• Korean Journal of Plant Resources
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• v.21 no.4
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• pp.336-340
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• 2008

Corilagin (CRN) isolated from Euphorbia helioscopia as rheumatoid arthritis drug. CRN was medicated to the abdominal cavity of collagen induced arthritis (CIA) mice that was an animal model for rheumatoid arthritis and its effects on incidence and arthritis index were studied. The results were as folllows; It was exhibited that medicating corilagin inhibited the infiltration of activated T lymphocytes into an inflammatory joint. The production of IgG and IgM that were RF (rheumatoid factor) and inflammatory cytokine, IL-6 and $TNF-{\alpha}$were reduced. After measuring $IFN-{\gamma}$and IL-4, it was found that it was shifted into Th2 immune response as increasing in IL-4. After liver function test, studies on liver poisoning of AST/ALT should be continued.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.3
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• pp.613-619
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• 2009

The Efficacy of SHI-1909 was investigated in comparision with predinisolone in acetic acid and Picrylsulfonic acid solution (TNBS)-induced rat inflammatory bowel disease (IBD) for 5 days. 7% Acetic acid and 5% TNBS solution were administered with polyethylene (P.E) tube inserted to rats intracolon, which causing colitis to the rats. The acetic acid and TNBS control group (the saline treated colitic rat) exhibited ulceration and inflammation of the distal colon with formation of granuloma and pathologic connections. We checked the inflammatory parameters like rat's weight, food intake quantity change during administration. After 5 days, we sacrificed the rats and checked the colon's length, ulcer and pathologic condition. Oral treatment with SHI-1909 resulted in significant recovery of macroscopic parameters like weight and diet intake change. Especially, SHI-1909 had a more potent effect than prednisolone on macroscopic colonic damage score. We can suggest that SHI-1909 could be a promising drug in the treatment of IBD.

• Proceedings of the Korean Nutrition Society Conference
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• 2004.05a
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• pp.122-122
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• 2004

골관절염은 관절연골의 퇴행성 변화로 연골기질의 분해로 인하여 연골 강도와 cushion으로서의 능력이 감소되는 질환이다. 골관절염의 대부분 약물치료는 통증과 염증을 감소시키는 목적으로 사용되며, 근본적인 치료효과를 주는 약물은 현재까지 개발되어 있지 않다. 영양약학 제품에 대한 질병의 예방적, 치료 보조적 차원에서 인체에 대한 기초적인 생리활성의 중요성을 인식하게 됨으로써 그 역할이 중요하게 인식되고 있다. 특히, 골관절염 치료에 쓰이는 glucosamine은 proteoglycan (PG)와 glucosaminoglycans(GAGs)의 합성의 전구물질로서 연골세포 생성을 자극하며, 통증, 염증의 경감 및 진행과정을 억제시키고, 관절기능 회복을 촉진하는 것으로 알려져 있다. 그러나 glucosamine이 어떤 기전에 의해 관절연골세포에 직접적인 영향을 주는지 밝혀져 있지 않다. 본 연구에서는 glucosamine sulfate가 연골세포에 미치는 영향을 규명하고자 하였다.

• Proceedings of the Korea Concrete Institute Conference
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• 2009.05a
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• pp.321-322
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• 2009

when the polluted soil with heavy metal ions was solidified using magnesia-phosphate cement, heavy metal ions were rarely eluted. Furthermore, the results cf SEM-EDS analysis showed that heavy metal ions in polluted soil turns into insoluble solid solution by magnesia-phosphate cement, it come to have the effect to stabilize heavy metals.

• 대한치주과학회:학술대회논문집
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• 1997.11a
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• pp.44-45
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• 1997

• The Journal of the Korean dental association
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• v.27 no.4 s.239
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• pp.385-395
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• 1989

• Proceedings of the Korean Society of Crop Science Conference
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• 1981.10a
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• pp.33-34
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• 1981

• The Hankook-Saengyark Bo
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• no.257
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• pp.6-6
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• 2003

사람 태반, 사향, 건강식품 사용 금지(복지부, 의약품 용도로만 사용원료 규정) - 영월 '동강더덕주'를 아시나요? - 생약성분 '신바로메틴' 미물질특허(골관절 치료 및 신경재생효과 탁월)

• 한국도로학회지:도로
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• v.13 no.4
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• pp.5-8
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• 2011

• Journal of Periodontal and Implant Science
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• v.14 no.1
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• pp.77.1-77.1
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• 1984