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A study on antioxidant and anti-inflammatory effects of domestic blended essential oils (국내산 블렌딩 정유의 항산화 및 항염 효과 연구)

  • Jung, Sook Heui;Lee, Eun Kyung
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.6
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    • pp.1370-1382
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    • 2021
  • Previous studies have been conducted on domestic materials as a single extract. Research on complex mixtures for maximizing plant characteristics by individual extraction and potential interference with effects is insufficient. Therefore, this study confirmed the GC-MSD according to the extraction of essential oils for Agastache rugosa O. Kuntze(AR), Pinus densiflora Sieb. et Zuccarini(PD), Curcuma longa, Curcuma domestica(CC), Zingiber officinale Roscoe(ZR), Foeniculum vulgare Miller(FV), and Citrus medica L. var. sarcodactylis Swingle(CS). The cytotoxicity, antioxidant, and anti-inflammatory properties of the blending oil were confirmed to confirm its potential as a cosmetic material. As a result of analyzing GC-MSD aroma components, the main components were estragole of AR, à-Pinene for PD, Zingiberene for CC and ZR, Anethole from FV, and D-Limonene for CS. At a concentration of 100 uL/mL with no confirmed cytotoxicity, NO production was inhibited by 70.62%, DPPH radical scavenging activity was 64.03%, and ABTS radical scavenging activity was 89.55%. Through this, blended essential oil suggests the possibility of useful application as a raw material with antioxidant and anti-inflammatory effects in the cosmetic and food industries.

Delphi Research on Usability Test Framework of Metaverse Platform - Case of Roblox, Zepeto, and Gathertown (메타버스 플랫폼 사용성 평가체계 구축에 관한 델파이연구 - 로블록스, 제페토, 게더타운 사례를 중심으로)

  • Lee, Han Jin;Gu, Hyun Hee
    • The Journal of the Korea Contents Association
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    • v.22 no.9
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    • pp.179-193
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    • 2022
  • Amid the explosive growth of various metaverse platforms, there is no unified indicator to measure, analyze, and evaluate based on customer experience. Therefore, the usability evaluation factors in metaverse were identified through a heuristic methodology and literature review, to evaluate the metaverse, a two-to three-dimensional virtual world platform. A measurable system was established by subdividing 20 items in 5 fields, including user control, information structure, design and content, and usage environment, derived through Delphi technique. Based on this, after experiencing the actual contents of major metaverse platforms such as Roblox and Zepeto, usability was evaluated and comparative verification was conducted. As a result, it was estimated that metaverse user experience could be improved as its utility was derived relatively high in terms of user control and content. This study constitutes a theoretical contribution by extending the usability evaluation system, which has been widely used in the field of service design, to the fields of extended reality and mixed reality. At the same time, it has practical key findings of providing basic judgment standards to stakeholders in the metaverse field, as well as policy implications for digital capability enhancement and industry revitalization.

Sequential Use of COMSOL Multiphysics® and PyLith for Poroelastic Modeling of Fluid Injection and Induced Earthquakes (COMSOL Multiphysics®와 PyLith의 순차 적용을 통한 지중 유체 주입과 유발지진 공탄성 수치 모사 기법 연구)

  • Jang, Chan-Hee;Kim, Hyun Na;So, Byung-Dal
    • The Journal of Engineering Geology
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    • v.32 no.4
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    • pp.643-659
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    • 2022
  • Geologic sequestration technologies such as CCS (carbon capture and storage), EGS (enhanced geothermal systems), and EOR (enhanced oil recovery) have been widely implemented in recent years, prompting evaluation of the mechanical stability of storage sites. As fluid injection can stimulate mechanical instability in storage layers by perturbing the stress state and pore pressure, poroelastic models considering various injection scenarios are required. In this study, we calculate the pore pressure, stress distribution, and vertical displacement along a surface using commercial finite element software (COMSOL); fault slips are subsequently simulated using PyLith, an open-source finite element software. The displacement fields, are obtained from PyLith is transferred back to COMSOL to determine changes in coseismic stresses and surface displacements. Our sequential use of COMSOL-PyLith-COMSOL for poroelastic modeling of fluid-injection and induced-earthquakes reveals large variations of pore pressure, vertical displacement, and Coulomb failure stress change during injection periods. On the other hand, the residual stress diffuses into the remote field after injection stops. This flow pattern suggests the necessity of numerical modeling and long-term monitoring, even after injection has stopped. We found that the time at which the Coulomb failure stress reaches the critical point greatly varies with the hydraulic and poroelastic properties (e.g., permeability and Biot-Willis coefficient) of the fault and injection layer. We suggest that an understanding of the detailed physical properties of the surrounding layer is important in selecting the injection site. Our numerical results showing the surface displacement and deviatoric stress distribution with different amounts of fault slip highlight the need to test more variable fault slip scenarios.

