• Journal of the Korea Society of Computer and Information
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• v.15 no.2
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• pp.119-125
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• 2010

Recently Hsiang-Shih proposed the user authentication scheme to improve Yoon et al's scheme. But the proposed scheme has not been satisfied security requirements considering in the user authentication scheme using the password based smart card. In this paper, we proved that Hsiang-Shih's scheme is vulnerable to the off-line password guessing attack. In other words, the attacker can get the user's password using the off-line password guessing attack on the scheme when the attacker steals the user's smart card and extracts the information in the smart card. Also, the improved scheme based on the hash function and random number was introduced, thus preventing the attacks, such as password guessing attack, forgery attack and impersonation attack etc. And we suggested the effective mutual authentication scheme that can authenticate each other at the same time between the user and server.

• Journal of Korean Medicine for Obesity Research
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• v.15 no.2
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• pp.68-74
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• 2015

Objectives: The purpose of this study was to investigate the effects of Shengmai-san and Pyungwi-san, a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice. Methods: The in vivo effects of Shengmai-san and Pyungwi-san on GI motility were investigated by measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. Results: In normal Institute of Cancer Research mice, ITRs were significantly and dose-dependently increased by Shengmaisan (0.01~1 g/kg) and Pyungwi-san (0.01~1 g/kg). The ITRs of acetic acid induced peritoneal irritation model and streptozotocin-induced diabetic model mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by Shengmai-san (0.01~1 g/kg) and Pyungwi-san (0.01~1 g/kg). Conclusions: These results suggest that both Shengmai-san and Pyungwi-san are a good candidate for the development of a prokinetic agent that may prevent or alleviate GMD.

• Journal of Sasang Constitutional Medicine
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• v.20 no.2
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• pp.72-84
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• 2008

1. Objectives The purpose of this study was to observe the anti-oxidant effects of Hyangsayangyi-tang(HY) in SD rats. 2. Methods This experiment was used the tissue of stomach, spleen and pancreas cells of 6, 52 and 68 weeks old SD rats. Each age group was again divided into three groups. One group, as normal group, was not-treated cells, another group, as control group, was saline-treated cells, and the last group, as experimental group, was HY-treated cells. After culture for 48 hours, each groups measured the level of SOD, GSH, MDA and NO in the tissue of stomach, spleen and pancreas cells. 3. Results and Conclusions The activity of SOD were significantly increased in spleen cell of 52, 68 w-HY group, pancreas cell of 68 w-HY group and in stomach cell of 52, 68 w-HY group compared with those of the normal and the control groups. The level of GSH were significantly increased in spleen cell of 52, 68w-HY group and in pancreas cell of 68w-HY group compared with those of the normal and the control groups. The level of MDA were significantly decreased in pancreas cell of 68 w-HY group compared with those of the normal and the control groups. The level of NO were significantly decreased in spleen cell of 68 w-HY group, pancreas cell of 52, 68w-HGD groups compared with those of the control groups. According to results, HY showed anti-oxidant effect. Investigation into the clinical use of the HY is suggested for future research.

• Proceedings of the KOR-BRONCHOESO Conference
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• 2003.09a
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• pp.108-108
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• 2003

