• Environmental Analysis Health and Toxicology
• /
• v.18 no.1
• /
• pp.27-32
• /
• 2003

고혈압은 다양한 유전적 요인과 환경적 요인이 상호작용하는 다인자성 질환으로 알려져 있으며, 최근의 연구에 의하면 사립체 DNA에 존재하는 유전적 다형성이 고혈압과 유의한 관련성을 나타낸다는 보고가 있다. 이에 본 연구에서는 한국인 집단을 대상으로 하여 사립체 DNA의 5178번째 위치의 염기서열에 존재하는 A/C 다형성이 고혈압과 관련성을 나타내는 지를 분석하였다. 환자-대조군 연구를 수행한 결과, 사립체 DNA의 5178번째 위치에 존재하는 다형성의 대립 유전자 빈도는 한국인에서 고혈압군과 정상 혈압군 사이에 유의한 차이를 나타내지 않았다. 따라서, 이 다형성은 적어도 한국인에 대해서는 고혈압에 유의하게 영향을 미치는 유전적 소인은 아닌 것으로 사료된다.

• Korean Journal of Microbiology
• /
• v.44 no.1
• /
• pp.1-9
• /
• 2008

Xanthomonas oryzae pv. oryzae (Xoo) is the causal agent of bacterial blight on rice. In this paper, current status on molecular genetic study of major virulence genes, hypersensitive response and pathogenicity (hrp), productions of extracellular polysaccharide (EPS), extracellular enzymes and lipopolysaccharides (LPS), avr genes were reviewed. The IS elements with 611 copies including 133 ORF IS were inserted in various regions of the Xoo genome and in expecially regions franking virulence genes. Whole genome sequence of X. oryzae pv. oryzae KACC10331 were used for defining genetic organization of the virulence genes. Futhermore, the virulence genes in Xoo genome were compared to those of other Xanthomonas species in Blast GenBank data base.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.27 no.1
• /
• pp.87-93
• /
• 1982

Dihaploid lines derived from the another of the $F_1$ of single cross, SC72 $\times$ Hicks (Nicotiana tabacum L.) were estimated the variation, heritablities, genetic correlations and path-co-efficients on agronomic characters and chemical compositions. Dinaploids exhibited reduced vigor and growth when comparecd with the mid-parent value but had increased nicotine contents, and the range of dihaploids characters were deviated more than that of their parents. Heritabilities of days to flowering, leaves per plant, nicotine. contents, leaf size and plant height appeared high value, and the yield, value per kg. and reducing sugar contents were low. There were positive genetic correlations between yield, and value per kg., leaf width, leaves per plant and reducing sugar contents and negative genetic correlations appeared between nicotine contents and the other characters except for index of leaf shape. Path-coefficient analysis of genotypic correlation coefficients showed that leaves per plant and leaf width lave a high direct effect, and plant height and days to flowering have a high indirect effect on yield, respectively.

• Electronics and Telecommunications Trends
• /
• v.14 no.5 s.59
• /
• pp.28-33
• /
• 1999

최근 정보사회에 따른 전파수요가 높아지고 있으며 이에 따른 주파수의 요구가 점차 고주파화되고 있고 미개척분야인 밀리미터파의 개발이 중요한 과제로 대두되고 있다. 본 고에서는 밀리미터파 대역 수동부품용 세라믹 유전체 소재에 관한 동향을 서술하였으며, 이 대역에서 세라믹 소재의 유전특성을 측정, 평가하는 여러 방법 중에서 자유공간법을 이용한 기술에 관하여 소개하고자 한다.

• Journal of Plant Biotechnology
• /
• v.42 no.4
• /
• pp.342-349
• /
• 2015

Kiwifruit is a new fruit crop that was commercialized in the late 1970s. Recently, its cultivation and consumption have increased rapidly worldwide. Kiwifruit is a dioecious, deciduous, and climbing plant having fruit with hairs and various flesh colors and a variation in ploidy level; however, the industry consists of very simple cultivars or genotypes. The need for efficient cultivar improvement together with the evolutional and biological perspectives based on unique plant characteristics, have recently encouraged genome analysis and bioinformatics application. The draft genome sequence and chloroplast genome sequence of kiwifruit were released in 2013 and 2015, respectively; and gene annotation has been in progress. Recently, transcriptome analysis has shifted from previous ESTs analysis to the RNA-seq platform for intensive exploration of controlled genetic expression and gene discovery involved in fruit ascorbic acid biosynthesis, flesh coloration, maturation, and vine bacterial canker tolerance. For improving conventional breeding efficiency, molecular marker development and genetic linkage map construction have advanced from basic approaches using RFLP, RAPD, and AFLP to the development of NGS-based SSR and SNP markers linked to agronomically important traits and the construction of highly saturated linkage maps. However, genome and transcriptome studies have been limited in Korea. In the near future, kiwifruit genome and transcriptome studies are expected to translate to the practical application of molecular breeding.

