• Journal of Life Science
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• v.21 no.4
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• pp.481-485
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• 2011

T0901317 is a potent synthetic ligand for liver X receptor (LXR, NR1H2/3), a member of the nuclear receptor superfamily that functions as a transcription factor. However, T0901317 has been also reported to modulate the activity at least four other nuclear receptors (NRs), acting as agonists for farnesoid X receptor (FXR, NR1H4) and pregnane X receptor (PXR, NR1I2) and as antagonists for androgen receptor (AR, NR3C4) and retinoid-related orphan receptor-${\alpha}$ (ROR-${\alpha}$, NR1F1). We report here that T0901317 can also function as an inhibitor for constitutive androstane receptor (CAR, NR1I3). Since CAR is a major player of xenobiotic and cholesterol metabolism in the liver, along with PXR, FXR and LXR, which are reported to be regulated by T0901317, this further complicates the interpretation of potential results with T0901317 in liver cells.

• Tuberculosis and Respiratory Diseases
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• v.57 no.1
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• pp.78-81
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• 2004

A 73-year-old man who had undergone a right pneumonectomy and open window thoracostomy due to tuberculous empyema, presented with purulent discharge from the previous operation site. The computed tomography of the chest showed diffuse pleural thickening and a low attenuated lesion, with air bubbles in a dependent portion of the right hemithorax. These air bubbles were revealed to be due to 7 pieces of retained surgical gauze by flexible bronchoscopy. The patient showed marked clinical improvement with diminished purulent discharge after removal of the foreign bodies.

• Tribology and Lubricants
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• v.31 no.6
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• pp.281-286
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• 2015

Automotive transmission systems are assembled with a large number of gears and shafts, and rolling bearings are used to ensure their smooth operation. Gear oil in the gear box contains solid particles such as wear debris from contacting gears and metallic chips. This particle-enriched lubricating oil can cause premature failure of the rolling bearings. Research aimed at improving the service life of these rolling bearings has been confined mainly to design and lubrication of the inner/outer rings and the rolling elements. In this paper, we redesigned the shape of the cage pocket of a deep groove ball bearing to reduce the premature failure due to particle contamination. Test bearings are assembled with this new cage design containing a hole punched in the cage pocket. Endurance tests are carried out using the contaminated lubricating oil with miracle grid as hard particle. The duration and damaged bearing component shapes are compared for two different cages. The B₁₀ life of bearing with new cage is increased by about 66% compared to the conventional cage. This is because the hard particles can be easily discharged through the pocket hole without staying for a long time in the lubrication regions. This greatly decreases abrasive wear and dents on the highly stressed ball bearing surfaces. Therefore, the cage design of this study, containing a pocket hole, can significantly delay the premature failure of rolling bearings and improve the endurance life.

• Journal of the Korean Society for Nondestructive Testing
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• v.28 no.4
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• pp.315-322
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• 2008

Valves in power plants are leaking internally by various damages including insertion of foreign objects on seat, seat crack, defects and fatigue crack of stem packing or welds etc. due to severe operating conditions such as high temperature and high pressure for extended period time. Acoustic emission(AE) technology should be applied in order to diagnose precisely and evaluate these valve internal leak. In this paper, results of studies which have accomplished in actual power plant are presented. We have analyzed background noise, AE signal level and frequency spectrum through laboratory tests on the basis of various actual conditions in power plant, and also have considered evaluation methods on the background noise, AE properties and the detectable minimum leak rate according to valve leak conditions through comparing with results of field tests in power plant. As a result of these studies, we conformed that evaluation of internal leak conditions including discrimination of leak or not, and the detectable minimum leak rate is possible, and also it is expected to contribute to safe operation and prevention of energy loss in power plants.

