• KSBB Journal
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• v.26 no.2
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• pp.107-111
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• 2011

The essential operating parameters in virus vaccine production are multiplicity of infection (MOI), harvest time, and infection time. Stimulating agents also can be applied in order to improve vaccine productivity further. We investigated the optimum operating conditions in porcine transmissible gastroenteritis virus (TGEV) vaccine production and the applicability of sodium butyrate (NaBu) as a stimulating agents for the improvement of vaccine productivity. The optimum MOI, infection time, and harvest time for high production of TGEV by swine testicle (ST) cells were found to be 0.0001 pfu/cell, 3 day after cell inoculation, and 24 hpi, respectively. NaBu is known as a histone deacetylase inhibitor that has been widely used for the high expression of recombinant protein using mammalian cells and for the enhancement of virus propagation. So we tried to examine the potential of NaBu as a stimulating agent and to determine the optimum concentration by comparing TGEV titers with different range of NaBu concentration. TGEV titer with 5 mM NaBu was 1.5 times higher than control. Therefore, we concluded that NaBu can be a promising agent for stimulating various vaccine production including TGEV and the optimum NaBu concentration for TGEV production was determined to be 5 mM.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1273-1281
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• 2009

To research the trends of study and the guidelines of investigation and management about gastrointestinal (GI) disease in oriental medicine, we reviewed and analysed articles published in Korea from 2004 to 2009. The western medicine in medical treatments of GI tract is notorious for their side effects. But, in oriental medicine, we couldn't find any side effects. Although we treat or manage clinical practices of the GI disease every day, however, we do not have abundant evidences about scientific mechanisms of those treated with oriental medicine therapy. Therefore, we suggest that the upward of qualities of life and the improvement of health-care system through the development of oriental medicine therapies in Korea will be need.

• The KIPS Transactions:PartC
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• v.16C no.3
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• pp.325-334
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• 2009

This paper demonstrates that an attacker can impersonate a random RFID tag and then perform the spoofing attack in the previous RFID authentication protocol. To resolve such a security problem, we also propose a new secure and efficient RFID mutual authentication protocol. The proposed RFID mutual authentication protocol is not only to resolve many security problems with the existing RFID authentication mechanism and the vulnerability against spoofing attack, but also to guarantee reliable authentication time as reducing computational overhead performing by tag. As a result, the proposed RFID mutual authentication protocol provides stronger security including the forward secrecy and more efficiency.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07a
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• pp.100-102
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• 2005

유비쿼터스는 현재의 제한된 컴퓨팅 환경을 떠나서 시간과 장소에 구애받지 않는 자유로운 컴퓨팅 환경을 제공함으로서 각광받고 있다. 그 중 언제어디서나 정보를 주고받을 수 있으며 가격과 성능 면에서 단연 뛰어난 RFID(Radio Frequency Identification)의 중요성은 점점 증가되고 있는 추세이다. 그러나, 이와 같은 우수성에도 불구하고, 정보 유출의 위험성을 내포하고 있으며, 개인의 위치 추적이나, 비 접근 권한자의 위장행세 등의 사용자 프라이버시 보호에 대한 많은 문제점들을 수반한다. 현재까지 이와 관련된 연구들이 활발히 진행되고 있다. 특히 그 중, Ohkubo의 해시함수를 이용한 프로토콜은 프라이버시 보호 측면에서 위치추적 공격(location tracking), 전방위보안성(forward security)과 같은 문제들에 대한 해결책을 제시하고 있으나, 해시함수를 태그에 직접 구현하는 것은 현재까지는 불가능한 상태이다. 또한, Martin Feldhofer는 대칭키 암호 알고리즘인 AES(Advanced Encryption Standard)를 태그에 구현을 함으로서 암호학적인 강도를 높였으나, 위치추적 공격에 대한 문제정과 물리적 공격에 대한 가정을 하지 않은 단점을 가지고 있다. 본 논문에서는 기존연구에서의 문제점들을 보완하고자 현실적으로 구현 가능한 AES를 사용하고, 위치추적 공격, 비권한자 접근(unauthorized access) 공격과 물리적 공격으로부터 안전하며 전방위보안성을 제공하는 기법을 제안한다.

