• Korean Journal of Optics and Photonics
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• v.28 no.4
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• pp.158-165
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• 2017

The physical shape of an ultrasound transducer has not been considered in previous studies of the photoacoustic saturation effect, where a photoacoustic signal's magnitude linearly increases as an absorption coefficient increases and it is finally saturated. In this paper, the effect of a spherically focused ultrasound transducer on photoacoustic nonlinearity is investigated. The focused ultrasound transducer's spatial filtering effect on photoacoustic signals is analytically derived considering the combined concept of a virtual point detector and Green function approach. The ultrasound transducer's temporal response (i.e., transfer function) effect on photoacoustic signals is considered by integrating photoacoustic signal values within the absorption area covered by a spatial resolution of the ultrasound transducer. Results from the analytically derived expression show that the magnitude of photoacoustic signals measured by a spherical focused ultrasound transducer shows a maximum at a specific absorption coefficient, and decreases after that maximum point as an absorption coefficient is increased. The origin of this photoacoustic nonlinearity is physically understood by comparing the ultrasound transducer's transfer functions and photoacoustic resonance spectra. In addition, this physical interpretation implies that the photoacoustic nonlinearity is strongly dependent on the irradiance distribution inside an absorption medium.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.117-124
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• 2015

Purpose: The purpose of this study was to compare the accommodative function of young adult in their 20s wearing monovision, modified monovision, and aspheric multifocal contact lenses at near task. Methods: Thirty young adults ($23.53{\pm}2.37years$) were fitted with monovision, modified monovision (the application of single vision contact lenses and center-near low addition aspheric multifocal contact lenses), and aspheric center-near multifocal contact lenses. After wearing these modalities during a week for adaption, and after watching visual display at computer for inducing accommodative pressure for 1 hour. The following assessments of accommodative function were made: contrast visual acuity (VA) at distance and near; accommodative response; near accommodative facility; and negative relative accommodation (NRA)/positive relative accommodation (PRA). All measurements were carried out binocularly. Results: In binocular distance VA with contrast of 10%, monovision was the worst among the four modalities (p=0.005). In accommodative response at 1 m (1.00 D), monovision was the lowest (p<0.05) and accommodative response at 40 cm (2.50 D) with monovision was lower than that of modified monovision and multifocal contact lens (p<0.05). We also found that there were no significant differences in accommodative facility and NRA/PRA among the four modalities. Conclusions: In young adult (20s), monovision with low add reduced the accommodative response at near task, however, modified monovision and multifocal lens with center-near type did not affect accommodative relaxation.

• Journal of Environmental Science International
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• v.4 no.4
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• pp.21-21
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• 1995

The effects of plant hormones (NAA, $GA_3$ and BA) and light qualities (white, red, green and blue light) on the changes of reducing sugar contents and invertase isozyme activities in leaves of maize (Zea mars L.) and mung bean (Phseolw radiatus L.) seedlings were investigated. NAA accelerated the increase of reducing sugar contents and invertase isozyme activities, on the contrary, $GA_3$ had little effect in the accumulation of reducing sugar and in the increase of enzyme activities from the leaves of maize and mung bean seedlings. On the other hand, BA accelerated an increase in the activities of the invertase isozyme from the leaves of mung bean seedlings whereas it had little effect in the increase of the enzyme activities from those of maize seedlings. The accumulation of reducing sugar in leaves of both seedlings was promoted by red light irradiation compared to white light irradiation, while the activities of the enzyme were little affected by various light Qualities. In the simultaneous applications of plant hormone and light quality, NAA with white light was very effective in the increase of reducing sugar contents and the enzyme activities from the leaves of mung bean seedlings, whereas NAA application with blue light showed a prominent enhancement in the reducing sugar contents and the enzyme activities from those of maize seedlings. These results suggest that plant hormone, particularly NAA, may be a more important factor than various light Qualities in the stimulation of invertase activity.

• Journal of Environmental Science International
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• v.4 no.4
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• pp.323-333
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• 1995

The effects of plant hormones (NAA, $GA_3$ and BA) and light qualities (white, red, green and blue light) on the changes of reducing sugar contents and invertase isozyme activities in leaves of maize (Zea mars L.) and mung bean (Phseolw radiatus L.) seedlings were investigated. NAA accelerated the increase of reducing sugar contents and invertase isozyme activities, on the contrary, $GA_3$ had little effect in the accumulation of reducing sugar and in the increase of enzyme activities from the leaves of maize and mung bean seedlings. On the other hand, BA accelerated an increase in the activities of the invertase isozyme from the leaves of mung bean seedlings whereas it had little effect in the increase of the enzyme activities from those of maize seedlings. The accumulation of reducing sugar in leaves of both seedlings was promoted by red light irradiation compared to white light irradiation, while the activities of the enzyme were little affected by various light Qualities. In the simultaneous applications of plant hormone and light quality, NAA with white light was very effective in the increase of reducing sugar contents and the enzyme activities from the leaves of mung bean seedlings, whereas NAA application with blue light showed a prominent enhancement in the reducing sugar contents and the enzyme activities from those of maize seedlings. These results suggest that plant hormone, particularly NAA, may be a more important factor than various light Qualities in the stimulation of invertase activity.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2002.05a
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• pp.315-322
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• 2002

