• The Korean Journal of Applied Statistics
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• v.35 no.2
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• pp.251-263
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• 2022

Phase I clinical trial is called 'Dose finding study'. It is first step of experimenting on humans with new drugs developed through animal experiments or vitro experiments. The important area of interest in designing Phase I clinical trial is determining the dose that acceptable level to the patients and provides the greatest efficacy. In this paper, we explain about methods to determine the maximum tolerated dose using various stopping rules. The SM3, NM, Rim, J3, BSM methods are compared through simulation. And we consider how the methods might be reformed. As a result of the simulation, BSM estimated the MTD closest to the target toxicity probability. J3 method required the least number of subjects. These results are due to the feature of the stopping rules of both methods. The BSM adds 2 or 1 subject at the same dose level when there is a toxic reaction. In addition, the J3 method has a smaller number of subjects than the other methods. If the methods are improved by combining these features, MTD can be estimated more efficiently. If the total number of subjects can be reduced while using the stopping rule of the BSM, accurate estimation is possible for a small number of subjects.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.15 no.1
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• pp.36-44
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• 2022

Reversible data hiding techniques have been developed to hide confidential data in the image by shifting the histogram of the image. These techniques have a weakness in which the security of hidden confidential data is weak. In this paper, to solve this drawback, we propose a technique of triple encrypting confidential data using pixel value information and hiding it in the cover image. When confidential data is triple encrypted using the proposed technique and hidden in the cover image to generate a stego-image, since encryption based on pixel information is performed three times, the security of confidential data hidden by triple encryption is greatly improved. In the experiment to measure the performance of the proposed technique, even if the triple-encrypted confidential data was extracted from the stego-image, the original confidential data could not be extracted without the encryption keys. And since the image quality of the stego-image is 48.39dB or higher, it was not possible to recognize whether confidential data was hidden in the stego-image, and more than 30,487 bits of confidential data were hidden in the stego-image. The proposed technique can extract the original confidential data from the triple-encrypted confidential data hidden in the stego-image without loss, and can restore the original cover image from the stego-image without distortion. Therefore, the proposed technique can be effectively used in applications such as military, medical, digital library, where security is important and it is necessary to completely restore the original cover image.

• Journal of Space Technology and Applications
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• v.1 no.2
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• pp.217-240
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• 2021

Upon the human exploration era of the Moon, this paper introduces lunar topography and geologic fundamentals to space scientists. The origin of scientific terminology for the lunar topography was briefly summarized, and the extension of the current Korean terminology is suggested. Specifically, we suggest the most representative lunar topography that are useful to laymen as 1 ocean (Oceanus Procellarum), 10 maria (Mare Imbrium, Mare Serenitatis, Mare Tranuillitatis, Mare Nectaris, Mare Fecundatis, Mare Crisium, Mare Vaporium, Mare Cognitum, Mare Humorum, Mare Nubium), 6 great craters (Tyco, Copernicus, Kepler, Aristachus, Stebinus, Langrenus). We also suggest Korean terms for highland, maria, mountains, crater, rille, rima, graben, dome, lava tube, wrinkle ridge, trench, rupes, and regolith. In addition, we introduce the standard model for the lunar interior and typical rocks. According to the standard model on the basis of historical impact events, the lunar geological eras are classified as Pre-Nectarian, Nectarian, Imbrian, Erathostenesian, and Copernican in chronologic order. Finally, we summarize the latest discovery records on the water on the Moon, and introduce the concept of water extraction from the lunar soil, which is to be developed by the Korea Institute of Geoscience and Mineral Resources (KIGAM).

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.2
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• pp.71-80
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• 2022

Although low translucency 3 mol% yttria stabilized tetragonal zirconia polycrystal has excellent mechanical properties, it has limited application as a monolithic prosthesis. To improve these optical limitations, translucent zirconia has improved esthetics due to an increase in the cubic phase; however, it is accompanied by a decrease in mechanical properties simultaneously. Lithium disilicate has improved its mechanical properties through crystal size reduction and various heat treatment methods; therefore, its clinical application range is continuously increasing. Translucent zirconia shows a wide distribution of physical properties depending on the yttria content and lithium disilicate according to the size and density of crystal grains. As a result, the indications for translucent zirconia and lithium disilicate are increasing. Therefore, in this literature review, we intend to examine the rationale behind the material selection criteria in clinical situations and considerations for designing fixed dental prostheses including pontic, in particular, by summarizing recent studies.

• Journal of Applied Biological Chemistry
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• v.65 no.2
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• pp.113-120
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• 2022

We examined the anti-inflammatory properties of Nostoc commune HCW0811 in lipopolysaccharide-stimulated RAW264.7 macrophage cells. The anti-inflammatory activity of HCW0811 on viability of treated cells was assessed by measuring the level of expression of NO, prostaglandin E₂ and pro-inflammatory cytokines, namely interleukin-1β, interleukin-6, and tumor necrosis factor-α in HCW0811 treated RAW 264.7 macrophages. HCW0811 was non-toxic to cells and inhibited the production of cytokines in a concentration-dependent manner. In addition its treatment suppressed the production of pro-inflammatory cytokines in a dose-dependent manner, and concomitantly decreased the protein expressions of inducible NO synthase and cyclooxygenase-2. Moreover, the levels of the phosphorylation of mitogen-activated protein kinase family proteins such as extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, and nuclear factor kappa B were reduced by HCW0811. These findings suggest that the HCW0811 collected from Daejeon National Cemetery have anti-inflammatory effects, and demonstrated its efficacy in cell-based in vitro assays.

