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랫트를 이용한 최기형시험에 있어서 효율적인 독성평가를 위한 기초연구

  • 정문구;한상섭
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.168-168
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    • 1993
  • 신의약품의 생식독성 평가를 위해서는 타독성시험의 경우와 마찬가지로 NOEL (no observed effect level) 의 범위를 확립하는 일이 매우 중요한데, 이것은 정상치(control values), 자연발생소견 (spontaneous findings)등과 비교함으로서 가능하다. SPF 동물을 이용한 독성실험은 선진국에 비해 역사가 짧을 뿐만 아니라 아직 풍부한 기초자료가 확립되지 않아 외국의 자료들을 인용하고 있는 실정이다. 본 연구에서는 랫트를 이용한 최기형 시험결과의 효율적인 평가를 위해 생식독성 검사항목의 기초 데이타를 확립하였다. 이를 위해 화학연구소 실험동물육종실에서 입수한 SPF: Sprague- Dawley 랫트를 이용해 1989년부터 1991년까지 실시한 생식독성 시험의 대조준 데이타 (체중, 사료소비량, 장기중량, 제왕절개성적, 외표, 내부장기 및 골격검사성적, 자연분만군 시험성적 등)를 분석하였다. 요늑의 발현율, 견인력 시험결과 및 피모발생 일평이 외국의 타 연구기판 데이타와 다소 차이를 나타냈을 뿐 기타 항목들은 거의 일치하는 정상치를 보였다. 아울러 기형, 변이, 골화지연 등으로 구분되는 골격소견의 합리적인 평가를 위해 랫트 골격소견 평가기준을 정했고 최기형 시험에서 얻어지는 데이터의 통계처리 방법을 보완, 체계화하였다. 본 연구결과는 Sprague-Dawley 계통 랫트외 생물학적 정외는 물론 효율적인 생식독성 평가를 위한 소중한 기초 자료가 될 것으로 사료된다.

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Analysis by Defensive Process Prerequisite and Offensive Cause of Action on the Merits of Lawsuit Cases in Urban and Housing Redevelopment - Based on Affirm-Rate and Staircase Matrix Tables - (도시정비사건 소송의 본안전항변사유와 본안쟁점사항에 관한 분석 - 인용률 및 행렬표식 분석기법을 활용한 -)

  • Kim, Yohan;Jung, Boseon;Lee, Sangyoub
    • Korean Journal of Construction Engineering and Management
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    • v.20 no.5
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    • pp.104-114
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    • 2019
  • This study explored to analyze the winning determinants of the lawsuit cases on the urban and housing redevelopment project based on jurimetric methods. Based on affirm-rate and staircase matrix tables, 441 lawsuit judgments are analyzed. Research findings in affirm-rate analysis indicate that past legal relation, no own defect of accreditation, no ownership or association member status, lapse of period of litigation, and no legal interest are identified as higher rate in order for the reason for plea on the merit. And so are defect on calculation of consent rate, defect in relation with written consent, approval before zoning designation, defect in relation with general meeting, and defect on zoning designation for the issue on the merit. It is noteworthy from the staircase matrix table analysis that the criteria for affecting the lawsuit outcome is determined based on key forecasting variables such as past legal relation and no ownership or association member status. This study intends to provide the implication that the unnecessary disputes can be reduced in the urban and housing redevelopment project by the implementation of jurimetric quantitative analysis methodology from the perspective of empirical law.

Combustion Characteristics of Volume Variation of Torch in a CVCC (토치 점화 장치의 체적에 따른 연소특성 파악)

  • Kwon, Soon-Tae;Kim, Hyeong-Sig;Choi, Chang-Hyeon;Park, Chan-Jun;Ohm, In-Young
    • Proceedings of the Korea Society for Energy Engineering kosee Conference
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    • 2010.04a
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    • pp.166-170
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    • 2010
  • Six different size of torch-ignition device were applied in a constant volume combustion chamber for evaluating the effects of torch-ignition on combustion. The torch-ignition device was designed six different volumes and same orifice size. The combustion pressures were measured to calculate the mass burn fraction and combustion enhancement rate. In addition, the flame propagations were visualized by shadowgraph method for the qualitative comparison. The result showed that the combustion pressure and mass burn fraction were increased when using the torch ignition device. And the combustion duration were decreased. The combustion enhancement rates of torch-ignition cases were improved in comparison with conventional spark ignition. Finally, the visualization results showed that the torch-ignition device the torch-ignition induced faster burn than conventional spark ignition due to the earlier transition to turbulent flame and larger flame surface, during the initial stage. And the initial flame propagation was effected torch-ignition volume.

