• Title/Summary/Keyword: 유전적 구조

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Models of Genetic Counseling Services and Quality Assurance: A Theoretical Inquiry (유전상담 서비스 모델 분석 : 이론적 탐색)

  • Jun, Myung-Hee;Anderson, Gwen
    • The Journal of Korean Academic Society of Nursing Education
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    • v.17 no.3
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    • pp.524-535
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    • 2011
  • 유전 위험 사정과 상담서비스가 임상실무에 널리 적용되어 감에 따라, 다양한 비용효율 면에서 다양한 상담서비스 모델을 사정하고, 대상자의 임상 요구와 건강문제를 해결하는데 어떤 모델이 유용한 지 확인할 필요가 있다. 본 연구의 목적은 114건의 현장 관찰과 문헌고찰을 통하여 3가지 유전상담 모형을 분석하였다. 유전의학 전문가 모델, 유전상담사 모델, 임상연구전문가 모델을 중심으로 각 모델의 구조, 전문가의 역할 및 기능, 목표, 물리적 세팅, 교육도구 등을 분석하였다. 각 모형 안에서 환자에게 기대되는 결과 면에서 질적 서비스가 보장되는지 확인하기 위하여 이론적 분석을 실시하였다. 본 연구를 통하여 각 모형의 상담 전, 중, 후 환자 만족, 지식 변화, 상담 효과 및 커뮤니케이션 효과 등을 분석하였지만, 결론적으로 상담서비스가 이루어지고 있는 기관의 구조를 충분히 고려하지 않은 상태에서 최상의 서비스 모델을 제시하기 어려울 것임을 논의하였다.

Population Genetic Structure of Potentilla discolor Bunge, Rosaceae in Korea (한국내 솜양지꽃의 집단 유전 구조)

  • Huh, Man-Kyu
    • Journal of Life Science
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    • v.16 no.6
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    • pp.898-903
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    • 2006
  • The genetic diversity and population structure of fifteen Potentilla discolor Bunge populations in Korea were determined using genetic variations at 19 allozyme loci. Fourteen of the 19 loci (73.7%) showed detectable polymorphism. Genetic diversity at the species level and at the population level was high ($H_{ES}\;=\;0.215$, $H_{EP}\;=\;0.196$, respectively), whereas the extent of the population divergence was relatively low $(G_{ST}\;=\;0.069)$. Total genetic diversity values $(H_T)$ varied between 0.0 and 0.656, giving an average overall polymorphic loci of 0.292. The interlocus variation of genetic diversity within populations $(H_S)$ was high (0.274). On a per locus basis, the proportion of total genetic variation due to differences among populations $(G_{ST})$ ranged from 0.010 for Pgm-2 to 0.261 for Pgd-2 with a mean of 0.069, indicating that about 6.9% of the total allozyme variation was among populations. Wide geographic ranges, perennial herbaceous nature and the persistence of multiple generations are associated with the high level of genetic variation in P. discolor. The estimate of gene flow based on $G_{ST}$ was high among Korean populations of P. discolor (Nm = 3.36).

The Mode Analysis for field pattern analysis of a Finite Periodic Dielectric Structure (유한한 유전체 격자구조에서 필드패턴 분석을 위한 모드연구)

  • Kim, Min-Nyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.9 no.3
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    • pp.645-648
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    • 2008
  • In this paper, we analyze inner- and far-field emitted field pattern by more exactly calculating modes formed from a finite periodic dielectric structure(FPDS). It is assumed that TE-modes are generated in FPDS, and the fields in each layer are determined by proper boundary conditions. Consequently, the fields generate modes in the FPDS and the number of modes depends on its structural characteristics. In this work, the modes betwween dielectric layers and their field patterns are calculated in a specific frequency. In addition. far field patterns are given by using FFT of the calculated modes.

Genetic Diversity and Spatial Genetic Structure of Dwarf Stone Pine in Daecheongbong Area, Mt. Seorak (설악산 대청봉 눈잣나무(Pinus pumila (Pall.) Regel) 집단의 유전다양성과 공간적 유전구조)

  • Song, Jeong-Ho;Lim, Hyo-In;Hong, Kyung-Nak;Jang, Kyung-Hwan;Hong, Yong-Pyo
    • Korean Journal of Plant Resources
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    • v.25 no.4
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    • pp.407-415
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    • 2012
  • Pinus pumila, which occurs in the northeast Asia, is found limitedly in Daecheongbong area of Mt. Seorak in the South Korea. This population was chosen to study spatial pattern, genetic diversity and spatial genetic structure. There were 48 polymorphic and 30 monomorphic I-SSR markers. A total of 65 individuals which distributed in the study site (40 m ${\times}$ 70 m) showed weakly aggregate distribution (Aggregate Index = 0.871). A total of 40 genets were observed from 65 individuals through I-SSR genotype comparison. Proportion of distinguishable genotype (G/N), genotype diversity (D) and genotype evenness (E) were 61.5%, 0.977 and 0.909, respectively. In spite of the small number and the limited distribution, Shannon's diversity index (I = 0.567) was relatively high as compared with those of other plant species. Spatial autocorrelation using Tanimoto's distance showed that the genetic patch was established within 12 m. Based on Mantel tests, there was relatively low correlation between genetic distance and geographic distance. Therefore, it seems the P. pumila population was formed by many parent trees in early stage. For ex situ genetic conservation of P. pumila, the sampling strategy is efficient at least above 12 m between individual trees.

