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Effect of Pharmacological Treatment for Attention-Deficit Hyperactivity Disorder on Motor Coordination: Open Label Study (주의력결핍 과잉행동장애 아동의 약물치료가 운동협응력에 미치는 효과: 개방연구)

  • Park, Kee Jeong;Kweon, Kukju;Lee, Saejeong;Lim, Yun Shin;Joung, Yoo Sook;Kim, Hyo-Won
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.28 no.4
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    • pp.244-251
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    • 2017
  • Objectives: The objective of this study was to investigate the effect of pharmacological treatments for attention-deficit hyperactivity disorder (ADHD) on motor coordination, using the Developmental Coordination Disorder Questionnaire (DCDQ). Methods: The participants were recruited from April 2015 to November 2016 from the Department of Psychiatry of Asan Medical Center and were treated for 3 months with methylphenidate or atomoxetine. The illness severity at baseline and 3 months were scored using the ADHD Rating Scale (ARS), Clinical Global Impression-Severity Scale (CGI-S) and/or Clinical Global Impression-Improvement Scale (CGI-I). A total of 39 children with ADHD (age $8.0{\pm}1.4years$, 36 boys) completed the Advanced Test of Attention (ATA) and their parents completed the DCDQ at baseline and 3 months. The paired t-test, mixed between-within analysis of variance and correlation analysis were used. Results: The CGI-S (p<0.001), ARS (p<0.001), and fine motor/hand writing (p=0.005) on the DCDQ were significantly changed between pre-treatment and post-treatment. When the participants were divided into those who were suspected of having developmental coordination disorder (DCD) (n=23) and those who probably did not (n=16), the control during movement, fine motor/hand writing and general coordination scores on the DCDQ showed the main effects for group (p<0.001, p<0.001 and p<0.001, respectively). The fine motor/hand writing on the DCDQ has a significant main effect for time [F(1,37)=7.31, p=0.010, ${\eta}^2=0.405$] and the interaction effect between group and time was also significant [F(1,37)=4.63, p=0.038, ${\eta}^2=0.111$]. The baseline visual commission error on the ATA is significantly correlated with the changes in the DCDQ total scores (r=0.330, p=0.040). Conclusion: Our results provide preliminary evidence that pharmacological treatment for ADHD improves not only the core symptoms of ADHD, but also the motor coordination. Further studies are needed to confirm the effect of the pharmacological treatment for ADHD on the motor coordination.

The Effect of Glass Fabric Separator Elongation on Electric Property in Structural Battery (유리섬유 분리막 인장으로 인한 구조전지의 전기적 물성 변화)

  • Shin, Jae-Sung;Park, Hyun-Wook;Park, Mi-Young;Kim, Chun-Gon;Kim, Soo-Hyun
    • Composites Research
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    • v.30 no.1
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    • pp.46-51
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    • 2017
  • Structural battery has been researched extensively to combine the functions of the battery and structure without gravimetric or volumetric increments compared to their individual components. The main idea is to employ carbon fabric as the reinforcement and electrode, glass fabric as the separator, and solid-state electrolyte which can transfer load. However, state-of-the-art solid-state electrolytes do not have sufficient load carrying functionality and exhibiting appropriate ion conductivity simultaneously. Therefore, in this research, a system which has both battery and load carrying capabilities using glass fabric separator and liquid electrolyte was devised and tested to investigate the potential and feasibility of this structural battery system and observe electric properties. It was observed that elongating separator decreased electrical behavior stability. A possible cause of this phenomenon was the elongated glass fabric separator inadequately preventing the penetration of small particles of the cathode material into the anode. This problem was verified additionally by using a commercial separator. The characteristic of the glass fabric and the interface between the electrode and glass fabric needed to be further studied for the realization of such a load carrying structural battery system.