최근에 경험적 지식을 체계화하는 방법으로 사례기반추론(CBR: Case Based Reasoning) 및 규칙기반추론(RBR: Rule Based Reasoning)이 여러 분야에서 이용되고 있다. CBR과 RBR이 각각 활용되기도 하지만 문제 해결의 정확성을 높이기 위해 복합된 형태로 사용되기도 하고, 흑은 효과적으로 문제를 해결하기 위해 문제 해결 단계별로 각각 사용되기도 한다 또한 데이터에서 지식을 추출하기 위한 세부 알고리즘으로는 인공지능과 통계적 분석기법 등이 활발하게 연구 및 적용되고 있다. 본 연구는 모니터의 핵심 부품인 섀도우마스크(Shadow Mask)를 개발하는데 있어 도면 협의부터 설계가지의 과정에 CBR과 RBR을 활용하고 발생되는 데이터를 이용하여 진화(Evolution)하는 지식기반시스템(Knowledge Based System)으로 구축하는 것을 목적으로 하고 있다. 특히 도면 협의시 인터넷상에 웹서버 시스템을 통하여 규격 (User Spec.)을 생성하고 이를 이용하여 자동으로 도면이 설계되도록 하고 저장된 사례들을 공유할 수 있도록 하여 도면 검토 시간이 단축되고 검토의 정확성을 기할 수 있어 실패비용을 감소시켰다. 그리고 실제 설계시 CBR과 RBR을 활용하여 자동설계를 할 수 있게 하였고 현장에서 발생되는 데이터를 지식화하여 유사사례 설계가 가능하도록 하였다. 지식기반시스템은 신속한 도면 검토가 가능하므로 인원 활용이 극대화되고, 섀도우 마스크 설계자와 마스터 패턴 설계자 사이의 원활한 의사소통을 통해 고객과의 신뢰성 확보와 신인도 향상을 기대할 수 있는 효과가 있다. 그리고 고급설계자에게만 의지되어온 것을 어느 정도 해결할 수 있고, 신입설계자에게는 훌륭한 교육시스템이 될 수 있다.한 도구임을 입증하였다는 점에서 큰 의의를 갖는다고 하겠다.운 선용품 판매 및 관련 정보 제공 등 해운 거래를 위한 종합적인 서비스가 제공되어야 한다. 이를 위해, 본문에서는 e-Marketplace의 효율적인 연계 방안에 대해 해운 관련 업종별로 제시하고 있다. 리스트 제공형, 중개형, 협력형, 보완형, 정보 연계형 등이 있는데, 이는 해운 분야에서 사이버 해운 거래가 가지는 문제점들을 보완하고 업종간 협업체제를 이루어 원활한 거래를 유도할 것이다. 그리하여 우리나라가 동북아 지역뿐만 아니라 세계적인 해운 국가 및 물류 ·정보 중심지로 성장할 수 있는 여건을 구축하는데 기여할 것이다. 나타내었다.약 1주일간의 포르말린 고정이 끝난 소장 및 대장을 부위별, 별 종양개수 및 분포를 자동영상분석기(Kontron Co. Ltd., Germany)로 분석하였다. 체의 변화, 장기무게, 사료소비량 및 마리당 종양의 개수에 대한 통계학적 유의성 검증을 위하여 Duncan's t-test로 통계처리 하였고, 종양 발생빈도에 대하여는 Likelihood ration Chi-square test로 유의성을 검증하였다. C57BL/6J-Apc$^{min/+}$계 수컷 이형접합체 형질전환 마우스에 AIN-76A 정제사료만을 투여한 대조군의 대장선종의 발생률은 84%(Group 3; 21/25례)로써 I3C 100ppm 및 300ppm을 투여한 경우에 있어서는 각군 모두 60%(Group 1; 12/20 례, Group 2; 15/25 례)로 감소하는 경향을 나타내었다. 대장선종의 마리당 발생개수에 있어서는 C57BL/6J-Apc$^{min/+}$계 수컷 이형접합체 형질전환 마우스에 AIN-76A 정제사료만을 투여한

