• Journal of the Korea Convergence Society
• /
• v.7 no.3
• /
• pp.185-193
• /
• 2016

The purpose of this study was to analyze the effects of combined exercise on body composition, funtional fitness and muscle protein synthesis related hormone in sarcopenic obesity elderly women. The subjects for the study were 20 obesity elderly women over 65 years old. They were divided into two groups, the sarcopenic obesity group(n=10) and non-sarcopenic obesity group(n=10). The variables of body composition and cardiovascular fitness were measured in all the subjects before and after 12-week combined exercise. The findings of this study were as follows; In the sarcopenic obesity elderly women (SG), % body fat significantly decreased in the SG group, FFM and ASM significantly increased. In the chair stand test and arm curl test, SG group significantly increased. SG group significantly changed in chair sit-and-reach test, back scratch test, 2-minute step test. In the muscle protein synthesis related hormone(growth hormone and IGF-1), SG group significantly increased.

• Tuberculosis and Respiratory Diseases
• /
• v.63 no.4
• /
• pp.362-367
• /
• 2007

Hormonal replacement therapy (HRT) has been proven for treatment of postmenopausal symptoms such as hot flushes, night sweats and urologic symptoms. HRT became very popular in the 1990's, when there were several reports showing that it also helped with other menopausal complications such as osteoporosis and cardiovascular disease. Recent studies report that the incidence of breast cancer, endometrial cancer, cerebral infarction, coronary artery diseases, deep vein thrombosis and pulmonary thrombembolism could rise after HRT. Among these side effects of HRT, the risk of pulmonary thromboembolism increases 2 to 4 fold after HRT, but can vary with the use of different doses and preparations. Here, we summarize the risk factors and clinical courses for 5 patients who developed pulmonary thromboembolism after postmenopausal HRT.

• Korean Journal of Biological Psychiatry
• /
• v.3 no.1
• /
• pp.96-101
• /
• 1996

Objects : There has been the controversy that menopause may or may not influence the psychological distresses. The purpose of this study was to investigate the correlation between the hormonal status and traits of depression & anxiety in menopausal women. Method : Among the women attending menopausal clinic. menopausal women, defined as who having a amenorrhea for more than 12 months, were selected as a study group(n=83). The control group(n=73), who visited to screen the cervix cancer with regular menstruation, hod no history of hormone replacement therapy. Individual data were collected by self-reporting questionnaires. Depression state was evaluated by Beck Depression Inventory(BDI) and anxiety state by Stale Trail Anxiety Inventory(STAI), and the female hormones such as E2, FSH, and LH were obtained by blood sampling at visting clinic. Statistically the data were processed by t-test and pearson correlation analysis(p<0.05). Results : 1) The mean age of menopausal was 45.3 years. 2) In menopausal women the scores of BDI & STAI were significantly higher than in control group(p<0.05). 3) There were significant differences between menopausal and control group by E2 & FSH. 4) There was no correlation between female hormonal status and the STAI & BDI scores in both groups. Conclusion : Although menopausal women had more traits of depression & anxiety than control group, it was difficult to insist that the lack of estrogen was the only etiological factor for the traits of depression & anxiety in menopausal period. In further studies, we must consider another factors, including biological, sociocultural, psychological factor, as the cause of psychological symptoms during menopausal period.

• Journal of Animal Science and Technology
• /
• v.46 no.3
• /
• pp.315-324
• /
• 2004

Cytochrome P450 aromatase is the enzyme responsible for biosynthesis of female sex hormone(estrogen) and 19-nortestosterone(nandrolone), a unique steroid hormone endogenously synthesized in the pig. By use of RT-PCR coupled with DHPLC technique (WAVE analysis), expression pattern of isoforms of porcine cytochrome P450 aromatase gene was investigated. Relatively higher expression of aromatase mRNA was observed in testis than in ovary and this result accounted for the previous findings of higher blood estrogen level in male compared with female in this species. The result from the DHPLC demonstrated that PCR amplified DNA fragments of ovary and testis tissues. using unique PCR primers for all three types of aromatase genes, were different from those of type II and ill genes. Further nucleotide sequence analyses of the plasmid clones containing the PCR products revealed that nucleotide sequences of all clones were identical to type I aromatase gene(ovary type). Thus, the result from the present study indicates that the ovary and testis express the same type of aromatase gene. Therefore, the efficacy of DHPLC techniques used for this study helped us to analyze tissue-specific expression of isoform of genes containing the nucleotide sequences with high homology.

• Journal of Life Science
• /
• v.29 no.9
• /
• pp.1023-1026
• /
• 2019

The purpose of this study was to investigate the estrogen-like activities of eight oriental medicines, including red ginseng, fenugreek, and dandelion. Hot water and ethanol extracts were prepared from Cervus nippon temminck (Nokgaksang), Cynanchum wilfordii (Baeksuo), Lespedeza cuneata (Yagwanmun), Panax ginseng (red ginseng), Smilax china (Toryeong), Taraxacum platycarpum (Mindeulre, dandelion), Tribulus terresteis (Namgase), and Trigonella foenum-graecum (Horopa, fenugreek). Then, estrogen-like activities were verified by the in vitro transcriptional activity assay. The extracts showing estrogen-like activities were red ginseng, Baeksuo, fenugreek, Yagwanmun, and dandelion in the ethanol extracts, and red ginseng, fenugreek, and Baeksuo in the hydrothermal extracts. Red ginseng extract showed a higher activity than the standard $10^{-8}M$ $17{\beta}$-estradiol in both the hydrothermal and ethanol extract at $500{\mu}g/ml$, while the $50{\mu}g/ml$ of the red ginseng ethanol extract and the $500{\mu}g/ml$ of the Baeksuo hydrothermal extract showed estradiol activities between $10^{-9}$ and $10^{-8}M$ $17{\beta}$-estradiol. This shows that it would be possible to contribute to the development of functional materials using red ginseng, Baeksuo, fenugreek, and dandelion.

