• Korean Journal of Food Science and Technology
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• v.27 no.3
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• pp.414-419
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• 1995

${\beta}-carotene$ was extracted from freeze-dried carrot by supercritical carbon dioxide $(SC-CO_2)$ and mixtures of $CO_2$ doped with ethanol or methanol as a cosolvent at temperatures of 40 to $60^{\circ}C$ and pressures of 138 to 276 bar. Solubility of ${\beta}-carotene$ in $SC-CO_2$ increased with the increase of extraction pressure and the decrease of extraction temperature. The highest solubility observed was $4.90\;{\mu}g/g\;CO_2\;for\;{\alpha}-carotene\;and\;0.604\;{\mu}g/g\;CO_2$ for ${\alpha}-carotene\;at\;40^{\circ}C$ and 276 bar. Addition of ethanol increased the solubility being the largest increase of 82% using a mixture of $CO_2$ and 17.4% ethanol. $SC-CO_2$ extraction can be used to selectively obtain natural carotenoids, free of solvent residuals, which can be used as food additives.

• The Safety technology
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• no.184
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• pp.19-21
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• 2013

경기도 평택시에 위치하고 있는 한미약품(주) 평택공단. 이 공단이 지난 2007년 준공됐을 당시 의약 제약 업계에서는 각별한 관심을 보였었다. 세파플랜트, 바이오플랜트 등 단 두 개의 공장만 들어섰지만 한미약품 자체적으로 '공단'이라고 명명할 만큼 어느 곳과도 비교할 수 없을 정도의 규모로 지어졌기 때문이다. 특히 이곳 세파플랜트는 국내 세파계 항생제의 약 70%까지 공급할 수 있는 전용 공장의 면모를 갖추고 있어 시장에 막대한 영향을 미칠 것으로 예상되기도 했다. 여기에 더해 이곳은 지역 안전인들 사이에도 남다른 관심을 받았다. 공장이 설계될 때부터 근로자들의 안전을 최우선 가치로 삼아 재해발생 요소를 최소화했기 때문이다. 아울러 공단이 가동된 직후부터 현재가지 빈틈없는 안전관리를 전개하면서 말 그대로 '안전 사업장'으로 유명세를 타고 있는 것이다. 안전경영을 바탕으로 제약산업을 선도해나가고 있는 한미약품(주) 평택공단을 찾아가 봤다.

• The monthly packaging world
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• s.270
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• pp.114-120
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• 2015

식품의약품안전처는 '의약품 표시 등에 관한 규정'을 일부 개정함에 그 취지와 주요 내용을 국민에게 널리 알려 의견을 구하고자 '행정절차법' 제46조에 따라 행정 예고한다고 밝혔다. 이번 개정은 의약품 식별표시 등록 근거를 상향 입법하는 약사법 개정 등에 따라 의약품 낱알식별표시 방법, 등록절차 등 식별표시 제도 운영에 필요한 사항은 총리령으로 정하고 신청 자료의 검토 등 세부사항은 고시에서 정하는 등 관련 규정을 정비하기 위해 마련됐다. 또 용기 또는 포장에 상호 등의 기재요령 및 식별표시 제외대상 확대 등 제도 운영에 따른 미비점을 개선 보완하려는 것이다. 주요 내용으로는 ${\triangle}$의약품 식별표시 등록 근거를 상향 입법함에 따라 하위 규정 정비 ${\triangle}$의약품의 용기 또는 포장에 상호 등의 세부 기재방법 마련 ${\triangle}$식별표시 제외 대상 확대 등이다. 본 고에서는 주요 내용을 살펴보도록 한다.

• The Korean Chronic Disease News
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• no.315
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• pp.1-18
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• 2007

대구광역시 서구 보건소 이재무 소장/포괄적 맞춤형 건강진단 실시/“공중보건의수급 대란 온다”/맞춤형 건강진단 어떤 내용 담고있나/“건강투자로 미래 성장 동력 확충”/한미 FTA,“ 보건의료계 영향 적다”/한미 FTA협상 주요 내용/교육.의료는 왜 협상서 빠졌나/성인 절반이 심뇌혈관질환 고위험군/암환자 암정보센터 HP로 오세요!/“꿈의 암치료 시대”열려/“구민이 함께 하는 건강한 사회.행복한 사회”/대구시 서구보건소 비만관리사업/‘제약산업 발전기금’조성 필요/“의약품위다국적 제약 참여할 수 없다”/공정거래자율준수프로그램(CP) 도입/중소제약 위한‘특별법’제정 요구/부실한 인적 자본, 미래 위한 건강투자 시급/

• Prospectives of Industrial Chemistry
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• v.22 no.6
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• pp.13-25
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• 2019

건강한 미래, 건강 사회 구현과 함께 질병 진단, 치료, 예방에 대한 관심이 급증하고 있다. 이에 따라 적시적기에 질병을 치료하고 예방하기 위한 건강 검진용 바이오센서 수요가 증가하였고 이에 따라 바이오센서 시장은 전세계적으로 급격히 확장되고 있다. 혈액 샘플을 기반으로 한 검진 방법이 보편적이지만 최근에는 고감도 센서 개발에 따라 소변, 침, 눈물 등과 같은 체액으로도 검진이 가능한 환자 친화적 비침습 센싱 방법도 활발하게 연구되고 있다. 이러한 센서 시장 패러다임의 변화 및 급속한 발전은 마이크로, 나노 재료 제작과 분석 기술 발전으로 체액 내 존재하는 나노 크기의 바이오 마커(단백질, 유전자, 펩타이드, 사이토카인)를 검출하는 소형화된 고감도의 센서를 개발할 수 있게 되었고 그 결과 화학, 물리, 재료, 의약 등 다양한 학문 분야에서 다양한 형태의 센서가 활발히 보고되었다. 본 기고문에서는 바이오센서용 소재 중에서 나노입자에 집중하여 첨단 센서 구현을 위해 사용된 입자의 종류, 센서 내에서의 입자의 역할을 소개하고 나노입자의 광학적, 물리적 특성에 따른 타겟 물질 검출 방법 및 동향에 대해 논의하고자 한다.

