• The Korean Journal of Nuclear Medicine
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• v.30 no.4
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• pp.484-492
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• 1996

To detect ischemic tissue in experimental model of cerebral ischemia made by middle cerebral artery(MCA)-occlusion, we acquired triple image of $^{99m}Tc$-glucarate, [$^{18}F$]fluoro-deoxyglucose (FDG), and 2,3,5- triphenyltetrazolium (TTC) staining. We made cerebral infarction either with reperfusion (after occlusion of 2 hours) or without reperfusion in 10 Sprague-Dawley rats by inserting thread to MCA through internal carotid artery. After 22 hours, we injected 740 MBq of $^{99m}Tc$-glucarate and 55.5 MBq of [$^{18}F$]FDG through tail vein. Each 1 mm slice of rat brains was frozen and exposed to imaging plate for 20 minutes in freezer to get an [$^{18}F$]FDG image. After 20 hours enough to fade radioactivity of [$^{18}F$]FDG, the slices were again imaged by BAS1500 for $^{99m}Tc$-glucarate uptake. Finally, these brain tissues were stained with TTC. Semi-quantitative visual analysis was done by grading 0 to 3 points according to the degree of uptakes($^{99m}Tc$-glucarate) and decreased uptakes([$^{18}F$]FDG and TTC). Ten rats survived with neurologic symptoms. TTC staining confirmed the development of infarction. The size of the infarction was relatively larger in the group without reperfusion. [$^{18}F$]FDG images were similar to TTC-stained images. However, we found regions with intermediate uptake which were not stained with TTC. We found regions with intermediate [$^{18}F$]FDG uptake where TTC staining was normal. $^{99m}Tc$-glucarate uptake was round only in TTC non-stained region. In the TTC stained regions, there were no uptake of $^{99m}Tc$-glucarate. We could not find clear relation between $^{99m}Tc$-glucarate uptake with [$^{18}F$]FDG uptake. This was partly because percent uptake of $^{99m}Tc$-glucarate was so small (less than 1 percent of injected dose) and because there were quite heterogeneity of patterns of [$^{18}F$]FDG uptake and TTC. With these findings, we could conclude that $^{99m}Tc$-glucarate were taken up only in part of ischemic tissues which were proven to be nonviable. The establishment of MCA-occluded rat model with or without reperfusion and triple imaging for $^{99m}Tc,\;^{18}F$ and TTC helped the characterization of $^{99m}Tc$-glucarate uptakes. Further work is needed to clarify the meaning or diversities or [$^{18}F$]FDG and TTC and their relation with $^{99m}Tc$-glucarate.

• Korean Journal of Agricultural and Forest Meteorology
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• v.8 no.3
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• pp.190-198
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• 2006

Radiation use efficiency (RUE), the amount of biomass produced per unit intercepted photosynthetically active radiation (PAR), constitutes a main part of crop growth simulation models. The objective of the present study was to evaluate the variation of RUE of rice plants under various nitrogen nutritive conditions. from 1998 to 2000, shoot dry weight (DW), intercepted PAR of rice canopies, and nitrogen nutritive status were measured in various nitrogen fertilization regimes using japonica and Tongil-type varieties. These data were used for estimating the average RUEs before heading and the relationship between RUE and the nitrogen nutritive status. The canopy extinction coefficient (K) increased with the growth of rice until maximum tillering stage and maintained constant at about 0.4 from maximum tillering to heading stage, rapidly increasing again after heading stage. The DW growth revealed significant linear correlation with the cumulative PAR interception of the canopy, enabling the estimation of the average RUE before heading with the slopes of the regression lines. Average RUE tended to increase with the increased level of nitrogen fertilization. RUE increased approaching maximum as the nitrogen nutrition index (NNI) calculated by the ratio of actual shoot N concentration to the critical N concentration for the maximum growth at any growth stage and the specific leaf nitrogen $(SLN;\;g/m^2\;leaf\;area)$ increased. This relationship between RUE (g/MJ of PAR) and N nutritive status was expressed well by the following exponential functions: $$RUE=3.13\{1-exp(-4.33NNNI+1.26)\}$$ $$RUE=3.17\{1-exp(-1.33SLN+0.04)\}$$ The above equations explained, respectively, about 80% and 75% of the average RUE variation due to varying nitrogen nutritive status of rice plants. However, these equations would have some limitations if incorporated as a component model to simulate the rice growth as they are based on relationships averaged over the entire growth period before heading.

