• Annual Conference on Human and Language Technology
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• 2006.10e
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• pp.183-188
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• 2006

본 논문에서 위치 정보 데이터란 텔레메틱스 분야의 응용을 위하여 웹상에서 수집한 Point-of-Interest (POI) 데이터로서 행정구역 및 지명 인명, 상호명과 같은 위치 검색에 사용되는 어휘로 구성된다. 본 논문은 음성 인식 시스템을 구성하는 발음 사전의 개발에 관한 것으로 250k 위치 정보데이터로부터 운율어를 이용하여 불규칙 발음과 발음 변이를 포함하는 가능한 모든 발음을 생성하는 방법을 제안하는 것을 목적으로 한다. 원래 모든 POI 는 한 번씩만 데이터에 포함되어 있으므로, 그 가운데 불규칙 발음을 포함하는 POI를 검출하거나 발음을 생성하기 위해서는 각각의 POI 하나하나를 일일이 검토하는 방법밖에 없는데, 대부분의 POI 가 복합명사구로 이루어졌다는 점에 착안하여 운율어를 이용한 결과, 불규칙 발음 검출과 다중 발음 생성을 효율적으로 수행할 수 있었다. 이러한 연구는 음성처리 영역에서는 위치정보데이터의 음성인식 성능을 향상하는 데 직접적인 기여를 할 수 있고, 무엇보다도 음성학과 음운론 이론을 음성 인식 분야에 접목한 학제적 연구로서 그 의미가 있다고 할 수 있다.

• The Journal of the Acoustical Society of Korea
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• v.17 no.5
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• pp.73-78
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• 1998

본 논문에서는 조음 효과에 대처할 수 있는 새로운 음성인식 단위로 반음절, 반음절 +반음절 단위 HMM을 제안하여 연속 숫자 음성인식을 하였다. 반음절 단위는 무음과 안정 구간으로, 반음절+반음절 단위는 안정, 천이, 안정구간으로 구성되어 있고, 음성인식 단위 분 할시 비교적 스펙트럼의 변화가 안정한 모음구간에서 분할하므로 분할 위치가 약간 변하여 도 인식성능에는 큰 영향을 주지 않게 된다. 또한, 제안된 반음절, 반음절+반음절 인식단위 는 그 패턴 안에 다음 숫자열의 정보를 포함하고 있기 때문에 모든 HMM 패턴들과 비교하 는 것이 아니라, 다음 숫자열의 정보를 포함한 HMM 패턴들과 비교한다. 인식실험결과 제 안된 방법이 효율적임을 확인하였다.

• The Journal of the Acoustical Society of Korea
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• v.17 no.1
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• pp.66-75
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• 1998

최근 음성인식을 위한 대표적인 방법으로써 은닉 마르코프 모델이 사용되고 있으며, 이러한 방법은 음성의 특성을 잘 표현하도록 하는 음향적인 모델링 방법에 따라서 성능이 좌우된다. 본 논문에서는 상태에서의 출력확률은 견고히 추정하기 위한 방법으로 상태에서 의 출력활률을 소스들의 분포와 그들의 빈도로 가중한 출력분포로 표시하는 상태 의존 소스 양자화 모델링 방법을 제안한다. 이 방법은 한 상태 내에서 특징 파라미터들이 유사한 특성 을 가지며, 그들의 변이가 다른 상태에 있는 특징 파라미터들에 비해서 작다는 사실에 기반 한다. 실험결과에 의하면, 제안된 방법이 기존의 baseline시스템보다 단어 인식율의 경우는 2.7%, 문장 인식율의 경우 3.6%의 향상을 보였다. 이러한 결과로부터 제안된 SDSQ-DHMM이 인식율 향상면에서 유효하며, HMM에 있어서 상태별 출력확률의 견고한 추정을 위한 대안으로 사용될 수 있을 것으로 판단된다.

• Journal of Korea Multimedia Society
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• v.10 no.8
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• pp.1004-1016
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• 2007

In this paper we proposed a Weight-Update-Control Adaptive Noise Canceller which improves speech when environmental noise is stationary and it is hard to acquire a reference signal. Adaptive Noise Canceller(ANC) needs a reference signal, but it is not easy to measure pure noise without voice for reference in factory. Because there are mixed various mechanical noise and workers' voice. Therefore ANC is not suitable to reduce background noise. So we proposed the method that uses an arbitrary constant as an input signal and inputs microphone signal to the reference signal. The noise is eliminated using updated weights in non-speech range. In speech range the weight is fixed and the modified voice is acquired then voice is restored through transversal filter. The proposed method is based on facts that the factory noise is stationary and the noise is not changed in short conversation range. As a result of simulation using MATLAB, we confirmed that the proposed method is effective for reducing factory noise and has high signal to noise ratio(SNR).