• Allergy, Asthma & Respiratory Disease
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• v.6 no.6
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• pp.303-309
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• 2018

Purpose: Foreign body aspiration in children is emergent and can cause serious complications. This study aims to show the clinical characteristics of foreign body aspiration and to analyze the clinical cases of delayed diagnosis to predict and prevent complications. Methods: We retrospectively reviewed the medical records of 63 children (48 in Inha University Hospital and 15 in Gachon University Gil Medical Center) who were diagnosed with foreign body aspiration through bronchoscopy from 1996 to 2017 in Incheon City, and analyzed clinical characteristics. Patients were divided into 3 groups: those were diagnosed within 24 hours, delayed after 24 hours, or delayed more than 7 days according to time elapse from the time of foreign body aspiration, and clinical characteristics of each group were compared. Results: Aspiration occurred in 58.7% at 1 year and 15.9% at 2 years. Cough (65.1%) and coarse breathing sound (41.3%) were most common, and radiologic findings were commonly presented as emphysema on the affected side (41.3%). Nuts were most common (42.9%), and there was no difference in the frequency between the right and left main bronchi. The documented history of foreign body aspiration was more frequently found in the early diagnosed group; however, sputum, fever, and complications were more frequent in the delayed diagnosed group. Conclusion: If a patient with respiratory disease has persistent fever or sputum, foreign body aspiration should be suspected.

• Korean Journal of Bronchoesophagology
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• v.15 no.1
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• pp.28-34
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• 2009

Background and Objectives: Foreign bodies of upper aerodigestive tract are common problem for primary care physicians. Delayed diagnosis or failure of removal might cause fatal problemsand complications. Therefore proper diagnosis and management is imperative. In this study, we described clinical features of upper aerodigestive tract foreign body, and analyzed efficacy of different management modality. Materials and Methods: 250 cases of foreign bodies in the esophagus and trachea, between Jan. 1998 through Jan. 2009 has been retrospectively analyzed. A total of 24 cases and 226 cases had been found each as airway foreign bodies and esophageal foreign bodies. The clinical features are described and treatment outcomes, prognosis, and rate of complications of each management modality have been compared. Results: In airway foreign bodies, ventilating bronchoscopy yielded better results, 19 success out of 19 trials than fiberoptic bronchoscopy, 3 success out of 5 trials. Hospitalization days after removal of foreign body didn't show difference between two treatment modalities, although patients who had ventilating bronchoscopy had gone through general anesthesia. And there was no complication after removal of foreign body. In esophageal foreign bodies, rigid esophagoscope yielded better results, 99% of successful removal rate, compared to the EGD, only 78% of successful removal rate. There was no difference of hospitalization days between two modalities. And complication rate was even low in patients who had done rigid esophagoscopic foreign body removal. Conclusion: In upper aerodigestivetract foreign body. Rapid diagnosis and successful foreign body removal is important. Removal by rigid scope(ventilating bronchoscope, rigid esophagoscope) revealed less failure in both airway and esophageal foreign bodies.

• Journal of IKEEE
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• v.27 no.1
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• pp.122-126
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• 2023

In this paper, a control system for a complex microbial incubator was proposed. The proposed control system consists of a control unit, a communication unit, a power supply unit, and a control system of the complex microbial incubator. The controller of the complex microbial incubator is designed and manufactured to convert analog signals and digital signals, and control signals of sensors such as displays using LCD panels, water level sensors, temperature sensors, and pH concentration sensors. The water level sensor used is designed and manufactured to enable accurate water level measurement by using the IR laser method with excellent linearity in order to solve the problem that existing water level sensors are difficult to measure due to foreign substances such as bubbles. The temperature sensor is designed and used so that it has high accuracy and no cumulative resistance error by measuring using the thermal resistance principle. The communication unit consists of two LAN ports and one RS-232 port, and is designed and manufactured to transmit signals such as LCD panel, PCT panel, and load cell controller used in the complex microbial incubator to the control unit. The power supply unit is designed and manufactured to supply power by configuring it with three voltage supply terminals such as 24V, 12V and 5V so that the control unit and communication unit can operate smoothly. The control system of the complex microbial incubator uses PLC to control sensor values such as pH concentration sensor, temperature sensor, and water level sensor, and the operation of circulation pump, circulation valve, rotary pump, and inverter load cell used for cultivation. In order to evaluate the performance of the control system of the proposed complex microbial incubator, the result of the experiment conducted by the accredited certification body showed that the range of water level measurement sensitivity was -0.41mm~1.59mm, and the range of change in water temperature was ±0.41℃, which is currently commercially available. It was confirmed that the product operates with better performance than the performance of the products. Therefore, the effectiveness of the control system of the complex microbial incubator proposed in this paper was demonstrated.