Effect of Kegel Exercise Using Pressure Biofeedback Unit for 2 Weeks on Maximum Voluntary Ventilation and Abdominal Muscle Thickness (2주간 압력 생체되먹임 기구를 이용한 케겔 운동이 최대 자발적 환기량과 배 근육 두께에 미치는 영향)

  • Park, Han-Kyu;Lee, Jung-Hee;Kim, Cho-Hee;Yoon, Ju-Mi;Jo, Ye-Eun;Lee, So-Hee
    • Journal of The Korean Society of Integrative Medicine
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    • v.10 no.4
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    • pp.175-185
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    • 2022
  • Purpose : This study was conducted to determine the effect of Kegel exercise using a pressure biofeedback unit (PBU) for 2 weeks on maximum voluntary ventilation (MVV) and abdominal muscle thickness based on previous studies. Methods : The subjects of this study were 20 healthy female students in their 20s. Subjects were randomly assigned to two groups. Eleven subjects were assigned to the experimental group (EG) and 9 subjects were assigned to the control group (CG). Subjects measured MVV with a spirometer. In hooklying position, transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) of the dominant side were measured using ultrasound. For the measurement value, the average value of three times was adopted. After 2 weeks of intervention, the measurements were measured in the same way. In the EG, pelvic setting training using PBU was performed before Kegel exercise. The PBU was first placed at the waist in the Kegel exercise position and the starting pressure was set at 40 mmHg and adjusted to 60 mmHg through pelvic floor muscle contraction. After performing pelvic control using PBU, Kegel exercise was performed with 8 seconds of contraction, 8 seconds of relaxation, and 3 sets of 10 reps per set. A significance level of 𝛼=.05 was used to verify statistical significance. Results : In the variable of MVV, a significant increase was confirmed in the EG (p<.05). In the abdominal muscle thickness variable, significant increases were confirmed in IO and TrA in the EG (p<.05). In addition, a significant increase in IO was confirmed in the CG (p<.05). Significant increases in IO and TrA were confirmed between groups (p<.05). Conclusion : Based on the previous study, this study confirmed that Kegel exercise using a PBU had a positive effect on MVV and abdominal muscle thickness based on a 2-week intervention.

A Convergence Study on the Meaningful Activity Experience of the Elderly (노인의 의미 있는 활동에 관한 융합 연구)

  • Hwang, Hey-Jeong;Kang, Kyung-hee;Kim, Doo-Ree;Chang, Kyung-Hee;Kim, Kwang-Hwan
    • Journal of the Korea Convergence Society
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    • v.13 no.5
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    • pp.45-52
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    • 2022
  • The purpose of this study, a self-written questionnaire was conducted on 110 people aged 65 or older to analyze the factors of meaningful activities in elderly. As a research methods were student t-test and one-way ANOVA were conducted using the SPSS statistical program, and hierarchical regression analysis was performed to identify factors affecting meaningful activities of the elderly. As a result of the study, the highest score was 3.95±0.64 in "I think my work (activity) with my family is rewarding." As a result of hierarchical regression analysis, the factors affecting the meaningful activities of the elderly were 'resident' in both stages 1(β=-.308, p=.002), 2(β=-.330, p=<.001), and 3(β=-.281, p=<.001), and 'age(β=-.215, p=.026)' in the second stage, indicating that the factors affecting the meaningful activities of the elderly were 'resident' and 'age'. In conclusion, it's necessary to develop and apply a systematic program that prioritizes conversation and communication while working with families for the younger elderly(65-74). In the future, it will be necessary to systematically apply various programs for meaningful activities in old age.

