• Applied Biological Chemistry
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• v.42 no.4
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• pp.288-292
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• 1999

It was previously reported that cobalt(II) effectively suppresses the postharvest gravitropic response of snapdragon (Antirrhinum majus L.) (Kim et al. (1997) Agric. Chem. and Biotechnol. 40, 567-571). In this study, several factors affecting the suppression of the gravitropic response by cobalt ion were examined. When flower stalks of snapdragon were pretreated with several different cobalt salts, cobalt nitrate turned out to be the most effective not only in reducing the response but also in preserving the flower quality. We also tested the effects of various detergents which were added to cobalt(II) solution, finding that Tween-40 was the best among the tested with respect to the effectiveness as well as the flower quality. Based on these results, we optimized a protocol for the chemical treatment; that is, a suppressor solution containing 10 mM $CO(NO_3)_2$ and 0.05% Tween-40 was directly sprayed on the gravitropically sensitive region of cut flowers of snapdragon. The suppressor treatment gave rise to a significantly improved results when the flower stalks were stored at a lower temperature after the chemical treatment.

• Journal of the Korean Applied Science and Technology
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• v.36 no.4
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• pp.1365-1372
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• 2019

The present study aimed to evaluate the effect of Lycii radicis CORTEX extract on rheumatoid related factors in CIA-induced Rheumatoid Arthritis model of DBA/1 mice. Lycii radicis CORTEX extract was administered orally at doses of 200 mg/kg/day for 4 weeks after direct injection of CIA into the mice' right paw. We evaluated the treatment effects based on serum biomarkers, morphological and histopathological analyses of the paw. Compared with those in control mice, the Lycii radicis CORTEX extract treatments significantly reduced the serum concentration of cytokine, kemokine and immunoglobulin levels. In addition, the Lycii radicis CORTEX extract treatments effectively preserved the paw bone joint, that in the H&E staining and masson-trichrome staining showed that there were histopathological improvements in Lycii radicis CORTEX extract treated group compared to those of control group. The results indicate that Lycii radicis CORTEX extract alleviated rheumatoid arthritis symptoms. Thus, Lycii radicis CORTEX extract may be a novel therapeutic option for the management of rheumatoid arthritis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.8
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• pp.1183-1189
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• 2013

We investigated the effects of oyster shell extract (OSE) on papain-induced osteoarthritis in C57BL/6J mice. Osteoarthritis was induced in mice by a papain injection into the knee joint. The mice were divided into a total of five groups (n=8). The normal group was untreated, whereas the papain group (negative control) was induced with osteoarthritis and treated with water daily. The papain+DS group (positive control) was treated with diclofenac sodium. Papain+OSE groups were treated with OSE concentrations of 100 and 200 mg/kg/bw for 20 days. Proteoglycan content in articular cartilage was analyzed through safranine-O fast green staining and H&E staining. The histopathological changes in cartilage were measured by the Rudolphi score approach. The contents of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin (IL)-$1{\beta}$, and IL-6 in plasma were analyzed by the ELISA method. After experiments, body weights of the treated groups were not significantly different compared with the normal group. Cartilage loss and joint instability significantly improved in a dose-dependent manner in the OSE-treated group compared with the papain group (P<0.05). Proteoglycan content was significantly higher in the OSE-treated group than the papain group (P<0.05). Osteoarthritis scores of the OSE-treated group were significantly decreased compared with the papain group (P<0.05). TNF-${\alpha}$, IL-$1{\beta}$, and IL-6 content in the plasma of the papain+OSE treated groups significantly decreased in a dose-dependent manner compared with the papain group (P<0.05). These results suggest that OSE treatment might have anti-arthritic effects on papain-induced osteoarthritis in C57BL/6J mice.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.8 no.2
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• pp.164-176
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• 2003

During summer, the DIN (dissolved inorganic nitrogen) and DIP (dissolved inorganic phosphate) observed in the Jindong Bay in the southern sea of Korea show much higher values in the inner area of the bay. In general, they have high values in the upper (0-1 m) and lower layers (8 m-bottom), but are relatively lower in the middle layer (1-8 m). These features in their distribution are examined using an ecosystem model with considering the wind, tidal current, horizontal gradient of water density and residual flow. The experiments were focused on how to influence nutrients associated with these conditions. In the experiment with tide-induced residual flow, the values of nutrients appeared lower than the observation, and were well corresponded to it when the effects of wind, tide-induced residual current and horizontal gradient of water density were additionally imposed. A statistical analysis identifies these results. This paper suggests that variation of nutrient in the Jindong Bay during summer should be seriously a(footed wind-driven current by the wind and density-driven current is induced by the horizontal gradient of water density as well as tidal current.

• Journal of Veterinary Clinics
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• v.23 no.4
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• pp.400-404
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• 2006

This study demonstrates the anti-arthritic effect of topical application of ketoprofen gel containing N-methyl-2-pyrrolidone (NMP) in adjuvant arthritis therapy. Adjuvant arthritis was induced by a single injection of Freund's complete adjuvant (FCA). Mature female Sprague-Dawley rats were designated to 3 groups such as control group, K10 group (ketoprofen 10 mg/rat), and NK10 group (ketoprofen 10 mg/rat containing NMP). The anti-arthritic activity of ketoprofen containing NMP was tested not only as to its capability to suppress the inflammatory edema, but also bone damage (X-ray score and regional bone uptake) of the hind paw in arthritis-induced rats. These results showed a higher efficacy of ketoprofen containing NMP than ketoprofen treatment in the adjuvant-induced arthritis. Ketoprofen containing NMP has good intrinsic characteristics for formulation in an efficacious anti-inflammatory topical application.