• Fire Science and Engineering
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• v.27 no.1
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• pp.39-45
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• 2013

This study analyzes the explosion hazard of dry cleaning solvent recovery machine in laundry shop in two aspects, i.e. combustible and ignition source, and determines the explosive conditions of this machine by conducting mockup explosion tests repeatedly, varying conditions and using real dry cleaning solvent recovery machines. As to combustibles, two kinds of combustibles used widely in Korea have been selected and tested. The flash points, LEL's, and saturation vapor pressures of those combustibles have been measured, and their explosion specific curves have been drawn, based on the results of the measurements, so that the explosion risks of those materials may be determined, depending on the temperatures. Potential voltages generated from materials for laundry and foreign materials of metals have been assumed to be the ignition sources in this application, and their potential voltages have been measured, depending on temperature, humidity, and antistatic agent, by using real materials for laundry and a potential voltage measuring device. Tests have been conducted, varying the quantities, concentrations, and operating temperatures of materials for laundry. As a result, explosions have not been generated with potential voltages of materials for laundry, but explosions have been observed when applying artificial spark energy of 2.0 mJ.

• Conservation Science in Museum
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• v.22
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• pp.53-68
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• 2019

Two lime-soil mixture barrier tombs were excavated from the tomb complex of the Woo Family of the Danyang Wu clan dating to the Joseon dynasty in Godeung-dong, Seongnam-si, Gyeonggi-do. Relevant records offer information for more precisely dating these tombs and identifying their occupants. Tomb No. 4, in which a married couple was interred, has a corbeled square ceiling and inscriptions and paintings on its outer walls. The conservation treatment and an infrared inspection revealed that they were intended to express mourning. Tomb No. 6 has a corbeled rectangular ceiling and a single individual interred within. As the basic structure of the tomb was partially damaged in the process of disassembling it while moving the burial site, it was planned to exhibit the tomb outdoors after the remains and relics are collected. However, as the conservation treatment revealed the presence of funeral fans and pitch, and since the remaining structure clearly demonstrates the features of lime-soil mixture barrier tombs from the Joseon dynasty, the plan was changed following a meeting of an advisory council that decided in favor of presenting the tomb indoors. According to the analysis, the pitch is assumed to be resin of a rather low purity due to the immixture of foreign substances. The two tombs are expected to serve as important materials for related research, such as changes by period in the forms of Joseon-era tombs.

• International Journal of Highway Engineering
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• v.12 no.4
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• pp.101-110
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• 2010

In this paper, it has been studied about the CRCO to maintain or rehabilitate the aged JCP. The CRCO and JCO was constructed at useless section of Seo-Hae-Ahn express highway in South Korea. The performance evaluation was conducted. Especially, it was focused on the roll of longitudinal reinforced steels inserted into the CRCO. On crack survey results from field construction section, the reflection cracks at joint of the existing pavement occurred in CRCO. However, due to the constraints of longitudinal reinforced steels, crack width was small. Total crack length and quantity in the CRCO more than that in the JCO. And crack spacing in the CRCO was narrower than it in the CRCP. Through the bonding strength test results, if the cold milling and cleaning as well as surface treatment is applied, there will be no debonding problem at interlayer in the early age. From analysis of the horizontal behavior at the joint, the longitudinal reinforced steels constrained crack width which became wider than initial state over time. Also, that steel in the CRCO reduced the horizontal movement due to temperature variation(4 times than that in the JCO). But, if interface is debonded, the roll decreased. Vertical VWG data showed that CRCO did not occur debonding problem at steel location, but there was some problem in JCO. It was confirmed by field coring. The tensile strain appeared in the CRCO, But the compressive strain occurred in the JCO in early age. Through the FWD test result, deflection in the CRCO was less than that in the JCO. And K value in the CRCO was greater than it in the JCO.