Evaluation of Tensile Property of Austenitic Alloys Exposed to High-Temperature S-CO2 Environment (고온 S-CO2 환경에 노출된 오스테나이트계 합금의 인장특성 평가)

  • Kim, Hyunmyung;Lee, Ho Jung;Jang, Changheui
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.38 no.12
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    • pp.1415-1420
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    • 2014
  • Super-critical $CO_2$ ($S-CO_2$) Brayton cycle has been considered to replace the current steam Rankine cycle in Sodium-cooled Fast Reactor (SFR) in order to improve the inherent safety and thermal efficiency. Several austenitic alloys are considered as the structural materials for high temperature $S-CO_2$ environment.. Microstructural change after long-term exposure to high temperature $S-CO_2$ environment could affect to the mechanical properties. In this study, candidate materials (austenitic stainless steels and Alloy 800HT) were exposed to $S-CO_2$ to assess oxidation resistance and the change in tensile properties. Loss of ductility was observed for some austenitic stainless steels even after 250 h exposure. The contribution of $S-CO_2$ environment on such changes was analyzed based on the characterization of the surface oxide and carburization of the materials in which 316H and 800H showed different oxidation behaviors.

The Effect of Heat Sterilization on the Surface Topography and the Tensile Properties in Various Nickel Titanium Wires Including a Korean Product (열멸균과정이 nickel titanium호선의 기계적 성질과 표면상태에 미치는 영향)

  • Kim, Byoung-Ho;Nahm, Dong-Seok;Yang, Won-Sik
    • The korean journal of orthodontics
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    • v.28 no.6 s.71
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    • pp.927-935
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    • 1998
  • The purpose of this study is to investigate the changes of mechanical properties and surface topography of various nickel titanium wires after heat sterilization for recycling with quantitative method. The materials used were four kinds of nickel titanium orthodontic wires including a Korean product. Experimental specimens were treated with two kinds of heat sterilization methods ; dry heat ($180^{\circ}C$, 60min) and autoclave ($121^{\circ}C$, 15-20psi, 30min). Mechanical properties were evaluated by tensile test with Instron 4466 (load cell capacity:.1000 kg, cross head speed:5mm/min, grip distince:40mm in room temperature). Surface topography of various wires was compared with each other qualitatively by using scanning electron microscopy and quantitatively by using profilometer. The findings were analyzed statistically with student t-tests. The results were as follows; 1. Neither method of heat sterilization had any effects on tensile properties of the nickel-titanium wires used in this experiment. 2. Before heat sterilization, the surface smoothness was highest in Optimalloy, followed by Align and Sentalloy, with NiTi showing the lowest smoothness value. 3. In surface topography, Align and Optimalloy were not influenced by heat sterilization. NiTi, on the other hand, had increased roughness after dry heat sterilization and Sentalloy showed the same tendency after each of the two heat sterilization procedures.

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A Study on the application of design in field research methods of Land Characteristic Survey for Individual Land Prices (개별공시지가 토지특성조사를 위한 현장조사방법 설계 적용에 관한 연구)

  • Lee, Seong-Kyu;Bae, Sang-Keun;Jung, Dong-Hun
    • Journal of Cadastre & Land InformatiX
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    • v.44 no.2
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    • pp.73-90
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    • 2014
  • The Officially Announced Land Price System has a limit, that is required to be able to reflect changes in land constantly every year, to implement Land Characteristic Survey for calculating land price during a specific period and human resources with limited. The purpose of this study is to apply the 'National Territory Space Usage status Survey' method to survey part of the territorial feature status information inside of selected the target sites, considering the core survey items (land category, the state of land use, altitude difference, standard site inclusion, etc) in the areas surrounding Yeonshinnae Station in which three dongs (Galhyeon-dong, Daejo-dong, Bulgwang-dong) of Eunpyeong-gu, Seoul share borders with. Based on the given budget, the manpower and period was taken into consideration to sort a total of 2,041 lots and conduct surveys on all sites. This study will be able to diagnose the efficient idle human resource utilization and work process construction plan through pilot projects specialized for providing real estate information services in preparation for cases in which national territory information survey projects that provide various business model, as well as major future core projects of the corporation will be carried out.

Comparison of Environmental Control Characteristics of High-barrier Films for Sealed Packaging of Cultural Heritage Objects (문화재 밀폐 포장용 고차단성 필름의 보존환경 제어 특성 비교)