• Journal of Adhesion and Interface
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• v.18 no.2
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• pp.75-81
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• 2017

In this study, we synthesized mesoporous carbon (Carbonized Ni-FDU-15) containing nanoporous structures and magnetic nanoparticles. Carbonized Ni-FDU-15 was synthesized via evaporation-induced self-assembly (EISA) and direct carbonization by using a triblock copolymer (F127) as a structure-directing agent, a resol precursor as a carbon-pore wall forming material, and nickel (II) nitrate as a metal ion source. The mesoporous carbon has a well-ordered two-dimensional hexagonal structure. Meanwhile, nickel (Ni) metal and nickel oxide (NiO) were produced in the magnetic nanoparticles in the pore wall. The size of the nanoparticles was about 37 nm. The surface area, pore size and pore volume of Carbonized Ni-FDU-15 were $558m^2g^{-1}$, $22.5{\AA}$ and $0.5cm^3g^{-1}$, respectively. Carbonized Ni-FDU-15 was found to move in the direction of magnetic force when magnetic force was externally applied. The magnetic nanoparticle-bearing mesoporous carbons are expected to have high applicability in a wide variety of applications such as adsorption/separation, magnetic storage media, ferrofluid, magnetic resonance imaging (MRI) and drug targeting, etc.

• Journal of Oral Medicine and Pain
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• v.23 no.3
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• pp.289-294
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• 1998

본 증례는 측두하악관절의 퇘행성 변화를 보이는 환자에서 악교정 수술의 시행 전에 중심위교합장치를 통해 측두하악관절의 안정화를 유도하고, 또한 골스캔을 이용하여 장치의 치료효과를 평가한 임상증례이다. 환자는 24세의 여성으로 5년 전부터 전치부 개교합이 발생되기 시작하였고, 고형식 저작시 좌측 전이부에 간헐적인 통증이 발생한다는 주소로 본원에 내원하였다. 임상검사상 촉진시 양측 관절낭 후방부에 압통을 호소하였으며, 각각 50, 45mm의 최대개구량 및 최대무통성 개구량을 보였다. 좌측 악관절부에서 단순 관절 잡음, 우측 악관절부에서 염발음이 청취되었으며, 저항검사 및 부하 검사에서는 특기할 반응을 보이지 않았다. 약 7mm의 전치부 개교합의 소견을 보였으며, 파노라마 사진과 횡두개 방사선 사진 소견상 양측 과두의 크기 및 하악지의 높이가 다소 작은 소견이 관찰되었고 자기공명영상 소견상 양측성 비정복성 관절원판의 전방전위가 관찰되었다. 1997년 10월 27일 첫 번째 골스캔 소견상 양측성 비정복성 관절원판의 전방위가 관찰되엇다. 골스캔의 전방 사진에서 Densitometer를 이용하여 좌, 우측 과두부위와 상악 골부위의 가장 어두운 부분의 흑화도를 측정하였다. 각각 3회씩 구하여 평균을 구하고 좌, 우측 과두 대 상악골의 흑화도의 비율을 계산하였다. 첫번째 골스캔의 평균 흑화도는 우측 과두, 좌측과두, 상악골이 각각 0.88, 0.81, 1.32 였다. 1997년 11월 4일 중심위교합장치를 장착하였고 지속적인 물리치료를 시행하였다. 1997년 12월 10일 두 번째 골 스캔을 평균 흑화도는 우측 과두, 좌측 과두, 상악골이 각각 0.33, 0.37, 088 이었다. 1998년 1월 30일 세 번째 골스캔 소견상 두 번째 골스캔과 비교하여 활성도가 감소된 소견을 보였다. 임상검사시 무통이었다. 1998년 2월 25일 술 전 교정 위해 중심위교합장치의 장작을 중지시켰다. 1998년 6월 5일 네 번째 골스캔 소견상 이전 검사들과 비교시 흡수가 감소된 소견을 보였다. 네 번째 골스캔의 평균 흑화도는 우측 과두, 좌측 과두, 상악골이 각각 0.24, 0.19, 0.85 였다. 현재 지속적인 관찰 중이며 본원 교정과에서 악교정수술 위한 술 전 교장을 시행중이다. 결국 첫 번째 골스캔의 과두 대 상악골의 평균 흑화도의 비율은 우측과 좌측이 각각 0.66, 0.61이었고 두 번째 골스캔에서는 우측과 좌측이 각각 0.37, 0.42였고, 네번째 골스캔에서는 우측과 좌측이 각각 0.28, 0.23 이었다. 각 골스캔의 과두 대 상악골의 평균 흑화도의 비율 사이에 유의한 차이가 있는지 검증하기 위해 Standard t-test 와 ANOVA를 시행하였다. 이상의 결과에서 첫 번째, 두 번째, 네 번째 골스캔으로 갈수록 좌, 우측 과두 대 상악골의 흑화도의 비율이 유의하게 감소했음을 알 수 있었다. 결론적으로 본 증례에서는 전치부 개교합이 발생되어 악교정수술이 필요한 환자에게 측두하악관절의 안정화를 위해 중심위교합장치를 사용함으로써 퇴행성 관절질환의 진행을 억제시킬 수 있고, 퇴행성 관절질환의 활성도에 대한 평가시 골스캔이 유용할 수 있음을 보여주었다고 사료된다.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.28 no.1
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• pp.245-259
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• 1998

