• Journal of Korean Biological Nursing Science
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• v.8 no.2
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• pp.5-12
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• 2006

목적 : 본 연구는 암환자 및 암의 유형에 따라 중요한 종양억제 조절인자로 알려져 있는 모노카인을 flowcytometry를 이용하여 분석, 비교하고자 하였다. 방법 : 연구대상은 고형종양(solid tumor)으로 진단받은 33세에서 76세 사이의 암환자 30명(유방암, 난소암, 폐암, 위암)을 대상으로 말초혈액 단구의 intracellular monokine 중 $TNF{\alpha}$, MIG, MIP를 분석한 유사실험설계 연구이다. 연구결과 : 암환자 군에서의 $TNF{\alpha}$, MIG, MIP 수치는 대조 군인 정상 군에 비해서 유의하게 증가되었으며 특히, 유방암과 난소암 환자 군에서의 $TNF{\alpha}$ 수치는 폐암과 위암의 대상자에 비해 의미 있는 차이를 보여주었다. 논의 : 본 연구에서 제시된 암환자 군에서의 모노카인 수치는 선행연구의 결과와 통일하게 종양 대상자의 면역에 중요한 역할을 하는 것으로 규명 되었으나, $TNF{\alpha}$는 고형종양 중에서도 여성생식기계 암환자 군에서 더 증가하였다. 이에 따라 종양 유형에 따른 모노카인의 역할과 호르몬과의 상호작용기전 규명에 대한 추후 연구가 필요하다.

• Progress in Medical Physics
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• v.3 no.2
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• pp.59-65
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• 1992

Carcimoma of the breast are first frequency malignancy in women in the world. third frequency in Korea. Radiation therapy in breast cancer were treated through opposed tangential fields with photon beam or electron beam. Density within the field and thickness to tumor are very importent factors determining dose distribution in radiation therapy of electron beam. Radiotherapy traetment planning using computed tomography in Breast cancer are able to ideal dose distribution. Authors concluded as following. 6MeV energy of electron beam propered below 1.5cm in chest wall's thickness or internal mammary lymphnode's depth. 9MeV energy of electron beam from 1.5cm to 2.0cm. 12 MeV energy of electron beam from 2.0cm to 2.5cm.

• The Journal of the Korea Contents Association
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• v.11 no.4
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• pp.244-252
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• 2011

This study was to estimate the radiation dose associated with 64-slice multidetector CT(MDCT) in clinical practice and quantify the potential cancer risk associated with these examinations. Lifetime attributable risks(LAR) were estimated with models developed in the national Academies' Biological Effects of Ionizing Radiation VII report. Mean effective dose were 1.48mSv in Brain axial scan, 7.66mSv in chest routine contrast, 12.17mSv in coronary angiogram, 24.52mSv in Dynamic abdomen scan. LAR estimates for brain routine varied from 1 in 7463 for man to 1 in 4926 for women. In chest routine with contrast, LAR varied from 1 in 1449 for men to 1 in 952. LAR of Abdomen dynamic CT varied from 1 in 453 for men to 1 in 298 for women. So, 64-slice MDCT scan is associated with non-negligible LAR of cancer. Doses can be reduced by careful attention to scanning protocol.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.05a
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• pp.13-18
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• 2004

최근 몇 년간 방사선 의학진단과 관련된 연구가 한층 높아진 가운데 유방암은 여성의 암 중에서 1위를 차지하고 조기에 진단하고 치료하기 위한 국가적인 노력이 필요한 시점이다. 이렇듯 여성들의 유방암 발생빈도수가 급증하면서 대두 되고 있는 것이 조기 진단방법인 Mammography와 초음파 진단이며 그로인하여 발생하는 오진률 역시 많은 연구가 진행 되고 있다. 먼저 Mammography 및 초음파 진단의 문제점 보면 첫째 촬영과정에서의 오차, 둘째 영상의 선명도 ,셋째 전문의의 판독에 대한오차, 넷째 의사의 경험으로 진단함으로 표준화가 존재하지 않는다는 공통적인 문제점을 가지고 있다. 본 연구에서는 CAD 시스템의 프레임웍 및 요소 기술을 제시하여 의사의 진단을 보조적 수행이 보다 수월하도록 하고자 한다. 본 연구에서는 CAD시스템의 기능은 Detection기능(Image enhancement, Morphology, segment detection)과 Diagnosis기능( Neural Natwork등을 이용하여 증상을 판단)이다. 또한 과거 자료를 이용한 변이 및 변화를 예측함으로써 향후 있을 위험요소에 대비가 가능한 모듈과 전문의사가 대화형으로 빠르게 진단지식을 구축할 수 있는 지능형, 대화형 온라인 진단기능을 추가함으로써 외국의 CAD시스템과는 많은 차이가 있다고 볼 수 있다.