• Journal of Labour Economics
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• v.26 no.2
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• pp.97-127
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• 2003

The purpose of this paper is to analyze the expected earnings differentials by major of university graduates. Usually the achievement in labor market has been measured by the earnings of those being with job. But such simple comparisons of earnings might fail to bring out correct evaluation once if the probabilities of getting a job are quite different across the major of university graduates. So it is necessary to compare the expected lifetime eatings which can be computed using the earnings of those with job and the probabilities of taking a job. In this paper, we showed that the expected earings of university graduates are quite different by major and not only the difference of earnings but also the difference of job-taking probabilities are considerably contributing such differentials. Especially the expected earnings of medicine and education are considerably higher than those of other majors. These results are maintained almost identically with the change of estimation methods. But despite of these findings. it should be admitted that it was not possible to exactly measure the magnitude of differentials by major.

• Korean Chemical Engineering Research
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• v.49 no.1
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• pp.56-61
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• 2011

Alkyl vinyl ethers such as methyl vinyl ether, propyl vinyl ether, isopropyl vinyl ether, butyl vinyl ether and isobutyl vinyl ether are usually used as industrial solvents and chemical intermediates in the chemical or pharmaceutical industry. Recently, they are popularly used as raw materials for polymer electrolyte membrane fuel cells and as cellulose dyeing assistants. However, very few investigations about process design and operation data were reported for alkyl vinyl ether compounds and there are no data for propyl vinyl ether(PVE) systems as far as we know. In this work, the isothermal VLE data are reported at 333.15 K for the ternary systems of {PVE + ethanol + benzene} by using headspace gas chromatography(HSGC) and these VLE data were correlated using Wilson, NRTL and UNIQUAC equations. The excess volumes($V^E$) and deviations in molar refractivity(${\Delta}R$) data are also reported for the sub binary systems {PVE + ethanol}, {ethanol + benzene} and {PVE + benzene} at 303.15 K. These data were correlated with Redlich-Kister equation. In addition, isoclines of $V^E$ and DR for ternary system {PVE + ethanol + benzene} were also calculated from Radojkovi equation.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.10
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• pp.1439-1443
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• 2006

This study was performed on the effects of extraction temperature, pressure, time on apparent solubility and extraction yield of perilla oil and tocopherol, and color and fatty acid composition of the residue in supercritical carbon dioxide $(SC-CO_2)$ extraction. Apparent solubility of perilla oil and tocopherol increased with the increase of $CO_2$ density and was found to strongly depend on extraction pressure rather than extraction temperature. The extract yield of tocopherol in $SC-CO_2$ extraction increased with an increase of temperature and decreased with an increase of pressure and extraction time. The perilla oil apparent solubility of dried perilla powder for $60\sim180$ min at $40^{\circ}C/276$ bar increased with an extraction time, on the other hands, tocopherol apparent solubility decreased. As the increase of $CO_2$ density, less redness and yellowness increased. Fatty acid composition of perilla oil showed that perilla oil extracted by $SC-CO_2$ had better unsaturated fatty acid and decreased in saturated fatty acid. $SC-CO_2$ extraction offers a safe natural method for gaining perilla oil from dried perilla seeds powder.

• The Journal of Korean Medical History
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• v.35 no.2
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• pp.89-99
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• 2022

The figures listed under the title of 'Photo Insert' in 『HanBangEuiYakGye』 No.2 are all those who were engaged in East Asian medicine, but they can be divided into several groups depending on the areas in which they were more focused. First, he served as a royal physician at the end of the Joseon Dynasty, or was an oriental medical doctor with outstanding medical skills during the family service. Second, he is an East Asian medicine doctor who established a school for Korean medicine education or conducted various academic activities. Third, he is an East Asian medical doctor who worked hard to lead a group of East Asian medical doctors by organizing Korean medical doctors. Looking at the reality of the oppression of ethnic medicine committed by the Japanese colonial government, they continued to seek a way to live in national medicine, which played a major role in continuing the existence of Korean medicine without destroying it. In this paper, we analyzed the 13 Korean medical doctors introduced in the "Photo Insertion" and examined the activities of modern and contemporary East Asian medical doctors.

• The Korean Journal of Mycology
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• v.35 no.2
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• pp.128-132
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• 2007

The aim of this study was to investigate the physiological functionalities of 60 wild mushroom methanol extracts. We determined their fibrinolytic and ${\alpha}-glucosidase$ inhibitory activities. Among them, 11 mushrooms showed fibrinolytic activity. In particular, Armillaria sp. showed the greatest enzyme activity (4.2 plasmin units/ml) in a fibrin plate assay. The fibrinolytic activities of Amanita virosa. Gymnophilus sp. and Lepista nuda were 2.3, and the activities of Amanita citrina and Cortinarius alboviolaceus were 2.1 and 2.0 plasmin units, respectively. In a ${\alpha}-glucosidase$ inhibitory activity test, Naematoloma fasciculare showed the greatest inhibitory activity at 98.5%. The ${\alpha}-glucosidase$ inhibitory activities of Suillus luteus and Gomphidius maculatus were 66.6% and 61.5%, respectively. This study suggests that both Armillaria sp. and N. fasciculare can be used as candidates for the development of new medicine effective to cardiovascular diseases and biofunctional food.