• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.177-177
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• 1993

뇌모세혈관내피세포로 구성된 혈액-뇌관문(BBB)은 tight junction으로 구성되어 있을뿐만 아니라 fenestra가 없는 등 BBB가 가진 특성으로 인해 물질 수송에 장벽역할을 하기 때문에 주로 중추신경계 질환시의 약물요법에 많은 제한이 따른다. 따라서 뇌로의 효율적인 약물 송달방법에 대해 많은 연구가 진행중에 있는데 본 연구에서는 BBB의 hyperosmotic opening법을 이용하여 뇌로 잘 수송되지 않는 약물의 뇌송달 방법에 대해 연구하고자 하였다. 먼저 수용성으로 인해 BBB 에 잘 통과하지 않는 물질로 신장 및 뇌영상 촬영시 사용되는 방사성 의약품이 Tc-DTPA를 이용하여, hyperosmotic opening법에 의한 뇌투과 증가정도를 검토하였으며, 실험방법이 확립됨에 따라 뇌암의 항암요법을 위해 뇌로의 투과가 적은 항암제(5-Fluorouracil, 5-FU)의 뇌송달에 대해 본 방법을 적용하여 검토하였다. 실험동물로는 S.D.계 웅성 랫트를 사용하였으며, 실험방법은 다음과 같이 하였다. 랫트의 좌측 외경동맥(left external carotid artery)에 혈류의 역방향으로 혈관 분지점에서 1-2mm 전까지 PE-50 catheter를 삽입하고, 1.6 molal L－(＋)－ arabinose 고장액(1580mOsm)을 0.12ml/sec의 일정한 속도로 30초간 infusion함으로 BBB를 opening 한 다음, 5분 후에 Tc-DTPA를 대퇴 정맥으로 주사하여 0, 10, 30초, 1, 1.5, 2, 3, 4, 5, 7 및 10분 간격으로 대퇴동맥에 설치한 카테타로부터 혈액을 채취하고 마지막 혈액을 취한 후 즉시 단두하여 뇌를 적출하였다. 채취한 뇌를 액체질소에 담근 후 tissue Tek으로 고정하고 autoradiography를 하기 위한 slice와 농도측정을 위해 필요한 부위를 취한 후 감마카운터로 Tc-DTPA의 brain각 부위별 및 혈장농도를 측정하였다. 뇌조직중 혈액부피의 측정은 Tc-albumin를 이용하여 구하였다. 같은 방법으로 5-FU에 대한 실험도 행하였고, 이때 각 혈장 및 조직중의 5-FU함량은 HPLC로 하였다.

• Journal of Korean Tunnelling and Underground Space Association
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• v.16 no.4
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• pp.387-402
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• 2014

In congested urban areas, constructions of tunnel structures have became necessary due to a lack of surface space. The excavation of any tunnel generated the ground disturbances of surrounding ground and displacements is major concern. Therefore, a study of tunnel stability is necessary. In this study, the authors have investigated the stability and failure pattern of tunnel through the model tunnel test. In this study, the close range photogrammetry was used to measure the ground deformation. The measured data was converted to displacement vectors and contours. And then it compared to FE analysis and empirical formula. In addition, this study presented the comparison between steel pipe reinforced model tunnel and unreinforced model tunnel. The ground deformation for both the steel pipe reinforced model tunnel and the unreinforced model tunnel was analysed.

• Journal of Environmental Science International
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• v.1 no.1
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• pp.41-46
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• 1992

To perform a long-term ambient sampling study at a residential site, an air sampler was constructed to collect 24-hour integrated air samples suitable for the volatile organic compounds (VOCs) analysis. It includes an esthetically acceptance due to proximity to homes, as fell as providing the required sampling specifications. The VOCs sampler accomodates four 5/8 "stainless steel(SS) traps packed with adsorbent(Tenax) and is capable of four flow rates in the range of 5 to 50 cc/min. Sintered metal filters(10 micrometer) were directly connected to the inlet of the trap adapters. Additional specifications include: 1) constructed of organically inert materials, 2) weatherproof, 3) battery operated, 4) collecting of VOCs at a breathing zone level, and 5) quiet operation with micro diaphragm pumps wrapped by the sponge. The pump/battery system was separated from the sampling shelter. Sound levels measured for this system were below permissible sound levels (NJDEP) at a residential site. The sampler has been successfully operated at both ground level in a residential area and on the roof of a one story elementary school.hool.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.53-53
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• 2021