• Journal of Practical Engineering Education
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• v.15 no.2
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• pp.495-502
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• 2023

Despite the fact that Korea has supported national cancer screening worldwide for a long time, the cancer screening screening rate is low compared to other health screenings and infant screening. In particular, women with disabilities show a lower screening rate for cervical cancer screening compared to women without disabilities. Therefore, from 2011 to 2019, this study investigated the trends in cervical cancer screening rates of women with disabilities and non-disabled women aged 30 and older, and analyzed the factors affecting cervical cancer screening of women with disabilities at the individual and regional level through the cervical cancer screening rates among regions. The purpose of this study is to identify the factors that affect regional variation by dividing into regions. From 2011~2019, the cervical cancer screening rate of people with disabilities was the highest in Daejeon and the lowest in Sejong and Jeju, and the gap in cervical cancer screening rate of people with disabilities by region was analyzed to be up to 13.1%.

• Radiation Oncology Journal
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• v.26 no.1
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• pp.65-73
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• 2008

Purpose: Women with breast cancer diagnosed at an age of 40 years or younger have a greater prevalence of germline BRCA1 and BRCA2 mutations than the prevalence of women with breast cancer diagnosed at older ages. Several immunohistochemical characteristics have been identified in breast cancers from studies of Caucasian women with BRCA1/2 mutations having familial or early-onset breast cancers. The aim of this study is to determine whether early-onset breast cancer in BRCA1 or BRCA2 mutation carriers, who were not selected from a family history, could be distinguished by the use of immunohistochemical methods and could be distinguished from breast cancer in women of a similar age without a germline BRCA1 or BRCA2 mutation. We also analyzed the prognostic difference between BRCA1/2 related and BRCA1/2 non-related patients by the use of univariate and multivariate analysis. Materials and Methods: Breast cancer tissue specimens from Korean women with early-onset breast cancers were studied using a tumor tissue microarray. Immunohistochemical staining of estrogen receptor(ER), progesterone receptor(PR) and HER-2, as well as the histology and grade of these specimens, were compared. The prognostic impact of immunohistochemical and histological factors as well as the BRCA1/2 mutation status was investigated separately. Results: There were 14 cases and 16 deleterious BRCA1/2 mutations among 101 patients tested. A family history(4/14) and bilateral breast cancers(3/9) were high risk factors for BRCA1/2 mutations. BRCA1/2-associated cancers demonstrated more expression of ER-negative(19.4% versus 5.1%, p=0.038) and HER-2 negative than BRCA1/2 negative tumors, especially for tumors with BRCA1 tumors The BRCA1/2 mutation rate for patients with triple negative tumors(negative expression of ER, PR and HER-2) was 24.2%. Tumor size, nodal status, and HER-2 expression status were significantly associated with disease free survival, as determined by univariate and multivariate analysis, but the BRCA1/2 status was not a prognostic factor. Conclusion: Breast cancer that occurs in women with a germline BRCA1 or BRCA2 mutations have recognizable immunohistochemical features, which may be useful in identifying individuals that are more likely to carry germline mutations. Although the BRCA1/2 mutation status was not a prognostic factor in Korean women with early-onset breast cancer, more cases with a longer follow-up period are needed for further study.