Effects of Blood Indicators and Stress on Obesity by Gender in Korean Adults (성별에 따른 혈액 지표 및 스트레스가 비만에 미치는 영향)

  • Lee, Kyung Hee
    • Science of Emotion and Sensibility
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    • v.25 no.2
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    • pp.45-54
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    • 2022
  • This study aimed to investigate the effect of subjective factors (figure recognition and stress) and objective factors (blood biochemical parameters) on body mass index by gender difference in Korean adults. This study analyzed 3,343 subjects older than 20 years according to gender using the Sixth Korean National Health and Nutrition Examination Survey database. Specifically, male subjects had higher body mass index than female subjects (p < .001) and were more frequent in the obese group. Female subjects had higher stress and platelet score than male subjects (p < .001). Male subjects had significantly higher white blood cell counts (p < .001). The factors affecting the occurrence of obesity by gender difference was highly associated with subjective figure recognition (95% CI = 0.026~0.045, p < .001), stress (95% CI = 0.487~0.925, p = .015) and white blood count (95% CI = 1.232~1.392, p < .001) in females. These findings demonstrate a gender-specific difference in recognizing subjective factors and especially the objective factors of white blood cells and platelets affecting obesity. These results can be used for obesity education or fundamental data for establishing a nursing arrangement program for Korean adults.

Damage Analysis of Manganese Crossings for Turnout System of Sleeper Floating Tracks on Urban Transit (도시철도 침목플로팅궤도 분기기 망간크로싱의 손상해석)

  • Choi, Jung-Youl;Yoon, Young-Sun;Ahn, Dae-Hee;Han, Jae-Min;Chung, Jee-Seung
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.5
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    • pp.515-524
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    • 2022
  • The turnout system of the sleeper floating tracks (STEDEF) on urban transit is a Anti-vibration track composed of a wooden sleeper embedded in a concrete bed and a sleeper resilience pad under the sleeper. Therefore, deterioration and changes in spring stiffness of the sleeper resilience pad could be cause changes in sleeper support conditions. The damage amount of manganese crossings that occurred during the current service period of about 21 years was investigated to be about 17% of the total amount of crossings, and it was analyzed that the damage amount increased after 15 years of use (accumulated passing tonnage of about 550 million tons). In this study, parameter analysis (wheel position, sleeper support condition, and dynamic wheel load) was performed using a three-dimensional numerical model that simulated real manganese crossing and wheel profile, to analyze the damage type and cause of manganese crossing that occurred in the actual field. As a result of this study, when the voided sleeper occurred in the sleeper around the nose, the stress generated in the crossing nose exceeded the yield strength according to the dynamic wheel load considering the design track impact factor. In addition, the analysis results were evaluated to be in good agreement with the location of damage that occurred in the actual field. Therefore, in order to minimize the damage of the manganese crossing, it is necessary to keep the sleeper support condition around the nose part constant. In addition, by considering the uniformity of the boundary conditions under the sleepers, it was analyzed that it would be advantageous to to replace the sleeper resilience pad together when replacing the damaged manganese crossing.

