• Proceedings of the Korean Society of Computer Information Conference
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• 2023.07a
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• pp.179-181
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• 2023

본 논문에서는 GAN 기반의 영상 생성 방법론을 이용해 delayed PET 영상을 생성하는 연구를 수행하였다. PET은 양전자를 방출하는 방사성 동위원소를 표지한 방사성의약품의 체내 분포를 시각화함으로서 암 세포 진단에 이용되는 의료영상 기법이다. 하지만 PET의 스캔 과정에서 방사성의약품이 체내에 분포하는 데에 걸리는 시간이 오래 걸린다는 문제점이 존재한다. 따라서 본 연구에서는 방사성의약품이 충분히 분포되지 않은 상태에서 얻은 PET 영상을 통해 목표로 하는 충분히 시간이 지난 후에 얻은 PET 영상을 생성하는 모델을 GAN (generative adversarial network)에 기반한 image-to-image translation(I2I)를 통해 수행했다. 특히, 생성 전후의 영상 간의 영상 쌍을 고려한 paired I2I인 Pix2pix와 이를 고려하지 않은 unpaired I2I인 CycleGAN 두 가지의 방법론을 비교하였다. 연구 결과, Pix2pix에 기반해 생성한 delayed PET 영상이 CycleGAN을 통해 생성한 영상에 비해 영상 품질이 좋음을 확인했으며, 또한 실제 획득한 ground-truth delayed PET 영상과의 유사도 또한 더 높음을 확인할 수 있었다. 결과적으로, 딥러닝에 기반해 early PET을 통해 delayed PET을 생성할 수 있었으며, paired I2I를 적용할 경우 보다 높은 성능을 기대할 수 있었다. 이를 통해 PET 영상 획득 과정에서 방사성의약품의 체내 분포에 소요되는 시간을 딥러닝 모델을 통해 줄여 PET 이미징 과정의 시간적 비용을 절감하는 데에 크게 기여할 수 있을 것으로 기대된다.

• Journal of the Korean Society of Radiology
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• v.15 no.6
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• pp.781-788
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• 2021

Due to the high sensitivity to radiation, excessive exposure needs to be prevented by accurately measuring the dose irradiated to the skin during radiation therapy. Although clinical trials use dosimeters such as film, OSLD, TLD, glass dosimeter, etc. to measure skin dose, these dosimeters have difficulty in accurate dosimetry on skin curves. In this study, to solve these problems, we developed a skin dosimeter that can be attached according to human flexion and evaluated its response characteristics. For the manufacture of the dosimeter, lead oxide (PbO) with high atomic number (Z_Pb: 82, Z_O: 8) and density (9.53 g/cm³) and silicon binders that can bend according to human flexion were used. In the case of a dosimeter made of PbO material, the performance degradation has been prevented by using parylene and others due to the presence of degradation due to oxidation, but the previously used parylene is affected by bending, so a new form of passive layer was produced and applied to the skin dosimeter. The characteristic evaluation of the skin dosimeter was evaluated by analyzing SEM, reproducibility, and linearity. Through SEM analysis, bending was evaluated, reproducibility and linearity at 6 MeV energy were evaluated, and applicability was assessed with a skin dosimeter. As a result of observing the dosimeter surface through SEM analysis, the parylene passive layer PbO dosimeter with the positive layer raised to the parylene produced cracks on the surface when bent. On the other hand, no crack was observed in the silicon passive layer PbO dosimeter, which was raised to silicon passive layer. In the reproducibility measurement results, the RSD of the silicon passive layer PbO dosimeter was 1.47% which satisfied the evaluation criteria RSD 1.5% and the linearity evaluation results showed the R² value of 0.9990, which satisfied the evaluation criteria R² 9990. The silicon passive layer PbO dosimeter was evaluated to be applicable to skin dosimeters by demonstrating high signal stability, precision, and accuracy in reproducibility and linearity, without cracking due to bending.

• Journal of the Korean Society of Radiology
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• v.15 no.6
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• pp.849-853
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• 2021

PET images used in medical diagnoses are created using positron emitting radionuclides. The radiation used for imaging is generated at 0.511 MeV by p-annihilation. The CSDA range is the distance the particle radiation flew physically, and it is different from the range shown in PET images. This study proposes a novel method that uses radiological criteria to measure this range. The experiment was conducted by applying the MCNP6 simulation to positron emitting nuclides ¹⁸F, ¹¹C, ¹³N, and ¹⁵O. Radiological criteria were based on the location of the p-annihilation event, which is also the image signal. Results showed the radiological range of positrons to be 2.3, 3.9, 5.0, and 7.9 mm for ¹⁸F, ¹¹C, ¹³N, and ¹⁵O, respectively. The higher the positron energy, the larger its difference from the CSDA range. Positron emitting nuclide is being developed and studied as a nuclide for dosimetry or radiotherapy. Further research needs to be conducted into various positron ranges.

