• 대한방사선방어학회:학술대회논문집
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• 2011.11a
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• pp.254-255
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• 2011

• Applied Microscopy
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• v.38 no.3
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• pp.245-250
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• 2008

Etoposide (Eto) is chemotherapeutic compounds that is currently used in the treatment of metastatic prostate cancer but new therapeutic agents are needed for the treatment of androgen-independent prostate cancer. The objective of the present study was to determine whether vitamin C (VC), the antioxidant, plays a role in regulating the growth of prostate cancer cell lines and whether VC has synergistic effect to tumor cell killing by chemotherapeutic drugs. Androgen-dependent LNCaP and androgen-independent DU-145 prostate cancer cell lines were used in this study. Both cells presented increase of dose- and time-dependent cytotoxicity in Eto-treated cultures. The combined treatment with Eto and VC significantly increased the percentage of apoptotic cells compared to Eto-treated cells(p<0.05). The present findings demonstrated that VC inhibited the growth of prostate cancer cell lines by Eto-mediated cytotoxicity and induced apoptosis. These results suggest that the chemotherapeutic effect of Eto on prostate cancer can be enhanced by VC.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.3
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• pp.171-176
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• 2014

The polarization characteristics of ultracompact polarization-insensitive directional coupler (PIDC) based on double sandwiched rib-type waveguide are explored in detail by using longitudinal modal transmission-line theory (L-MTLT). To obtain the polarization-insensitive condition of ultracompact directional coupler, the coupling length and coupling efficiency as functions of the refractive index and thickness of sandwiched rib-type waveguide are analyzed for quasi-TE and quasi-TM modes. The numerical results show that the ultracompact polarization-insensitive coupler with hundreds of micrometer scales is realized by properly choosing structural and material parameters of double sandwiched layers. Furthermore, the influence of fundamental mode profile, which is distributed in lateral waveguide of coupler, on the coupler performance has been investigated.

• Korean Journal of Optics and Photonics
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• v.16 no.3
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• pp.287-294
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• 2005

In this paper, an optical true time-delay (TTD) for two-dimensional (2-D) phased array antennas (PAAs), composed of a multi-wavelength optical source and a fiber optic delay line matrix consisting of $2\times2$ optical switches with optical fiber connected between cross ports, has been proposed. A 2-bit $\times4-bit$ optical TTD for 10-GHz 2-D PAAs has been implemented by cascading a wavelength dependent TTD (WD-TTD) and a wavelength independent TTD (WI-TTD). The unit time delay for WD-TTD and WI-TTD have been chosen as ${\Delta}T=12ps$ and $\Delta\tau=6ps$, respectively. Time delay have been measured at all radiation angles. The maximum delay error for WD-TTD was measured to be 3 ps due to jitter incurred from gain switching. For the case of WI-TTD, error was within ${\pm}\;1\;ps$. The proposed optical TTD for a 2-D PAA has the following advantages: 1) higher gain compared to one-dimensional linear PAAs, 2) stabilization of optical power and wavelength by using a multi-wavelength optical source, and 3) fast beam scan and simple operation due to electronic control of the $2\times2$ optical switches matrix on a column-by-column basis.

• Journal of the Korean Vacuum Society
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• v.17 no.5
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• pp.400-407
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• 2008

In this study, Two dimensional spatial profile of electromagnetic field for capacitively coupled plasma source is calculated. Based on one dimensional fluid equation, spatial profile for the axial direction of electric field and conduction current density is firstly calculated. The two dimensional spatial profile for the electromagnetic field is calculated from solution of Maxwell equation that is expanded to power series for ${\omega}r/c$ into the radial direction.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.24 no.1
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• pp.1-7
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• 2011

In this paper, based on an isogeometric approach, we have developed a shape design optimization method for plane elasticity problems subjected to design-dependent loads. The conventional shape optimization using the finite element method has some difficulties in the parameterization of geometry. In an isogeometric analysis, however, the geometric properties are already embedded in the B-spline basis functions and control points so that it has potential capability to overcome the aforementioned difficulties. The solution space for the response analysis can be represented in terms of the same NURBS basis functions to represent the geometry, which yields a precise analysis model that exactly represents the normal and curvature depending on the applied loads. A continuum-based isogeometric adjoint sensitivity is extensively derived for the plane elasticity problems under the design-dependent loads. Through some numerical examples, the developed isogeometric sensitivity analysis method is verified to show excellent agreement with finite difference sensitivity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.1
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• pp.239-244
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• 2016

The polarization characteristics of polarization-insensitive directional coupler based on double sandwiched rib-type and curved waveguides are explored in detail by using conformal transformation method (CTM) and longitudinal modal transmission-line theory(L-MTLT). To obtain the polarization-insensitive condition of polarization-insensitive curved directional coupler(PI-CDC), the coupling length and coupling efficiency according to the inner radius of PI-CDC are analyzed for quasi-TE and quasi-TM modes. The numerical results show that the PI-CDC with a few micrometer scales can be realized by properly choosing the curvature and structural and material parameters of double sandwiched layers. Furthermore, the mode profiles propagating through PI-CDC are evaluated, and the influence on coupler performance has been investigated.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.20 no.6
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• pp.761-767
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• 2007

In centralized control system, complicated control systems including sensors, power supply and dampers should be required to satisfy the target response of large-scale structures. The practical applications of the centralized control system, however, is very difficult due to high order finite element model of structures, uncertainty of models, and limitations of the excitation system. In this study, the decentralized response-dependent MR damper of which magnetic field is automatically modulated according to the displacement or velocity transferred to the damper without any sensing and computing systems. this decentralized response-dependent MR damper are investigated according to the ranges of relative magnitude between the control force of MR damper and the story shear force of structures by nonlinear time history analysis. Finally, its performance is compared with centralized LQR algorithm which is used in general centralized control theory for a three story building structure.

• Computational Structural Engineering
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• v.28 no.1
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• pp.22-28
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• 2015

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.2
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• pp.285-290
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• 1997

The insulin-like growth factors(IGFs) are bound to several binding proteins(IGFBPs) that appear to regulate IGF transport, receptor binding, and its action. The concentration of these peptides are altered by catabolic conditions. To determine IGF-I and IGFBP levels in noninsulin-dependent diabetes mellitus (NIDDM), sera was obtained from 5 patients and 7 controls. Serum levels of IGF-I in NIDDM were lower than those in either of the controls. By western immunoblot analysis, especially IGFBP-1 levels are increased, whereas IGFBP-3 levels decreased and their fragments was increased in NIDDM serum. IGFBP-3 proteolytic activity in NIDDM sera was inhibited by phenylmethylsulfonylfluoride (PMSF), aprotinin, and ethylenediaminetetraacetic acid(EDTA). This pattern of inhibition was consistent with a metal-dependent serine protease. By gelatin zymography, these proteolytic enzymes were identified as the size of 97 and 69 kDa. IGFBP-1, which is primarily insulin regulated, was increased in NIDDM and may modulate circulating IGF-I levels by regulating capillary passage of IGF-I. IGFBP-3 proteolysis markedly reduces its affinity for the IGFs, particularly for IGF-I. This accelerates their kinetics of dissociation, thereby increasing the proportions of IGF-I in free form and its availability to the cells.