Antioxidant Activity of Cannabidiol (CBD) and Effect on Its Proliferation in Human Dermal Papilla Cells (칸나비디올(CBD)의 항산화 활성 및 인간 모유두 세포 증식에 미치는 영향)

  • Soo Hyun Kim;Kyu-Sang Sim;Jung Yoon Cheon;Jae-Woong Jang;Su Jin Jeong;Ye Hei Seo;Hye Myoung Ahn;Bong-Geun Song;Gi-Seok Kwon;Jung-Bok Lee
    • Journal of Life Science
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    • v.33 no.3
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    • pp.234-241
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    • 2023
  • At present, many countries around the world are legalizing cannabis and its products, and research on various treatments using cannabis is being actively conducted. However, the cannabis plant contains other compounds whose biological effects have not yet been established. We investigated the effect of cannabidiol (CBD) on hair growth in human dermal papilla cells (HDPCs). 2,2'-Azino-bis (3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays were performed to determine the antioxidant activity of CBD. The HDPCs viability of CBD was examined via water-soluble tetrazolium salt (WST-1) assay. The expression of hair-loss-related markers in HDPCs by CBD treatment was analyzed by real-time PCR and western blotting. The DPPH, ABTS radical scavenging activity assay showed that CBD had superior antioxidant activities. In HDPCs, CBD increased cellular proliferation at concentrations without cytotoxicity. It also increased the expressions of fibroblast growth factor 1 (FGF1), fibroblast growth factor 7 (FGF7), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF). These results correlated with a decrease in the expression of inhibition-related factors, such as androgen receptor (AR) and transforming growth factor beta 1 (TGF-B1). Moreover, CBD resulted in a significant increase in the phosphorylation of AKT and extracellular signal-regulated kinase (ERK). Therefore, it is suggested that CBD may be a potential remedy for the treatment of alopecia.

A comparison of synthetic data approaches using utility and disclosure risk measures (유용성과 노출 위험성 지표를 이용한 재현자료 기법 비교 연구)

  • Seongbin An;Trang Doan;Juhee Lee;Jiwoo Kim;Yong Jae Kim;Yunji Kim;Changwon Yoon;Sungkyu Jung;Dongha Kim;Sunghoon Kwon;Hang J Kim;Jeongyoun Ahn;Cheolwoo Park
    • The Korean Journal of Applied Statistics
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    • v.36 no.2
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    • pp.141-166
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    • 2023
  • This paper investigates synthetic data generation methods and their evaluation measures. There have been increasing demands for releasing various types of data to the public for different purposes. At the same time, there are also unavoidable concerns about leaking critical or sensitive information. Many synthetic data generation methods have been proposed over the years in order to address these concerns and implemented in some countries, including Korea. The current study aims to introduce and compare three representative synthetic data generation approaches: Sequential regression, nonparametric Bayesian multiple imputations, and deep generative models. Several evaluation metrics that measure the utility and disclosure risk of synthetic data are also reviewed. We provide empirical comparisons of the three synthetic data generation approaches with respect to various evaluation measures. The findings of this work will help practitioners to have a better understanding of the advantages and disadvantages of those synthetic data methods.

Appropriateness Evaluation of Train Vibration Evaluation Method Considering Vibration Levels of Retaining Wall Adjacent to Railway Tunnels (철도터널과 인접한 흙막이 가시설의 진동 수준을 고려한 열차진동 평가방법의 적정성 평가)

  • Donghee Woo;Yeongjin Lee;Yongjae Song;Kangil Lee
    • Journal of the Korean GEO-environmental Society
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    • v.24 no.10
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    • pp.5-13
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    • 2023
  • With the recent increase in development projects centered on urban areas, the construction of building structures is increasing in areas adjacent to the urban railway operation section. In this case, since ground vibration is generated by the train in operation and affects the adjacent structure, the building structure needs appropriate vibration reduction against train vibration generated at the adjacent location from the desing phase. However, the vibration levels calculated vary depending on the train vibration evaluation method, which means that the implementation of vibration reduction may vary depending on the train vibration evaluation method. Therefore, this study calculated the vibration level according to ground conditions, tunnel depth and separation distance between vibration sources and adjacent structures using numerical analysis and train vibration evaluation methods, and compared them to designning phase. And the appropriate separation distance between the tunnel and the adjacent structure was evaluated by comparing the vibration level with the allowable standards. As a result of the study, the Ungar and Bender evaluation method is evaluated as the most appropriate among the train vibration evaluation methods, and the appropriate separation distance between the tunnel and the adjacent structure is evaluated to be more than 4.5D.