• Applied Chemistry for Engineering
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• 제26권1호
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• pp.111-115
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• 2015

Two new analogs of bestatin were prepared from $\small{D}$-leucine and $\small{D}$-valine in a stereoselective and efficient way. An aminopeptidase inhibitor bestatin shows significant biological effects on immunomodulation and is marketed for the treatment of acute myelocytic leukemia. The key intermediates, trans-oxazolidine methyl esters 2a and 2b, were obtained with more than 20 to 1 stereoselectivity in a one-pot procedure by the three cascade reactions between N-hydroxymethyl protected ${\alpha}$-amino aldehydes (4a and 4b) and phenylsulfonylnitromethane ($PhSO_2CH_2NO_2$) and the following in-situ ozonolysis. Basic hydrolysis of 2a and 2b, and then the peptide coupling with $\small{L}$-Leu-OMe produced the protected derivatives of two new bestatin analogs, 3a and 3b, respectively. The new isobutyl and isopropyl analogs of bestatin (1a and 1b) were produced in overall 51% and 38% yields, respectively, with high stereoselectivity from the corresponding protected ${\alpha}$-amino aldehydes 4 in a six-step process.

• Journal of Korean Society of Steel Construction
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• 제22권1호
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• pp.67-74
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• 2010

The cases of collapse of greenhouses in rural areas have been increasing due to the unexpected heavy snow load. Studies on how to prevent the collapse of greenhouses are rare, however, and the damages are repeated annually. This studysuggests two reinforcing methods: the use of ahigh-strength tapered module, and the addition of a pre-tension tie. The high-strength tapered section is installed where the bending moment is maximum. The design of a plastic greenhouse is controlled by its strength rather than its deflection. The shape of a greenhouse resembles that of an arch system, but its actual structural behavior is the frame behavior, because it is non-continually composed of a curved element (a beam) and vertical elements (columns). This system is too weak and slender to resist a vertical load, because an external load is resisted by the moment rather than by axial force. In this study, a new method, the installation of a temporary tie at the junction of the arch and the column only during snow accumulation, is proposed. The tie changes the action of the greenhouse frame to an arch action. The arch action is more effective when the pre-tension force is applied in the tie, which results in a very strong temporary structural system during snowfall. As a result of using this high-strength tapered section, the combined strength ratio of what? decreased from 10% to 30%. In the case of the additional reinforcement with a tie, it was reduced by half.

• Journal of Korean Society of Steel Construction
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• 제29권6호
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• pp.479-486
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• 2017

Steel beams with corrugated web have been widely used in the steel structures. However, it is challenging to weld the section between the corrugated web and the flange straight, which increases the cost of production. In order to solve this issue, steel beam with intaglio and embossed web (It is called an IEB) was invented. A web with embossment is produced by cold pressing and welded to flange by automatic welding machine. The loading tests were conducted to investigate the load-carrying capacity of IEB, and its test result was compared with that of H-shaped beam having a same size of flange and web. The test results of IEB series showed about 40% higher load capacities than H-shaped series. As a result of comparing the IEB specimen with Eurocodes for steel beams with corrugated web, all of specimens tested in this study did not meet the design value. Therefore, it is difficult to apply existing formula to IEB and new design formula should be presented for field application.

• Journal of the Korean Applied Science and Technology
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• 제35권3호
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• pp.595-605
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• 2018