• Korean Journal of Food Science and Technology
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• v.23 no.2
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• pp.188-191
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• 1991

A study was carried out to investigate the control effect of sodium and potassium phosphates, sodium citrate and three different salts mixtures on kimchi fermentation when they were added into half-fermented kimchi in the concentration range of $0.001{\sim}0.01\;M$. The salts mixtures added were sodium phosphates mixture(CA-A), addition of $NaNO_2$, Ca-EDTA and BHA to CA-A(CA-B) and substitution of BHA with sodium citrate in CA-B. The results showed that sodium phosphates and sodium citrate significantly inhibited the kimchi fermentation while potassium phosphate had little effect. The order of control effect was $Na_3PO_4-Na_2HPO_4-sodium\;citrate-NaH_2PO_4-K_2HPO_4-KH_2PO_4$. Among the salts mixtures, CA-A showed the most reducing effect in the fermentation rate followed by CA-C and CA-A. The mixture of CA-C could extend the time of holding pH $4.2{\sim}4.4$ by approximately 6 times at $4{\sim}25^{\circ}C$ when it was compared to control. The microbial growth study of total and Leuconostoc mesenteroides also showed a very significant decrease in their numbers.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.8
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• pp.1207-1216
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• 2014

Vegetables contain high levels of nitrate, which can be converted to nitrite for reaction with secondary amines to form nitrosamines. In this study, we evaluated safety effects against nitrite and nitrosamine as well as anti-mutagenic activities of vegetable juices. To do this, the contents of nitrate, nitrite, and nitrosamines were determined in vegetable juices. The safety effects against nitrite and nitrosamine formation were also investigated under simulated human gastric conditions. The contents of nitrate and nitrite in common and organic kale and Angelica keiskei juices were 931~2,052 mg/kg and 13~82 mg/kg, respectively. However, seven kinds of nitrosamines were not detected in the vegetables juices. The nitrate content decreased when vegetable juices were digested under simulated human gastric conditions. Nitrosamine (N-nitrosodimethylamine) formation under simulated human gastric conditions was inhibited by addition of vegetable juices. In addition, vegetable juices, especially organically cultivated juices, showed anti-mutagenic effects in a Salmonella assay system. These results suggest that organically cultivated vegetable juices are a promising health-promoting source.

• Feed Journal
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• v.3 no.4 s.20
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• pp.124-127
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• 2005

''지금은 소비자 시대'' 최근 원유 생산은 늘어나고, 소비는 줄어들면서 낙농산업이 일대 위기를 맞고 있는 가운데 量(양) 보다는 質(질) 위주로 변화고 있다. 국가에서도 이러한 시대에 부응하기 위하여 유질과 매우 밀접한 관계가 있는 체세포수 위생등급을 더욱 강화하고 있다. 이러한 현상은 낙농가들로 하여금 체세포수와 직접적으로 관련이 있는 유방염 관리에 보다 많은 관심과 투자를 하게 하고 있다. 특히, 요즘처럼 원유 과잉 생산 시대에는 무엇보다도 원유생산량을 늘리는 것보다는 체세포수를 관리하여 1 등급을 받음으로써 그 만큼의 추가 소득을 올리는 것이 바람직한 낙농 경영 방법이 될 것이다. 이러한 체세포의 등급강화 조치에 따라 효과적으로 유방염을 예방하므로 원유의 질을 올려 농가에서는 경제적으로 이득을 볼 수 있는 방법에 대해서 논하고자 한다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.4
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• pp.477-484
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• 2014

The purpose of this study was to examine the anti-inflammatory effects of ginger and processed (Beopje) ginger on colitis induced by 2.5% dextran sulfate sodium (DSS) in Balb/c mice. Beopje means a process that herbal medicines are treated by a specific Korean traditional method in order to obtain better pharmacological effects. Mice were fed saline or two different doses of ethanol extracts (ginger and processed (Beopje) ginger) once a day for 14 days. Colitis was induced from day 7 to 14 via administration of 2.5% DSS in drinking water. Experimental animals were divided into four groups: Nor (Normal, 200 ${\mu}L$ of saline without 2.5% DSS-treated group), Con (Control, 200 ${\mu}L$ of saline and 2.5% DSS treated group), G (500 mg/kg of ginger and 2.5% DSS treated group), and BG (500 mg/kg of Beopje ginger and 2.5% DSS treated group). Body weights of both ginger-administered groups increased compared to the control. Colon length increased to 7.6, and 8.0 cm in the G and BG groups, respectively, whereas that of control was 5.7 cm. Histological colon injury induced by DSS-induced colitis was reduced (P<0.05). In serum and DSS-treated colon tissues, mRNA expression levels of IFN-${\gamma}$, IL-6, TNF-${\alpha}$, and IL-12 of the Beopje ginger-treated group were significantly suppressed compared to those of the ginger-treated groups. Expression levels of iNOS and COX-2 of the Beopje ginger-treated group were significantly reduced compared to those of the ginger-treated groups (P<0.05), and BG showed stronger anti-inflammatory effects on colitis. These results indicated that ginger exerted anti-inflammatory effects on DSS-induced colitis in mice, and its effects could be increased through Beopje.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2009.10a
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• pp.149-149
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• 2009

도막의 밀착성 및 내식성 향상을 위하여 인산염처리가 주로 이용되고 있다. 인산염피막은 결정구조로 되어있어 피막사이에 핀홀이 존재하여 일부 특성을 저하하기도 한다. 인산피막의 특성 향상을 위해 실란화합물에 대한 효과를 조사하였다.