• Journal of Pharmaceutical Investigation
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• 제27권2호
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• pp.125-131
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• 1997

Ethoxycarbonyloxyethyl ester of ceftezole (CFZ-ET) was synthesized as a prodrug by esterification of ceftezole (CFZ) with ethoxycarbonyloxyethyl chloride and was confirmed by spectroscopic analyses. CFZ-ET was more lipophillic than CFZ as assessed by n-octanol and water partition coefficients at various pH. CFZ-ET itself did not show any microbiological activity in vitro, but showed substaintial microbiological activity after oral administration of CFZ-ET, indicating that CFZ-ET is converted to microbiologically active metabolite, probably CFZ, in the body. When CFZ-ET was incubated in blood, liver and intestine homogenates of rabbits, liver homogenate showed the fastest conversion of CFZ-ET. CFZ-ET appears rapidly metabolized in the liver when given orally due to the hydrolysis of the ester to CFZ, the parent drug of CFZ-ET. In vivo metabolism of CFZ-ET to CFZ was confirmed in rabbit by HPLC analysis. CFZ-ET were higher than those in the serum samples taken after oral administration of equivalent amount of CFZ. Oral bioavailability of CFZ-ET was 1.5-fold higher than that of CFZ in rabbits because of enhanced lipophilicity and absorption. Based on these findings, CFZ-ET appears useful as a prodrug of CFZ to improve the oral bioavailability of CFZ.

• Journal of Pharmaceutical Investigation
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• 제30권2호
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• pp.107-112
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• 2000

The changes in pharmacokinetic parameters of tolbutamide, such as the area under the plasma concentration-time curve from time zero to time infinity (AUC) and elimination rate constant (Kel) were evaluated after oral administration of the drug to rabbits with acute and chronic alloxan-induced diabetes mellitus (AIDRs). After oral administration, the plasma concentrations of tolbutamide were significantly higher between 9 and 12 hr in chronic AIDRs compared with these in control rabbits. Therefore, the AUC was significantly greater in chronic AIDRs $(3,490{\pm}649\;versus\;5,020{\pm}1,030{\mu}gml{\cdot}hr)$. This could be due to inhibition of tolbutamide metabolism by liver in AIDRs since tolbutamide is essentially completely metabolized in liver. Impaired liver and kidney function in AIDRs were based on blood chemistry and tissue microscopy. The absorption rate constant and Kel were significantly slower in chronic AIDRs compared with those in control rabbits.

• Journal of Pharmaceutical Investigation
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• 제21권2호
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• pp.73-78
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• 1991

The influence of different suppository bases on the rectal absorption and the dissolution rate of propranolol was investigated. The bioavailability of propranolol in rectal suppository was determined by comparing the area under the concentration-time curves(AUC) for oral administration with rectal suppositories in rabbits. The dissolution $rates(D_{20min})$ were higher in such order as tween (TWE), witepsol H-15(WIT), polyethylene glycol(PEG) suppository. The maximum blood concentrations $(C_{max})$ were 803.9 ng/ml for TWE suppository, 770.2 ng/ml for WIT suppository, 281.2 ng/ml for PEG suppository and 177.1 ng/ml for oral administration. The relative bioavailabilities were 233.5% for TWE suppository, 218.1% for TWE suppository, 191.3% for PEG suppository. The correlation between $D_{20min}$ and AUC, the time for dissolution in 75% and $C_{max}$, the mean dissolution time and the mean residence time showed significant linear relationship respectively.

• Journal of Pharmaceutical Investigation
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• 제19권3호
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• pp.131-136
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• 1989

This study was attempted to investigate the dissolution rate and the bioavailability after oral administration of commercially available aspirin tablets in normal volunteers. The dissolution test was conducted in artificial gastric juice using basket method with three aspirin preparations (A, B and C) which were chemically equivalent. The results were as follows; The dissolution rate was higher in the order of three different brand B>A >C. Area under the blood concentration and peak blood concentration were larger in the order of brand A>B>C. Absorption rate constant and peak time were larger in the order of brand B>A>C, and there was a little difference in elimination rate constant and biological half-life. The correlation of the dissolution rate and absorption rate constant, as well as correlation of the dissolution rate and peak time showed significant linear relationship respectively. From the results of this experiment, it can be concluded that the bioavailability of aspirin tablets showed much difference according to commercial preparations, and that the bioavailability of aspirin tablets in human may be predicted from the results of dissolution rate studies.

• 문화기술의 융합
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• 제4권4호
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• pp.95-100
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• 2018

본 연구의 목적은 경증치매 환자를 대상으로 인지프로그램의 적용이 인지기능 개선에 미치는 효과를 알아보고자 하였다. 대상자는 경증치매를 가진 환자를 30명을 대상으로 실험을 하였다. 실험대상자들은 6주간 주3회 인지기능 재활프로그램을 적용하였고, 한국형 간이 정신상태검사(MMSE-K) 를 통해 실험전과 실험 후의 값을 평가하여 분석 하였다. 결과는 실험대상자들에서 한국형 간이 정신상태 검사의 평균이 증가하였으며 통계적 유의성이 있었다. 따라서, 경증치매 환자를 대상으로 하는 인지기능재활 프로그램은 치매환자의 인지기능을 개선하기위한 효과적인 중재이다.