식도 천공의 치료는 최근 치료법의 발전에도 불구하고 여전히 난해한 문제이다. 이 환자들은 천공의 원인이나 위치, 심한 정도가 다양한 이질적인 군이며, 반수 이상이 이미 식도에 기존의 질환을 가지고 있어 문제를 더욱 복잡하게 한다. 따라서 절대적이고 획일적인 치료방법은 아직 확립되어 있지 않으며 많은 다양한 방법들이 제시되고 있다. 2002년 11월부터 2003년 7월까지 총 8명의 환자가 식도 천공으로 동아대학교병원 흥부외과에서 치료를 받았으며, 원인별로는 의인성(iatrogenic) 손상이 6례, 자발성(spontaneous) 손상이 2례였고 부위별로는 경부가 3례, 흥부가 5례였다. 의인성 손상에는 내시경 검사중 정상 경부 식도에 발생한 1례, 부식성 식도협착 환자의 풍선 확장술과 스텐트 삽입시 흉부 식도에 발생한 경우가 각각 1례씩, 외상성 경추손상의 수술시 정상 경부 식도에 발생한 경우가 2례, 선천성 식도폐쇄증(esophageal atresia)의 술후 문합부 누출이 생긴 경우가 1례 있었으며, 자발성 손상에는 하부식도에 발생한 기압성(barogenic) 손상 1례와 상흉부 식도암 천공 1례가 있었다. 경부 식도 천공 3례는 모두 경부 배액(drainage)과 식이용 장루술(feeding jejunostomy)을 시행하였고, 부식성 식도협착이 있던 환자 2례는 식도절제술과 흉부내 식도-위 문합을 시행하였으며, Boerhaave씨 증후군 환자는 1차 봉합술, 술후 문합부 유출이 있었던 환자와 식도암 천공이 있었던 환자는 식도절제 및 경부 식도루(esophagostomy), 배액용 위루(gastrostomy), 식이용 장루술을 시행하였다. 모든 환자는 패혈증 등의 심각한 합병증으로의 진행 없이 회복되었다. 현재 위장관의 연속성이 유지 혹은 복원된 환자는 경구식이 중이며 그 외의 환자들은 장루를 통해 영양을 공급하며 식도재건술을 기다리고 있다. 식도 천공은 최근 항생제의 사용, 과영양요법(hyperalimentation), 술후 환자관리의 개선 등으로 치료에 많은 발전이 있었으나, 치료 방침에 있어서는 여전히 논란이 있으며 높은 사망률을 보이는 난제로 남아있다. 비록 일반적인 지침이 도움이 되겠지만, 치료 방침은 환자 개개인의 상황에 따라 적절하게 선택해야 하며, 임상경과에 따라 언제라도 방침을 변경할 수 있는 유연함이 필요하리라 생각한다.

• Proceedings of the Ginseng society Conference
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• 1984.09a
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• pp.169-183
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• 1984

인삼의 주된 사포닌으로서 Rg,과 Rb,을 흰쥐에 투여하였을 경우에 이들 물질이 흰쥐의 장기에 흡수 또는 분포되는 상태와 배설에 대하여 연구하였다. 진세노사이드 $Rg_{1}$은 경구 투여량의 약 $1.9{\%}$가 소화관의 상부에서 흡수되었으며, 투여한지 30분 후에 최고 혈중 농도에 이르렀고 조직에서는 1.5시간 걸렸다. 그러나 뇌에서는 확인되지 않았으며 뇨와 당즙에는 2 : 5의 비로 배설되었다. $Rb_{1}$을 100mg/kg 경구투여한 결과, 소화관에서는 거의 흡수가 되지 않았으며, 한편 정맥주사(5mg/kg)의 경우는 혈중 $Rb_{1}$의 농도가 지수적으로 감소하였으며, B-phase의 반감기는 14.5시간이었다. 정맥주사후 혈청과 조직에 장시간 잔존은 활성을 나탄내는 혈청단백과의 결합과 관련이 있는 것으로 사료되며 시간에 따라 뇨로 배설되나 담즙에서는 확인되지 않았다. $Rg_{1}$과 $Rb_{1}$을 경구투여한 후 TLC와 $^{13}C$-NMR을 이용하여 위와 대장에서의 분해 상태를 연구한 결과 위에서 $Rg_{1}$의 일부가 분해, 6종류의 분해 산물이 r-everse phase TLC상에서 관찰되었고 이들 분해 산물은 약산성 (0.1N HCl, $37^{\circ}C$) 조건하에서 $Rg_{1}$의 가수분해산물과 동일하였다. 한편, $Rb_{1}$ 경구투여후 위장에서 얻은 시료중에서 미확인 분해산물이 관찰되었으며, 이 분해산물은 약산성 조건하에서 $Rb_{1}$의 가수분해산물과는 상이하다는 사실을 확인하였다. 대장에서, $Rg_{1}$은 미생물 tetracycline-susceptible bacteria와 tetracycline-resist bacteria에 의해 $Rb_{1}$과 $F_{1}$으로 분해되었으며, $Rb_{1}$은 장내의 효소와 tetracycline-resistantant bacteria에 의해 Rd와 2 종류의 미확인 물질로 분해되었다.

