• Childhood Kidney Diseases
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• v.14 no.1
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• pp.32-41
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• 2010

Purpose : Glomerulonephropathy (GN) often manifests as proteinuria and progresses to chronic renal failure without specific therapy. Mesenchymal stem cell (MSC) has been tried as a therapeutic agent in experimental GN, and previous studies showed that administration of MSC concomitantly to the insult inducing GN or via intra-renal administration ameliorated proteinuria. The purpose of this study was to test the therapeutic potential of MSC administered via intravenous route at the time of clinically evident proteinuria. Methods : MSCs were administered intravenously via tail vain into the mice with adriamycin (ADR) induced nephropathy (ADR-GN), two weeks after ADR injection when massive proteinuria was evident. To test the capacity of MSC modulate the cytokine production in the inflammatory milieu, the concentrations of IFN-$\gamma$ and IL-10 were measured in the supernatant of in vitro mixed lymphocyte culture (MLC) with or without additional MSC. Results : MSCs administered intravenously into the proteinuric mice with ADR-GN accelerated the recovery of this experimental GN with disappearance of proteinuria in two weeks when the saline treated (control) mice still showed significant proteinuria. The mice treated with MSC also had a tendency of better survival. Addition of MSC decreased IFN-$\gamma$ and increased IL-10 in the supernatant of MLC. Conclusion : This study showed that MSC had a therapeutic potential even when administered in a more clinically relevant setting into a proteinuric glomerulonephropathy model. Further study to verify the mechanism and long-term safety of this phenomenon is required.

• Journal of Nutrition and Health
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• v.52 no.3
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• pp.258-267
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• 2019

Purpose: Upper respiratory tract infections are major causes of the common cold throughout the world. Cordyceps militaris (C. militaris) is a well-known functional food for its anti-fatigue and immunomodulating activities. On the other hand, there are no reports on the protective effect against upper respiratory tract infections (URI). This study was a 12 week randomized, double-blind, and placebo-controlled trial in healthy volunteers. Methods: A total of 100 subjects 20 ~ 70 years of age with a history of at least two colds in the year were enrolled in the study. The participants were required to record any adverse events and rate any cold-related incidents in a diary during the investigation period. The efficacy end point was the symptoms and incidence of URI, and changes in cytokines, IgA and natural killer (NK) cell activity. Results: The Cordyceps militaris group over 12 weeks showed no significant impact on the incidence and symptomatology of URI compared to the placebo group. On the other hand, the experimental group showed significantly higher NK cell activity (p = 0.047) and IgA level (p = 0.035) compared to the placebo group. The NK-cell activity and IgA level were increased significantly by Cordyceps militaris over 12 weeks. Conclusion: The results suggest the possible beneficial immunomodulating effects, but the protective effects on URI could not be demonstrated under these conditions. Additional research will be needed to determine the efficacy and mechanisms of Cordyceps militaris function.

• Food Science of Animal Resources
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• v.31 no.3
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• pp.469-476
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• 2011

This study was conducted to evaluate the functional effects of adding oyster shell powder on the quality properties and storage stability of emulsion-type pork sausages to substitute phosphates as a curing agent. Seven treatments were prepared: T1 (Control), T2 (0.3% STPP), T3 (1.5% NaCl), T4 (1.5% NaCl + 0.5% whey protein), T5 (1.5% NaCl + 0.5% whey protein + 0.15% oyster shell powder), T6 (1.5% NaCl + 0.5% whey protein + 0.3% oyster shell powder), and T7 (1.5% NaCl + 0.5% whey protein + 0.5% oyster shell powder). Significant differences were observed for ash in the proximal analysis. Adding 0.5% oyster shell powder significantly increased pH values when compared to the other treatments. Pork sausages with 0.3% oyster shell powder had significantly improved water holding capacity and cooking loss. Adding oyster shell powder (0.15, 0.3, and 0.5%) resulted in significantly higher hardness, cohesiveness, springiness, and chewiness values than those in the other treatments. No significant differences were observed among treatments during 14 d of cold storage at $4^{\circ}C$.

• Journal of the Korean Applied Science and Technology
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• v.38 no.3
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• pp.771-785
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• 2021