• The Korean Journal of Nuclear Medicine
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• v.38 no.6
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• pp.528-531
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• 2004

Purpose: PET has some disadvantage in the imaging of small animal due to poor resolution. With the advent of microPET scanner, it is possible to image small animals. However, the image quality was not good enough as human image. Due to larger brain, cat brain imaging was superior to mouse or rat. In this study, we established the cat brain infarction model and evaluate it and its temporal charge using microPET scanner. Materials and Methods: Two adult male cats were used. Anesthesia was done with xylazine and ketamine HCl. A burr hole was made at 1cm right lateral to the bregma. Collagenase type IV 10 ${\mu}l$ was injected using 30 G needle for 5 minutes to establish the infarction model. $^{18}F$-FDG microPET (Concorde Microsystems Inc., Knoxville, TN) scans were performed 1, 11 and 32 days after the infarction. In addition, $^{18}F$-FDG PET scans were performed using human PET scanner (Gemini, Philips medical systems, CA, USA) 13 and 47 days after the infarction. Results: Two cat brain infarction models were established. The glucose metabolism of an infarction lesion improved with time. An infarction lesion was also distinguishable in the human PET scan. Conclusion: We successfully established the cat brain infarction model and evaluated the infarcted lesion and its temporal change using $^{18}F$-FDG microPET scanner.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.6
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• pp.785-795
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• 2018

The International Maritime Organization (IMO) has recognized the risk of hull fouling and announced '2011 Guidelines for the control and management of ship's biofouling to minimize the transfer of invasive aquatic species'and is planning international regulations to enforce them in the future. In this study, to effectively respond to future international regulation, we introduce the case of leading countries related to management of hull fouling and also investigate environmental risk assessment techniques for in-water cleaning. Australia and New Zealand, the leading countries in hull fouling management, have established hull fouling regulations through biological and chemical risk assessment based on in-water cleaning scenarios. Most European countries without their government regulation have been found to perform in-water cleaning in accordance with the IMO's hull fouling regulations. In the Republic of Korea, there is no domestic law for hull fouling organisms, and only approximately 17 species of marine ecological disturbance organisms, are designated and managed under the Marine Ecosystem Law. Since in-water cleaning is accompanied by diffusion of alien species and release of chemical substances into aquatic environments, results from biological as well as chemical risk assessment are performed separately, and then evaluation of in-water cleaning permission is judged by combining these two results. Biological risk assessment created 40 codes of in-water cleaning scenarios, and calculated Risk Priority Number (RPN) scores based on key factors that affect intrusion of alien species during in-water cleaning. Chemical risk assessment was performed using the MAMPEC (Marine Antifoulant Model to Predict Environmental Concentrations), to determine PEC and PNEC values based on copper concentration released during in-water cleaning. Finally, if the PEC/PNEC ratio is >1, it means that chemical risk is high. Based on the assumption that the R/V EARDO ship performs in-water cleaning at Busan's Gamcheon Port, biological risk was estimated to be low due to the RPN value was <10,000, but the PEC/PNEC ratio was higher than 1, it was evaluated as impossible for in-water cleaning. Therefore, it will be necessary for the Republic of Korea to develop the in-water cleaning technology by referring to the case of leading countries and to establish domestic law of ship's hull fouling management, suitable for domestic harbors.

• Economic and Environmental Geology
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• v.39 no.2 s.177
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• pp.129-149
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• 2006

Previously published stratigraphic, sedimentologic, paleontologic, paleomagnetic and geophysical data are reviewed to make an understanding on the tectonic evolution of the Cretaceous Gyeongsang (Kyongsang) basin, southeast Korea. A stratigraphic framework and a tectonic model on the formation and deformation of the Gyeongsang Basin are newly proposed on the basis of integration these data with magmatism and mineralization ages in the basin. A newly proposed stratigraphic framework indicates that strata in the basin can be subdivided into five distinct stratigraphic units that represent pre-rifting, syn-rifting, inversion I, II, and III stages. The Gyeongsang Basin was formed initially as a pre-rifting stage due to north-south extension in the Late Jurassic prior to a syn-riftins stage that resulted from east-west extension during the Early Cretaceous. In the Late Cretaceous, the basin was deformed by three-staged sequential deformation of north-south, northwest-southeast, and east-west compressions. The tectonic history of the basin has been largely controlled by the change of motion of the Izanagi Plate from north to northwest during the Cretaceous. In the early Cretaceous, the Izanagi Plate began to subduct northward beneath the Eurasian Plate and caused the left-lateral strike-slip fault systems in the southern part of the peninsula. The left-lateral wrenching of these fault systems was causally linked to development of pull-apart basins, such as the Gyeongsang Basin in the southeastern part of the peninsula. However, northwestward movement of the Izanagi Plate during the Late Cretaceous probably led to the extensive volcanism as well as sequential deformations in the basin. The stratigraphic and tectonic model, which is newly proposed as a result of this study, may be expected to enhancing the efficiency for exploration and exploitation of useful mineral resources in the basin as well as establishing geologic history in the Cretaceous Gyeongsang Basin. Together with the spatial and temporal correlation of the Cretaceous basins in adjacent areas, this stratigraphic and tectonic model provides a new geologic paradigm to delineate the sophisticated tectonic history of East Asia turing the Cretaceous.