  • Jeong, Jaeung;Park, Insik;Huh, Ilkwon
    • Conservation Science in Museum
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    • v.16
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    • pp.96-113
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    • 2015
  • High-barrier films are used to store cultural heritage objects in a safe environment sealed from oxygen and moisture. One of the high-barrier films use populary E manufactured by Japanese company M from the 1990's. However, this product has stayed in wide use, due to dearth of research on related subjects - including studies comparing it with other similar products-, in spite of the fact that high price information about its characteristics and environmental conditions is largely lacking. This study examines the characteristics of a number of high-barrier films with the goal to establish environmental standards for safer conservation of cultural heritage objects. E by the Japanese manufacturer M is compared with four other films; an electronics packaging films by a Korean firm, a film specially produced for the purposes of experiment in this study and a zipper bag-type film. Experiments were performed to compare the properties and gas blocking ability of the films by looking at their cross-section and measuring the thickness, tensile strength, elongation, absorbance of UV and visible light, yellowing and the permeability for oxygen and vapor. Based on these experiments, there are observed changes under different environmental conditions and depending on the length of use through temparature and humidification reproucing test. The results showed that while the high-barrier film by the Korean manufacturer was suitable for use as a packaging material for cultural heritage objects, the zipper bag-type film (P) was ill-adapted for this purpose. Based on the experiments reproducing the real-world environment, the length of useful life was also determined for each.

A Study on the Characteristics of Low Pb Sn-5%Pb-1.5%Pb-1.5Ag-x%In Solder Alloys (저 Pb Sn-5%Pb-1.5%Ag-x%In계 솔도 합금의 특성에 관한 연구)

  • Hong, Sun-Guk;Ju, Cheol-Hong;Gang, Jeong-Yun;Kim, In-Bae
    • Korean Journal of Materials Research
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    • v.8 no.11
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    • pp.1011-1019
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    • 1998
  • This work designed Sn-5%Pb-1.5%Ag-x%In solder alloy to develop the solder alloy with low Pb content. This solder alloy doesn't cause environmental pollution. and this study reviewed the probability of replacement of Sn-37%Pb solder as evaluation of melting range, wettability. microstructure, microhardne'ss, tensile strength, drossability of this new solder alloys. The level of international regulation in dissolution amount of Pb ion was 3ppm. But dissolution amount of Pb ion in Sn-5%Pb solder alloy confirmed not to threat the global environmental is 0.46ppm. The melting range of this solder alloy was $183-192^{\circ}C$. Also the range of solidification was very narrow within $5^{\circ}C$. The wettability was similar to Sn-37%Pb solder, and the effect of amount of In addition of wettability couldn't be founded. The probability of replacement in the melting range and wettability is very high. And microhardness of this solder alloy was 1.5 times of conventional type solder. Tensile strength of new solder alloys was a little high than that of conventional type solder. With increasing amount of In% addition, tensile strength was increased, but elongation was decreased. The solder alloy of l%In addition revealed AgSn and Pb on dendrite microstructure boundary, and $Ag_3Sn$, $Ag_3In$ and Pb were revealed on it at the solder alloy of 3% In addition. The drossability was superior to Sn-37%Pb solder alloy and the solder alloys of 2% In addition was not generated for 3hrs.

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Applications of Mathematical Optimization Method for Chemical Industries (화학 산업에서 수학적 최적화 기법을 적용한 사례)

  • Kim, Eun-Yong;Heo, Soon-Ki;Lee, Kyu-Hwang;Lee, Hokyung
    • Korean Chemical Engineering Research
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    • v.58 no.2
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    • pp.209-223
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    • 2020
  • Executions of SCM in a chemical company of which divisions produce petrochemicals, compounds, batteries, IT material and medicine directly affect their own profit. Execution level of SCM or optimization is very important. This work presents activities of SCM and optimization of inefficient issues in several industrial divisions using mathematical optimization method. The meaning is not only academic research but also making a useful tool which active partner deals with in his work. It is explained how to do beforehand and afterward optimization problem. The benefits are mentioned in the sections. The first of examples would be cover supply plan optimization, optimal profit business plan, and scheduling of a stretching process of polarizer based on minimizing raw material loss in polarizer production. The second example would be cover the optimization of production/packaging plans to maximize productivity of Poly Olefin processes, and the third example is minimization of transition loss in the production of battery electrodes. The fourth example would be cover scheduling of vessel approaching to berth. Because transportation of large portion of raw material and products of petrochemical industry is dealt with vessel, scheduling of vessel approaching to berth is important at the shore of large difference of tide. The final example would be scheduling problem to minimization of change over time of ABS semi products.