• Composites Research
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• v.35 no.3
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• pp.127-133
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• 2022

Polypropylene (PP) has been received great attention as a next-generation high-voltage power cable insulation material that can replace cross-linked polyethylene (XLPE). However, the PP cannot be used alone as an insulation material because of its high elastic modulus and vulnerability to impact, and thus is mainly utilized as a form of a copolymer with rubber phases included in the polymerization step. In this paper, a soft PP-based blend was prepared through melt-mixing of impact PP, polyolefin elastomer, and propylene-ethylene random copolymer. The elastic modulus and impact strength of the blend could properly be decreased or increased, respectively, by introducing elastomeric phases. Furthermore, the blends showed a high storage modulus even at a temperature of 100℃ or higher at which the XLPE loses its mechanical properties. In addition, the blend was found to be effective in suppressing the space charge compared to the pristine PP as well as XLPE.

• Journal of Korea Entertainment Industry Association
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• v.15 no.4
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• pp.349-357
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• 2021

Recently, drones are rapidly becoming common and expanding. There is a great need for diversity in whether drone flight data can be used as entertainment technology analysis data. In particular, it is necessary to check whether it is possible to analyze and utilize the flight and operation process of entertainment drones, which are developing through autonomous and intelligent methods, through data analysis and machine learning. In this paper, it was confirmed whether it can be used as a machine learning technology by using FC data in the evaluation of drones for entertainment. As a result, FC data from DJI and Parrot such as Mavic2 and Anafi were unable to analyze machine learning for entertainment. It is because data is collected at intervals of 0.1 second or more, so that it is impossible to find correlation with other data with GCS. On the other hand, it was found that machine learning technologies can be applied in the case of Fixhawk, which used an ARM processor and operates with the Nuttx OS. In the future, it is necessary to develop technologies capable of analyzing the characteristics of entertainment by dividing fixed-wing and rotary-wing flight information. For this, a model shoud be developed, and systematic big data collection and research should be conducted.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.57-65
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• 2021

A hyper-connected intelligence information society is emerging that creates new value by converging IoT, AI, and Bigdata, which are new technologies of the fourth industrial revolution, in all industrial fields. Everything is connected to the network and data is exploding, and artificial intelligence can learn on its own and even intellectual judgment functions are possible. In particular, the Internet of Things provides a new communication environment that can be connected to anything, anytime, anywhere, enabling super-connections where everything is connected. Artificial intelligence technology is implemented so that computers can execute human perceptions, learning, reasoning, and natural language processing. Artificial intelligence is developing advanced technologies such as machine learning, deep learning, natural language processing, voice recognition, and visual recognition, and includes software, machine learning, and cloud technologies specialized in various applications such as safety, medical, defense, finance, and welfare. Through this, it is utilized in various fields throughout the industry to provide human convenience and new values. However, on the contrary, it is time to respond as intelligent and sophisticated cyber threats are increasing and accompanied by potential adverse functions such as securing the technical safety of new technologies. In this paper, we propose a new data modeling method to enable IoT integrated security control by utilizing artificial intelligence technology as a way to solve these adverse functions.

• Journal of the Society of Disaster Information
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• v.18 no.3
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• pp.542-549
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• 2022

Purpose: Pipes are widely used as applied devices in many industrial fields such as machinery, electronics, electricity, and plants, and are also widely used in safety-related fields such as firefighting and chemistry. With the diversification of products, the importance of technology in the piping field is also increasing. In particular, when changing the existing copper pipe to stainless steel, it is necessary to evaluate safety and flow characteristics through structural analysis or flow analysis. Method: This study investigated the structural stability of the 6.35 and 15.88 socket models, which are integrated insert type connectors developed by a company, using FEM. For structural analysis, HyperMesh as pre-processor, HYPER VIEW as post-processor, and LS-DYNA as solver were used. Result: In the case of 6.35 socket, the maximum stresses at hook, holder and hinge were 95.02MPa, 19.59MPa and 44.01MPa, respectively, and in case of 15.88 socket, it was 127.7 MPa, 40.09MPa and 45.23MPa, respectively. Conclusion: Comparing the stress distribution of the two socket models, the stress in the 15.88 socket, which has a relatively large outer diameter, appears to be large overall, but it is significantly lower than the yield stress of each material, indicating that there is no problem in structural safety in both models.

• Journal of the Korea Computer Graphics Society
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• v.28 no.2
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• pp.29-41
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• 2022

In this paper, we introduce a novel real-time, interactive animation system which uses real-time motion inputs from a low-cost motion-sensing device Kinect. Our system generates interaction motions between the user character and the counterpart character in real-time. While the motion of the user character is generated mimicking the user's input motion, the other character's motion is decided to react to the user avatar's motion. During a pre-processing step, our system analyzes the reference motion data and generates mapping model in advance. At run-time, our system first generates initial poses of two characters and then modifies them so that it could provide plausible interacting behavior. Our experimental results show plausible interacting animations in that the user character performs a modified motion of user input and the counterpart character properly reacts against the user character. The proposed method will be useful for developing real-time interactive animation systems which provide a better immersive experience for users.