• Journal of Life Science
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• v.28 no.12
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• pp.1545-1553
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• 2018

The International Society of Rare Sugars (ISRS) defines rare sugars as monosaccharides and their derivatives that rarely occur in nature. Rare sugars have recently received much attention because of their many uses including low-calorie sweeteners, bulking agents, and antioxidants, and their various applications including as immunosuppressants in allogeneic rat liver transplantation, as potential inhibitors of various glycosidases and microbial growth, in ischemia-reperfusion injury repair in the rat liver, and in segmented neutrophil production without detrimental clinical effects. Because they rarely exist in nature, the production of rare sugars has been regarded as one of the most important research areas and, generally, they are produced by chemical synthesis. However, the production of rare sugars by bioconversion using enzymes from microorganisms has been receiving increased attention as an environmentally friendly alternative production method. In particular, D-allulose, D-allose, and D-tagatose are of interest as low-calorie sweeteners in various industries. To date, D-tagatose 3-epimerase, D-psicose 3-epimerase, and D-allulose 3-epimerase have been reported as D-allulose bioconversion enzymes, and L-rhamnose isomerase, Galactose 6-phosphate isomerase, and Ribose 5-phosphate isomerase have been identified as D-allose production enzymes. Elsewhere, D-tagatose has been produced by L-arabinose isomerase from various microorganisms. In this study, we report the production of D-allulose, D-allose, and D-tagatose by microorganism enzymes.

• Industry Promotion Research
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• v.9 no.1
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• pp.81-87
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• 2024

This research aims to empirically investigate the innovative effects of 2012 Cosmetics Act amendment on the cosmetics industry. By utilizing production data from the Korea Food and Drug Administration for the period 2008-2014 and estimating a panel fixed-effects model, the study demonstrates a significant positive correlation between the legislative revision and firm production. Additionally, it is observed that both the number of brands and new products per manufacturer significantly increased following the amendment. Further, this study shows a significant positive correlation between the amendment and the potential market size, with the potential market size positively correlated with innovation. The findings of this study highlight that government regulatory improvements can positively impact industrial innovation and promotion.

• Proceedings of the Korean Information Science Society Conference
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• 2006.10c
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• pp.535-539
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• 2006

미래 U-city 시대의 Health care 산업과 금융상거래 보안 및 사회안전 인증 장치로써 활성화 방안인 생체 칩은 2004년 10월 미 식품의약국(FDA)의 승인으로 더 큰 힘을 얻었다. 산업 전반적인 부분에 응용 가능한 생체 칩은 RFID 기술을 핵심기술로 사용하고 있으며, U-city 시대의 혁신적인 기술인 반면 개인정보 침해 및 법제도적, 윤리적, 전자파 유해성 이라는 문제점을 안고있다. 이 모든 문제점은 RFID 자체적인 문제점으로 많이 언급되어져 왔지만 생체 칩은 인체에 직접 사용한다는 점에서 더 큰 의미를 둔다. 현재 기술의 도입 시점인 생체 칩의 규제는 미국을 중심으로 가이드라인을 진행 중 이며, 우리 나라에서도 우려의 목소리가 높다. 본 연구는 사회적 인식이 부족한 생체 칩 기술 도입 전 미리 정보 보호 측면에서의 문제점을 분석하고 개선방향을 검토해 보고자 한다.

• KOREAN POULTRY JOURNAL
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• v.47 no.9
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• pp.119-121
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• 2015

본회(회장 오세을)는 지난 10~11일 양일간 충북 청풍리조트에서 2015 전국 산란계농가 교육 및 토론회를 개최했다. 이날 식품의약품안전처 축산물기준과 변성근 사무관(축산물 중 알가공품의 가공기준 및 성분규격), 축산물품질평가원 연구개발팀 김동준 과장(파각란 판정기준 및 파각란 발생 현황), 한국산업관계연구원 이석 본부장(난가공산업 활성화 방안)이 주제 발표를 하였으며 계란연구회 이상진 회장이 좌장을 맡은 가운데 본회 채란분과위원회 이상호 위원장, 계란자조금관리위원회 안영기 위원장, 농림축산식품부 축산경영과 김영민 사무관이 토론자로 나섰다. 이번 토론회로 난가공 활성화 방안이 마련되고 소비자들의 만족도를 충족시켜 계란 소비량 향상에 도움이 되길 기대한다. 본지는 이날 토론회 내용을 요약 정리 하였다.

• 동물약계
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• no.106
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• pp.4-7
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• 2006

동물약사감시 행정처분 결과 홍보/동물용의약품등 취급규칙 하위 규정 작업단 규정/양식어류용 약제 개발을 위한 협의회 개최/검역원 동물약품 관련 세미나 참석/품질관리우수업체 간담회 개최/2/4분기 가축전염병중앙예찰협의회 참석/VIV CHINA 2006 중소기업청 지원사업 선정/수출촉진협의회 개최/VIV ASIA 2007 참가업체 수요조사 실시/가축전염병 병원체 해외분양 관련 협의회 개최/동물의약연구회 창립 및 학술세미나 개최/2007년도 병역지정업체 선정 신청/(주)제일바이오 산업재해 동탑산업훈장 수상/협회 직원 인사/수해지역 방역용 동물약품 지원/검역원 방역약품 지원현황/소독약품 사용방법 개선시험 추진 현황

• Prospectives of Industrial Chemistry
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• v.22 no.1
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• pp.3-11
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• 2019