In recent years, researches on organic-inorganic coating films have conducted a nanocomposite system composed of organic resin matrices having excellent flexibility and chemical stability and inorganic materials having excellent mechanical properties. The o-phenylphenoxyethyl acrylate (OPPEA) used as the acrylate monomer has a high refractive index of 1.58, and the bisphenol A ethoxylate diacrylate (BAEDA) has a low refractive index but improves the chemical stability of the organic resin. In addition, zirconia used as an inorganic material exhibits excellent durability and optical properties. In this study, the BAEDA contents in acrylate monomer were controlled to produce a film with suitable optical transparency. And optimum conditions were established by comparing the changes in surface properties of PET films detected with pencil hardness tester, Abbe's refractometer, and UV-vis spectrophotometer. The hydrophobicity and the dispersibility of zirconia in acrylate monomer were much improved after modification with ${\gamma}$-methacryloxypropyltrimethoxysilane (MPS), which is a silane coupling agent. And the existence of ester C=O bond peak at $1716cm^{-1}$ introduced by MPS through FT-IR ATR spectrophotometer confirmed the completion of surface modification of zirconia with MPS. In addition, the presence of silicon atom on the surface modified zirconia was also proved using X-ray fluorescence spectrometer. When the photocurable hybrid coating was prepared by introducing chemically modified zirconia into acrylate monomer, the refractive index of this coated PET film was improved by 1.2%, compared to the only acrylate coated PET film. The homogeneous distribution of zirconia in acrylate coating layer on PET film was also identified through SEM/EDS mapping analysis technique.

• Korean Chemical Engineering Research
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• 제40권6호
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• pp.669-675
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• 2002

The alkenylation of o-xylene with 1,3-butadiene to make OTP(ortho-tolyl Pentene) was carried out over liquid phase NaK alloy, Na metal and the metallic sodium dispersed on the specific support such as NaX and $Al_2O_3$. Liquid phase NaK alloy showed the improved conversion and selectivity when they were pretreated by ultrasound to increase the dispersion. For the case of metallic sodium, the induction period for the formation of homogeneous metal sodium solution with high dispersion was needed before the reaction. In the case of metallic sodium dispersed on support, more than 80 % conversion could be obtained without induction period regardless of supports used. But 85 % of the metallic sodium was resolved into the reaction mixture after reaction for 7 hours. The amount of byproducts, oligomers, produced from OTP and 1,3-butadiene increased with the amount of 1,3-butadiene introduced and the selectivity to OTP was in inversely proportional to the conversion.

• The Korean Journal of Zoology
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• 제39권4호
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• pp.337-351
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• 1996

Melatonin Is a multifunctional hormone secreted from the pineal gland in the middle of cerebrum and cerebellum. Its synthesis and release reflect photopedod;Photopedod is a yearly predictable ambient factor that most animals utilize as an environmental cue for maximum survival. Hamsters maintaln reproductive activity in summer during which day length exceeds night time. Upon the advent of autumnal equinox they undergo gonadal regression. The photoperiodic effects are prevented by removal of the pineal gland and restored by the timed repiacument of melatonin. The results suggest that melatonin constitutes part of control mechanism whereby environmental information is transduced to neuroendocrine signal responsIble for the functional integrity of the reproductive system. From the studies for the action site of melatonin following the treatment of photopedod or melatonin in the lesion of a spedflc portion of hypothalamus, suprachiasmatic nuclei and pars tuberalis are shown to be a consensus site for melatonIn. The action of melatonin. In the regulation of reproduction is largely unknown. It is mainly due to the lack of acute effect of melatonin on gonadotropin secretion. However, reduction of the gonadotropln release and augmentation of the hypothalamic gonadotropin-releasing hormone (GnRH) content by long-term treatment of melatonln Indicate that constant presence of melatonln may partidpate in the regulation of sexual activity via the GnRH neuronal system. The action mechanism by which melatonin exerts Its effect on GnRH neuron needs to be eluddated. The inability of opiold analogues to affect the reproductive hormones in sexually regressed animals by inhibftory photopedod and melatonin suggests that the opioldergic neuron may be a prime intervening mediator. Recent cloning of melatonin receptor will contribute to investigate its anatomical Identification and the action mechanism of melatonin on target tissues at the molecular level.