• 건강소식
• /
• v.30 no.12 s.337
• /
• pp.6-11
• /
• 2006

남성도 갱년기를 겪는다. 중년 여성의 전유물로 여겨졌던 갱년기가 남성에게도 나타나는 것이다. 40세 이후 남성의 신체기능 저하는 최근까지 자연적인 노화현상으로 치부됐다. 그러나 평균수명의 연장과 의학의 발달 등으로 건강한 노년 생활에 대한 욕구가 커지면서 남성의 갱년기 증상이 발견되기 시작했다. 특히 20대에 최고조로 증가하는 남성 호르몬(테스토스테론)이 점차 줄어들다가 40~55세 사이에 급격히 감소하면서 여러 가지 신체적, 정신적, 심리적 변화가 나타난다. 남성호르몬 감소의 첫 번째 징후는 부부관계에 관심이 없어지고, 좀 더 진행되면 만성피로를 느끼고 얼굴이 달아오르거나 식은 땀을 흘리며 손발이 저리기도 하다. 그리고 감정이 잘 조절되지 않아 사소한 일에도 짜증을 내게 되는데, 남성 호르몬 부족 때문에 나타나는 이러한 증상들을‘남성 갱년기’라 한다. 이번 호에서는 서울아산병원 비뇨기과 안태영 교수와 성의학클리닉 연구소 강동우 전문의의 도움으로 남성 갱년기에 관해 자세히 알아본다.

• 대한치주과학회:학술대회논문집
• /
• 2005.11a
• /
• pp.77-77
• /
• 2005

• Proceedings of the KSCN Conference
• /
• 2003.05a
• /
• pp.125-125
• /
• 2003

비만인구의 증가는 전 세계적인 문제이며, 우리나라도 비만인구의 증가와 함께 인구 전반의 체질량지수가 증가하고 있다. 여성의 경우 폐경을 맞이하면서 호르몬의 변화 등으로 비만 발생율이 높아지는데, 폐경 후 비만은 만성퇴행성질환 등 여러 질병의 원인이 될 수 있으나, 골밀도에 있어서는 체질량지수와 양의 상관관계를 보인다는 결과와, 어느 수준 이상의 체질량지수 증가는 골밀도에 좋지 못한 영향을 미친다는 상반된 결과들이 제시되고 있다. (중략)

• Proceedings of the KSCN Conference
• /
• 2004.05a
• /
• pp.406.1-406
• /
• 2004

유방암은 선진국형 질병으로 미국의 경우 가장 흔한 암으로 보고되고 있으며, 우리나라의 경우 과거에는 유방암 발생률이 낮았으나, 생활방식이 서구화되고 영양상태가 좋아지면서 점차 증가하고 있다. 유방암이 증가하는 이유는 명확히 밝혀지지는 않았지만, 서구화 되어가는 생활 패턴으로 초경 연령이 빨라지고, 폐경연령이 늦어지는 등 유방암 발생에 중요한 역할을 하는 여성호르몬에 노출되는 기간이 길면 길수록 유방암 발생이 증가하는 것으로 알려져 있다. 가족 중에 유방암이 있거나 출산하지 않을 경우 등에서도 유방암의 발생률이 다소 높다고 한다.(중략)

• Journal of the Korea Convergence Society
• /
• v.13 no.3
• /
• pp.337-343
• /
• 2022

The aim of this study was to evaluate anxiety, depression and stress in women with polycystic ovary syndrome(PCOS) and to investigate the risk factors related to psychological difficulties. Sixty women with PCOS were evaluated for level of psychological stress using Beck depression inventory(BDI) and Depression anxiety stress scale(DASS) questionnaire. Serum antimullerian hormone, total testosterone, lutenizing hormone, follicle stimulating hormone, estradiol, lipid profile and 75g oral glucose tolerance test were measured. Thirty healthy women served as the control. Fifty two women with PCOS and 29 healthy women completed a questionnaire. Women with depression who scored >13 by BDI and >10 by DASS were 38.5 %, women with anxiety who scored >8 by DASS were 23.1 %, and women with stress who scored >15 by DASS were 30.8 %, which were significantly higher than control. In PCOS women, total testosterone, LH and AMH were significantly correlated with depression and stress. Weight, body mass index and waist-hip ratio were also significantly correlated with depression. In women diagnosed as diabetes and hyperlipidemia, depression and stress were significantly prevalent. Women with PCOS seemed to be more vulnerable to depression, anxiety and stress. Early diagnosis and management should be considered.