• Title/Summary/Keyword: 약학

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Synthesis and Evaluation of Biological activities of New Imine Derivatives of Apicidin

  • Jin, Cheng-Hua;Kim, Hyung-Kyo;Han, Jeong-Whan;Lee, Hyang-Woo;Lee, Yin-Won;Zee, Ok-Pyo;Jung, Young-Hoon
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.253.2-253.2
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    • 2002

  • Apicidin. a natural product HDAC inhibitor. is recently isolated from Fusarium sp. at Merk Research Laboratories, induces therapeutic applications as a broad spectrum antiprotozoal agent to muti-drug resistant malaria and a potential antitumor agent. The biological activity of apicidin appears to be apicocomplexan HDAC at low nanomolar concentrations. (omitted)

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Total synthesis of deoxy-azasugars

  • Pyun, Sung-Jae;Oh, Chang-Young;Lee, Kee-Young;Kim, Yong-Hyun;Lee, Yiu-Suk;Pharm, Van-Thoai;Ham, Won-Hun
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.233.1-233.1
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    • 2002

  • Azasugars, which have been called the "sugar-shaped" alkaloids from plants. are reversible. competitive inhibitors of glycosidases. The purpose of these natural products is possibly to inhibit the carbohydrate metabolism and consequently the growth of plant consuming pests. Since selective glycosidase inhibitors have a large number of interesting potential applications including treatment of AIDS, diabetes. and tumor metastasis. they have received a considerable attentions. (omitted)

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