• Journal of Pharmaceutical Investigation
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• v.30 no.2
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• pp.119-125
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• 2000

In an attempt to develop a non-aqueous liquid formulation of practically insoluble biphenyl dimethyl dicarboxylate (DDB), dissolution and permeation studies were performed. Various non-aqueous DDB solutions were formulated and filled into empty hard capsules. Dissolution rates of a new formulation were compared with those of commercially available DDB preparations using one and eight dose units. Dissolution rates after 2 hr of DDB tablets (DDB 25 mg), hard capsules (DDB 7.5 mg) and soft capsules (DDB 7.5 mg) on market and new formulation (DDB 7.5 mg) were 6.3, 15.0, 84.5 and 98.0%, respectively. Higher doses (8 units) resulted in a supersaturation within one hr of dissolution, and dissolved amounts were reduced markedly. Due to the saturation and precipitation, a directly proportional dose-dissolution relationship was not observed. The addition of copolyvidone and/or glycyrrhizic acid ammonium salt to DDB solution in polyethylene glycol 300 and 400 inhibited the formation of precipitates during dissolution and markedly enhanced the rabbit duodenal permeation of DDB. From the site-specific gastrointestinal permeation studies, it was found that permeation rates of DDB after mixing of non-aqueous DDB solutions with aqueous buffered solutions were faster in the order of $rectal\;<\;colonic\;{\risingdotseq}\;ileal\;{\risingdotseq}\;duodenal\;<\;jejunal\;<\;gastric$.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.12
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• pp.5895-5901
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• 2011

This paper shows that a scheme provided by An[7] is not enough to satisfy security requirements for a user certification using a password-based smart card. In order to compensate this weakness, this study provides an improved user scheme with a hash function and ElGamal signature. This new scheme has some advantages protecting password guessing attack, masquerade, and replay attack as well as providing forward secrecy. Compared to An's certification scheme, this scheme suggests that the effect of computational complexity is similar but the efficiency of safety is better.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.24 no.2
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• pp.335-343
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• 2014

It is more important to ensure the credibility of internet media which influence the public opinion. However, there are vague suspicions in public from the examples of manipulation of online reviews with anonymity. In this study, we explore the possibility of manipulating public opinion in online web sites. We investigate the characteristics of comments posted by users on web sites and compare each comments by using the cosine similarity function. Our result shows followings. First, we found a correlation between the similarities of comments and the article ranks in the web sites. Second, it is possible to identify abnormal user activities indicating excessive multiple posting, double posting and astroturf activities.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.299-302
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• 2010

Recently, the malicious code is not easily detectable in the vaccine for the virus, malicious code as a compressed file by modulation pattern is the tendency to delay. Among the many antivirus engines on the market a compressed file that can be modulated by malicious code, and test whether the pattern will need to know. We cover a multi-compressed files, malicious code modulated secreted by examining patterns of test engine is being detected is through a computer simulation. Analysis of secreted activities of malicious code and infect the host file tampering with the system driver files and registry, it gets registered is analyzed. this study will contribute hidden malicious code inspection and enhance vaccine efficacy in reducing the damage caused by malicious code.

• Annual Conference of KIPS
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• 2018.10a
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• pp.669-672
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• 2018

캡술내시경은 식도부터 항문까지 소화기관 전체를 한번에 촬영할 수 있는 의료기기로, 한번의 검사에 평균 8~12 시간 정도의 길이와 5만장 이상의 프레임으로 구성된 영상을 생성한다. 그러나 생성된 영상에 대한 분석은 수작업으로 진행되고 있어, 캡술내시경 영상 분석 자동화에 대한 기술적인 수요가 높아지고 있는 추세이다. 이를 위해, 캡슐내시경 영상 분석에 대한 많은 연구가 진행되고 있는데, 본 연구에서는 그 중에서도 폴립 영상에 대한 검출 자동화 연구에 주목하였다. 폴립이란 위장관 내에서 발견될 수 있는 융기성 병변으로, 많은 연구에서 기계학습 혹은 딥러닝 방식을 적용하여 이를 검출하기 위한 연구를 수행하였다. 그러나 캡슐내시경 영상의 특성상, 병번이 있는 영상이 굉장히 적기 때문에 일반적인 딥러닝 방식의 적용으로 좋은 성능을 내기 어렵다. 따라서 본 논문에서는 폴립 검출 컨볼루션 신경망 설계를 위한 멀티 스케일에 대한 원형 검출기법을 결합하여 폴립이 의심되는 영역을 추출해주는 특징 추출 기법으로, 수집한 데이터 150장에 대한 실험한 결과 약 82%의 성능을 보였다.

• Journal of Chest Surgery
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• v.31 no.4
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• pp.422-426
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• 1998

Progressive dysphagia in a 53 year old man was caused by a giant polypoid tumor in the lower intrathoracic esophagus. Radical transthoracic esophagectomy and esophagogastrostomy were carried out. Microscopic examination of the tumor revealed a true carcinosarcoma, composed of a mixture of basaloid squamous cell carcinoma and chondrosarcoma with multiple cartilagenous productions. Carcinoma metastases were found in the subcarinal and perigastric lymph nodes. Immunohistochemically, squamous area displayed strong positive to cytokeratin, and basaloid area showed positive immunoreaction to high molecular weight cytokeratin (34${\beta}$E12). Spindle cell sarcoma reacted to vimentin and smooth muscle actin. Chondrosarcomatous area reacted to vimentin and S-100 protein. He received postoperative chemotherpy and radiotherapy. He has been free of disease for 11 months.