• Women's Health Nursing
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• v.18 no.1
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• pp.17-27
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• 2012

Purpose: This study aimed to identify sexuality for women with gynecological cancer. Methods: A total of seven women with gynecological cancer agreed to participate in this study. The data were collected utilizing in-depth semi-structured interviews style. A descriptive study design was used in this study. The interviews were analyzed using inductive content analysis methodology. Results: Three themes identified were: 'women with gynecological cancer who give up their sexual life due to misunderstanding and fear', 'women with gynecological cancer who control their body and mind for recovery', 'women with gynecological cancer resume their sexual life with their partner's will'. Conclusion: To improve sexual health and quality of life for women with gynecological cancer, we need to develop programs related to sexual health. An adjusted sexual health program will contribute to increased sexual health and quality of life for women with gynecological cancer.

• Korean Journal of Organic Agriculture
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• v.3 no.1
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• pp.1-9
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• 1994

한국의 급속한 경제발전과 공업화 과정에서 특히 연령층이 20∼49세의 젊은 농촌의 여성들이 대단히 많이 도시로 이동하였다. 농촌에서 농작업에 종사하는 여성들은 주로 수도, 채소 및 과수재배에서 많은 육체적인 노동을 하고 있다. 특히 농촌에서 농약을 산포하는 일은 여성들이 많이 하고 있다. 1960년도 이후 1992년도에 달하는 지난 32년 기간동안에 국민소득 수준이 1%증가됨에 따라서 농촌여성이 667명씩 감소되었다는 사실이 단순회귀 분석에 의하여 증명되었다. 그리고 농약을 산포한 여성들의 암에 의한 사망률이 산포하지 아니한 여성들 보다 높다는 사실이 실증적으로 증명되었다. 1968년도에 2정보의 농경지 규모에서 전체 노동시간 가운데 여성의 노동시간이 차지하는 비율이 55,72%로서 나타나고 있다. 그런데 1992년도에 동일규모에서 여성들이 노동시간이 차지하는 비율은 44.58%로서 감소되고 있다. 앞으로 건전한 농촌의 환경을 지속적으로 보존하기 위하여서는 여성들의 귀중한 생명을 보존하고 동시에 소비자들의 건강을 보호하는 유기농법이 실천되어야 할 것이다.

• Journal of agricultural medicine and community health
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• v.40 no.3
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• pp.115-125
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• 2015

Objectives: Colorectal cancer is one of the major cancers in South Korea. We described the time trends in colorectal cancer incidence in Daejeon, a metropolitan city, and Chungcheongnam-do (Chungnam), a rural province, South Korea. Methods: Using the databases from the Daejeon Cancer Registry (DCR) and the Chungnam Cancer Registry (CCR), age-standardized (to world standard population) rates for incidence (ASRW) were calculated. Average annual percent change (AAPC) was assessed as a trend indicator. The completeness (such as the mortality/incidence ratio) and validity (such as the death certificate only %, microscopic verification %, primary site uncertain %, and age unknown %) were analyzed to examine the data quality of DCR and CCR. Results: Incidence of colorectal cancer showed increasing trend in both sexes. Over the years 2000-2012 in Daejeon, ASRW was increased significantly from 37.2 to 51.7 per 100,000 person-years (AAPC, 3.9%) among men and from 17.1 to 28.4 (AAPC, 3.9%) among women, respectively. In Chungnam, ASRW was also increased from 29.8 to 50.1 per 100,000 person-years (AAPC, 5.1%) among men and from 15.9 to 26.6 (AAPC, 3.2%) among women, respectively. The AAPC for colon cancer was greater than rectal cancer in both Daejeon and Chungnam. The trend of rectal cancer incidence was differ by sex (AAPC in men vs women, 2.7% vs 1.7% in Daejeon; 3.5% vs 0.8% in Chungnam). Indices of completeness and validity showed that the quality control of DCR and CCR was adequate to describe the trends of ASRW. Conclusions: Both Daejeon and Chungnam have had a rapid increase in colorectal cancer incidence. Monitoring and intervention are required on the risk factors which may contribute to this trend.

• 건강소식
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• v.36 no.12
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• pp.26-27
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• 2012

유방암에 비하면 그리 흔한 편도 아닌데, 성(性)과 관련 있다 보니 자궁경부암에 대한 관심은 매우 큰 편. 더욱이 예방백신이 나와 있는 유일한 암이라 '선택'이란 걸 할 수 있다는 점도 영향을 주는 것 같다. 관심을 가지고 있었지만 자세히 몰랐던 자궁경부암에 관한 궁금증을 풀어보자.