• Korean Journal of Fisheries and Aquatic Sciences
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• v.22 no.2
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• pp.70-78
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• 1989

This experiment was carried out to develop the preparation method of chitosan which has strong antimicrobial activity, and also tried to investigate as a natural food preservative with this chitosan. The antimicrobial activity of chitosan was the strongest when deacetylation of chitin was conducted at $146^{\circ}C$ for 8 hours with $50\%$ sodium hydroxide. The growth of Escherichia coil was completely inhibited by adding this low molecular weight chitosan (M. W, 35,000) at the level of concentration of 75ppm to the medium. The antimicrobial activity was strong enough against such Gram positive bacteria as Staphylococcus sp. and Bacillus sp.. The growth of these strains was inhibited by the concentration of 50ppm but it was varied in its kinds against Gram negative bacteria. The concentration of chitosan re-quired for growth inhibition of microorganisms was 100ppm against Pseudomonas sp. and Vibrio sp., 2,000ppm against Salmonella sp.. The growth of Saccharomyces sp. was inhibited by the concentration of 100ppm, but Hansenula sp., Aspergillus sp., Penicillium sp. and Mu-cor sp. did not inhibited by even more than the concentration of 5,000ppm. The shelf life of Mulkimchi (pickle type Kimchi), containing $0.2\%$ chitosan was 10 days longer than control stored at $5^{\circ}C$.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.3
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• pp.95-102
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• 2009

Purpose: The purpose of this study is to investigate antimicrobial activity of ally derivative of garlic against eye diseases, and to get basic data for an application development of the derivative, as a natural preservative, to multi-purpose solution (MPS). Methods: Antimicrobial activity of allyl derivative of garlic, diallyl sulfide (DAS), against Pseudomonas aeruginosa (P. aeruginosa) and Staphyloccus aereus (S. aereus) was determined. After DAS treatment in MPS of no microbial activity, its growth inhibition effect to bacteria was also determined. Results: DAS concentrations of $IC_{50}$ against P. aeruginosa and S. aereus were found when both bacteria were treated with DAS concentration of 0.25% and 0.64%, respectively. At MPS test, a product from Company A did not show any effects against both bacteria, but one from Company B showed antimicrobial activity against both bacteria. Antimicrobial activity test of the product from Company B in MPS did not showed any significant difference on both gram-negative and gram-positive bacteria. For a trial application of antimicrobial activity of DAS as a natural preservative, DAS was added to MPS of Company A which did not show any antimicrobial activity at treated concentration. Addition of DAS into MPS of Company A resulted in antimicrobial activity of DAS, which suggested a possible application of DAS as a germicide for contact lenses. Conclusions: This study showed allyl derivative of garlic has antimicrobial activity against both P. aeruginosa and against S. aereus, but more effects on P. aeruginosa. The result suggests that allyl derivative derived from garlic can be developed to a preservative of MPS as a natural substance.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.3
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• pp.233-240
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• 2021

Evaluation of the resected margins of the frozen section during breast-conserving surgery can determine the presence of cancer cells in a short time and have a significant impact on the scope of surgery and the prognosis of the patient. However, breast tissue is composed of adipose tissue, which affects the accuracy of the test. In this study, a new method was applied to the resected surface of the frozen section in which wiping the surface of the frozen section block with alcohol was expected to expose the parenchyma to the surface as the adipose tissue would melt momentarily. Indeed, of the total of 98 cases, 37 cases showed a better exposure ratio of the parenchyma in the improved frozen section test than in the previous frozen section test. Of the 37 cases with increased visibility of parenchymal sections obtained by this method, two cases of ductal carcinoma in situ (DCIS) were detected. Although there are limitations such as turnaround time (TAT), the diagnostic accuracy of histopathologic examination of the frozen section may improve through this method and may have a direct impact on patient safety, and should therefore be researched further.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.3 no.1
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• pp.26-31
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• 2010