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A Study on the State of Convenience Facilities for the Accessibility of a Disabled Person in Dental Institutions in the City of Cheongju (청주시 소재 치과의료기관의 장애인 접근성 확보를 위한 편의시설 실태조사)

  • Lim, Soon-Ryun;Kim, Sun-Ju
    • Journal of dental hygiene science
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    • v.11 no.3
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    • pp.235-241
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    • 2011
  • The purpose of this study was to examine the state of convenience facilities for the disabled in dental institutions in an effort to provide some information on the improvement of the accessibility of disabled people to dental institutions. A survey was conducted on the licensed dental institutions in the city of Cheongju, North Chungcheong Province, from March to April, 2011. The findings of the study were as follows. The dental offices were the majority of the dental institutions investigated, and for the establishment of the dental institutions. Some of the offices were established before 1990, and some were established in 2011. The time period of establishment varied within the offices. As for the location of the dental institutions within the buildings, they were mostly on the second or third floor. Regarding the convenience facilities for the disabled, the most installed convenience facilities were boardwalks and elevators, and the least installed ones were parking lots and restrooms for the disabled. The hospitals and public dental centers were equipped with all the convenience facilities investigated in this study. Overall, the dental institutions that were established in and after 2006 were equipped with more convenience facilities than the dental institutions that were established before 1990. And the dental clinics that were on the third or higher floor were more equipped with elevators and outdoor slope ways than those that were on the first or second floor. Therefore the revision of the law is required to urge even the primary dental institutions to compulsorily install the convenience facilities. The findings of the study are expected to make a contribution to the improvement of the accessibility of disabled people to dental institutions.

The Effect of Venture Capital Investment on Corporate Innovation Performance (벤처캐피탈 투자가 벤처기업 혁신성과에 미치는 영향)

  • Park, Jiyoung;Shin, Hyun-Han
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.15 no.1
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    • pp.1-15
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    • 2020
  • This study analyzes the innovation performance of venture firms according to existence of venture capital investment, and according to type and ownership of venture capital. Venture firms are IPO firms that are registered on KOSDAQ between the year 2000 and 2016. They are categorized as corporate venture capital-backed firms (CVC) and independent venture capital-backed firms (IVC). Using patent data from KIPO (Korean Intellectual Property Office), we employ the number of patents and the citations per patent as the measurement of the innovation output. We find the positive association between the venture capital-backed firms and the number of patents before going public. Corporate venture capital-backed firms are positively associated with the number of patents before and after IPO. However, we do not find strong evidence between the number of citations and the existence of venture capital investment or the type of venture capital. Lastly, we provide an inverse U-shaped relationship between the innovation performance and venture capital's ownership. In other words, the innovation output, both the number of patents and the number of citations, gradually increases as the venture capitalist's ownership increases, but also shows a decrease pattern, suggesting that the venture capitalist's ownership does not only spur the innovation but also gives a negative effect on venture firm's innovation output such as excessive intervention. Overall, we reveal that the most important factor for the innovation performance is not the existence of venture capital investment or the type of venture capital, but the ownership of the venture capitalist.