• Journal of the Korean Data and Information Science Society
• /
• v.25 no.5
• /
• pp.1095-1106
• /
• 2014

Symbolic data analysis extends the data mining and exploratory data analysis to the knowledge mining, we can suggest the SDA tree model on clinical and genomic data with new knowledge mining SDA approach. Using SDA application for huge genomic SNP data, we can get the correlation the availability of understanding of hidden structure of HCC data could be proved. We can confirm validity of application of SDA to the tree structured progression model and to quantify the clinical lab data and SNP data for early diagnosis of HCC. Our proposed model constructs the representative model for HCC survival time and causal association with their SNP gene data. To fit the simple and easy interpretation tree structured survival model which could reduced from huge clinical and genomic data under the new statistical theory of knowledge mining with SDA.

• Journal of KIISE:Databases
• /
• v.41 no.4
• /
• pp.249-255
• /
• 2014

Copy number variations(CNVs) are a recently recognized class of human structural variations and are associated with a variety of human diseases, including cancer. To find important cancer genes, researchers identify novel CNVs in patients with a particular cancer and analyze large amounts of genomic and clinical data. We present a tool called CNVDAT which is able to detect CNVs from NGS data and systematically analyze the genomic and clinical data associated with variations. CNVDAT consists of two modules, CNV Detection Engine and Sequence Analyser. CNV Detection Engine extracts CNVs by using the multi-resolution system of scale-space filtering, enabling the detection of the types and the exact locations of CNVs of all sizes even when the coverage level of read data is low. Sequence Analyser is a user-friendly program to view and compare variation regions between tumor and matched normal samples. It also provides a complete analysis function of refGene and OMIM data and makes it possible to discover CNV-gene-phenotype relationships. CNVDAT source code is freely available from http://dblab.hallym.ac.kr/CNVDAT/.

• Pediatric Infection and Vaccine
• /
• v.26 no.3
• /
• pp.129-139
• /
• 2019

The human respiratory tract hosts both pathogenic and commensal bacteria. The development of well-conserved 16S rRNA sequencing and culture-independent techniques has enabled many achievements in the study of the human microbiome. Microbial composition of the respiratory tract in early childhood has been shown to correlate to respiratory health in later stages of life. This review highlights current understandings of respiratory microbiota development in healthy children, examples of microbial interactions, impacts on the host immune system, and the relationship between respiratory tract microbiome and respiratory health.

• Proceedings of the KIEE Conference
• /
• 2000.07c
• /
• pp.1527-1529
• /
• 2000

본 연구는 펄스 정전 응력법을 이용하여 공간전하분포를 교류전압 하에서 측정을 하였다. 이와 동시에 교류 고전압에서의 방전발생과 방전패턴의 변화를 측정하고, 공간전하분포와 방전과의 상관관계를 분석하였다. 교류 전압에서의 공간전하는 교류 한 주기를 18$^{\circ}$ 간격으로 등분하여 각 위상에서 그 분포를 측정하였으며, 공간전하분포와 방전패턴 사이의 관계를 분석하였다 실험 결과 유전체 장벽 방전이 많이 일어나는 위상에서의 공간전하분포 역시 크게 변하는 것을 볼 수 있었다. 이러한 사실을 통해 공간전하분포 특성이 유전체 장벽 방전 특성의 연구에 있어서 중요한 부분임을 알 수 있다.

• Journal of the Institute of Convergence Signal Processing
• /
• v.6 no.1
• /
• pp.27-32
• /
• 2005

As a large quantity of Genome sequencing has happened to be done a very much a surprising speed in short period, an automatic genome annotation process has become prerequisite. The most difficult process among with this kind of genome annotation works is to finding out the protein-coding genes within a genome. The main 2 subjects of gene prediction are Eukaryotes and Prokaryotes ; their genes have different structures, therefore, their gene prediction methods will also obviously varies. Until now, it is found that among of the 231 genome sequenced species, 200 have been found to be prokaryotes, therefore, for study of biotechnology studies, through comparative genomics, prokaryotes, rather than eukaryotes could may be more appropriate than eukaryotes. Even more, prokaryotes does not have the gene structure called an intron, so it makes the gene prediction easier. Former prokaryotes gene predictions have been shown to be 80%～ to 90% of accuracy. A recent study is aiming at 100% of gene prediction accuracy. In this paper, especially in the case of the E. coli K-12 and S. typhi genomes, gene prediction accuracy which showed 98.5% and 98.7% was more efficient than previous GLIMMER.