Purpose: The purpose of this study is to evaluate the clinical usefulness of ultrasound in treatment of patella fracture. Material and Methods: Twenty cases of twenty patients with patella fracture radiographically from March, 2006 to September, 2009 were involved in this study, there were 8 males and 12 females, there were 13 right knees, 7 left knees, the average age was 43 years (range, 14~72 years). We decided the methods of treatment by using the ultrasound in conjunction with Drayer's test that examining the intactness of patella retinaculum. There were 10 transverse, 8 vertical and 2 comminuted fractures, we examined the patella retinaculum by using the ultrasound and performed Drayer's test. Results: In 12 cases of intact retinaculum, Drayer's test was negative and we allowed patients ambulation without surgical fixation especially. In 4 cases of completely ruptured retinaculum, Drayer's test was positive and we treated the patella fractures by the use of ORIF (open reduction and internal fixation) method, in 2 cases of partially ruptured retinaculum, Drayer's test was negative but displacement of fractures were more than 2 mm, we treated the patella fractures by the use of CRIF (closed reduction and internal fixation) method and obtained clinically satisfactory results. Conclusion: In conjunction with radiographs and Drayer's test, an ultrasound would be one of the useful diagnostic modality for determining treatment method of the patella fracture.

• The Journal of the Acoustical Society of Korea
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• v.23 no.1
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• pp.82-89
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• 2004

This paper describes how to reduce the effect of an occupation threshold by that the transform of mixture components of HMM parameters is controlled in hierarchical tree structure to prevent from over-adaptation. To reduce correlations between data elements and to remove elements with less variance, we employ PCA (principal component analysis) and ICA (independent component analysis) that would give as good a representation as possible, and decline the effect of over-adaptation. When we set lower occupation threshold and increase the number of transformation function, ordinary WLLR adaptation algorithm represents lower recognition rate than SI models, whereas the proposed MLLR adaptation algorithm represents the improvement of over 2% for the word recognition rate as compared to performance of SI models.

• Applied Biological Chemistry
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• v.37 no.6
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• pp.456-462
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• 1994

Lysozyme-dextran hybrids were prepared by incubated storage at $60^{\circ}C$ and 80% relative humidity for 16 days. The emulsifying properties of the hybrids were about 14 times higher than those of native lysozyme and were about 3 times higher than those of commercial emulsifiers. Lytic activity of the hybrids remained about 83% that of native lysozyme when mesured against Micrococcus lysodeikticus as a substrate. The excellent emulsifying properties of the hybrids were maintained even at pH 3 and were further improved at pH 10. The emulsifying properties of the hybrids were greatly improved by preheating the hybrids at $100^{\circ}C$. In addition the lysozyme-dextran hybrids showed an antimicrobial effect on Gram-negative bacteria.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.38 no.5
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• pp.27-36
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• 2001

This paper proposes new design algorithms based on stochastic relaxation (SR) for an on-line vector quantizer (VQ) design. These proposed SR methods solve the local entrapment problems of the conventional Kohonen learning algorithm (KLA). These SR methods cover two different types depending upon the use of simulated annealing (SA) : the one that uses SA is called the OLVQ SA and the other the OLVQ SR. These methods arc combined with the KLA and therefore preserve the its convergence properties. Experimental results for Gauss Markov sources, real speech and image demonstrate that the proposed algorithms can consistently provide better codebooks than the KLA.

