kinesin-1은 kinesin superfamily (KIF) 단백질 중에서 처음으로 확인된 모터 단백질로 세포내 미세소관 의존하여 세포내 cargo를 수송한다. Kinesin-1은 두 개의 중쇄(KHC, 또는 KIF5)와 두 개의 경쇄(KLC)로 구성된다. KIF5A의 C-말단의 93개 아미노산은 KIF5B와 KIF5C의C-말단 꼬리 영역과는 상동성이 없다. 본 연구에서 우리는 KIF5A의 C-말단 영역과 특이적으로 결합하는 단백질을 분리하기 위해 효모 2-하이브리드 스크리닝을 하였다. 본 연구에서 우리는 KIF5A와 결합하는 단백질로 유비퀴틴화 경로 및 단백질 수송에 관여하는 어댑터 단백질로 기능하는 CUE 도메인을 가진 CUEDC2를 확인하였다. CUEDC2는 KIF5A의 C-말단 영역과 결합하지만, KIF5B, KIF3A 및KLC1과는 결합하지 않았다. KIF5A는 CUEDC2의 C-말단 영역과 특이적으로 결합하였지만, CUEDC2의 다른 isoform인 CUEDC1과는 결합하지 않았다. 또한, KIF5A와 CUEDC2의 결합은 글루타티온 S-트랜스퍼라제(GST) 풀다운으로 단백질간 결합을 확인하였다. HEK-293T 세포에서 myc-KIF5A와 FLAG-CUEDC2을 공동 발현되었을 때, CUEDC2는 kinesin-1과 공동 면역 침전되었고, myc-KIF5A와 EGFP-CUEDC2는 세포내의 같은 위치에서 발현하였다. 이러한 결과들은 kinesin-1에 의한 세포내 화물 수송에서 CUEDC2는 KIF5A에 결합하여 kinesin-1과 화물을 연결하는 어댑터 단백질 역할을 시사한다.

• 대한족부족관절학회지
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• 제23권1호
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• pp.31-34
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• 2019

Chondroblastoma is a rare benign tumor that produces giant cells and cartilage matrix. The tumor occurs in people between 10 and 25 years with slightly higher incidence in males. The condition occurs in the proximal epiphysis of the tibia and humerus, distal epiphysis of the femur, but its occurrence in the talus is relatively rare, accounting for 4% of the total number of chondroblastoma cases. Chondroblastoma is often misdiagnosed as a primary aneurysmal bone cyst, giant cell tumor, chondromyxoid, and lesion of a secondary aneurysmal bone cyst by fibrous dysplasia. The most commonly used surgical method for chondroblastoma is broad curettage with bone grafting. In general, an aneurysmal bone cyst is associated with a second degree chondroblastoma, which is approximately 20%. Chondroblastoma of the talus and secondary aneurysmal bone cysts can be misdiagnosed as primary aneurysmal bone cysts. This paper reports a case of a young male patient with chondroblastoma of the talus, which was initially misdiagnosed as an aneurysmal bone cyst with involvement of the talo-navicular joint.

• 대한족부족관절학회지
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• 제22권4호
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• pp.173-176
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• 2018

Pigmented villonodular synovitis (PVNS) is a proliferative disease that affects the synovial joint, tendon and bursa. PVNS can form a nodular structure in any joint, but it most commonly affects the knee joint and is rare in the foot and ankle joint. PVNS is divided into two types. Localized-type PVNS exhibits focal involvement with a nodular mass, while diffuse-type PVNS involves the entire synovium. Synovitis of the affected joint can also destroy cartilage and bone. Diffuse type accounts for 75% of PVNS and has a reported recurrence rate of 12.2% to 46%; aggressive synovectomy is recommended as the most effective treatment. In localized-type PVNS, only arthroscopic partial synovectomy is effective with a lower recurrence rate. We report a patient with severe ankle joint arthritis induced by diffusetype PVNS. The patient was treated by lateral malleolar ostectomy and ankle arthrodesis with a plate and screws via a lateral approach.

• 대한족부족관절학회지
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• 제26권2호
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• pp.103-106
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• 2022

Peroneal tendon disorders are one of many causes of chronic lateral ankle pain. They are related to chronic conditions and anatomical factors and can cause persistent pain and functional impairment if neglected. Peroneal tendon tears are frequently misdiagnosed due to the absence of clear symptoms. For subacute or chronic peroneal tendon ruptures, tendons often became irreparable, and hence various surgical options have been introduced to address this issue. Current surgical treatment options include debridement and tubularization, tenodesis, tendon transfer, and reconstruction with a graft. There have been a few reports on the use of reconstruction techniques with an allograft. In this report, we present a rare case of a peroneal tendon reconstruction technique using an allograft in a young male with simultaneous irreparable peroneus longus and a complete rupture of the brevis tendon. The management plan, prognostic outlook, and a subsequent review of the relevant literature are also presented.

• 대한족부족관절학회지
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• 제26권3호
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• pp.143-147
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• 2022

Past research has reported that the common causes of ankle arthritis include trauma, congenital deformity, and degeneration. Among them, fracture-induced post-traumatic arthritis is most common. For patients with ankle fractures, an anatomical reduction is performed through surgical treatment. However, insufficient reduction or malunion of the fracture site may change the alignment of the ankle joint, resulting in valgus or varus deformities. Currently, most operative options for valgus arthritis aim to either restore joint alignment and/or reduce the uneven load on the cartilage. In this report, we would like to share our clinical experience of a patient with posttraumatic valgus ankle arthritis caused by severely comminuted fracture and dislocation. A satisfactory outcome could be obtained with combined fibular lengthening osteotomy and medial displacement calcaneal osteotomy.

• 대한족부족관절학회지
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• 제26권3호
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• pp.136-142
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• 2022

Lateral compartment syndrome of the lower leg is rarely observed. Hence, there may be difficulty in diagnosis as its clinical patterns are different and more complicated than usual. We report two rare cases of a 20-year-old and a 28-year-old diagnosed with isolated lateral compartment syndrome who had either a surgical or conservative treatment. The comparison was done by analyzing the progression of neurological manifestation, electromyography, and nerve conduction study for two years. In the final follow-up, the patient who underwent the surgical treatment showed a shorter recovery time. However, both patients showed a full recovery from neurologic deficits.

• 대한족부족관절학회지
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• 제27권2호
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• pp.71-74
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• 2023

A medial opening wedge supramalleolar osteotomy (SMO) introduced by Takakura et al. is a useful realignment procedure for patients with ankle joint arthritis and varus malalignment by shifting the weight-bearing axis laterally and redistributing the loads on the ankle joint. When pain persists after arthroscopic microfracture in patients with medial osteochondral lesion of the talus (OLT), redo arthroscopy, osteochondral autograft transplantation, autologous chondrocyte implantation, or matrix-induced chondrogenesis might be indicated. On the other hand, there is insufficient scientific evidence for realignment surgery through SMO, while the effect of realignment surgery has been studied consecutively for osteochondral lesions of the knee. Therefore, this paper reports a patient with medial OLT who underwent redo arthroscopy combined with SMO for persistent pain after primary arthroscopic microfracture.