• 건강소식
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• v.39 no.7
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• pp.16-17
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• 2015

여드름은 나이와 계절을 가리지 않고 발생하는 피부 최대의 적이다. 사계절 내내 스트레스를 불러오는 여드름의 치료에는 많은 방법이 있지만, 많은 사람들이 여드름 치료 방법을 찾을 뿐 단계에 따른 치료 방법을 찾지는 않는다. 여드름은 잘못 치료하게 되면 흉터가 남거나 오히려 피부트러블이 증기하게 되므로 단계별, 증상별로 치료를 달리하는 것이 중요하다.

• Journal of the Korean Applied Science and Technology
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• v.37 no.5
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• pp.1441-1453
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• 2020

The purpose of this study was to compare acne recognition and management methods for those in their 20s and 30s who live in China and have acne. A total of 600 questionnaires were distributed and 533 copies were used for final analysis, excluding 27 of the 560 collected questionnaires. As a result of the study, the difference in perception of the cause of acne, management perception, and exacerbation factor of Chinese people according to age showed'management perception' t=3.380, and deteriorating factor recognition' t=2.314, indicating that there was a difference in perception of acne according to age. It was found that the recognition degree of acne is higher in the 20s than in the 30s. Through this study, by comparing and analyzing the perceptions and management methods of acne according to the age of Chinese people, the changes in acne management perception and behavior according to the change of the times were identified, and the difference between Korean and Chinese perceptions of acne, and later acne skin It is believed that it can be provided as a basic data for finding an effective management method.

• 건강소식
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• v.35 no.11
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• pp.28-29
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• 2011

전 국민의 85% 정도는 한 번쯤 겪는다는 피부 불청객 '여드름'. 여드름은 주로 사춘기에 발생하여 20대 중반에 사라지지만, 2,30대에 시작해 수년간 지속되기도 한다. 특히 사춘기 여드름은 성호르몬의 영향으로 주로 피지 분비가 왕성한 이마나 볼, 등, 앞가슴에 많이 생긴다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.2
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• pp.163-170
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• 2021

This study was conducted to create a technology to remove acne bacteria with human-friendly materials. First, the Cutibacterium acnes (C. acnes) were adsorbed to the mica disc to grow, and then the biofilm was checked through an atomic microscope to see if the biofilm had grown. Based on the topographic image, the shape changed round, the size was 17% longer on average, and the phase value of the resonance frequency separating materials was observed as a single value, the biofilm grown by covering the extracellular polymeric substrate (EPS). As a result of processing 50 mM of amino acids in the matured biofilm, the concentration of C. acnes decreased when valine, serine, arginine and leucine were treated. Scanning with nanoindentation and AFM contact modes confirmed that the hardness of biofilms treated with Valine (Val) increased. This indicates that an AFM tip measured cell which may have more solidity than that of EPS. The experiment of fluorescent tagged to EPS displays an existence of EPS at the condition of 10 mM Val, but an inhibition of growth of EPS at the 50 mM Val. Number of C. acnes was also reduced above 10 mM of Val. Weak adhesion of biofilm generated from an inhibition of EPS formation seems to induce decrease of C. acnes. Accordingly, we elucidated that Val has an efficiency which eliminates C. acnes by approach of an inhibition of EPS.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.1 s.60
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• pp.29-32
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• 2007

We investigated new ingredients with real efficacy in both in vitro and in vivo all together. Especially we focused on the real improving effort in the clinical experiments. Because most products containing effective materials evaluated in vitro failed to show a real improving effect in the human with acne. We evaluated the well-known ingredients in a small scale clinical experiment with half-finished goods containing each ingredient. Among these products, product formulating SeleMix AN composed with germinating soy bean and magnolias bark extract remarkably improved acne and acne scar. Moreover skin redness caused by severe acne was improved. There was statistical significance between placebo and sample. Two hundred volunteers participated in our pilot study with written informed consent. After then we performed in vitro efficacy test this ingredient. SeleMix AN inhibited the growth of propionibacterium acnes at a concentration of 0.0125% and suppressed histamine release by 16.9%. Moreover human fibroblast cell activity was increased by 57% compared to control. Lastly, we performed a clinical study. Consisting of groups of 23 volunteers. Although the period of the test was in summer accelerating sebum secretion and recurring a high tate of acne, inflammation lesions were especially improved after applying product containing SeleMix AN for 4 weeks.