• YAKHAK HOEJI
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• v.49 no.3
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• pp.237-243
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• 2005

Present study was performed for the development of a new supplementary product with gastroprotective effect. The preliminary screening were conducted for the effects of HCl-ethanol-induced gastric lesions in rats. Samples were aloe gel, active hexose correlated compound (AHCC) mentioned that have GI protective property and pulmuone healthy aloe gel (PHAG) that mixture of natural products from Pulmuone company. Aloe gel significantly inhibited HCl-ethanol-induced gastric lesions at the oral dose of 5 ml/kg. AHCC showed the strongest effectiveness at the oral dose of 1,200 mg/kg. PHAG also showed the significant effects at the oral dose of 10, 20 g/kg. In pylorus ligated rats, the treatments of aloe gel, AHCC and PHAG showed decrease in the volume of gastric secretion and acid output. And aloe gel, AHCC and PHAG significantly suppressed the aspirin-induced ulcer and chronic ulcer in pylorus ligated rats. The treatments of aloe gel and PHAG significantly reduced acetic acid-induced ulcer at the oral dose of 5 ml/kg and 10 g/kg for 12 days. In this study; we have found that PHAG had significant improvement in acute gastritis and ulcer at the dose of 20 g/kg and in chronic gastritis and ulcer at the dose of 10 g/kg. Also we evaluated the anti-bacterial activity against H. pylori treated with aloe gel, AHCC and PHAG. PHAG had a equivalent anti bacterial activity with ampicillin against H. pylori at the dose of 1 g/kg.

• Journal of Korean Medical classics
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• v.13 no.1
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• pp.1-16
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• 2000

대태극적내용화재인신내응장하처간작태극적문제진행료고찰(對太極的內容和在人身內應將何處看作太極的問題進行了考察), 득도료여하결론(得到了如下結論). 1. 태극최조재주역계사전중유공자장태극제시위팔괘생성적기본원리(太極最早在周易繫辭傳中由孔子將太極提示爲八卦生成的基本原理), 지후(之後), 량한도당대적저일기간내(兩漢到唐代的這一期間內), 인위태극시창조만물적원시적혼돈지기(認爲太極是創造萬物的原始的混沌之氣), 중앙원기(中央元氣), 몰유분화위음양적기적개념(沒有分化爲陰陽的氣的槪念), 당시피해석위우주간최초적혼연일체적원기적사상점료주류(當時被解釋爲宇宙間最初的渾然一體的元氣的思想占了主流). 2. 주돈신작태극도설(周敦?作太極圖說), 최초제시료무극적개념(最初提示了無極的槪念), 지후(之後), 이주자위대표(以朱子爲代表), 송대적성리학자장태극해석위만물중적궁극지리(宋代的性理學者將太極解釋爲萬物中的窮極之理), 최초장태극해석위리(最初將太極解釋爲理). 3 한동석계승료금일부적삼극설(韓東錫繼承了金一夫的三極說), 이삼극적변화원리설명료태극(以三極的變化原理說明了太極).. 손일규(孫一奎), 조헌가(趙獻可), 장개빈등주장명문설(張介賓等主張命門說), 견지명문위태극(堅持命門爲太極), 인위저명문위우태극적본체수기작용적신장지간(認爲這命門位于太極的本體水起作用的腎臟之間), 동통제수화(同統制水火), 추동인체생명력적원천(推動人體生命力的源泉), 인차여철학상소론급적태극적개념유류사지처(因此與哲學上所論及的太極的槪念有類似之處). 4. 황원어주장적중기위태극설(黃元御主張的中氣爲太極說) 인위태극내창조생명적근원지기(認爲太極乃創造生命的根源之氣), 창조지후야불단공급생명(創造之後也不斷供給生命) 력적중기구유태극적속성(力的中氣具有太極的屬性). 재저일점상가이해석위수토합덕지공적위치(在這一点上可以解釋爲水土合德之空的位置), 대차환유대진일보적고찰(對此還有待進一步的考察). 5. 소동진주장적비위태극설인위비위십토(邵同珍主張的脾胃太極說認爲脾爲十土), 위생명통일적기초(爲生命統一的基礎), 인차응파타인위시무극위타(因此應把?認爲是無極爲妥). 6. 소강절주장적심위태극설인위만물중매일물도시일개태극(邵康節主張的心爲太極說認爲萬物中每一物都是一?太極), 구유태극적속성(具有太極的屬性), 심재오행중속화(心在五行中屬火), 위발동광명지처(爲發動光明之處), 인차이삼극적원리래간(因此以三極的原理來看), 이오토장태극수진행분열(以五土將太極水進行分裂), 지칠화적황극적위치급통치병주재만물적군주지위(至七火的皇極的位置及統治幷主宰萬物的君主之位). 7. 당종해주장적미분지란위태극지설(唐宗海主張的未分之卵爲太極之說), 장태극비유위계란적원시물질(將太極比喩爲鷄卵的原始物質), 란핵등(卵核等), 단정자여란자상결합(但精子與卵子相結合), 상미진행분열적상태위원시적혼륜지물(尙未進行分裂的狀態爲原始的渾淪之物), 위장분화위음양지처(爲將分化爲陰陽之處), 인차본인인위장기정위태극적상법최위첩절(因此本人認爲將其定爲太極的想法最爲貼切).