• Journal of Biomedical Engineering Research
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• v.25 no.5
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• pp.421-430
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• 2004

Clinically, it is almost impossible for a physician to distinguish subtle changes of frequency spectrum by using a stethoscope alone especially in the early stage of thrombus formation. Considering that reliability of mechanical valve is paramount because the failure might end up with patient death, early detection of valve thrombus using noninvasive technique is important. Thus the study was designed to provide a tool for early noninvasive detection of valve thrombus by observing shift of frequency spectrum of acoustic signals with computer aid diagnosis system. A thrombus model was constructed on commercialized mechanical valves using polyurethane or silicon. Polyurethane coating was made on the valve surface, and silicon coating on the sewing ring of the valve. To simulate pannus formation, which is fibrous tissue overgrowth obstructing the valve orifice, the degree of silicone coating on the sewing ring varied from 20％, 40％, 60％ of orifice obstruction. In experiment system, acoustic signals from the valve were measured using microphone and amplifier. The microphone was attached to a coupler to remove environmental noise. Acoustic signals were sampled by an AID converter, frequency spectrum was obtained by the algorithm of spectral analysis. To quantitatively distinguish the frequency peak of the normal valve from that of the thrombosed valves, analysis using a neural network was employed. A return map was applied to evaluate continuous monitoring of valve motion cycle. The in-vivo data also obtained from animals with mechanical valves in circulatory devices as well as patients with mechanical valve replacement for 1 year or longer before. Each spectrum wave showed a primary and secondary peak. The secondary peak showed changes according to the thrombus model. In the mock as well as the animal study, both spectral analysis and 3-layer neural network could differentiate the normal valves from thrombosed valves. In the human study, one of 10 patients showed shift of frequency spectrum, however the presence of valve thrombus was yet to be determined. Conclusively, acoustic signal measurement can be of suggestive as a noninvasive diagnostic tool in early detection of mechanical valve thrombosis.

• Journal of KIISE:Computing Practices and Letters
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• v.9 no.2
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• pp.146-157
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• 2003

Our experience with Internet-based scientific collaboratories indicates that they need to be user-extensible, allow users to add tools and objects dynamically to workspaces, per mit users to move work dynamically between private and shared workspaces, and be easily accessible on the Internet. We present the software architecture of a development environment, called Collaboratory Builder's Environment(CBE), for building collaboratories to meet such needs. CBE provides user extensibility by allowing a collaboratory to be constructed as a collection of collaborative applets. To support dynamic reconfiguration of shared workspaces, CBE uses the metaphor of room that can contain applets, users, and arbitrary data objects. Rooms can be used not only for synchronous collaboration but also for asynchronous collaboration by supporting persistence. For the access over the Internet room participants are given different roles with appropriate access rights. A prototype of the model has been implemented in Java and can be run from a Java-enabled Web browser. The implemented system had been used by 95 users including 79 space scientists around the world in a scientific campaign that ran for 4 days. The usage evaluation of the campaign is also presented.

• Membrane Journal
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• v.22 no.4
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• pp.235-242
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• 2012

Ammonium perchlorate (AP) is primarily derived from the process of liquid incineration treatment when dismantling a solid rocket propellant. A series of batch dead-end nanofiltration (NF) and reverse osmosis (RO) membrane experiments were conducted to explore the retention mechanisms of AP under various hydrodynamic and solution conditions. Low levels of silicate type of siloxane had been detected through the GC/MS and FTIR analysis of liquid solutions extracted from solid ammonium perchlorate composite propellant (APCP). It is indicated that NF/RO membranes fouling in the presence of APCP was mainly attributed to the AP interactions because the concentration of silicate type of siloxane was negligible compared to that of AP. The osmotic pressure of AP was presumably resulted in the flux declines ranging from 13 to 17% in the case of the application of low-pressure (551 and 896 kPa for NF and RO) compared to those in application of high-pressure. The retention of AP by NF/RO membranes significantly varied from approximately 10 to 70% for NF and 26 to 87% for RO, depending on the operating and solution water chemistry conditions. The results suggested that retention efficiency of AP was fairly increased by reducing concentration polarization (i.e. application of low-pressure and stirring speed of 600 rpm) and increasing the pH of a solution. The result of this study was also consistent with the previous modeling of 'solute mass transfer of NF/RO membranes' and demonstrated that hydrodynamic and solution water chemistry conditions are to be a key factor in the retention of AP by NF/RO membranes.