$Si_3N_4$를 이용한 금속-유전체-금속 구조 커패시터의 유전 특성 및 미세구조 연구

  • 서동우;이승윤;강진영
    • Proceedings of the Korean Vacuum Society Conference
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    • 2000.02a
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    • pp.75-75
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    • 2000
  • 플라즈마 화학증착법(Plasma Enhanced Chemical Vapor Deposition, PECVD)을 이용하여 양질의 Si3N4 금속-유전막-금속(Metal-Insulator-Metal, MIM) 커페시터를 구현하였다. Fig.1에 나타낸 바와 같이 p형 실리콘 웨이퍼의 열 산화막 위에 1%의 실리콘을 함유하는 알루미늄을 스퍼터링으로 증착하여 전극을 형성하고 두 전극사이에 Si3N4 박막을 증착하여 MIM구조의 박막 커패시터를 제조하였다. Si3N4 유전막은 150Watt의 RF 출력하에서 반응 가스 N2/SiH4/NH3를 각각 300/10/80 sccm로 흘려주어 전체 압력을 1Torr로 유지하면서 40$0^{\circ}C$에서 플라즈마 화학증착법을 이용하여 증착하였으며, Al과 Si3N4 층의 계면에는 Ti과 TiN을 스퍼터링으로 증착하여 확산 장벽으로 이용하였다. 각 시편의 커패시턴스 및 바이어스 전압에 따른 누설 전류의 변화는 LCR 미터를 이용하여 측정하였고 각 시편의 커패시턴스 및 바이어스 전압에 따른 누설 전류의 변화는 LCR 미터를 이용하여 측정하였고 각 시편의 유전 특성의 차이점을 미세구조 측면에서 이해하기 이해 극판과 유전막의 단면 미세구조를 투과전자현미경(Transmission Electron Microscope, TEM)을 이용하여 분석하였다. 유전체인 Si3N4 와 전극인 Al의 계면반응을 억제시키기 위해 TiN을 확산 장벽으로 사용한 결과 MIM커패시터의 전극과 유전체 사이의 계면에서는 어떠한 hillock이나 석출물도 관찰되지 않았다. Fig.2와 같은 커패시턴스의 전류-전압 특성분석으로부터 양질의 MIM커패시터 특성을 f보이는 Si3N4 의 최소 두께는 500 이며, 그 두께 미만에서는 대부분의 커패시터가 전기적으로 단락되어 웨이퍼 수율이 낮아진다는 사실을 알 수 있었다. TEM을 이용한 단면 미세구조 관찰을 통해 Si3N4 층의 두께가 500 미만인 커패시터의 경우에 TiN과 Si3N4 의 계면에서 형성되는 슬릿형 공동(slit-like void)에 의해 커패시터의 유전특성이 파괴된다는 사실을 알게 되었으며, 이러한 슬릿형 공동은 제조 공정 중 재료에 따른 열팽창 계수와 탄성 계수 등의 차이에 의해 형성된 잔류응력 상태가 유전막을 기준으로 압축응력에서 인장 응력으로 바뀌는 분포에 기인하였다는 사실을 확인하였다.

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Genetic Diversity and Structure of a Rare and Endemic, Spring Ephemeral Plant Corydalis filistipes Nakai of Ullung Island in Korea (울릉도 희귀.특산 식물 섬현호색의 유전적 다양성과 구조)

  • Kim, Jin-Seok;Yang, Byeong-Hoon;Chung, Jae-Min;Lee, Byeong-Cheon;Lee, Jae-Cheon
    • Journal of Ecology and Environment
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    • v.29 no.3
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    • pp.247-252
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    • 2006
  • For the spring ephemeral and myrmecochorous perennia, Corydalis filistipes Nakai (Fumariaceae), rare and narrow endemic to Ullung Island in Korea, genetic diversity and structure of 4 subpopulations of the species were investigated with allozyme markers. Levels of genetic diversity (A=1.73, $P_{95%}$=61..2%, Ho=0.201, He=0.167) were relatively lower than those of other endemic species with widespread distribution range, but considerably higher than other endemic species with similar life history traits isolated in island. The moderate level of genetic diversity within subpopulations in C. filistipes is characteristic of the species with predominantly outcrossing, myrmecochorous seed dispersal by dual function of the elaisome and mode of sexual and asexual reproduction by the cleistogamy. The analysis of fixation indices showed an overall excess of heterozygotes (mean $F_{IS}=-0.1889,\;F_{IT}=-0.1226$) relative to H-W expectations. About 5.6% of the total genetic variation was found among subpopulations ($F_{ST}$=0.0557). The strategies of reasonable conservation and management, and the maintenance mechanism of genetic diversity of Corydalis filistipes Nakai, endemic plant species in Korea were discussed.