• Restorative Dentistry and Endodontics
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• v.27 no.3
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• pp.270-276
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• 2002

치근단 수술시 구동형 수술현미경과 미세수술기구들이 사용됨에 따라 치근단 절제술 후 역충전와동의 효과적인 형성 및 충전을 위해 새로운 초음파기구가 개발되었다 따라서 본 연구에서는 최근 상품화되어 사용되고 있는 초음파기구중 신속하게 역충전와동을 형성할 뿐아니라 충분한 깊이를 제공하여 역충전재료의 변연누출 감소에 효과적인 것으로 알려져 있는 3종의 초음파기구를 사용하여 역 충전와동을 형성 한 후 SuperEBA로 충전하여 그 변연누출을 비교하였다. 모두 56개의 근첨형성이 완료된 단근치를 선택하여 Profile .06를 사용하여 근관형성한 후 음성대조군 2개를 제외한 54개의 치아를 수직가압법으로 충전하였다. 근단부 3mm를 절제한 뒤 KaVo Isthmus, KaVo T-shape 그리고 KiS tip을 각각 18개의 치아에 사용하여 역충전와동을 형성하고 그중 각각 2개의 양성대조군 치아를 제외한 나머지 치아에 SuperEBA로 충전하였다. 각치아는 1% methylene blue dye에 침윤시켜 1주일 후 종절단하여 그 색소침투정도를 측정, 비교하였다. 실험결과 측정된 평균 변연누출은 KaVo Isthmus가 $1.5\pm$1.4mm, KaVo T-shape이 1.7$\pm$1.2mm이고 KiS tip은 1.1$\pm$0.7mm 이었으며, 통계적으로 유의할만한 차이는 없었다. 따라서 초음파기구를 사용한 역충전와동의 임상시술 성공여부는 술자의 편의도와 임상적 사용시 조작능력에 달려 있는 것으로 사료된다.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.888-889
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• 2023

문서를 통해 기록을 남기는 과거의 기록 방식은 현대에 이르러 블로그, 인스타그램 등 다양한 SNS를 활용하는 방식으로 변모하고 있다. SNS의 발달과 대중화는 현대인에게 일반적인 일기 작성 포맷으로 자리 잡고 있다. 증가하는 수요와 디지털 기술 혁신에 대비되는 기존의 수동적인 일기 작성 애플리케이션을 대체하기 위해 본 논문은 DALL-E2와 블록체인을 활용한 일기 작성 및 민팅 애플리케이션 구현을 제안한다. 사용자는 제안하는 애플리케이션을 통해 음성인식, 광학 문자인식을 통한 다양한 일기 작성 방식을 제공받고, 완성된 일기 이미지를 디지털 자산으로서 보존할 수 있다.

• Radiation Oncology Journal
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• v.24 no.1
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• pp.21-29
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• 2006

Purpose: This study explored the anal sphincter-saving rate and down-staging rate after preoperative chemoradiotherapy for treating lower rectal cancer. We also explored the prognosis of the patients who refused surgery after preoperative chemoradiotherapy. Materials and Methods: Thirty seven patients with histologically proven lower rectal cancer who underwent preoperative chemoradiotherapy were retrospectively analyzed. In each case, the tumor location was 0 to 5 em from the anal verge, and curative resection of the cancer with performing a sphincter-saving procedure was not feasible before chemoradiotherapy. In each case, the staging examinations, including biopsy, were done before starting radiotherapy and this was repeated at 1 month after radiation therapy. Results: After chemoradiotherapy, among the 37 included patients, 56.8% and 32.4% were downstaged to the T stage and N stage, respectively, when comparing the postradiotherapy stage with pre-radiotherapy stage. Twenty five patients underwent complete resection of cancer at 6 weeks after radiotherapy: eleven, eight and six patients underwent abdominoperineal resection, low anterior resection and local excision, respectively. The sphincter-saving rate among the 24 completely resected cases was 54.2%. Twelve patients refused surgery after radiotherapy. Among 6 patients who refused surgery with biopsy-proven complete remission after chemoradiotherapy, 5 patients were alive without disease at a median follow up period of 31 months, and only 1 patient had local failure. Conclusion: For lower rectal cancer, a high sphincter-saving rate was accomplished with preoperative chemoradiotherapy. The prognosis of the patients who refused surgery with biopsy proven complete remission after chemoradiotherapy was good and these patients need to be kept under close surveillance.