• Journal of the Earthquake Engineering Society of Korea
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• v.13 no.5
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• pp.11-21
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• 2009

Considering that the weight of a biaxial hollow slab system is not increased with an incremental increase in its thickness, and that the flexural stiffness of a biaxial hollow slab is not significantly lower than that of a general solid slab, there has been a growing need for biaxial hollow slab systems, because long span structures are in great demand. In a long span structure, the problem of vibration of floor slabs frequently occurs, and the dynamic characteristics of a biaxial hollow slab system are quite different from the conventional floor systems. Therefore, in this study, the floor vibration of a biaxial hollow slab system subjected to walking load is investigated in comparison with a conventional floor slab system. For the efficiency of time history analysis, an equivalent plate slab model that can precisely represent the dynamic behavior of a biaxial hollow slab system is used. From the analytical results, it was determined that vibration of a biaxial hollow slab system subjected to walking load is evaluated as "office-level vibration," according to the classifications of the architectural institute of Japan and ANSI.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.159-159
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• 2017

스마트 시설환경은 대표적으로 원예, 축산 분야 등 여러 형태의 농업현장에 정보 통신 및 데이터 분석 기술을 도입하고 있는 시설화된 생산 환경이라 할 수 있다. 근래에 하드웨어적으로 급증한 스마트 시설환경에서 생산되는 방대한 생육/환경 데이터를 올바르고 적합하게 사용하기 위해서는 일반 산업 현장과는 차별화 된 분석기법이 요구된다고 할 수 있다. 소프트웨어 공학 분야에서 연구된 빅데이터 처리 기술을 기계적으로 농업 분야의 빅데이터에 적용하기에는 한계가 있을 수 있다. 시설환경 내/외부의 다양한 환경 변수는 시계열 데이터의 난해성, 비가역성, 불특정성, 비정형 패턴 등에 기인하여 예측 모델 연구가 매우 난해한 대상이기 때문이라 할 수 있다. 본 연구에서는 근래에 관심이 급증하고 있는 인공신경망 연구 소프트웨어인 Tensorflow (www.tensorflow.org)와 대표적인 Open source인 OpenNN (www.openn.net)을 스마트 시설환경 환경변수 상호간 상관성 분석에 응용하였다. 해당 소프트웨어 라이브러리의 운영환경을 살펴보면 Tensorflow 는 Linux(Ubuntu 16.04.4), Max OS X(EL capitan 10.11), Windows (x86 compatible)에서 활용가능하고, OpenNN은 별도의 운영환경에 대한 바이너리를 제공하지 않고 소스코드 전체를 제공하므로, 해당 운영환경에서 바이너리 컴파일 후 활용이 가능하다. 소프트웨어 개발 언어의 경우 Tensorflow는 python이 기본 언어이며 python(v2.7 or v3.N) 가상 환경 내에서 개발이 수행이 된다. 주의 깊게 살펴볼 부분은 이러한 개발 환경의 제약으로 인하여 Tensorflow의 주요한 장점 중에 하나인 고속 연산 기능 수행이 일부 운영 환경에 국한이 되어 제공이 된다는 점이다. GPU(Graphics Processing Unit)의 제공하는 하드웨어 가속기능은 Linux 운영체제에서 활용이 가능하다. 가상 개발 환경에 운영되는 한계로 인하여 실시간 정보 처리에는 한계가 따르므로 이에 대한 고려가 필요하다. 한편 근래(2017.03)에 공개된 Tensorflow API r1.0의 경우 python, C++, Java언어와 함께 Go라는 언어를 새로 지원하여 개발자의 활용 범위를 매우 높였다. OpenNN의 경우 C++ 언어를 기본으로 제공하며 C++ 컴파일러를 지원하는 임의의 개발 환경에서 모두 활용이 가능하다. 특징은 클러스터링 플랫폼과 연동을 통해 하드웨어 가속 기능의 부재를 일부 극복했다는 점이다. 상기 두 가지 패키지를 이용하여 2016년 2월부터 5월 까지 충북 음성군 소재 딸기 온실 내부에서 취득한 온도, 습도, 조도, CO2에 대하여 Large-scale linear model을 실험적(시간단위, 일단위, 주단위 분할)으로 적용하고, 인접한 세그먼트의 환경변수 예측 모델링을 수행하였다. 동일한 조건의 학습을 수행함에 있어, Tensorflow가 개발 소요 시간과 학습 실행 속도 측면에서 매우 우세하였다. OpenNN을 이용하여 대등한 성능을 보이기 위해선 병렬 클러스터링 기술을 활용해야 할 것이다. 오프라인 일괄(Offline batch)처리 방식의 한계가 있는 인공신경망 모델링 기법과 현장 보급이 불가능한 고성능 하드웨어 연산 장치에 대한 대안 마련을 위한 연구가 필요하다.