• Journal of Digital Convergence
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• v.20 no.1
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• pp.221-229
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• 2022

This study is to develop and validate the academic motivation scale for medical students(AMSMS) based on self-determination theory. After composing preliminary questions from 74 students, a preliminary and main survey were conducted with 148 and 300 students from September to November 2020. Factor analysis, reliability analysis, and correlation analysis were used. As a result of exploratory and confirmatory factor analysis, construct validity was verified. The fitness index of the five-factor model of amotivation, external regulation, introjected regulation, identified regulation, intrinsic motivation was good. The reliability of each factor was ranged from 0.760 to 0.933. The criterion validity of AMSMS was verified by showing a correlation with academic self-efficacy and school life satisfaction. This results show that the AMSMS is both valid and reliable, and it is expected to be used in research related to academic motivation of medical students in the future.

• The Korea Journal of Herbology
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• v.39 no.3
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• pp.49-56
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• 2024

Objective : Obesity, which has recently been rapidly increasing in the obese population, is caused by an imbalance in energy intake and consumption. The reason why we need to manage obesity well is that the prevalence of complications such as diabetes, atherosclerosis, insulin resistance, and cardiovascular disease increases. In this study, the effect of FO (Fragaria orientalis) water extract on fat metabolism in 3T3-L1 cells was observed to develop a new anti-obesity material based on Mongolian medical books. Methods : The effect of FO extract on adipogenesis in 3T3-L1 cells was observed using DPPH scavenging, pancreatic lipase inhibitory activity, MTT analysis and Oil-red-O staining method. And the expression of proteins related to lipid metabolism was analyzed by Western blot. Results : The FO group significantly increased the DPPH radical scavenging activity at 5 mg/ml compared to the positive control BHA at 0.1 mg/ml. In oil red O staining at a safe concentration without cytotoxicity, lipid accumulation was significantly inhibited by less than 80% compared to the control group at all concentrations. Moreover, treatment of FO significantly increased the expression of proteins related to lipid metabolism, such as p-AMPK and p-ACC, in 3T3-L1 cells, and the expression of CPT-1 tended to increase in a dose-dependent manner. However, the expression of PPAR-γ was significantly decreased in a dose-dependent manner. Conclusion : These results suggest that FO water extract has a potential anti-obesity effect and are expected to be utilized in the development of materials for obesity prevention and treatment.

• The Korea Journal of Herbology
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• v.39 no.2
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• pp.27-33
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• 2024

Objective : Obesity is a disease caused by energy imbalance and increases the risk of complications such as cardiovascular disease and cancer. Additionally, a recent study reported that excessive production of ROS stimulates the expression of transcription factors related to adipogenesis, such as PPAR-𝛾, C/EBP-𝛼 and 𝛽, in 3T3-L1 cells. In this study, Paeonia anomala L. (PAL) was selected as a candidate for improving and preventing obesity from Mongolian medical literature, and its effect on fat metabolism was observed in vitro. Methods : The activity of PAL extract against lipid accumulation was measured in 3T3-L1 cells through Oil red O staining. Additionally, the expression of lipid metabolism-related proteins was measured by western blot. Results : Intracellular lipid accumulation was significantly lower in the treatment group than in the control group. In addition, pAMPK/AMPK protein expression in the treatment group tended to increase in a concentration-dependent manner, and PPAR-𝛾 protein expression in the treatment group showed a significant decrease in a concentration-dependent manner compared to the control group. Conclusion : These results suggest that PAL extract may have an anti-obesity effect, and it is believed that it can be used to develop functional materials for the treatment of obesity.

• The Korea Journal of Herbology
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• v.39 no.4
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• pp.1-9
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• 2024

Objective : In this study, the anti-obesity effect of Fragaria orientalis (FO) on high-fat diet-induced obese mice was investigated. Drug treatment methods are widely used as obesity treatment methods, but research using various natural products is being conducted due to safety concerns. This study aims to evaluate the anti-obesity effect of FO extract, a natural product derived from Mongolia. Methods : C57BL/6 mice were used and divided into three groups, normal diet group, high-fat diet group, and high-fat diet with FO oral treatment group at a dose of 300 mg/kg. Extract was orally provided everyday for 6 weeks. Body Weight and food intake were measured every 2 days and blood lipid profiles and liver function in the sacrificed mice were evaluated. In addition, protein expression in hepatic tissue and histomorphological changes in liver and adipose tissue were observed. Results : Body weight, adipose tissue weight and FER were significantly lower in a high-fat diet with FO treatment than fed only high-fat diet. There was a significant difference between the high-fat diet and the FO-treated high-fat diet mice. As a result of analyzing lipid metabolism-related genes in hepatic tissue, all of p-AMPK, p-ACC, PPAR-α, CPT-1, and UCP-1 showed significant increases, and PPAR-γ also decreased significantly compared to the high-fat diet group. Conclusion : Overall, these results indicate that FO is effectual in improving obesity, suggesting that it can be used as a possible material for anti-obesity agents or functional supplements for weight control.