A Study for Predictions of In-Cylinder Residual Gas Fraction in SI Engines (SI 엔진 내부의 잔류가스 추정 기법에 관한 연구)

  • Kim, Sung-Cheol;Lee, Sang-Jin;Kim, Duk-Sang;Ohm, In-Yong;Cho, Yong-Seok
    • Proceedings of the KSME Conference
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    • 2001.11b
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    • pp.903-908
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    • 2001
  • Residual gas acts as a diluent which results in reducing the in-cylinder temperature as well as the flame speed, significantly affecting fuel economy, NOx emissions and combustion stability. Therefore it is important to determine the residual gas fraction as a function of the engine operating parameters accurately. However, the determination of the residual gas fraction is very sophisticated due to the unsteady state of induction and exhaust process. There has been little work toward the development of a generally applicable model for quantitative predictions of residual gas fraction. In this paper, a simple model for calculating the residual gas fraction in SI engines was formulated. The effects of engine operating parameters on the residual gas were also investigated. The amount of fresh air was evaluated through AFR and fuel consumption. After this, from the intake temperature and pressure, the amount of total cylinder-charging gas was estimated. The residual fraction was derived by comparing the total charging and fresh air. This results coincide with measured value very well.

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암스텔담은행(銀行)의 스미스 금융이론상(金融理論上)의 의의(意義)와 세계통화제도(世界通貨制度) 개선방향(改善方向)에 대한 시사(示唆)

  • Jwa, Seung-Hui
    • KDI Journal of Economic Policy
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    • v.10 no.4
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    • pp.19-37
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    • 1988
  • 본고(本稿)는 "스미스"의 "국부론(國富論)"에 인용된 17세기초의 암스텔담은행(銀行)(The Bank of Amsterdam)의 제도적(制度的) 특징(特徵)을 분석하고 동(同) 은행(銀行)의 "스미스"의 금융이론(金融理論)에 있어서의 의의(意義)를 분석함으로써 현재 논의중인 세계통화제도(世界通貨制度) 개선방향(改善方向)에 대한 시사점(示唆點)을 도출하고자 한다. 동(同) 은행(銀行)의 가장 중요한 특징은 첫째로 시장가격(市場價格)에 의한 은행화폐(銀行貨幣)의 금은교환(金銀交換)을 제도화함으로써 은행화폐(銀行貨幣)의 교환성유지(交換性維持)를 보장할 수 있었으며, 둘째로는 100% 금은지급준비(金銀支給準備)를 보유함으로써 은행화폐(銀行貨幣)의 초과발행(超過發行)을 방지하고 은행화폐(銀行貨幣)의 실질구매력(實質購買力)을 유지할 수 있었다는데 있다. 이상의 두가지 특징은 자유은행사상(自由銀行思想)을 바탕으로 하는 "스미스"의 미시금융이론상(微視金融理論上)의 은행제도(銀行制度)의 안전성유지(安全性維持)를 위한 진성어음원리 및 지폐의 교환성유지 주장의 약점을 보완하는 의미를 가질 뿐 아니라 현국제통화제도(現國際通貨制度) 개선방향(改善方向)에 대한 중요한 시사가 된다. 교환성(交換性)을 기본으로 하는 실물본위(實物本位) 국제통화제도(國際通貨制度)로의 개선을 위해서는 여러 가지 여건을 감안할 때 부분지급준비제도(部分支給準備制度), 시장가격(市場價格)에 의한 교환(交換), 그리고 지급준비율(支給準備率)의 법제화(法制化)를 도입하는 것이 바람직할 것이라는 시사점(示唆點)을 얻게 된다.

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RELIABILITY OF IMPEDANCE AUDIOMETRY IN OTITIS MEDIA WITH EFFUSION (고막천자를 시행한 소아 삼출성 중이염환자에 대한 Impedance 청각검사의 신뢰도)

