• Korean Journal of Biological Psychiatry
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• v.23 no.1
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• pp.1-11
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• 2016

Development of various antidepressants such as monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and noradrenergic and specific serotonergic antidepressant has led to a tremendous progression of pharmaceutical treatment for depression, but still there are some limitations of current antidepressants, such as treatment-resistant depression and delayed onset of antidepressants. The pathogenesis of depression is unclear because depression is a heterogeneous disease state, and the mechanisms of antidepressants remain uncertain as well. Nevertheless, in an attempt to develop novel antidepressants, some trials have been conducted based on the potential biological mechanism discovered in the numerous research results. This review will provide information about the potential novel antidepressants and the current states of clinical studies using them. In particular, some potential novel antidepressants anti-inflammatory agents, antioxidants, anticholinergics, modulators of Hypothalamic Pituitary Adrenal Axis, glutamate, and opioid systems, as well as some neuropeptides such as susbstance P, neuropeptide Y, and galanin will be discussed.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.401-402
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• 2015

본 연구는 스마트폰 중독에 따른 통합치료 방안을 모색한 것이다. 스마트폰의 심리적 요인으로 자기통제력 상실과 우울증을 들었다. 기존 치료방안의 문제점을 소개하였고, 스마트폰 중독의 치료방안으로는 환자에 맞춘 다중치료 프로그램을 소개하였다.

• Korean Journal of Biological Psychiatry
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• v.15 no.4
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• pp.275-287
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• 2008

Depression and coronary artery disease are both highly prevalent diseases. Many previous studies suggest that depression is a common comorbid condition in patients with coronary artery disease and has a significant negative impact on the onset, course, and prognosis of coronary artery disease. However, the exact mechanisms that underlie the association between these two diseases remain unclear. Pathophysiologic mechanisms that may explain the effect of depression on coronary artery disease include hypercoagulability, hypothalamus-pituitary-adrenal axis and autonomic nervous system dysregulation, altered inflammatory response. On the contrary, pathophysiologic mechanisms in coronary artery disease that affect depression are less well known. It is also suggested that both diseases may share a common genetic vulnerability. The authors reviewed the literature on the pathophysiologic relationships of depression and coronary heart disease.

• Proceedings of the Korean Society of Computer Information Conference
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• 2017.07a
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• pp.291-292
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• 2017

우울증은 매우 보편적인 정신병이다. 보건복지부에 따르면 지난해 우리나라 우울증 환자는 61만 3000명으로 전체 국민의 1.5%를 차지했다. 그러나 대부분의 환자들은 본인이 우울증인지도 모르거나 정신병원 진료 기록이 남는다는 이유로 치료를 거부하여 상태를 악화시키는 경우가 적잖다. 그럴 때 다른 이의 도움이 필요하나 정신적인 질환은 겉으로 봐서는 알아차리기가 어렵고 폐쇄적인 우울증 환자의 특성상 직접 만나는 등의 물리적인 도움을 주기는 많이 어려운 것이 사실이다. 그래서 우리는 인터넷이라는, 가장 광범위하고 가장 긴밀한 플랫폼을 통하여 이런 우울증 환자들에게 다가가고자 '선플 로봇'을 고안하게 되었다.

• Journal of Korean Society of Forest Science
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• v.85 no.4
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• pp.586-595
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• 1996

The purpose of this study was to examine the effects of participation in a forest program on the level of depression changes in the participants. Total of 501 university students residing in the middle province of Korea were administered Beck Depression Inventory(BDI). Among them, 32 students were selected as participants of the program based on the scores of the BDI. A 5-day forest program included climbing, sharing experience with others and so on. Pre and post tests control group research design was employed for this study, with BDI measures taken from each of 32 participants on three time frames : 2 weeks before the program, immediately before participation, and immediately after participation. BDI scores were expected to decrease as a result of forest program participation. The study results supported this hypothesis.

