• The Korean Journal of Pharmacology
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• v.28 no.2
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• pp.129-136
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• 1992

As it has been reported that the depolarization-induced acetylcholine (ACh) release is modulated by activation of presynaptic $A_1-adenosine$ heteroreceptor in hippocampus and various lines of evidence indicate the involvement of adenylate cyclase system in $A_1-adenosine$ post-receptor mechanism in hippocampus, it was attempted to delineate the role of adenylate cyclase system in the $A_1-receptor-mediated$ control of ACh release in this study. Slices from rat hippocampus were incubated with $[^3H]-choline$ and the release of the labelled products was evoked by electrical stimulation $(3\;Hz,\;5\;Vcm^{-1},\;2\;ms,\;rectangular\;pulses)$, and the influence of various agents on the evoked tritium-outflow was investigated. $N^6-cyclopentyladenosine$ (CPA), a specific $A_1-adenosine$ receptor agonist, in concentrations ranging from 0.1 to $10\;{\mu}M$, decreased the $[^3H]-ACh$ release in a dose-dependent manner without the changes of basal rate of release. 8-cyclopentyl-1,3-dipropylxanthine $(DPCPX,\;1{\sim}10\;{\mu}M)$, a selective $A_1-receptor$ antagonist, increased the $[^3H]-ACh$ release in a dose-related fashion with slight increase of basal tritium-release. And the CPA effects were significantly inhibited by DPCPX $(2\;{\mu}M)$ pretreatment and the dose-response curve produced by CPA was shifted to the right. The responses to N-ethylmaleimide $(NEM,\;10\;&\;30\;{\mu}M)$, a SH-alkylating agent of G-protein, were characterized by increments of the evoked ACh-release and the basal release, and the CPA effect were completely abolished by NEM pretreatment. Forskolin, a specific adenylate cyclase activator, in concentrations ranging from 0.3 to $10\;{\mu}M$, increased the evoked ACh-release in a dose-dependent manner and the CPA effects were inhibited by forskolin. These results indicate that the $A_1-adenosine$ heteroreceptor plays an important role in ACh-release via nucleotide-binding protein Gi in the rat hippocampus and that the adenylate cyclase system might be participated in this process.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.6
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• pp.3990-3996
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• 2014

Because the physical properties can be decreased when a Nylon 66/glass fiber composite is injected into a mold over $300^{\circ}C$, a systematic study of the thermal history in the case of re-use is needed. Nylon 66/glass fiber extrudates as a function of the extrusion number were prepared using a twin screw extruder at 305/290/273/268/265/$260^{\circ}C$. The chemical structure, thermal properties, melt index, crystal structure, Izod impact strength, and rheological properties were measured by Fourier transform infra-red (FT-IR), melt indexer, DSC, TGA, XRD, Izod impact tester, and dynamic rheometer. The FT-IR spectra indicated that the number of extrusions did not affect the chemical structure. The decrease in molecular weight with increasing extrusion number was confirmed by the melt index and the complex viscosity of extrudates. Based on the DSC and TGA results, the thermal history had no effect on the melting temperature, regardless of the number of extrusions, but the degradation temperature decreased up to $20^{\circ}C$ with increasing extrusion number. The Izod impact strengths of the extrudates were found to decrease with increasing extrusion number. No structural change after extrusion was also confirmed because there was no change in the slope and shape of the G'-G" plot.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.2
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• pp.101-107
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• 2016

Laser-Assisted machining (LAM) is a new method for processing hard-to-cut materials. However, curved shapes are difficult to predict the preheating effect of by LAM because heat sources are changed by moving laser module. So, it is necessary to study the preheating effect of the laser heat source irradiated on a 3-dimensionally shaped workpiece, such as a NURBS shaped workpiece. In this study, thermal analysis and preheating experiment of the LAM for the NURBS shaped workpiece are performed. Also, two machining methods are proposed to avoid interference of laser module and cutting tool. The results of the analysis can be applied to various shaped workpieces by LAM.

• Korean Journal of Computational Design and Engineering
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• v.3 no.2
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• pp.135-139
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• 1998

The hodograph, which are usually defined as the derivative of parametric curve or surface, is useful far various geometric operations. It is known that the hodographs of Bezier curves and surfaces can be represented in the closed form. However, the counterparts of rational Bezier curves and surface have not been discussed yet. In this paper, the equations are derived, which are the closed form of rational Bezier curves and surfaces. The hodograph of rational Bezier curves of degree n can be represented in another rational Bezier curve of degree 2n. The hodograph of a rational Hazier surface of degree m×n with respect to a parameter can be also represented in rational Bezier surface of degree 2m×2n. The control points and corresponding weight of the hodographs are directly computed using the control points and weights of the given rational curves or surfaces.