본 연구에서는 수심센서가 장착된 고성능 GPS 전자부자를 활용하여 하천 수리량 측정에 대한 방법과, 개발 된 고성능 GPS 전자부자의 성능 검증을 위해서 수리량 측정장비인 Flowtracker 측정데이터와 비교분석을 하고자 하였다. 국내 하천환경에서의 수리량 조사는 필수적인 요소이다. 최근 국내 첨단기술을 활용한 수리량 계측 기술들은 ADCP, ADV, UVM, SIV와 같은 많은 계측 기술들이 있다. 이러한 기술들은 장비가 매우고가이며, 많은 시간과 인력이 필요하고 상황에 따른 한계점들이 존재한다. 이러한 수리량 계측 기술들은 오일러리안 타입 계측 방식의 측정으로 계측 구간이 한정되어 있어 수질 오염사고와 같은 장구간의 지속적인 정보가 필요한 하천상황에 따라 라그랑지안 방식의 계측도 필요하다. 본 연구에서 개발 된 고성능 GPS 전자부자는 IoT 기술이 접목되어 실시간 데이터 활용이 가능하며 실시간 데이터 분석을 통해 라그랑지안 타입의 장구간 계측이 가능하다. 고성능 GPS 전자부자는 외경 197mm 지름 88mm, 무게 700g 이내로 간편하게 소지 및 사용 시 투척이 간단하여 인력 및 현장 접근성에 대한 장점을 가지고 있다. 또한 기존 선행 연구들의 GPS 전자부자들의 경우 홍수 발생 시에 유량 측정에서 어려움이 있었기 때문에 본 연구에서 개발된 고서은 GPS 전자부자의 경우 수심센서의 장착으로 유량까지 산정할 수 있기 때문에 홍수 발생이나, 오염물질 발생으로 인한 접근성이 어려운 하천상황에서 유용하게 사용될 수 있다. 고성능 GPS 전자부자를 활용하여 중·소하천인 경북 김천 및 구미시에 위치한 감천에서 성능 평가를 진행하였으며 Flowtracker 수리량 측정 데이터 대비 오차율이 10% 이내로 들어오는 것을 확인하였다. 이러한 성능 검증을 바탕으로 고성능 GPS 전자부자를 활용한 측정법을 제시하였다.

• Journal of Chest Surgery
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• v.30 no.8
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• pp.739-746
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• 1997

A variety of experiments concerning the development of ideal prosthetic grafts for correcting circumferential tracheal defects have been performed. The requirements for an ideal tracheal prosthesis are impermeability to air, consistency to prevent collapse, and acceptance by the host tissue causing a minimum inflammatory reaction, allowing fibroblastic infiltration and epithelialization. The synthetic material, polyurethane(PU), is known as a biocompatible polymer with an inert component. In this study, the tracheal prosthesis was made from microporous PU(30 micrometer in diameter) coated with gelatin and reinforced with isoplastic rings. This procedure provides the prosthesis with a compression strength. The out side diame er of the prosthesis was 20 mm with a length of 30 mm. The gelatin used in the study was obtained from pig skin and immobilized and cross-linked by irradiation(60 Co gamma ray) to promote host tissue incorporation and render the prosthesis epithelization after implantation. Animal experiments using 10 mongrel dogs were performed to compare three kinds of prosthesis; gelatin coated polyurethane graft, uncoated polyurethane graft, and prosthesisf pericadium complex graft. After 6 weeks of implantation, the epithelialization of implants was seen on the gelatin-coated and prosthesisfpericadium complex grafts. Implanted prosthesis were complicated by airway obstruction due to anastomosis granuloma. Early tracheal stenosis was found in the uncoated graft group. Two kind of anastomosis techniques were tested on the gelatin-coated prosthesis. Everted anastomosis resulted severe granuloma than the inverted anastomosis. In the prosthesislpericadium complex graft, bacteria and inflammation at a anastomotic site was found. Based on these results, gelatin coated porous polyurethane trachea prosthesis is biocompatible and may be useful in clinical application with further investigation.

• Investigative Magnetic Resonance Imaging
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• v.12 no.2
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• pp.188-196
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• 2008

Purpose : To describe the clinical, MR imaging, and pathologic findings of pediatric meningiomas. Materials and Methods : The authors retrospectively reviewed the medical records and MR images of 16 pediatric patients with pathologically proven meningioma. Mean patient age at diagnosis was 14 years (range, 3-18). MR images were reviewed for details of lesion sizes, locations, signal intensity (SI), marginal characteristics, internal architectures, enhancements, and dural and parenchymal changes. The findings of other imaging modalities and of pathological examinations were also analyzed. Results : Mean tumor size was 5.24 cm (range, 1.3-18.1 cm) and locations were supratentorial in 12 and infratentorial in 4. SI of masses were variable, that is, high in 9, iso in 4, and low in 3 on T2 weighted images (T2WI), and low (n=11), iso (n=4), or high (n=1) on T1WI images. All lesions were visualized as well-demarcated enhancing masses. Five of the tumors were heterogeneous with cystic or necrotic components. Dural attachment was observed in 11 patients and adjacent brain edema in 10. Tumors exhibited hyperdense (n=6) or isodense (n=4) on non-enhanced CT scans, and 3 of the 7 angiograms demonstrated blood supply from the internal carotid artery. Pathologic examinations revealed the following subtypes; transitional cell (n=4), meningotheliomatous (n=4), chordoid (n=2), fibrous (n=2), clear cell (n=1), hyalinized (n=1), rhabdoid papillary (n=1), and atypical (n=1). Conclusion : Pediatric meningiomas occur usually in teenagers, have diverse pathological types, and may produce atypical imaging findings, such as, a heterogeneous internal content or findings suggestive of intraaxial tumors.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.1
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• pp.49-54
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• 2010