• Journal of Life Science
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• 제22권12호
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• pp.1614-1620
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• 2012

Transgenic rice plants with increased resistance to rice brown planthopper (Nilaparvata lugens St${\aa}$l) were generated by particle bombardment-mediated transformation of plants with a gene encoding snowdrop lectin (Galanthus nivalis agglutinin; GNA) under control of the rice Rubisco small subunit (rbcS) promoter.. A large number of transgenic rice plants containing the GNA gene were generated. The integration, expression, and inheritance of this gene in the $R_1$ and $R_2$ generations were demonstrated by Southern and western blot analyses. The plants contained one to five copies of the transgene. The GNA protein comprised approximately 0.01-2.0% of total soluble protein in the $R_1$ and $R_2$ transgenic plants. Insect bioassays and feeding studies showed that the GNA protein expressed in the $R_2$ transgenic rice plants reduced the survival of brown planthoppers. The introduction of GNA into rice plants therefore can help to control insect pests.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제19권11호
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• pp.750-757
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• 2018

The mechanically stabilized earth wall abutment is an earth structure using a mechanically stabilized earth wall and it uses in-extensional steel reinforcements having excellent friction performance. In order to analyze the pullout behavior of in-extensional steel reinforcements usually applied on the mechanically stabilized earth wall abutment, effects of stiffness and particle-size distributions of backfills and also horizontal spacings were considered in this study. As a result of parametric analyses, the highest pulling force acted on the uppermost reinforcement, and the stiffness and the particle-size distributions of the backfill significantly affected the pulling resistance of the reinforced soils. The internal friction angle of backfills should be at least 25 degrees, the coefficient uniformity factor should be at least 4, and the horizontal spacing of the uppermost steel reinforcement should be less than 25cm. Therefore, in order to secure the pullout resistance of the reinforced soil, it is necessary a properly spacing of reinforcement and more strict quality control for the backfill.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• 제47권7호
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• pp.469-478
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• 2019

Multirotor configurations such as VTOL and urban air mobility have been focused on today due to the high maneuverability. Aerodynamic and aeroacoustic characteristics of multirotor have much difference to those of a single rotor. In this study, a numerical analysis based on the free wake vortex lattice method is used for identifying the wake interaction effect. In order to compare the various configurations and operating conditions, the effects of the spacing between the rotors in hovering flight and the effects of the advancing ratio and the formation in forward flight are discussed. In the hovering flight, the unsteady loading of multirotor changes periodically and loading fluctuation increases as decreasing the spacing. It causes the variation in unsteady loading noise and the noise directivity pattern. In the forward flight, the difference in loading fluctuation and noise characteristics are observed according to the diamond and square formation of rotors. By comparing with results of single rotor analysis, multirotor configurations have different directivity pattern and amplitude of loading noise according to the location of each rotor. As a result, wake interaction effect becomes a highly important factor for aerodynamic and aeroacoustic analysis according to multirotor configurations and operating conditions.

• Korean Journal of Heritage: History & Science
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• 제52권2호
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• pp.106-121
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• 2019

Sustainable development in society has become the center of focus in many fields such as industry, environment, health, culture, etc. Considering that the concept of heritage involves understanding it as a 'resource' to improve the quality of people's lives, sustainability is an important goal that heritage policy has to achieve. Adopting the definition of sustainability in the 1987 Brundtland Report, this paper defines the concept of sustainability with respect to heritage, as well as their respective roles. Following that, three action principles are presented: value-based conservation, rational decision-making, and community involvement. Two cases demonstrating how the three principles should be practiced in managing change are then illustrated. Considering that heritage can play its role as a resource once its significance is protected, this paper argues that value-based rational decision-making is of paramount importance and the first principle. Conservation aims to manage change by practicing a cyclic process of value identification, value sustaining, and value dissemination. Therefore, this paper argues that all processes should be connected in the context of heritage values. A rational decision-making process practicing value-based conservation is then suggested. This paper argues that rational decision-making can only be practiced once values are identified by objective criteria and managed by rational judgment upon impact assessment. Community involvement, the third principle, is necessary to realize value-based conservation and rational decision-making. Recognizing that a community is a beneficiary of heritage and a creator of a beneficial process at the same time, it discusses the role of community and the importance of this role in policies for the sustainability of heritage. This paper concludes with a set of recommendations to improve policies after examining the two decision-making cases.