• Journal of Society of Occupational Therapy for the Aged and Dementia
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• v.12 no.2
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• pp.107-115
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• 2018

Objective : The purpose of this study is to investigate the effect of a group occupational therapy program on the depression and quality of life of the elderly with Mild Cognitive Impairment(MCI). Method : The elderly with Mild Cognitive Impairment were selected based on the Mini Mental State Examination-Dementia Screening(MMSE-DS). The group occupatinal therapy program consisted of various cognitive domains and was performed 12 times for 6 weeks. The Geriatric Depression Scale(SGDS-K) and Quality of Life(QOL) were used to assess depression and quality of life of the subjects before and after the intervention. Result : The elderly with MCI improved significantly on the SGDS-K and QOL after the intervention program(p<0.05). Particularly, in some items of the QOL, there was a statistically significant difference, but the results of the SGDS-K and QOL did not show any correlation(p>0.05). Conclusion : In the case of the elderly with MCI, the QOL scale and the depressive symptom test were statistically significant when the group occupational therapy program was applied for 6 weeks.

• Korean Journal of Psychosomatic Medicine
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• v.27 no.2
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• pp.164-172
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• 2019

Objectives : The purpose of this study was to examine personality traits associated with suicidal symptoms (with history of suicide attempt or suicidal idea) in depressed patients. Methods : A sample 186 patients diagnosed with major depressive disorder was divided into two groups : suicidal group (with history of suicide attempt or suicidal idea, n=70) and non-suicidal group (without history of suicide attempt or suicidal idea, n=116). NEO Personality Assessment System were used to evaluate personality trait. Results : Neuroticism was high in suicidal group (p=0.041). In multivariate logistic regression, Neuroticism was also a significant influence on suicidal symptoms (Odds Ratio=1.04, 95% Confidence Interval 1.01-1.07, p=0.0145). Conclusions : High Neuroticism is a useful information to identify individuals at high risk of suicide in depressive patients.

• Journal of Digital Convergence
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• v.19 no.12
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• pp.369-376
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• 2021

The purpose of this study is to identify the effect of depression on chewing problems and the importance of oral aids through a point-in-time analysis. The data are the 4th(2008, 2^nd year) and the 7th(2018, 3^rd year) of the National Health and Nutrition Survey. The analysis method was frequency analysis and regression analysis using the SPSS/WIN 24.0 program. Studies have shown that depression has affected chewing problems(p<.001). Chronic diseases and the use of oral aids affected the chewing problem. The prevalence and treatment of depression affected the chewing problems(p<.001). In addition, private health insurance coverage increased in 2018 compared to 2008. In the future, the comparative studies considering various subjects and chronic diseases, the educational methods for the use of oral aids are needed.

• Journal of Digital Convergence
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• v.17 no.6
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• pp.439-446
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• 2019

Poststroke depression can have a secondary effect on social cognition, and this can lead to behavioral problems. The purpose of this study was to verify the effects of a Cognitive Stimulation Circulative Program(CSCP) based on occupational therapy. The participants of this study were 12 stroke patients. The CSCP was organized in such a way to promote the cognitive process. This program were carried out as a circuit program(16 sessions). As a result of this study, the depression scale of the subjects had statistically significant benefit(p<.05). Also, the evaluation results verified partial improvement in quality of life, and the relationship change scale which was used to evaluate role of physical and social cognitive function ability had statistically significant benefit(p<.05). The above results of this study verified that the CSCP was an efficient intervention program that reduces the depression of stroke patients and improve their social cognitive function ability, thus enhancing the quality of life.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.1041-1043
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• 2010

만성 통증 환자의 우울증 및 삶의 질 저하에 대한 많은 보고가 있으며, 통증 조절을 위해 심리적 측면도 중요한 요소로 포함된다. 온열 수치료는 통증 조절을 위하여 가장 많이 시행되는 치료법 중의 하나이며 다양한 방법으로 임상에서 적용될 수 있다. 현재까지 전신 온열 수치료가 통증, 심리, 주관적인 삶의 질에 미치는 영향에 대하여 포괄적인 연구가 시행된 사례가 없으므로, 본 연구에서는 만성 통증 환자에게 제주도내 상수원을 이용한 온습포치료, 즉 통증 부위의 부분치료 또는 전신 온열 수치료를 시행한 후 통증의 정도, 정서, 주관적 삶의 질 평가 결과에 변화가 있는지 알아보기로 하였다.