• Clinical and Experimental Pediatrics
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• v.53 no.2
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• pp.190-194
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• 2010

Purpose : To investigate the nature of deviant voice physiology in preoperative children with congenital heart disease. Methods : Ninety-four children with congenital heart disease were enrolled. Their cries and related acoustic variables (fundamental frequency, duration, noise to harmonic ratio, jitter and shimmer) were analyzed using a multi-dimensional voice program. Results : The average fundamental frequency showed a significant decrease in patent ductus arteriosus, ventricular septal defect, and tetralogy of Fallot, except in atrial septal defect and pulmonary stenosis. The length of the analyzed sample (duration) did not show a significant difference when compared with the control group. There was a significant increase in jitter percent in ventricular septal defect, patent ductus arteriosus, and atrial septal defect. There was an increase in shimmer in ventricular septal defect, patent ductus arteriosus, and atrial septal defect. The noise-to-harmonic ratio increased in ventricular septal defect, patent ductus arteriosus, and atrial septal defect but there was no significant difference in pulmonary stenosis and tetralogy of Fallot. While analyzing acoustic variables, the voice change was significantly higher, especially in patent ductus arteriosus followed by ventricular septal defect and atrial septal defect. Most of these acoustic variables were deviant in left-to-right shunt lesions in congenital heart disease, especially in patent ductus artriosus. Conclusion : The results of the voice change analysis of preoperative children with congenital heart disease revealed that the acoustic variables differed by each congenital heart disease. Moreover, the acoustic variables were prominently deviant in congenital heart disease with left-to-right shunts.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.7 no.1
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• pp.54-60
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• 2004

Purpose: Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP) is a small-vessel vasculitic disease that most often affects the skin. Abdominal symptoms precede the typical purpuric rash of HSP in 14~36%. It is a challenge to diagnose HSP in the absence of a rash, because there are no biologic tests that can identify HSP with certainty, so we tried to find out the characteristic features of HSP gastroenteropathy without purpura before diagnosis. Methods: This study included 82 children with HSP who had been admitted or visited outward of the Department of Pediatrics, Pusan National University Hospital from 1995 to 2000. The cases that the onset of purpura preceded or coincided that of abdominal pain were defined as purpura-positive group. The cases that the onset of abdominal pain preceded purpura more than 1 week and purpura was not presented till diagnosed as HSP gastroenteropathy were defined as purpura-negative group. We compared and analyzed the clinical features of the two groups by reviewing the medical records retrospectively. To ensure the diagnosis of HSP gastroenteropathy, we conducted upper GI series, abdominal ultrasonogram, abdominal CT, endoscopy and/or skin biopsy. Results: The number of cases of purpura-positive group and purpura-negative group were 72 and 10, respectively. There is no difference between two groups in the incidence of clinical symptoms and laboratory findings. Children with HSP gastroenteropathy had characteristic erosive or ulcerative lesions in the stomach or duodenum on esophagogastroduodenoscopy, or mural thickening of the small bowel on abdominal ultrasonogram, CT or upper GI series. Skin biopsy revealed leukocytoclastic vasculitis in 3 of them, although biopsy specimen was taken from any areas of normal- appearing skin. In purpura-negative group, 9 patients improved by steroid therapy. Conclusion: In purpura-negative group, there is no diagnostic feature on the laboratory findings and clinical features. Therefore, to diagnose HSP gastroenteropathy in patients with abdominal pain in the absence of the characteristic rash, careful observation of clinical features and laboratory data, and prompt application of available diagnostic tools such as gastrointestinal endoscopy, radiologic study and skin biopsy are recommended. Early use of corticosteroid may reduce the suffering in these patients.

• Biomedical Science Letters
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• v.5 no.1
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• pp.17-26
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• 1999

To evaluate the spreading possibilities of the marRAB mutation of E. coli Mar mutant among gram-negative bacilli, chromosomal marRAB mutations of Mar mutants were transduced by $\lambda$placMu9 into pUC19 (Lac$^{+}$, Ap$^{r}$) cloning site in another strains of E. coli or onto the chrmosome of S. typhimurium and P. aeruginosa, selected for transduction by Mar phenotype, Lac$^{-}$, or Ap$^{r}$, and tested for their antimicrobial resistance with or without addition of salicylate (SAL). Compared with wild type strains of JM109, NM522, harboring pUC19 or not, respectively, all strains of JM109 or NM522 carrying pUC19::marRAB mutation showed higher levels of antimicrobial resistance and SAL induction of Mar phenotype than those of wild type. However, in contrast to the original Mar mutants, there were some tendencies of decreased antimicrobial resistance of JM109 or NM522 harboring pUC19::marRAB mutation with SAL induction against chlorarnphenicol (Cm) and tetracycline (Tc), or Tc and ciprofloxacin (Cp), respectively. Almost the same results, as shown as the cases of E. coli JM109 or NM522, were obtained from all transductants of S. typhimurium and P. aeruginosa, except Cp, against which increased antimicrobial resistance with SAL induction was shown. This study, employed the methods of transformation or transduction among intercellular gene transfer methods between gram-negative bacteria, shows the evidences that suggest indirectly the spreading possibilities of marRAB mutation among gram-negative bacilli.