• Journal of radiological science and technology
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• v.44 no.4
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• pp.359-365
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• 2021

A heavy particle accelerator is a device that accelerates particles using high energy and is used in various fields such as medical and industrial fields as well as research. However, secondary neutrons and particle fragments are generated by the high-energy particle beam, and among them, the neutrons do not have an electric charge and directly interact with the nucleus to cause radiation of the material. Quantitative evaluation of the radioactive material produced in this way is necessary, but there are many difficulties in actual measurement during or after operation. Therefore, this study compared and evaluated the generated radioactive material in the concrete shield for protons and carbon ions of specific energy by using the simulation code FLUKA. For the evaluation of each energy of proton beam and carbon ion, the reliability of the source term was secured within 2% of the relative error with the data of the NASA Space Radiation Laboratory(NSRL), which is an internationally standardized data. In the evaluation, carbon ions exhibited higher neutron flux than protons. Afterwards, in the evaluation of radioactive materials under actual operating conditions for disposal, a large amount of short-lived beta-decay nuclides occurred immediately after the operation was terminated, and in the case of protons with a high beam speed, more radioactive products were generated than carbon ions. At this time, radionuclides of ⁴⁴Sc, ³H and ²²Na were observed at a high rate. In addition, as the cooling time elapsed, the ratio of long-lived nuclides increased. For nonparticulate radionuclides, ³H, ²²Na, and for particulate radionuclides, ⁴⁴Ti, ⁵⁵Fe, ⁶⁰Co, ¹⁵²Eu, and ¹⁵⁴Eu nuclides showed a high ratio. In this study, it is judged that it is possible to use the particle accelerator as basic data for facility maintenance, repair and dismantling through the prediction of radioactive materials in concrete according to the cooling time after operation and termination of operation.

• Journal of the Korean Society of Radiology
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• v.15 no.3
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• pp.391-399
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• 2021

Eu²⁺ doped polyphosphate NaSr(PO₃)₃ blue-emitting phosphors were synthesized by the conventional solid state method in a reductive atmosphere. The phase formation of NaSr(PO₃)₃ phosphors were characterized by using the X-ray powder diffraction (XRD) measurement. The photoluminescence emission and excitation spectra of the NaSr(PO₃)₃:Eu²⁺ phosphor, and decay curves were measured. Under the near-UV excitation, the phosphor exhibits a band emission around 420 nm assigned to the 4f⁶5d→f7(8S^7/2) transition of Eu²⁺. The temperature dependent emission spectra and decay curves were measured to elevate the thermal properties of the Eu²⁺ doped phosphors. The as-prepared NaSr(PO₃)₃:Eu²⁺ phosphors show a strong temperature dependent performance, which can serve as a promising temperature sensor.

• Journal of the Korean Society of Radiology
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• v.15 no.4
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• pp.445-453
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• 2021

CT scan is reported to have a high risk of cancer due to a relatively high dose among medical radiological examinations. In particular, exposure to radiation to the breast, which is sensitive to radiation, is inevitable during a chest CT scan for female patient. In this study, the dose reduction effect of wearing a compression band during chest CT scans in women was evaluated, and the lifetime attributable risk due to the effective dose exposed during the CT scan was estimated. As a result, when the compression band was used, the effective tube current decreased as the outer perimeter of the chest became smaller, and it was analyzed that the CT dose index and effective dose were also reduced. In addition, the lifetime attributable risk by chest CT scan was found to reduce the cancer risk by 3.2 per 100,000 for all cancers, 0.2 per 100,000 for solid cancer, and 0.8 per 100,000 for breast cancer, based on women in their 30s when using a compression band. It is judged that the risk of cancer can be reduced through the use of appropriate scan parameters and dose optimization measures such as compression bands for future CT examinations.