• Journal of Convergence for Information Technology
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• v.9 no.10
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• pp.264-271
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• 2019

Currently, teenagers value the beauty of appearance due to the proximity of the media. Therefore, acne on the skin is not a serious disease, but if it is managed incorrectly, it will leave scars and marks on the face, which leads to students' depression, stress and loss of confidence. Therefore, this study analyzed how acne skin afects adolescent's stress, depression and self-esteem and recognized that acne is not a simple skin disease but is closely related to mental health. And three hypotheses were established to be more effective in managing acne skin and to be used as basic data for skin care. As a result, it was found that acne development of junior high school students had an actual effect on stress and depression. Acne skin care is considered to be necessary for mental health, not superficial management.

• Fashion & Textile Research Journal
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• v.8 no.5
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• pp.571-576
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• 2006

Thirty P. acnes were isolated from the 30 acne patients who visited some skin care shops from Feburary of 2001 to August of 2001. They were identified by morphological features (gram stain), biochemical properties. Only P. acne strains are isolated among Propionibacteria sp. and biochemical properities of P. acnes were not different from P. acnes ATCC 11827 strain significantly. The results of the biotyping was as follow: twenty three strains of biotype I from comedone, 1 strain of biotype II from pauple, 5 strains of biotype III from pauple and pustule, and 1 strain of biotype IV from pauple were isolated respectively.

• Journal of Mushroom
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• v.6 no.1
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• pp.32-37
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• 2008

This study was carried out to investigate the growth inhibition of Propionibacterium acnes by mycelial culture broth of Paecilomyces japonica in the Mulberry leaf extract. The growth inhibition effect of P. japonica mycelial culture broth against P. acnes in various concentration of Mulberry leaf extract was the most effective in 3% Mulberry leaf extract. The inhibition effect of P. japonica mycelial culture broth against P. acnes according to the culture time was the moust effective after 25 days mycelial cultivation. As the treating amount of the mycelial culture broth was increased, the growth inhibition effect against P. acnes was increased gradually. The growth inhibition effect of mycelial culture broth against P. acnes according to the time of heat treatment was active by 45min at $100^{\circ}C$, while it was inactive more than 60min at $100^{\circ}C$. This result suggested that the antibacterial materials are possible to be glycoside or peptides. Taken together P. japonica mycelial culture in the Mulbarry leaf extract has a possibility to be an element of skin-care cosmetics regulating the acnes.

• Journal of the East Asian Society of Dietary Life
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• v.19 no.5
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• pp.750-760
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• 2009

In this study, the various effects of Salicornia herbacea, including antioxidative function, antibiotic, and anti-inflammatory effect, and the effect of sebiparous reduction due to intervention of the DHT hormone were investigated using. The result of this study Based on this analysis, the serum total cholesterol, triglyceride, and WBC were found to be significantly decreased and SOD, Ca, K, and Zn were shown to be significantly increased significantly in the group that received the SH pill group after trial fora 12 week trials. Testosterone and DHT were increased in the SH pill group, but it was not statistically significant. In the case of the skin condition measurements, the number of blackhead pores, skin oiliness, keratin and, MIC were significantly decreased, and the pH was decreased to normal pH in the SH pill group. Therefore, it was confirmed that overall skin condition was improved due to Salicornia herbacea diet. The results of this research result can contribute so demonstrate the potential of actively using that the Salicornia herbacea can be actively developed as a health supplement, and a medication.

• Journal of Life Science
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• v.33 no.4
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• pp.343-348
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• 2023

Acne is one of the most common skin diseases, mainly occurring in adolescence. The pathophysiology of acne involves not only hormonal, genetic and environmental factors, but also other factors including hyperseborrhea, inflammation, over-keratinization of follicular keratinocytes and overgrowth of Cutibacterium acnes (C. acnes). Cannabidiol (CBD) is known to relieve pain, stress and inflammation. Moreover, cannabis extracts containing CBD have been reported to be effective in treating acne. However, the therapeutic effect of CBD on acne remains unclear. Therefore, this study aimed to investigate the effect and mechanism of CBD on lipogenesis in SEB-1 sebocytes. We treated sebocytes with CBD and found that it not only inhibited lipid synthesis, but also inhibited cell proliferation by inducing apoptosis. We then demonstrated that sterol response element-binding protein-1 (SREBP-1) mediates the inhibitory effect of CBD on lipogenesis. Furthermore, Akt and adenosine monophosphate-activated protein kinase (AMPK), upstream regulators of SREBP-1, were regulated by CBD treatment. Taken together, our studies demonstrate that CBD inhibits adipogenesis by regulating the Akt/AMPK-SREBP-1 signaling pathway, providing potential for use as a therapeutic agent for acne. Further research is needed to confirm the effect of CBD on inflammation caused by hyperkeratosis, which will increase the possibility of using CBD for acne treatment.