최근 화장품 산업은 제약사들을 중심으로 기업들이 보유한 바이오 및 의약 기술을 접목하여 기능성 화장품 개발에 주목하고 있다. 화장품과 의약품의 경계가 무너지고 코스메슈티컬이 화장품 산업의 블루오션 시장으로 각광받고 있다. 특히 현대병으로 알려진 고질적 피부질환 아토피성 피부 인구가 늘면서 아토피 기능성 스킨케어 시장이 급부상하고 있다. 98년부터 시작된 아토피 관련 시장은 국내 약국 아토피성 화장품 시장 100억 원을 포함해 현재 700억원대로 급성장하고 있어 앞으로 확고한 수익 시장으로 자리잡을 것이라 전망되고 있다. 현 사회에서 심각한 문제로 인식되는 아토피 피부를 치료할 수 있는 다양한 화장품 제품들이 급증하고 있으므로, 본 기획에서는 아토피 화장품 시장의 현황, 동향 및 전망을 분석하여 살펴보고자 한다.

• Journal of Technology Innovation
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• v.24 no.1
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• pp.143-167
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• 2016

The purpose of this study is to analyze changes of innovation activities and their performance in pre-IPO and post-IPO of KOSDAQ IPO listed companies in medical and pharmaceutical fields, which require high R&D investment, from 2000 to 2005 in Korea. The innovation efficiencies of the IPO companies were measured before and after three years based on the DEA model. The financial data and patent information of the listed company during total 6 years, which were 3 years before IPO and 3 years after IPO, were collected. The main results of this research are as follows. First, it took an average 12.86 years until IPO in the start-up of the IPO companies in the pharmaceutical sector, and innovation was on average more active than the IPO before. R&D investment was higher than the IPO before, and the number of the applied patent during 3 years after IPO was 16.67 which was increased from 8.43 during 3 years before IPO. In addition, the average scope of technology of the IPO companies was expanded from 11 to 22 technology fields during previous 3 year and after 3 year each, and financial growth after IPO was lower than the previous IPO. Second, the financial performance of R&D investment and the performance of patent activity were weakened in the efficiency after the IPO, and the integrated performance from the patenting activities and the R&D investment was decreased after the IPO. Finally, the efficiency of the financial performance of the patenting activity was lower than the efficiency of the financial performance of the patent and R&D investment and patent activities under the R&D investment. In particular, the inefficiency of the firms' patenting activities performance after the IPO was caused by the decreasing return to scale, according to the results of this study. This results implicate that the expansion of R&D investments through the IPO had not lead to the financial performance of the market, and that the overall inefficiency since the IPO is due to the inefficiencies at the stage for the outcome of innovation activity rather than the output obtained through the R&D investments that appear to lead the performance of the market.

• KSBB Journal
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• v.18 no.5
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• pp.356-362
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• 2003

This study defines the biotechnology industry, examines its position in the domestic economy, and analyses its structure with I-O tables of year 1985, 1990 and 1995. Structural decomposition analysis is used in order to estimate the impact of different sources of growth. We classifies Korean biotechnology industry into 6 sectors, based on the survey of domestic biotechnology industry by Bioindustry Association of Korea. Empirical results indicate that each sector of bioindustry has various sources of growth and industrial demand has led the growth in all sectors except for food-bio and agriculture-bio. For the growth of the industry, each sector needs to cope with the change of the private demand and to improve the import and export structure.

• Korean Journal of Food Science and Technology
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• v.27 no.3
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• pp.414-419
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• 1995

${\beta}-carotene$ was extracted from freeze-dried carrot by supercritical carbon dioxide $(SC-CO_2)$ and mixtures of $CO_2$ doped with ethanol or methanol as a cosolvent at temperatures of 40 to $60^{\circ}C$ and pressures of 138 to 276 bar. Solubility of ${\beta}-carotene$ in $SC-CO_2$ increased with the increase of extraction pressure and the decrease of extraction temperature. The highest solubility observed was $4.90\;{\mu}g/g\;CO_2\;for\;{\alpha}-carotene\;and\;0.604\;{\mu}g/g\;CO_2$ for ${\alpha}-carotene\;at\;40^{\circ}C$ and 276 bar. Addition of ethanol increased the solubility being the largest increase of 82% using a mixture of $CO_2$ and 17.4% ethanol. $SC-CO_2$ extraction can be used to selectively obtain natural carotenoids, free of solvent residuals, which can be used as food additives.

• Korean Journal of Plant Resources
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• v.31 no.4
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• pp.322-329
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• 2018

A diarylheptanoid, (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one-5-O-${\beta}$-D-xylopyranoside, named oregonin (1), was isolated from the of Alnus japonica (A. japonica), which is a species of the genus Betulaceae, growing throughout Korea, Japan and China. The structure was elucidated by various spectroscopic methods including negative and positive LC/MS, 1H-NMR, and 13C-NMR techniques or by comparison with authentic samples. In order to evaluate the anti-oxidative activities of oregonin (1) isolated from A. japonica, 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and 2,2'-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid] (ABTS) radical scavenging activity were measured in vitro. Oregonin from A. japonica exhibited potent DPPH and ABTS radical scavenging activities. A. japonica shows not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and ABTS radical scavenging activity, but also apoptosis modulative effects. The present results indicate that A. japonica could be a hair-growth-promoting agent for cosmetic products.