Cellular transforming genes have been identified in a number of different tumor cell lines and tumor types. A significant number of these oncogenes belong to the ras gene family. The ras gene family consists of three closely related genes:H-ras, K-ras and N-ras which code for a related 21 kDa protein. Mutations in codon 12, 13 and 61 of one of the three ras genes convert these genes into acute oncogenes. The presence of H-ras gene mutations has important prognostic implications in various tumors. Each genomic DNA was isolated from tumors induced by implantation with DMBA, or by treatment with DMBA -implantation/irradiation. When genome DNA was transfected into NIH 3T3 cells and investigated by two-step PCR-RFLP, the fOllowing results were concluded: 1. Transformation foci developed in two groups when the genome DNA of two experimental groups were transfected into NIH 3T3 cells. 2. Transformation efficiency was 0.01-0.02 foci/㎍DNA in the experimental group with the DMBA-implantation, 0.01-0.03 foci/㎍lgDNA in the experimental group with the DMBA-implantation/irradiation according to results of transfection assay. 3. When the point mutation of H-ras gene was investigated by a two-step PCR-RFLP, there was 13.9％ (5/36) in the experimental group with the DMBA implantation, 15.4 ％ (6/39) in the experimental group with the DMBA -implantation/irradiation. 4. The point mutation in codon 12 and 61 of H-ras was 5.6％(2/36) and 8.3％(3/36) in the experimental group with the DMBA implantation. 5. The point mutation in codon 12 and 61 of H-ras gene was 7.7％(3/39) in the experimental group with the DMBA -implantation/irradiation.

• Journal of the Korean Magnetics Society
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• v.27 no.3
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• pp.92-97
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• 2017

It is widely known that pulsed magnetic field (PMF) is very useful tool to manipulate chemical and physiological processes in human body. The purpose of our study is to observe dynamics of rouleaux patterns of red blood cells (RBC) under PMF. The aggregation of RBCs or rouleaux formation is caused by fibrinogen in blood plasma. The maximum magnetic field intensity is 0.27 T and pulse time of 0.102 msec and pulse repetition rate was 1 Hz. PMF stimulus was applied to the palm of left hand for 5, 10, 15 and 20 min. Live blood analysis was used in vitro in order to quantitatively estimate the velocity of RBC exposed to PMF stimulus. The velocity of stacked-RBC of 10 minute PMF stimulus was increased up to $8{\times}10^{-4}m/sec$, but it decreased rapidly as the time passed. The results of present study have adduced that PMF stimulus on hand provide the improvement of RBC rouleaux formation, increase of RBC's moving velocity as well as low blood viscosity.

• Geophysics and Geophysical Exploration
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• v.5 no.4
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• pp.299-308
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• 2002

We have derived an analytical expression for the sensitivity of the frequency domain small-loop electromagnetic (EM) surveys over a two-layer earth in order to estimate the depth of investigation with an instrument having the source-receiver separation of about 2 m. We analyzed the sensitivities to the lower layer normalized by those to the upper half-space and estimated the depth of investigation from the sensitivity analyses and the mutual impedance ratio. The computational results showed that the in-phase components of the sensitivity to the lower layer dominates those to the upper layer when the thickness of the upper layer is less than 20 m, while the quadrature components are not sensitive to the lower layer over the entire frequency range. Hence we confirmed that the accurate measurement of the in-phase component is essential to increase the depth of investigation in the multi-frequency small-loop EM survey. When conductive basement of 10 ohm-m underlies the upper layer of 100 ohm-m, an accurate measurement of the in-phase components ensures the depth of the investigation more than 10 m even accounting a noise effect, from which we conclude that the small-loop EM survey is quite effective in imaging the conductive plume down to a considerable depth. On the other hand, in the presence of the resistive basement of 1,000 ohm-m, the depth of investigation may not exceed 5 m considering the instrumental accuracy, which implies that the application of the small-loop EM survey is not recommended over the resistive environment other than detecting the buried conductor.