This study was performed to provide detailed and comprehensive information on inflammation-related blood indicators, joint range of motion, pain scale, and psychological indicators by patient characteristics by performing a 12-week home-based exercise program for ankylosing spondylitis patients. For the purpose of this study, 10 patients with ankylosing spondylitis were selected by age (30s vs. 40s vs. 50s), gender (male vs. female), and duration (less than 5 years vs. 5 years or more). The home-based exercise program was a combination of aerobic exercise and Pilates-based resistance exercise, and was performed 4 times a week for 12 weeks at an intensity of 50-70% of maximal heart rate (MHR). As a result, after 12 weeks of home-based exercise intervention, the blood C-reactive protein (CRP) concentration of patients with ankylosing spondylitis decreased (-35.6%, p=.002), and the blood inflammation level was improved, and each joint (hip, lumbar, cervical) improved mobility (p<.05). In addition, the bath ankylosing spondylitis disease activity index (BASDAI) was decreased by -67% (p=.001) and the visual analogue scale (VAS) was decreased by -64.8% (p=.001), stiffness and pain has been alleviated. In particular, as the degree of depression decreased by -65.5% (p=.001) and the degree of anxiety by -55.2% (p=.003), 12 weeks of home-based exercise improved not only physical changes but also psychological factors. On the other hand, there was no difference in exercise effect according to age, gender, and disease duration in ankylosing spondylitis patients (p>.05). These results suggest that the 12-week home-based exercise applied in this study can be an effective exercise program that can be universally used for ankylosing spondylitis patients regardless of patient characteristics.

• Journal of Nutrition and Health
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• v.48 no.4
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• pp.310-318
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• 2015

Purpose: The aim of this study is to investigate anti-arthritis activity using natural eggshell membrane (NEM). Methods: NEM was administered at 52 mg/kg, 200 mg/kg, and 400 mg/kg to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines including IL-$1{\beta}$, and IL-6 were measured by Luminex and $PGE_2$, MMP-2, MMP-9, TIMP-1, $LTB_4$, and hs-CRP were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Results: Production of NO, IL-$1{\beta}$, IL-6, $PGE_2$, MMP-2, MMP-9, TIMP-1, $LTB_4$, and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane, and transformation of fibrous tissue. Conclusion: The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease the symptoms mentioned above.

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.261-262
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• 2007

• Journal of the korean veterinary medical association
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• v.37 no.10
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• pp.949-954
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• 2001

착유효과는 시간 당 소에 대한 일정한 일을 주로 측정하는 것이다. 그러나 시간 당 착유우유 kg에서 일정한 일의 양 또는 시간 당 더 좋은 우유 kg까지가 바라는 것이다. 소/시간에 대한 초점은 착유 전 유두준비에 소비시간을 감소 시키는 것이다. 그리고 이 검토는 우유생산, 안정된 우유흐름에 대한 시간, 유질과 유방건강에 중점을 둔 것이다. 우유의 질이나 유방염에 대하여 착유준비는 대단히 중요하다. 우리는 권장된 기준에 맞추어 착유준비를 하고 있는가? 스스로 검토하여 보아야 한다. 또한 그 기준에 정확히 따라서 함은 물론이고, 필요한 기구와 약제의 사용에도 하자가 없는지 재 확인하여 보아야 한다 그렇지 안으면 자기의 책임을 다른 곳에 돌리고 실제작업의 교정에는 실패를 하는 경우가 될 것이다.

• 전기의세계
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• v.32 no.3
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• pp.142-149
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• 1983

지금까지 알려진 내부마찰측정방법으로는 자유감쇄법(free decay method), 강제진동법(forced vibration method), 비공진강제진동법(non-resonance forced vibration method) 및 초음파법(ultrasoni method) 등이 있다. 이상의 모든 내부마찰실험방법에 관한 실험장치는 그 기계의 동작특성에 따라 실험주파수가 극히 한정되어 있어 연속적인 변화를 시킬 수 없으므로 완화효과를 연속적으로 추적하기 위하여 온도를 변화시키는 방법이 널리 사용되고 있다. 이상에서 소개한 방법들중 본인들이 국산제작실험에 성공한 바 있는 장치는 자유감쇄법에 속하는 염회진자장치(torsion pendulum device) 이므로 이 장치를 중심으로 내부마찰측정원리와 그의 장치에 관하여 소개하고저 한다.

• 한국경영정보학회:학술대회논문집
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• 2007.06a
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• pp.168-173
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• 2007

인터넷 쇼핑몰들은 저조한 수익성에도 불구하고 소비자를 끌어들여 매출을 증대시키기 위해 다양한 유인가격전략을 사용하고 있으나 이러한 유인전략이 과연 효용성이 있는가 하는 문제를 주제로 6 개 인터넷 쇼핑몰의 실제 web logdata 를 활용하여 소비자의 실제 쇼핑행동을 파악하여 유인가격전략의 효용성을 실증적으로 측정하였다. 방대한 클릭데이터를 효과적으로 정리하는 방법을 제시했고 인터넷 쇼핑몰 업체의 유인가격전략 수립에 대한 가이드를 제시하였다.

• Biomolecules & Therapeutics
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• v.5 no.2
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• pp.158-164
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• 1997

To investigate the effects of trypsin inhibitors, aprotinin and urinary trypsin inhibitor (UTI), on the cute pancreatitis, this study was carried out in dogs of acute pancreatitis induced by oleic acid (0.28 mg/kg). Administration with aprotinin and UTI seemed to have a therapeutic effect on the clinical sign, ultrasonographic finding, histopathologic finding. But in amylase and lipase activity, there were no significant differences among three groups.