• Title/Summary/Keyword: 유전체

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Alignment Benefits of Merging Paired-End Reads in Genome Analysis (유전체 연구를 위한 Paired-End Reads 병합 데이터의 정렬 이득에 관한 분석)

  • Kwon, Sun Young;Yoon, Sungroh
    • Proceedings of the Korea Information Processing Society Conference
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    • 2014.11a
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    • pp.59-61
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    • 2014
  • 유전체 연구를 위한 분석 작업은 표준유전체에 시퀀스 데이터를 정렬하는 과정을 필수적으로 요구한다. 정렬에는 single-end 또는 paired-end reads가 사용된다. Paired-end reads는 유전체 조각의 양쪽에서 시퀀싱 된 데이터로 좀 더 긴 길이에 대한 정보를 얻을 수 있어 많이 이용된다. 정렬 툴 자체적으로 paired-end reads를 다룰수 있으나, 병합툴을 활용하는 것이 더 좋은 결과를 보인다. 다섯 가지 병합툴 중에서 CASPER와 pear에서 정렬 이득이 가장 크게 나타난다.

Design of a Ultra Miniaturized Voltage Tuned Oscillator Using LTCC Artificial Dielectric Reson (LTCC 의사 유전체 공진기를 이용한 초소형 전압제어발진기 설계)

  • Heo, Yun-Seong;Oh, Hyun-Seok;Jeong, Hae-Chang;Yeom, Kyung-Whan
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.23 no.5
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    • pp.613-623
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    • 2012
  • In this paper, we present an ultra miniaturized voltage tuned oscillator, with HMIC-type amplifier and phase shifter, using LTCC artificial dielectric resonator. ADR which consists of periodic conductor patterns and stacked layers has a smaller size than a dielectric resonator. The design specification of ADR is obtained from the design goal of oscillator. The structure of the ADR with a stacked circular disk type is chosen. The resonance characteristic, physical dimension and stack number are analyzed. For miniaturization of ADRO, the ADR is internally implemented at the upper part of the LTCC substrate and the other circuits, which are amplifier and phase shifter are integrated at the bottom side respectively. The fabricated ADRO has ultra small size of $13{\times}13{\times}3mm^3$ and is a SMT type. The designed ADRO satisfies the open-loop oscillation condition at the design frequency. As a results, the oscillation frequency range is 2.025~2.108 GHz at a tuning voltage of 0~5 V. The phase noise is $-109{\pm}4$ dBc/Hz at 100 kHz offset frequency and the power is $6.8{\pm}0.2$ dBm. The power frequency tuning normalized figure of merit is -30.88 dB.

Automatic Orthologous-Protein-Clustering from Multiple Complete-Genomes by the Best Reciprocal BLAST Hits (유전체 상호간의 BLAST 최대 히트(best-hit)를 사용하여 서열화가 완성된 다수의 유전체로부터 Orthologous 단백질그룹을 자동적으로 클러스터링하는 기법)

  • Kim Sun-Shin;Rhee Chung-Sei;Ryu Keun-Ho
    • The KIPS Transactions:PartD
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    • v.13D no.2 s.105
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    • pp.207-214
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    • 2006
  • Though the number of completely sequenced genomes quickly grows in recent years, the methods to predict protein functions by homology from the genomes have not been used sufficiently. It has been a successful technique to construct an OPCs(Orthologous Protein Clusters) with the best reciprocal BLAST hits from multiple complete-genomes. But it takes time-consuming-processes to make the OPCs with manual work. We, here, propose an automatic method that clusters OPs(Orthologous Proteins) from multiple complete-genomes, which is, to be extended, based on INPARANOID which is an automatic program to detect OPs between two complete-genomes. We also Prove all possible clustering mathematically.

An Approach to Estimate Dielectric Constant of Low-Loss Materials Using Dielectric Slab Loaded Cylindrical Cavity Resonators (유전체 슬랩이 삽입된 원통형 공진기를 이용한 저손실 물질의 유전 상수 측정)

  • Lee, Won-Hui
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.19 no.10
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    • pp.1115-1121
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    • 2008
  • In this paper, dielectric slab loaded cylindrical cavity resonator measurement technique is presented to determine the dielectric constant of a dielectric material. The dielectric constant is measured by the resonant frequency deviation of empty and dielectric slab loaded cavity. Characteristic equations are derived by th exact field analysis. The measurement configurations are formed using HP8719A vector network analyzer and an experimental cylindrical metallic cavity with circular cross-section. The validity of the theory is confirmed by experiments and CST MWS 4.0(3D simulator). The results were in the whole satisfactory. The measured dielectric constant of teflon and bakelite are 2.03 and 4.44, respectively.