  • 김희남;박기현;박인용;임상빈;이승철;홍지헌
    • Proceedings of the KOR-BRONCHOESO Conference
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    • 1987.05a
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    • pp.11.3-12
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    • 1987
  • 삼출성 중이염은 소아연령군의 이비인후과질환중 유병율이 가장 높은 질환의 하나로 1867년 Politzer가 최초로 기술하고 치료법을 소개한 이후 그 병인 및 치료법이 다양하게 연구 개발되어 왔으며 1950년대 및 1960년대 electroacoustic impedance unit의 발전에 따라 진단법에 많은 변혁이 이루어졌다. 연자들은 1981년 1월1일 부터 1986년 12월31일까지 삼출성 중이염으로 중이내 통기관유치술 및 고막천자를 시행한 15세 이하의 290명의 환자를 대상으로 tympanogram의 양상 및 술전 기골도차를 조사하여 중이내 삼출액의 유무 및 점성도의 예측도에 대하여 살펴 보았다. Tympanometric peak pressure (T. P. P.) 가 -50mm$H_2$O 미만이며 compliance가 0.4 c.c.미만인 영역을 B영역으로. T.P.P.가 -50mm$H_2$O 미만이며 compliance가 0.4 c.c. 이상인 영역을 C영역으로 정하였을 때 중이내 삼출액 유무의 예측도는 B영역이 87.5%. C영역은 81.48%였으며 삼출액이 장액성일 경우의 예측도는 B영역이 24.51%, C영역이 22.72%이었고, 삼출액이 점액성일 경우의 예측도는 B영역이 70.39%, C영역이 54.54%이었다. 연령을 15세 - 7세군과 6세이하의 군으로 세분하였을 경우에도 비슷한 결과를 얻었다.

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Chunking Using Automatic Constructed Syntactic Pattern Dictionary and Rule (자동 구축된 구문패턴사전과 규칙을 이용한 구묶음)

  • Im, Ji-Hui;Choe, Ho-Seop;Lee, Jung-Chul;Ock, Cheul-Young
    • Annual Conference on Human and Language Technology
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    • 2004.10d
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    • pp.35-39
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    • 2004
  • 본 논문은 실용적인 구문분석기의 전단계로서, 자동 구축된 구문패턴사전과 규칙을 이용하여 구묶음하는 방법을 제안한다. 우선 규칙은 구문분석 말뭉치(30,875어절)를 대상으로 자동 추출된 고빈도의 규칙(Rewriting Rule)을 본 논문에 맞게 수동으로 구축하였다. 규칙은 조건부, 행위부로 이루어진 이진 규칙(binary rule)의 형태를 이루며, 명사구(NP), 수식어구(AP, DP), 인용구(X), 용언구(VP, VC)을 대상으로 15개를 구축하였다. 그리고 구문패턴은 중심어와 중심어 선행 요소의 특성뿐만 아니라 중심어 후행 요소도 고려하여 형식화시킨 것으로, 중심어의 복합용언 여부에 따라 일반용언패턴과 본+보조용언패턴으로 구분한다. 부분적인 언어 현상의 처리보다는 실세계에서 사용되는 수많은 문장들에 내재되어 있는 매우 광범위한 언어 현상의 처리를 하기 위해, 구문패턴은 형태소주석 말뭉치(460만 어절)을 대상으로 자동 구축하였다. 구축된 구문패턴사전과 규칙을 이용하여 구묶음을 수행한 결과 정확율 83.09%가 나타났다.

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Sulfuric Acid Leaching of Zinc and Manganese from Spent Zinc-Carbon Battery (황산에 의한 폐망간전지로부터 아연과 망간의 침출)

  • Sohn Hyun-Tae;Ahn Jong-Gwan;Sohn Jeong-Soo;Park Kyoung-Ho;Park In-Yong
    • Resources Recycling
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    • v.11 no.4
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    • pp.44-50
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    • 2002
  • Characteristics on the sulfuric acid leaching of zinc and manganese from the spent zinc-carbon battery powders obtained by cushing and magnetic separation, were investigated with the variation of sulfuric acid concentration, reaction temperature, stir-ring speed and solid/liquid ratio. The sample powders were composed of Zn metal, ZnO, $MnO_2$ and $Mn_2$$O_3$. and it was found that the selective leaching of zinc was difficult in this system. At the condition of S/L ratio 1:10, IM H$_2$$SO_4$, $60^{\circ}C$ and 200 rpm, leaching rate of Zn and Mn are 92% and 35% respectively. The concentration of Zn and Mn in the leaching solution are 19.5 g/l, 7.8 g/l and pH of that solution is 0.75. It was confirmed at reducing agent should be added to increase e leaching rate of manganese with sulfuric acid.