• Journal of The Korean Society of Clinical Toxicology
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• v.7 no.2
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• pp.113-120
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• 2009

Purpose: Though caustic injury of the upper digestive tract can lead to severe sequelae, there are few clinical studies on this subject. This study was undertaken to evaluate the clinical characteristics, the endoscopic findings and the risk factors of the upper digestive lesions in patient with caustic ingestion injury. Methods: We retrospectively reviewed the medical records of 137 patients who ingested caustic materials and who visited to our emergency room from January, 2000 to June, 2009. Results: The most common ingested agent was sodium hypochlorite (44.5%), followed by acetic acid (19.7%), hydrochloric acid (11.7%) and lye (8.0%). Ingestion for suicidal attempt (62.0%) was more frequent than accidental ingestion (30.7%). Grade IIa injury was the most frequent finding on endoscopy of the esophagus and Grade 1 injury was the most frequent finding on endoscopy of the stomach. For the late sequelae, there were 9 cases (6.6%) of esophageal stricture and 2 cases (1.5%) of gastric outlet obstruction. The initial signs and symptoms did not correlate with the development of stricture, but leukocytosis, and grade III injury were related to the risk of developing stricture. Conclusion: Caustic injury of the upper gastrointestinal tract is frequently observed on early endoscopy and it can cause significant late sequelae such as stricture. Therefore, it is necessary to evaluate these patients with regular follow up endoscopic examinations for the management of late sequelae.

• The Korean Journal of Zoology
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• v.33 no.1
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• pp.22-27
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• 1990

The gastro-endocrine cells were examined in the fundic region of stomach of the frog, Rana rugosa, by transmission electron microscope. In the present paper, at least three kinds of cell type distributed in this region were idendfted according to their morphological charactedstics based on the size, shape and electron density of the secretory granules. Type I cells were characterized by the presence of round or oval granules (300-5OOnm in diameter) with high electron density. The granules showed a wide lucent between the contents and the limiting membrane. This cell was reminiscent of the ECL cell in the human alimentary mucosa. Type II cells were characterized by the presence of spherical or oval granules (11O-230nm in diameter) with low or high electron density. The granules showed a clear halo between the homogenous contents and the limiting membrane. This cell was reminiscent of the G cell in the human alimentary mucosa. Type Ill cells were characterized by the presence of elongated oval or pheomorphic granules (50-2OOnm in diameter) with low or moderate electron density and abundant microfilament bundles in the cytoplasm. The granules contained a very thin halo.

• Journal of the Korea Society of Computer and Information
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• v.15 no.3
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• pp.91-97
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• 2010

Recently Hu-Niu-Yang proposed the user authentication scheme to improve Liu et al's scheme. But the Hu-Niu-Yang's scheme has not been satisfied security requirements considering in the user authentication scheme using the password based smart card. In this paper, we proved that Hu-Niu-Yang's scheme is vulnerable to the off-line password guessing attack in case that the attacker steals the user's smart card and extracts the information in the smart card. Also, the improved user authentication scheme solving the security vulnerability was introduced, thus preventing the attacks, such as password guessing attack, forgery attack impersonation attack, and replay attack. For preventing those attacks, the our proposed scheme need more hash functions and exclusive-OR operations than Hu-Niu-Yang's scheme.