• Radiation Oncology Journal
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• v.25 no.1
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• pp.43-53
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• 2007

[ $\underline{Purpose}$ ]: To evaluate the relationship between the expression of EGFR, p53, Cox-2, Bcl-2 and the clinical parameters of NPC (nasopharyngeal carcinoma) patients treated with radiotherapy with/without chemotherapy, and to determine if these could be used as a biologic marker. $\underline{Materials\;and\;Methods}$: This study retrospectively examined 75 NPC patients who were pathologically diagnosed at St. Mary's Hospital and Kangnam St Mary's Hospital from March 1988 to August 2002 and treated with radiotherapy with/without chemotherapy. The levels of EGFR, p53, Cox-2, and Bcl-2 expression were determined immunohistochemically. The relationship between the levels of EGFR, p53, Cox-2 and Bcl-2 expression and the H- E staining findings including the WHO classification, TNM stage, tumor response to chemotherapy and radiotherapy, disease free survival (DFS), and overall survival (OS) was analyzed. $\underline{Results}$: At a median follow up of 50.8 months (range: $5.5{\sim}201$ months), the 3 years OS rate and PFS rate were 68.7% and 68.2%, respectively. The five year OS rate and PFS rate were 53.5% and 51.1%, respectively. The median OS duration and PFS duration were 85.5 months and 61.1 months, respectively. The WHO classification correlated with the complete response rate, lymph node metastasis and distant metastasis. The expression of p53 was associated with increased mitosis and poor overall survival. The expression of Bcl-2 correlated with the DFS and WHO classification. The expression of Cox-2 correlated with a poor overall survival and response rate in the lymph node. However, EGFR was not correlated with any factors. $\underline{Conclusion}$: These results suggest that the expression of p53, Cox-2, Bcl-2 plays role in predicting prognostic factors for NPC treated with radiotherapy with/without chemotherapy. However, further study on a larger number of patients will be needed to identify more useful biomarkers of NPC.

• Tuberculosis and Respiratory Diseases
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• v.50 no.6
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• pp.676-685
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• 2001

Background : Angiogenesis is an essential component of tumor growth and metastasis, and the vascular endothelial growth factor (VEGF) is one of the most important angiogenic factors. Several solid tumors produce substantial amounts of VEGF, which stimulates proliferation and the migration of endothelial cells, thereby inducing neovasculization by a paracrine mechanism. To evaluate the prognostic roles of angiogenesis and VEGF expression in patients with non-small cell lung cancer, the relationship between VEGF expression in tumor tissues, the clinicopathologic features and the overall survival rate were analysed. Methods : Sixty-nine resected primary non-small cell lung cancer specimens were evaluated. The paraffin-embedded tumor tissues were stained by anti-VEGF polyclonal antibodies using an immunohistochemical method to assess VEGF expression. Results : In Forty-one patients (59%), the VEGF antigen was expressed weakly in their tumor tissue, whereas in twenty-eight patients (41%) the VEGF antigen was expressed strongly. The median survival time of the weak VEGF expression group was 24 months, and that of the strong VEGF expression group was 19 months. The three year-survival rates were 35%, 33%, respectively. The survival difference between both groups was not statistically significant. Conclusion : Although results were not statistically significant, the strong expression group tended to poorer prognosis than the weak expression group.

• The Journal of the Korean bone and joint tumor society
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• v.19 no.1
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• pp.9-13
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• 2013

Purpose: We evaluated oncologic outcomes of chondrosarcomas and analyzed the disease-free survival rate of chondrosarcomas according to the various factors. Materials and Methods: We performed a retrospective study for the disease-free survival rate of 48 chondrosarcomas, 44 of which underwent surgical treatment and followed up more than 18 months since 1993, and in the remaining 4 cases, the patients died before 18 months after surgery. The vsariables were location, tumor volume, histologic grade, stage, age at presentation and treatment performed. The mean follow up period was 43.8 months (1-196 months). Results: The overall disease-free survival rate was 77.1% at mean 43.8 month follow up. The 5 year- and 10 year disease-free survival rates were 64% and 58% respectively. The histologic grade, stage, age at presentation revealed statistical significance on disease-free survival. All 9 patients treated with extended curettage for grade 1 central chondrosarcomas revealed disease-free survival with excellent functional outcome. Conclusion: The disease-free survival rate of chondrosarcomas mainly depended on histologic grade, stage and age at presentation. Local recurrence and distant metastasis also revealed statistically significant differences of disease-free survival rate. Comparing to wide resection, extended curettage for low-grade central chondrosarcomas in extremities were efficient methods with similar survival rate and less functional losses and complications.