EFFECT OF RESIN MATRIX ON DEGREE OF CONVERSION AND FRACTURE TOUGHNESS OF DENIAL COMPOSITES (기질레진의 조성에 따른 복합레진의 물리적 성질에 관한 연구)

  • Lee, Yun-Shin;Choi, Kyoung-Kyu;Park, Sang-Jin
    • Restorative Dentistry and Endodontics
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    • v.27 no.1
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    • pp.77-86
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    • 2002
  • Current composites are made with dimethacrylate monomers and silane-treated silica microfillers, either alone or with silane treated glass fillers The main reasons for clinical failure of dental composites are secondary caries, wear and fracture. Most of practitioner want to get a composite which is more tougher under occlusal stress, less polymerization contraction, and better handling properties in application clinically. The aim of this study was to investigate the influence of resin matrix with various flows on the physical proper-ties such as fracture toughness and degree of conversion of the experimental resins. It was hypothesized that flexible or tough resin composites can be designed by judicious choice of monomer composition Various flow resin matrices containing Bis-GMA, UDMA, and TEG-DMA were made by altering the pro-portion of the monomers. After the unfilled resins were light-cured for different light intensity, the fracture toughness(K$_{1c}$) was measured according to ASTM standard using the single edge notched geometry, and degree of conversion(DC) was measured by FTIR. And experimental composites were formulated with variations in the proportion of silanated quartz and strontium glass fillers as 60, 75, and 77wt%. Also, the physical properties of composites with various filer contents were evaluated as same manner. All resulting data were compared by ANOVA/Tukeys test at 0.05 level. The results were as follows; 1. The degree of conversion of high flow resin containing less Bis-GMA was higher than that of low flow unfilled resin 2. While the degree of conversion of unfilled resin was increased according to light intensity for polymerization, there was no significant increase with moderate and high light intensity. Also, the fracture toughness was not increased by high light intensity. 3. The fracture toughness was high in the low flow unfilled resin containing higher contents of Bis-GMA. 4. There was a significant increase for fracture toughness and a tendency for degree of conversion to be reduced when the content of fillers was increased. 5. In the experimental composites, the flow of resin matrix did not affected on the fracture toughness, even, which was decreased as increase of viscosity. These results showed that the physical properties of a dental composite could be attributed to the flow of resin matrix with relative content of monomers. Specific combination of resin monomers should be designed to fulfil the needs of specific indication for use.

Study on Health Risk Assessment of Carcinogenic Chemicals in Drinking Water (음용수 중 유해 화학 물질에 대한 위해성 평가에 관한 연구 - I. 발암성 화학 물질을 중심으로 -)

  • Chung, Yong;Shin, Dong-Chun;Kim, Jong-Man;Park, Seong-Eun;Yang, Ji-Yeon;Lee, Ja-Koung;Hwang, Man-Sik;Park, Yeon-Shin
    • Environmental Analysis Health and Toxicology
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    • v.10 no.1_2
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    • pp.1-14
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    • 1995
  • The purpose of this research is to assess the health risk of pollutants in drinking water and recommend the guidelines and management plans for maintaining good quality of drinking water. This study has been funded as a national project for three years from 1992 to 1995. This study(the second year, 1993-1994) was conducted to monitor 32 species of carcinogenic chemicals such as volatile organic compounds(VOCs), polynuclear aromatic hydrocarbons(PAHs), pesticides and heavy metals of drinking water at some area in six cities of Korea, and evaluate health risk due to these chemicals through four main steps of risk assessment in drinking water. In hazard identification, 32 species of carcinogenic chemicals were identified by the US EPA classification system. In the step of exposure assessment, sampling of raw, treated and tap water from the public water supply system had been conducted from 1993 to 1994, and 32 chemicals were analyzed. In dose-response assessment, cancer potencies, unit risk estimates and virtually safe doses of carcinogens were obtained by TOX-RISK (Version 3.1). In risk characterization of detected chemicals, health risk due to carcinogens such as vinyl chloride, carbon tetrachloride, dichloromethane, 1, 2-dichloromethane, chloroform, benzene and arsenic of tap water in several cities exceeded 10$^{-5}$ level. We suggest that non-regulated chemicals which exceed 10$^{-5}$ excess cancer risk level, such as vinyl chloride, carbon tetrachloride and 1, 2-dichloroethane, should be monitored periodically and be regulated by the Drinking Water Management Act, and database for exposure parameter of our own situation should be established.

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