Fretting wear behavior under elastic deformable contacts was experimentally examined by using a simulated dual cooled fuel rod and its supporting structure. As this fuel rod has larger outer diameter than the typical solid rod to accommodate sufficient internal flow, new supporting structure geometries should be designed and their reliabilities (i.e. vibration characteristics, fretting wear resistance, etc.) are also examined with both analytical and experimental methods. In this study, the supporting structure characteristics and fretting wear behaviors are analyzed and examined by using one of the supporting structure candidates which has an embossing shape. The supporting structure characteristics were examined by using a specially designed test rig and their results were compared with that of analytical method. Based on the test results, the relationship between the supporting structure characteristics and their fretting wear behaviors was discussed in detail.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.6-11
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• 2009

최근 경제발전과 산업화를 통한 도시화로 인하여 많은 자연하천이 심하게 훼손되고 있으며 도시하천의 경우 치수의 효율성을 강조한 하천정비를 실시함으로써 하천의 외경은 깨끗하게 바꾸어 놓았지만 그로 인한 하천생태계의 파괴가 문제점으로 대두되고 있다. 이에 따라 생태적으로 훼손된 하천의 생태복원이 최근 들어 활발히 추진되고 있으며 하천변의 식물 및 어류 등 다양한 생물에 대한 서식공간의 마련이 주요 이슈로 연구되어지고 있다. 본 연구에서는 2차원 수리서식모형인 River2D를 대표적인 도시하천인 대전천에 적용하여 대전천의 멸종위기에 처해 있는 감돌고기 및 우점종인 피라미를 대상으로 대상 어류의 서식처 제공을 위한 수리학적 분석을 시도하였다. 또한 자연친화적 서식처 개선 공법으로서 거석을 하도 내에 배치함에 따른 가중가용면적의 변화를 비교 검토하였으며 감돌고기를 위한 최적의 서식처 개선 방안을 제시하였다. 현재 상태의 대상하천에 대한 어류서식처를 모의분석한 결과, 현재 직선화되고 단조로운 하천흐름은 피라미의 서식환경에 적합한 것으로 나타났으며 가중가용면적의 경우 감돌기에 비하여 피라미가 약 20배정도 크게 나타났다. 어류서식처 조성공법의 WUA를 산정한 결과 V형 여울공법이 감돌고기의 서식환경을 360%, 징검다리 거석공법이 60%, 외톨이 거석공법이 8%이상 상승시키는 것으로 나타났다. 반면, 거석(Boulder)을 적절히 배치하여 서식처를 개선하는 방법의 경우에도 거석간 간격을 3.5m로 하여 배치하는 경우가 가장 효율적인 것으로 나타났으며 거석을 이용한 여러 가지의 배치형태 중에서 수류를 중앙으로 집중시켰을 때 감돌고기의 서식처가 급격하게 상승하는 것으로 나타났다. 따라서 하도 내 거석의 배치시 하도 및 대상어종의 특성을 고려하여 적절한 배치간격 및 배치방법을 연구하여 시행되어야 할 것이다.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.2
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• pp.175-181
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• 2018

Electric pump system is new technology for next generation propulsion unit. The system has simple structure which dose not need gas generator, injector and turbine and might better pump for low cost and low payload rocket. Therefore, this paper suggests conceptual design of electric-pump Permanent-Magnet Synchronous Motor (PMSM) which has 50 kW & 50,000 RPM for rocket. To satisfy the system's requirement, electromagnetic analysis is conducted for suitable inner and outer diameter of stator and rotor which uses 4000 Gauss cylinder magnet and Inconel 718 can to fix whole rotor. Futhermore, to confirm rotational vibration, rotordynamics analysis is conducted. By this analysis, Campbell diagram is printed. From the diagram, natural frequency could be determined for the only motor and dynamo meter test bench.

• Composites Research
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• v.15 no.4
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• pp.17-22
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• 2002

Small diameter composite helical springs (CS) are developed using a hot plated mold for reinforcement of common optical fiber jumper cord (OJC). The outer diameters of the springs are about 2 ~ 3mm. These springs are inserted into the OJC to protect the damage of an optical fiber from the sudden lateral load. Two types of CS, Yarn type (Y-type) and Band type (B-type), are manufactured to compare the effectiveness for the damage protection. The experimental works were conducted to check the effect of the CS covered around OJC on the mechanical and optical properties. Experimental observations show a considerable effect on the flexural resistance, hence slowing down the deterioration of the optical power by the internal damage of the fiber. Obtained main results are as follows: (1) Y-type CS has better protection abilities to lateral loading than B-types. (2) Compared with bare OJC, CS-OJC has less power loss under the loading. (3) OJC covered with the composite coil spring has a possibility for a practical usage with full fruits.