• Korean Journal of Computational Design and Engineering
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• v.4 no.4
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• pp.312-317
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• 1999

An inflection point on a curve is a point where the curvature vanishes. An inflection point is useful for various geometric operations such as the approximation of curves and intersection points between curves or curve approximations. An inflection point on planar Bezier curves can be easily detected using a hodograph and a derivative of hodograph, since the closed from of hodograph is known. In the case of rational Bezier curves, for the detection of inflection point, it is needed to use the first and the second derivatives have higher degree and are more complex than those of non-rational Bezier curvet. This paper presents three methods to detect inflection points of rational Bezier curves. Since the algorithms avoid explicit derivations of the first and the second derivatives of rational Bezier curve to generate polynomial of relatively lower degree, they turn out to be rather efficient. Presented also in this paper is the theoretical analysis of the performances of the algorithms as well as the experimental result.

• Korean Journal of Computational Design and Engineering
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• v.4 no.4
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• pp.350-354
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• 1999

The problem of the computation of derivatives arises in various applications of rational Bezier curves. These applications sometimes require the computation of derivative on numerous points. Therefore, many researches have dealt with the representation for the computation of derivatives with the small computation error. This paper compares the performances of the representations for the derivative of rational Bezier curves in the performances. The performance is measured as computation requirements at the pre-processing stage and at the computation stage based on the theoretical derivation of computational bound as well as the experimental verification. Based on this measurement, this paper discusses which representation is preferable in different situations.

• Journal of the Korean Society for Precision Engineering
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• v.16 no.5 s.98
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• pp.160-168
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• 1999

This paper describes one method of reverse engineering that machines a free form shape without descriptive model. A portable five-axes 3D CMM was used to digitize point data from physical model. After approximation by rational B-spline curve from digitized point data of a geometric shape, a surface was constructed by the skinning method of the cross-sectional design technique. Since a surface patch was segmented by fifteen part, surface merging was also implemented to assure the surface boundary continuity. Finally, composite surface was transferred to commercial CAD/CAM system through IFES translation in order to machine the modeled geometric shape.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.162-167
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• 2004

The low velocity impact characteristics of composite laminate curved beams are investigated to increase damage tolerance and reduce the deflection. Drop weight impact tests of the composite curved beam were performed with respect to pre-load, then the damage after impact was measured by macrography. Also, finite element analyses were performed using ABAQUS to investigate the stress state of composite curved beam with respect to pre-load and impact. From the investigation, it was found that pre-load of the composite curved beams had much influence on impact damage of the curved beam, which showed good agreement with the experiment results.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.228-232
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• 2010

두 가지 어류 이동용 여수로 설계안에 대하여 유한요소법 기반의 레블�V 기법을 이용하여 흐름을 모의하고 적용성을 검토하였다. 첫 번째 설계안은 저수지에서 여수로로 직각 형태의 유입부를 가지고 있으며, 두 번째 설계안은 부드러운 곡면 형태의 유입부를 가지고 있다. 수치해석 결과를 자유수면의 위치, 압력분포 등의 특성을 중심으로 여수로 수리모형 실험 결과와 비교하였다. 그 결과, 직각 형태의 유입부를 갖는 설계안의 경우, 유입부의 응력분포의 영향으로, 평탄하지 않은 자유수면형과 압력분포를 보이는 것을 관찰할 수 있었다. 반면에 곡선형태의 유입부를 갖는 여수로의 경우에는 수면형과 압력분포에서 완만한 변화를 보이는 것이 관측되었다. 여수로 정상부에서 대기압보다 작은 부압의 분포는 두 가지 설계안 모두 비슷한 분포를 보였다. 여수로의 출구부에서는 측면부에서는 와류의 영향으로 인하여 수면의 상승을 관찰할 수 있었다. 결론으로서 곡면 유입부 형태의 여수로가 완만한 천이역을 갖고 있으며, 어류이동측면에서 유리함을 확인할 수 있었다.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.577-578
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• 2023

외발자전거는 서커스 곡예의 소재로 사용될 정도로 일반인이 타기 어렵다. 하지만, 구조가 단순하고 부피가 작고 가벼워 개인용 이동 수단으로 장점이 많다. 바퀴가 하나이므로 자유도가 높아서 좁거나 곡선반지름이 작은 길에서도 유리하다. 최근 전기자전거뿐만 아니라 전동보드, 전동휠 등 다양한 형태의 전력 구동형 개인 이동 수단들이 많이 등장하고 이용되고 있는데 스스로 균형을 유지하여 안전하고 쉽게 탈 수 있는 외발 전동차를 개발을 위해 인공지능 강화학습을 적용한 자동제어장치를 시뮬레이션을 통해 구현하고자 한다.