A study of system development for multiple sequence alignment (복수 서열 정렬을 위한 시스템 개발에 관한 연구)

  • Kim, Dong-Hoi;Kim, Jin
    • Proceedings of the Korea Information Processing Society Conference
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    • 2003.05b
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    • pp.1027-1030
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    • 2003
  • 유전체 서열결정이 폭발적으로 증가해 가고 있다. 인간 유전체사업(Human genome project)의 궁극적인 목적은 인간 염색체에 있는 30억개의 뉴클레오티드와 10만개의 유전자를 밝혀내는 것이고 생의학에서 새로운 발견이나 옹용을 위한 정보로 이용하는 것이다. 이 사업은 1980년대 후반에 시작되었고 현재 서열의 결정이 완료된 상태이다. 본 논문에서는 인간 유전체 사업에서 파생된 가장 중요한 문제 중의 하나인 복수 염기서열 정렬 문제와 복수 염기서열 정렬 시스템의 구현에 대하여 논한다.

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ZnS:Mn/Cu,Cl계 나노 형광체 EL의 발광 특성 연구

  • Kum, Jeong-Hun;Lee, Seong-Eui
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2009.06a
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    • pp.291-291
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    • 2009
  • ZnS:Mn/Cu,Cl 계 나노 형광체의 특성을 살펴보았다. 실험에서는 ZnS:Mn 과 ZnS:Cu,Cl 형광체 파우더를 이용하여 밀링을 통하여 분쇄하여 EL 소자를 제작하였다. 형광체 파우더를 볼밀에 $\Phi5mm$의 지르코나이 볼과 에탄올과 함께 넣고 2, 4, 6, 8, 10일간 밀링을 하였다. 밀링한 형광체 파우더를 SEM을 통하여 파우더의 사이즈를 관찰하였다. 또 이 파우더를 이용하여 EL 소자를 제작하였다. 소자의 구조는 기판은 알루미나 기판을, 하부 전극은 Au, 유전체는 $BaTiO_3$ 유전체 페이스트를 사용하였으며, 형광체 적층 후 ITO 전극을 스퍼터를 이용하여 증착하여 제작하였다. 제작한 소자를 이용하여 소자의 휘도 등 발광 특성을 살펴보았다.

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Microstrip Antenna using Multi-layer and Folded Structure for GPS Application (적층 폴디드 구조를 이용한 GPS용 마이크로스트립 안테나)

  • Keum, Jae-min;Woo, Jong-myung
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.16 no.2
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    • pp.171-179
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    • 2017
  • In this paper, microstrip antenna using multi-layer and folded structure for GPS application is presented for aircraft loading. Existing microstrip patch antenna used dielectric of high specific inductive capacity to miniaturize that cause smaller bandwidth and decline of efficiency due to dielectric loss. To compensate the existing flaws, Rogers TMM 10i(dielectric constant=9.8, loss tangent=0.002) is used for multi-layer dielectric miniaturization, and we construct folded radiating element on the surface of the dielectric applying perturbation effect. The antenna is designed in the bandwidth of GPS $L_1$ band, and the size of the antenna's radiating element is $20.3mm{\times}19.93mm$, and it gets 94.2% miniaturized characteristic of basic ${\lambda}/2$ microstrip patch antenna. Also the measured -10 dB bandwidth is 32.3 MHz(2.05%), 3 dB axial ratio bandwidth is 6.7 MHz(0.43%). Measured radiation patterns was maximum gain of 0.56 dBi at x axis polarization, 1.23 dBi at y axis polarization.

Validation of diacylglycerol O-acyltransferase1 gene effect on milk yield using Bayesian regression (베이지안 회귀를 이용한 국내 홀스타인 젖소의 유량형질 관련 DGAT1유전자 효과 검증)

  • Cho, Kwang-Hyun;Cho, Chung-Il;Park, Kyong-Do;Lee, Joon-Ho
    • Journal of the Korean Data and Information Science Society
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    • v.26 no.6
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    • pp.1249-1258
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    • 2015
  • DGAT1(diacylglycerol O-acyltransferase1) gene is well known as a major gene of milk production in dairy cattle. This study was conducted to investigate how the DGAT1 gene effect on milk yield was appeared from the genome wide association (GWA) using high density whole genome SNP chip. The data set used in this study consisted of 353 Korean Holstein sires with 50k SNP genotypes and deregressed estimated breeding values of milk yield. After quality control 41,051 SNPs were selected and locations on chromosome were mapped using UMD 3.1. Bayesian regression of BayesB method (pi=0.99) was used to estimate the SNP effects and genomic breeding values. Percentages of variance explained by 1 Mb non-overlapping windows were calculated to detect the QTL region. As the result of this study, top 1 and 3 of 2,516 windows were seen around DGAT1 gene region and 0.51% and 0.48% of genetic variance were explained by these two windows. Although SNPs on the DGAT1 gene region are excluded in commercial 50k SNP chip, the effect of DGAT1 gene seem to be reflected on GWA by the SNPs which are in linkage disequilibrium with DGAT1 gene.