• PNF and Movement
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• 제11권2호
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• pp.77-85
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• 2013

Purpose : The purpose of this study is to investigate the effects school business hospital-based integrated health education on learning transfer factor and level. Methods : This study conducted a questionnaire survey of 60 students at D college using metastatic diagnostic tool who took the integrated health education curriculum, statistical analysis utilized the SPSS 17.0 for window version. Results : On comparison of the details 5 clauses, 29 questions using LTSI, this study found that the integrated health education based on the school business hospital is effective for learning transfer. Conclusion : What the integrated health education based on clinic practice system at D college to overcome the limitations of health and medical line is effective for learning transfer and it will be useful to cultivate professional.

• PNF and Movement
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• 제11권1호
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• pp.43-54
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• 2013

Purpose : The purpose of this research was to verify the effects of the clinical practice and the educational satisfaction through internship program on students of health-related majors. Methods : We investigated 120 students using a self-reporting method with experience of internship program. A statistical analysis was performed using SPSS 17.0 for window version. Results : It showed that educational satisfaction had scored 4.18 in curriculum, 4.16 in environment, 4.16 in schedule, 4.32 in teaching and 3.82 in evaluation, 4.21 in satisfaction for clinical practice. Conclusion : It was revealed by this survey that the educational satisfaction of internship program in school hospital had higher score in curriculum, environment, schedule, evaluation, teaching and clinical practice. To maximize the effects of internship program, a clinical internship program in school hospital is needed and further research and attention are suggested.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송∙미디어공학회 2020년도 하계학술대회
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• pp.144-145
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• 2020

본 논문에서는 정밀한 3차원 복원 및 시점 합성을 위해 매칭 비용을 반복적으로 업데이트하는 Generalized Soft 3D Reconstruction (GenSoft3D) 알고리즘을 제안한다. 먼저 다시점 영상들과 카메라 자세정보가 주어지면 GenSoft3D는 볼륨 기반의 다시점 스테레오 매칭 알고리즘으로 시점별 초기 매칭 비용 볼륨 및 시차 맵을 계산한다. 그 후 정제 과정에서 각 시점은 모든 시차 맵을 이용하여 표면 확률 및 가시 확률을 계산한다. 표면 확률은 초기 매칭 비용 업데이트에 사용하며, 가시 확률은 폐색 영역의 정확한 시차를 계산하기 위해 사용된다. 해당 정제 과정을 일정 횟수 반복할 경우 시점별 고정밀의 시차 맵 획득이 가능하다. 또한 시차 맵의 정확도가 향상됨에 따라 정확한 시점 합성이 가능하다.

• 한국정보통신학회논문지
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• 제23권1호
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• pp.77-83
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• 2019

최근 의료 기술의 발달로 제1형 당뇨에 대한 진단율이 높아지면서 당뇨 환아가 증가하고 있다. 이러한 상황에서 환아들에게 당뇨 교육이 필요하지만, 효율적이고 적절한 교육 콘텐츠는 부재한 상황이다. 특히 이러한 교육은 혈당 변화 대처요령과 행동치료에 대한 꾸준하고 반복적인 학습이 필요하다. 따라서 본 연구에서는 10-11세 환아들의 눈높이에 맞춰 주도적으로 학습할 수 있는 에듀테인먼트 콘텐츠를 제안하고자 한다. 효과적인 학습을 위해 주사 실습콘텐츠를 구성하였고 반복적인 학습을 위해 하이브리드방식을 사용하였다. 사용성 테스트를 통해서 이러한 구성이 효과적임을 알 수 있었다. 본 연구는 상대적으로 당뇨 교육을 받기 어려운 지역의 환아들이 쉽게 접근 가능함과 동시에 앞으로 개발될 아동의 눈높이에 맞춘 당뇨 교육 콘텐츠 연구의 기반 연구로써 공헌할 것으로 기대된다.

• 인지과학
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• 제22권4호
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• pp.347-364
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• 2011

본 논문에서는 fMRI를 사용하여 뇌신경 반응을 측정한 후, 자극으로 주어진 $10{\times}10$ 크기의 이진 영상을 사전 정보 없이 복원하기 위해 비음수 행렬 분해를 이용한 자동화된 영상 기저 추출 방법을 제안한다. 영상 기저란 영상을 표현하는 기본 단위로, 기존 연구에서는 사전에 정의된 $1{\times}1$, $2{\times}1$, $1{\times}2$, $2{\times}2$의 크기를 갖는 총 361개의 영상 기저에 반응하는 뇌 신호를 분석하여 기저 영상으로 복원하고, 모든 기저에 대한 복원 결과를 선형 결합하여 최종복원 영상을 획득하였다. 사람이 사전에 정의한 영상 기저를 필요로 하는 기존 연구와는 달리, 본 연구에서는 비음수 행렬 분해를 기반으로 학습 데이터로 주어진 이진 영상을 가장 잘 표현하는 영상 기저를 자동 추출하였다. 자동으로 추출된 영상 기저를 사용하여 이진 영상을 복원한 결과, 기존 연구 방법보다 개선된 복원 정확도를 보였다.