• The Journal of the Korea Contents Association
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• v.17 no.1
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• pp.402-411
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• 2017

To develop a more efficient computer-based empathy program that enables medical students to increase their empathy levels, and to test its applicability to medical students. We developed PACP (the Pain Assessment Computer Program) for measurement of medical students' levels of recognition of another's pain. An empathy questionnaire was administered to 145 medical students before and after the PACP. In the high empathy group, the scores for cognitive empathy increased significantly after completion of the PACP, while affective empathy scores showed no significant change. In contrast, in the low empathy group, both cognitive and affective empathy scores increased significantly after the PACP. The PACP effectively increased cognitive empathy for the high empathy group, and increased both cognitive and affective empathy, particularly for the low empathy group. Given the fact that existing empathy education programs are time-consuming and costly, and the demand for more efficient empathy education is high, the PACP as a useful tool can be applicable to medical students, particularly those with low empathy in order to enhance their empathic abilities within a short period of time.

• Pediatric Infection and Vaccine
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• v.27 no.3
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• pp.147-157
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• 2020

Purpose: We investigated the trend of antibiotic susceptibility of Haemophilus influenzae over 5 consecutive years. Methods: We analyzed the antibiotic susceptibility of H. influenzae isolated from children aged <18 years, who were admitted to the Asan Medical Center Children's Hospital from March 2014 to April 2019. Antibiotic susceptibility of H. influenzae was determined by the disk diffusion test according to the European Committee on Antimicrobial Susceptibility Testing guidelines. Results: Excluding duplicates, 69 isolates were obtained over the past 5 years. The median age of the patients was 5 years (range, 2.8-8.6 years). The antibiotic susceptibility patterns were as follows: ampicillin (AMP)-susceptible/amoxicillin-clavulanate (AMC)-susceptible (AS/ACS; n=15 [21.7%]), AMP-resistant/AMC-susceptible (AR/ACS; n=21 [30.4%]), and AMP-resistant/AMC-resistant (AR/ACR; n=33 [47.8%]). The prevalence of isolates with AR/ACR phenotype tended to increase from 42.1% in 2014-2015 to 54.5% in 2018-2019 (P=0.342). Compared to 2014-2015, the resistance rates to cefuroxime and ceftriaxone in 2018-2019 increased from 31.6% to 77.3% and from 0.0% to 59.1%, respectively (P=0.003 and P<0.001, respectively). Conclusions: Over the last 5 years, H. influenzae isolates with AR/ACR phenotype and ceftriaxone resistance were frequently observed at our institute. The incidence of resistance to cefuroxime and ceftriaxone has increased significantly.

• The Inventors News
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• no.31
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• pp.2-2
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• 2005

지난해 특허출원 사상 최대치 기록하다 - 유명 PC게임 `디아블로` 상표등록 무효 - 가천의대$\cdot$하버드대 인체 영상 특허 공유 - `우리은행` 상표권 등록 무효 소송 추진 - 토지공사 `KoLand` 상표 무단 사용 1억여 원 배상 판결 - 강진 `옴천 토하 젓` 상표 주인은 누구?

• RED RIBBON
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• s.27
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• pp.10-12
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• 1999

이 글은 본회 사무국에서 보건복지부 협찬으로 지난 1월5일부터 19일까지 총 15일간 방영된 TV 에이즈광고 후 상담실적을 비교한 것이다. 광고 내용은 향락업소 등지에서 이성과의 성적 접촉을 한 청소년들이 에이즈 검진을 받고 싶어도 신분노출 때문에 고민하는 경우 익명으로 검사를 받을 수 있다는 것을 홍보하는 것으로 연세대 의대 황수관 박사가 무료로 출연했다.

• 대한한약신문
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• s.113
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• pp.1-12
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• 2006

한약재 취급관련 법원판결에 대한 건의/동대문 한의약박물관 13일 개관/서울약령시한의약문화축제 열려/이달 26일, 지부장 간담회 개최/서울대 의대 한의학 관련 강의 본격 실시/국립대에 한의학전문대학원 설치한다/지부탐방-지부장에게 듣는다/칼럼-한약과 음식물의 차이점/초석잠-동맥경화.뇌세포 활성화 등의 효험 있어/명칭이 비슷하여 감별하기 어려운 한약재/강의개괄내용-우선방합의 과신을 걸러내야/우리 약초를 찾아서-쪽/민간약선방

• The Science & Technology
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• no.1 s.404
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• pp.12-13
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• 2003

미생물 조작 새로운 생명체 창조/ 병을 따지 않고도 포도주 맛 감지/ 나노튜브를 분자 단위로 용접/ 초전도체의 원자 구조 영상/ 다이아몬드 칩 제조 방법 개발/ 쥐 유전자 99%가 인간과 비슷/ 목성의 위성 아말데아에 많은 구멍/ 의대에서 살아있는 동물 실험 줄어든다