• Korean Journal of Microbiology
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• v.37 no.4
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• pp.259-264
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• 2001

It has been well known that the expression of S. typhimurium cadBA operon requires at least two extracellular signals: low pH and high concentration of lysine. To better understand the nature of pH-dependent and lysine dependent signal transduction, mutants were isolated in JF2238(cadA-lacZ) by Tn10 insertion, spontaneous mutagenesis, and EMS treatment. Two mutants were isolated from JF2238, expressed as a cadA-lacZ operon fusion in various growth conditions, and analyzed to have mutations in cadC, a gene encoding a function necessary for transcriptional activation of cadBA. One isolate (cadC6) conferred pH-independent and lysine-independent cadBA expression and the other(cadC4) showed pH-independent and lysine-dependent cadBA expression. cadR::Tn10 and cadR4 mutants were expressed in the absence of exogenously added lysine. They were also resistant to thiosine and complemented by lysP clone from E. coli. Thus, in the absence of exogenous lysine, cadR is a negative regulator of cadBA expression. Cadaverine, the product of lysine decarboxylation, was shown to inhibit expression of cadA-lacZ fusion in cad $C^+$ cell.

• Tuberculosis and Respiratory Diseases
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• v.51 no.4
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• pp.325-333
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• 2001

Background : This study aimed to estimate the clinical outcome and identify the characteristics of a group of patients with pulmonary tuberculosis who completed anti-tuberculosis therapy with the First-line drugs in spite of having positive smear results with negative sputum culture results over the previous six months. Method : A retrospective chart review of 21 patients who fulfilled the above criteria between 1995 and 1999 was performed. The laboratory data as well as the clinical data of the patients with positive smear results and negative culture results over a six months period were reviewed. Results : The negative conversion of sputum culture results was achieved within $1.3{\pm}1.2$ months and the negative conversion of the sputum smear results was accomplished during $9.5{\pm}3.3$ months. Chest X-rays at 5 months following the institution of anti-tuberculosis therapy from all patients revealed improvements. Four out of 21 patients(19%) relapsed during the follow up, $15.2{\pm}13.4$ months after administering anti-tuberculosis therapy for $13.3{\pm}3.1$ months. Relapses were confirmed from between 3 months and 4 months after the treatment completion. Only one of the four relapses had no past history of anti-tuberculosis therapy and the others had prior treatment twice (p<0.01). The period of anti-tuberculosis treatment was extended to a mean of $4.6{\pm}2.6$ months in 12 patients. However, prolongation of anti-tuberculosis therapy had no affect on the relapse rate (odds ratio, 95% CI 0.18, 2.15). Conclusion : Prolongation of therapy with the First-line drugs is not necessary for patients with persistently positive smear results over 6 months and negative culture results. A patient who has had prior anti-tuberculosis therapy more than twice should be paid the closest attention.

• Proceedings of the KSMRM Conference
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• 1999.04a
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• pp.130-136
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• 1999

척추의 MR촬영은 두부 다음으로 흔하게 시행되고 있는데, 척추의 해부학 적 구조물들은 일반적으로 널리 알려져 있고 이해하기가 쉽기 때문에 척추의 MR영상을 분석하는데 큰 어려움이 없을 수 있다. 관절부위를 포함한 근골격계 MR영상에서는 MR ar디facts가 병변을 관찰하는데 장애를 초래하여 위양성 혹은 위음성의 결과를 나타낼 수 있기 때문에 빈번히 언급되고 있다. 척추 MR영상을 판독하는 데는 다른 근골격계 영상에 비하여 artifact의 빈도 나 정도는 작지만, 의외로 많은 pitfall이나 ar디fact들이 관찰된다. 척추 MR 영상의 pitall과 artifact에 대한 정확한 인지와 이해가 필요한 이유는 MR영상에서 병변이 관찰되지 않거나 정상조직이 병변처럼 관찰될 수 있고, 또 병변의 특정을 잘못 판단할 수 있기 때문에 artifact를 교정하거나 최소화시키고, 방지할 수 있는 방법들을 사용하여 더욱 정확한 척추 MR영상의 결과를 얻는데 있다. 지면 관계상 모든 종류의 MR artifact를 언급하기 보다는 척추 MRI를 판독하면서 병변과 혼동을 주는 MR artifacts를 먼저 살펴보고, 진단적 오류를 범할 수 있는 pitfall들에 대하여 알아보도록 하겠다. 여기에서는 편의상 MR 촬영과 관계된 artifact들만을 artifact라고 하고 MR artifact와 직접적으로 연관이 없으면서 위양성이나 위음성을 초래할 수 있는 pitfall이나 variant를 pitfall로 묵어서 설명하겠다.