• Journal of Cadastre & Land InformatiX
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• v.47 no.2
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• pp.107-120
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• 2017

There are many wildfire risk indices worldwide, but objective comparisons between such various wildfire risk indices and surface dryness indices have not been conducted for the wildfire cases in Korea. This paper describes a sensitivity analysis on the wildfire risk indices and surface dryness indices for Korea using LDAPS(Local Analysis and Prediction System) meteorological dataset on a 1.5-km grid and MODIS(Moderate-resolution Imaging Spectroradiometer) satellite images on a 1-km grid. We analyzed the meteorology-based wildfire risk indices such as the Australian FFDI(forest fire danger index), the Canadian FFMC(fine fuel moisture code), the American HI(Haines index), and the academically presented MNI(modified Nesterov index). Also we examined the satellite-based surface dryness indices such as NDDI(normalized difference drought index) and TVDI(temperature vegetation dryness index). As a result of the comparisons between the six indices regarding 120 wildfire cases with the area damaged over 1ha during the period between January 2013 and May 2017, we found that the FFDI and FFMC showed a good predictability for most wildfire cases but the MNI and TVDI were not suitable for Korea. The NDDI can be used as a proxy parameter for wildfire risk because its average CDF(cumulative distribution function) scores were stably high irrespective of fire size. The indices tested in this paper should be carefully chosen and used in an integrated way so that they can contribute to wildfire forecasting in Korea.

• Journal of Chest Surgery
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• v.36 no.5
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• pp.348-355
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• 2003

Background: The prognostic significance of lymph node micrometastasis in non-small cell lung cancer remains controversial. We therefore investigated the clinicopathologic factors related to lymph node micrometastsis and evaluated the clinical relevance of micrometastasis with regard to recurrence. Material and Method: Five hundred six lymph nodes were obtained from 41 patients with stage 1 non-small ceil lung cancer who underwent curative resection between 1994 and 1998. Immunohistochemical staining using anti-cytokeratin Ab was used to detect micrometastasis in these lymph nodes. Result: Micrometastatic tumor cells were identified in pN0 lymph nodes in 14 (34.1%) of 41 patients. The presence of lymph node micrometastasis was not related to any clinicopathoiogic factor (p) 0.05). The recurrence rate was higher in patients with micrometastasis (57.1%) than in those without (37.0%), but the difference was not significant (p=0.22). Patients with micrometastasis had a lower 5-year recurrence-free survival rate (48.2%) than those without micrometastasis (64.1%), with a borderline significance (p=0.11), The S-year recurrence-free survival rate (25.0%) in the patients with 2 or more micrometastatic lymph nodes was significantly lower than that in the patients with no or single micrometastasis (p=0.02). In multivariate analysis, multiple lymph node micromestasis us was a significant independent predictor of recurrence (p=0.028, Risk ratio=3.568). Conclusion: Immunehistochemical anti-cytokeratin staining was a rapid, sensitive, and easy way of detecting lymph node micrometastasis. The presence of lymph node micrometastasis was not significantly associated with the recurrence, but had a tendency toward a poor prognosis in stage 1 non-small cell lung cancer. Especially, the presence of multiple micrometastatic lymph nodes was a significant and independent predictor of recurrence.

• Korean Business Review
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• v.17 no.2
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• pp.63-87
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• 2004

To create and maintain comparative supremacy as a strategic tool of business, many organizations have introduced informational technology and system. By using this system, Some companies got a beneficial value for achieving organizational goals but others could not obtain their effectiveness and efficiency. In particular, a lot of organizations that tried to make strategic supremacy with e-commercial trade are under hard condition because of poor profit. It implies that it is essential to identify and analyse the consumer who uses e-commercial trade. This paper, therefore, focusing on internet shopping malls between business and consumer as one of areas of e-commercial trades, shows the difference between consumer expectation and performance. The results of this study are as follows: First, as for the significant difference of influencing factors to consumer satisfactions according to the types of internet shopping malls, there is a meaningful difference in consumer anxiety and internet usefulness, but not in consumer service. Prior to verify the differences in detail on consumer's anxiety and internet usefulness, we examined that there is any difference between expectation and performance. T-test was used for the variants of consumer anxiety and internet usefulness, and its meaningful probability was 0.000, which means that both showed statistically significant difference. Based on the results, we also found that regardless of the types of internet shopping malls, consumer expectation was greater than performance. although the difference between expectation and performance was not equal according to the internet shopping malls. Second, a regression analysis was performed to understand the relation between consumer service, internet usefulness, consumer anxiety, and consumer satisfaction, it was found that consumer service, internet usefulness, consumer anxiety had significantly effected on consumer satisfaction. Third, To verify the relation between consumer satisfaction and repurchase-intentions, intentions to spread out, Pearson correlation analysis was used. it was found that consumer satisfaction had positive effect on both intentions. This study has some limitations because of the shorts of money and time. since the sample of this study was consumers who have ever bought one or more products via internet shopping mall, this sample was appropriate. but the major parts of sample were college students, and the sample size was so small. therefore this results should carefully be generalized. For further study, it is required to select more precise samples and to include more variables.

