• STIMA Bulletin
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• s.4
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• pp.15-17
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• 2006

• 동위원소뉴스
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• no.5 s.65
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• pp.6-7
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• 2002

• 기계와재료
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• v.6 no.4 s.22
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• pp.141-158
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• 1994

• 동위원소뉴스
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• no.9 s.117
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• pp.6-8
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• 2006

• Journal of Radiation Industry
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• v.5 no.1
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• pp.15-20
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• 2011

Protein kinases are the most important drug targets for the treatment of numerous diseases. The involvement of protein kinase C (PKC) in many biological processes such as development, memory, cell differentiation, and proliferation has been demonstrated. PKC is recognized as an important player in carcinogenesis. Thus, a variety of PKC inhibitors have been investigated. Among them, flavonoids have been demonstrated to affect the activity of many mammalian in vitro enzyme systems. The recent investigation was performed to evaluate the inhibitory effects of hesperidin, which is a flavonoid, on the proliferation and carcinogenesis of many cancers. In this study, an efficient kinase assay based on a biochip using radio-phosphorylation was established and performed for an examination of the inhibitory effects of hesperidin on PKC activity at different concentrations of 50, 200, 500 nM. It was found that hesperidin shows inhibitory potency on PKC, and that the biochip can be used to rapidly screen kinase inhibitors resulting in the therapeutic agents.

• Journal of Radiation Industry
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• v.10 no.4
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• pp.181-187
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• 2016

Selective ${\beta}_1$-agonist and antagonists are used for the treatment of cardiac diseases including congestive heart failure, angina pectoris and arrhythmia. Selective ${\beta}_1$-antagonists including nebivolol have high binding affinity on ${\beta}_1$-adrenergic receptor, not ${\beta}_2$-receptor mainly expressed in smooth muscle. Nebivolol is one of most selective ${\beta}_1$-blockers in clinically used ${\beta}_1$-blockers including atenolol and bisoprolol. We tried to develop clinically useful cardiac PET tracers using a selective ${\beta}_1$-blocker. Nebivolol is $C_2$-symmetric and has two chromane moiety with a secondary amino alcohol and aromatic fluorine. We adopted the general synthetic strategy using epoxide ring opening reaction. Unlike formal synthesis of nebivolol, we prepared two chromane building blocks with fluorine and iodine which was transformed to diaryliodonium salt for labelling of $^{18}F$. Two epoxide building blocks were readily prepared from commercially available chromene carboxylic acids (1, 8). Then, the amino alcohol building block (15) was prepared by ammonolysis of epoxide (14) followed by coupling reaction with the other building block, epoxide (7). Diaryliodonium salt, a precursor for $^{18}F$-aromatic substitution, was synthesized in moderate yield which was readily subjected to $^{18}F$-aromatic substitution to give $^{18}F$-labelled nebivolol.

• Journal of Radiation Industry
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• v.10 no.1
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• pp.13-20
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• 2016

In order to identification of the possibility of manufacturing soybean paste (doenjang) with soybean mutant lines induced from gamma-ray mutagenesis, this study was performed to investigate the quality characteristics of doenjang using two soybean mutant lines, Baekwon-1 (BW-1) and Baekwon-2 (BW-2) and their original cultivar (cv. Baekwon, BW) for 8 weeks. The BW and two mutant lines (BW-1 and BW-2) were showed higher content of amino type nitrogen than control (cv. Taegwang). The pH decreased and the titratable acidity increased all the samples during aging period. The lightness, redness and yellowness of doenjang were the lowest in BW. Total free sugar content of doenjang was the highest in control (10.43%) after 4 weeks and composed mainly fructose and glucose. The order of the free amino acid content was Glutamic acid>Leucine>Lysine>Phenylalanine>Aspartic acid in control, Glutamic acid>Leucine>Arginine>Lysine>Phenylalanine in BW, Glutamic acid>Lysine>Phenylalanine>Aspartic acid>Valine in BW-1 and Glutamic acid>Arginine>Lysine>Phenylalanine>Aspartic acid in BW-2, respectively. Our results showed that it is possible to increase the quality of doenjang using soybean mutant lines in manufacturing soybean paste.

• Journal of Radiation Industry
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• v.4 no.4
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• pp.313-317
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• 2010

The struvite crystallization was applied to remove $NH_4{^+}$ in livestock wastewater. The ammonium ions can be very toxic to the aquatic creatures. In this experiments, the livestock wastewater from Gongju livestock wastewater treatment plant was used. The behaviors of various parameters such as pH, mole ratio of $Mg^{2+}$ : $NH_4{^+}$ : $PO{_4}^{3-}$ and reaction temperature for struvite crystallization of livestock wastewater and the effect of gamma ray irradiation were evaluated. As results, for the pH variation, the $NH_4{^+}$ removal efficiency showed the highest, 88%, at pH 9~9.25. The removal efficiency of $NH_4{^+}$, $Mg^{2+}$ and $PO{_4}^{3-}$ was showed highest when same molar ratio of $Mg^{2+}$ and $PO{_4}^{3-}$ were applied. The $NH_4{^+}$ removal efficiency showed 82% at $7^{\circ}C$, and 90% at $30^{\circ}C$ with temperature. When the wastewater was irradiated with 20 kGy of gamma ray, $NH_4{^+}$ was removed as much as 83%.

• Nuclear industry
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• v.16 no.12 s.166
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• pp.70-77
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• 1996

원자력발전소에서 발생되는 방사성 폐기물 드럼 안에 있는 핵종과 그 양을 비파괴적인 방법으로 분석할 수 있는 방사성 폐기물 핵종 분석 장치가 개발되었다. 한전 전력연구원이 한국원자력연구소와 공동으로 개발한 이 장치는 기존의 계측 방법과 달리 슬라이드형 콜리메이터를 이용해 방사선량률 변화에 따라 드럼 안의 고방사능량까지 효율적으로 측정할 수 있는 시스템을 갖추고 있다. 현재 이 시스템은 실험실 성능 시험을 마치고 고리 제4폐기물 저장고에 설치되어 시험 운전중이며, 성능 검증 시험을 마친 후 전 원전에 설치될 예정이다.

• Nuclear industry
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• v.16 no.5 s.159
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• pp.59-68
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• 1996

한국원자력연구소는 최근 원자력 선진국인 프랑스로부터 원자로 격납 용기 실험 용역 사업을 국내 최초로 수주, 그동안 꾸준히 수행해 온 중대 사고에 대한 원전 안전성 확보를 위한 연구 성과를 국외에서 인정받게 되었다. 본 실험의 목적은 프랑스 900MWe 표준 원전 캐비티 모형에 대한 중대 사고시 고압 방출에 의해 캐비티 밖으로 방출되는 용융 노심 파편물의 방출량을 측정하고, 방출분율을 예측하는 상관식의 검증과 캐비티의 구조 특성을 고려할 수 있는 상관식을 개발하는 것으로서, 금년 2월부터 내년 1월까지 수행한다.