Genetic variation in populations of the Korean endemic Eranthis byunsanensis (Ranunculaceae) (한국 특산식물 변산바람꽃(Eranthis byunsanensis)의 유전적 변이)

  • So, Soonku;Lee, Byongsoon;Park, Ki-Ryong
    • Korean Journal of Plant Taxonomy
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    • v.42 no.4
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    • pp.253-259
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    • 2012
  • The genetic variation in populations of Eranthis byunsanensis, an endemic and rare species of Korea, was studied using starch gel electrophoresis. All five known populations were sampled for allozyme electrophoresis of nine enzymes coded by 10 loci. The overall genetic variation of E. byunsanensis population was shown to be considerably high within the populations (A = 2.4, P = 90.0, $H_E$ = 0.311). A positive $F_{IS}$ value of E. byunsanensis indicated an overall deficiency of heterozygotes, and a low $F_{ST}$ value (0.131) showed little differentiation among populations. The high genetic variation, less genetic differentiation among populations, and a significant amount of heterozygote deficiency propose the hypothesis that they have an experience of recent isolation and fragmentation of their habitat. Thus, the rate of gene flow has been drastically reduced, and the rate of inbreeding in E. byunsanensis populations has increased. Current habitats in Mai-san and Naro-do are vulnerable due to their small population size and the levels of anthropogenic activity in the region constantly threatening survival of this species. Because of the high genetic variation and low levels of differentiation among populations in E. byunsanensis, it is not issue which populations have a priority for protection, but we may concern the plan to maintain population continuously and diminish the rate of inbreeding.

Size and Shape Optimization of Truss Structures using Micro Genetic Algorithm (마이크로 유전 알고리즘을 이용한 트러스 구조물의 단면 및 형상 최적화)

  • Kim, Dae-Hwan;Yoon, Byoung-Wook;Lee, Jae-Hong
    • Journal of Korean Society of Steel Construction
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    • v.23 no.4
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    • pp.465-474
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    • 2011
  • In this study, a microgenetic algorithm was used to find the optimum cross-section and shape of dome structures. The allowable stress and Euler buckling stress were considered constraints when the weight of the trusses was minimum. The design optimization of the truss structures involved arriving at the optimum sizes of the cross-section and geometric coordinate. The features of the proposed method, which helped in the modeling of and application to the optimal design of truss structures, were demonstrated using the microgenetic algorithm, by solving sample problems.

Leaky Wave Radiation and Surface Wave Launching Problem in a Dielectrically Covered Periodically Slitted Parallel-Plate Waveguide (주기적인 슬릿을 갖고 유전체층으로 덮힌 평행평판 도파관에서의 누설파 복사 및 표면파 launching)

  • 이종익;이철훈;조영기
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.36D no.4
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    • pp.25-33
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    • 1999
  • Leaky wave radiation and surface wave launching problems in a dielectrically covered and periodically slitted parallel-plate waveguide(PPW) are considered for the TEM wave incidence case. Both the infinite and finite periodic geometries are analyzed by use of the method of moments. Some numerical results for the reflected and transmitted powers in the PPW, radiation efficiency into the free space, surface wave launching efficiency into the slab, antenna gain, and radiation patterns against dielectric thickness are presented to show the effect of the dielectric cover on the performances of the slitted leaky wave antenna. In addition, the method for improving surface wave launching efficiency using the proposed periodic geometry is described and maximum launching efficiency of 97.5% is obtained theoretically. So this structure is thought to be promising as an efficient feeder of dielectric grating antenna as well as image guide.

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Distributed Hybrid Genetic Algorithms for Structural Optimization (분산 복합유전알고리즘을 이용한 구조최적화)

  • 우병헌;박효선
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.16 no.4
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    • pp.407-417
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    • 2003
  • Enen though several GA-based optimization algorithms have been successfully applied to complex optimization problems in various engineering fields, GA-based optimization methods are computationally too expensive for practical use in the field of structural optimization, particularly for large- scale problems. Furthermore, a successful implementation of GA-based optimization algorithm requires a cumbersome and trial-and-error routine related to setting of parameters dependent on a optimization problem. Therefore, to overcome these disadvantages, a high-performance GA is developed in the form of distributed hybrid genetic algorithm for structural optimization on a cluster of personal computers. The distributed hybrid genetic algorithm proposed in this paper consist of a simple GA running on a master computer and multiple μ-GAs running on slave computers. The algorithm is implemented on a PC cluster and applied to the minimum weight design of steel structures. The results show that the computational time required for structural optimization process can be drastically reduced and the dependency on the parameters can be avoided.