• Journal of the Korean Society of Radiology
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• v.16 no.6
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• pp.687-695
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• 2022

To find a 3D printer material that can replace lead used as a shield for high-energy electron beam treatment, the shielding composites were simulated by using MCNP6 programs. The Percent Depth Dose (PDD), Flatness, and Symmetry of linear accelerators emitting high-energy electron beams were measured, and the linear accelerator was compared with MCNP6 after simulation, confirming that the source term between the actual measurement and simulation was consistent. By simulating the lead shield, the appropriate thickness of the lead shield capable of shielding 95% or more of the absorbed dose was selected. Based on the absorption dose data for lead shield with a thickness of 3 mm, the shielding performance was analyzed by simulating 1, 5, 10, and 15 mm thicknesses of ABS+W (10%), ABS+Bi (10%), and PLA+Fe (10%). Each prototype was manufactured with a 3D printer, measured and analyzed under the same conditions as in the simulation, and found that when ABS+W (10%) material was formed to have a thickness of at least 10mm, it had a shielding performance that could replace lead with a thickness of 3mm. The surface morphology and atomic composition of the ABS+W (10%) material were evaluated using a scanning electron microscope (SEM) and an energy dispersive X-ray spectrometer (EDS). From these results, it was confirmed that replacing the commercialized lead shield with ABS+W (10%) material not only produces a shielding effect such as lead, but also can be customized to patients using a 3D printer, which can be very useful for high-energy electron beam treatment.

• Journal of the Korean Society of Radiology
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• v.17 no.6
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• pp.889-896
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• 2023

Changes in the energy spectrum were analyzed using ^99mTc as a point source and a scattering phantom, and the shielding effect of the lead apron according to the changed gamma ray energy was evaluated. In the gamma ray energy spectrum of the scattering phantom, the photo peak area decreased and the compton scattering area increased compared to the point source. The coefficients for each energy range according to the change in the shape of the gamma ray source showed a reduction rate of up to 66.1 % at a distance of 20 cm compared to the coefficient of the point source, and in the compton scattering area, the coefficient of the scattering phantom was 122.2 % at a distance of up to 40 cm compared to the coefficient of the point source. In the difference in shielding rate according to the distance between the source and the scattering phantom using a gamma camera, the photo peak area showed similar results, but in the Compton scattering area, the shielding rate of the scattering phantom at a distance of 20 cm increased by 29.2 % compared to the shielding rate of the point source. As the distance increased, the difference in shielding rate decreased. In measuring the shielding rate of the lead apron using a radiation dosimeter, the difference in the shielding rate of the scattering phantom was up to 15.3 %, and as the distance increased, the difference in the shielding rate between the two sources decreased. The shielding rate of the lead apron of the scattering phantom is higher than that of the point source, and the effectiveness of the lead apron increases as the distance to the source increases. As a result, wearing a lead apron when directly confronting a patient who has injected radioactive pharmaceuticals is expected to be helpful in reducing radiation exposure.

• Journal of the Korean Society of Radiology
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• v.18 no.3
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• pp.239-248
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• 2024

Radiation therapy uses high energy, which can have side effects on the human body. Therefore, it is important to ensure that the appropriate dose is set for irradiation and to have confidence in the radiation produced by the generator. The EPR/Alanine dosimetry system is characterized by water equivalence, dose response linearity, and low fading, which makes it useful for quality control of radiation therapy equipment. In this study, we compared the signal and dose response curves of EPR/Alanine dosimetry by mass of alanine using 6 MV energy of a LINAC. An alanine dosimeter and EPR spectrometer from Burker, and a LINAC from Elekta, were used. A dose response curve and a 1st order regression equation were constructed from the irradiated dose and the EPR signal from the alanine dosimeter. We compared the signal magnitude and dose response curve with mass and checked the confidence through the measurement uncertainty of the dose response curve. As a result, it was found that the magnitude of the EPR signal increased by about 1.3 times at 64.5 mg, and the sensitivity of the dose response curve increased as the mass increased. The measurement uncertainty was evaluated to be between 5.84 % and 8.93 %. Through this study, it is expected that the EPR/alanine dosimetry system can be applied to the quality assurance and quality control of a LINAC.

• Journal of Radiation Protection and Research
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• v.36 no.2
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• pp.64-70
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• 2011

The intercomparison exercise on internal dose assessment has been carried out for the purpose of the evaluation for harmonization of internal dosimetry between the nuclear-related institutes in Korea. The exercises of 9 items on internal dose assessment have been developed for the unknown internal dosimetric parameters such as the intake pathway, absorption type, AMAD, and intake time of a radionuclide. Solutions to these exercises were reported by 7 participants from 5 institutes. The range of the ratio between the individual values and the geometric mean value of the evaluated doses for the exercises was $5.75{\times}10^{-4}$ ~ 9.81. But without the extreme partial solution, the range of the ratio was 0.216 ~ 3.12.