• Economic and Environmental Geology
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• v.44 no.6
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• pp.463-474
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• 2011

The Haenam epithermal mineralized zone is located in the southwestern part of South Korea, and hosts low sulfidation epithermal Au-Ag deposit (Eunsan-Moisan) and clay quarries (Okmaesan, Seongsan, and Chunsan). Epithermal deposits and accompanying hydrothermal alteration related to Cretaceous volcanism caused large zoned assemblages of hydrothermal alteration minerals. Advanced argillic-altered rocks with mineral assemblages of alunite-quartz, alunite-dickite-quartz, and dickite-kaolinite-quartz exposed on the Okmaesan, Seongsan, and Chunsan area. Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), with three visible and near infrared bands, six shortwave infrared bands, and five thermal infrared bands, was used to identify advanced argillic-altered rocks within the Haenam epithermal mineralized zone. The distinct spectral features of hydrothermal minerals allow discrimination of advanced argillic-altered rocks from non-altered rocks within the study area. Because alunite, dickite, and kaolinite, consisting of advanced argillic-altered rocks within the study area are characterized by Al-O-H-bearing minerals, these acid hydrothermal minerals have a strong absorption feature at $2.20{\mu}m$. The band combination and band ratio transformation cause increasing differences of DN values between advanced argillic-altered rock and non-altered rock. The alunite and dickite-kaolinite of advanced argillic-altered rocks from the Okmaesan, Seongsan, and Chunsan have average DN values of 1.523 and 1.737, respectively. These values are much higher than those (1.211 and 1.308, respectively) of non-altered area. ASTER images can remotely provide the distribution of hydrothermal minerals on the surface. In this way good relation between ASTER spectra analysis and field data suggests that ASTER spectral analysis can be useful tool in the initial steps of mineral exploration.

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.6
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• pp.968-974
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• 2010

We assessed the feasibility of discrete wavelet transform (DWT) applied for the spectral processing to enhance the estimation performance quality of soil organic matters using visible-near infrared spectra and mapped their distribution via block Kriging model. Continuum-removal and $1^{st}$ derivative transform as well as Haar and Daubechies DWT were used to enhance spectral variation in terms of soil organic matter contents and those spectra were put into the PLSR (Partial Least Squares Regression) model. Estimation results using raw reflectance and transformed spectra showed similar quality with $R^2$ > 0.6 and RPD> 1.5. These values mean the approximation prediction on soil organic matter contents. The poor performance of estimation using DWT spectra might be caused by coarser approximation of DWT which not enough to express spectral variation based on soil organic matter contents. The distribution maps of soil organic matter were drawn via a spatial information model, Kriging. Organic contents of soil samples made Gaussian distribution centered at around 20 g $kg^{-1}$ and the values in the map were distributed with similar patterns. The estimated organic matter contents had similar distribution to the measured values even though some parts of estimated value map showed slightly higher. If the estimation quality is improved more, estimation model and mapping using spectroscopy may be applied in global soil mapping, soil classification, and remote sensing data analysis as a rapid and cost-effective method.

• Journal of Korea Water Resources Association
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• v.56 no.2
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• pp.75-89
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• 2023

As the Mekong River basin is a nationally shared river, it is difficult to collect precipitation data, and the quantitative and qualitative quality of the data sets differs from country to country, which may increase the uncertainty of hydrological analysis results. Recently, with the development of remote sensing technology, it has become easier to obtain grid-based precipitation products(GPPs), and various hydrological analysis studies have been conducted in unmeasured or large watersheds using GPPs. In this study, rainfall-runoff simulation in the Mekong River basin was conducted using the SWAT model, which is a quasi-distribution model with three satellite GPPs (TRMM, GSMaP, PERSIANN-CDR) and two GPPs (APHRODITE, GPCC). Four water level stations, Luang Prabang, Pakse, Stung Treng, and Kratie, which are major outlets of the main Mekong River, were selected, and the parameters of the SWAT model were calibrated using APHRODITE as an observation value for the period from 2001 to 2011 and runoff simulations were verified for the period form 2012 to 2013. In addition, using the ConvAE, a convolutional neural network model, spatio-temporal correction of original satellite precipitation products was performed, and rainfall-runoff performances were compared before and after correction of satellite precipitation products. The original satellite precipitation products and GPCC showed a quantitatively under- or over-estimated or spatially very different pattern compared to APHPRODITE, whereas, in the case of satellite precipitation prodcuts corrected using ConvAE, spatial correlation was dramatically improved. In the case of runoff simulation, the runoff simulation results using the satellite precipitation products corrected by ConvAE for all the outlets have significantly improved accuracy than the runoff results using original satellite precipitation products. Therefore, the bias correction technique using the ConvAE technique presented in this study can be applied in various hydrological analysis for large watersheds where rain guage network is not dense.