• Title/Summary/Keyword: 약학

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Antiplatelet Activity of NQ12 May Be Mediated by Inhibition of Cyclooxygenase and Generation of 12-HETE

  • Jin, Yong-Ri;Shin, Hye-Jun;Cho, Mi-Ra;Ryu, Chung-Kyu;Yun, Yeo-Pyo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.278.1-278.1
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    • 2002
  • In the previous study, we reported that NQ12, a vitamin K antagonist. showed a potent antithrombotic and antiplatelet activities. In order to elucidate the antiplatelet activity of NQ12. we investigated the effect of NQ12 on arachidonic acid cascade parameters such as cPLA2. cyclooxygenase (COX), and the downstream production such as TxA2, PGD2 and 12-HETE. N012 inhibited COX activity in a concentration-dependent manner in U937 cells. (omitted)

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The ermKleader peptide alterations leading to differential efficiency of induction by erythromycin

  • Kim, Jeong-A;Min, Yu-Hong;Yun, Hee-Jeong;Lim, Jung-A;Lee, Sang-Won;Kim, ung-Hoon;Park, Eung-Chil
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.335.1-335.1
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    • 2002
  • The ermK gene from Bacillus lichenformis encodes an inducible rANA methylase that confers resistance to the macrolide-lincosamide-streptograminB antibiotics. The ermKmANA leader sequence has a total length of 357 nucleotides and encodes a 14-amino acid leader peptide together with its ribosome binding site. The secondary structure of erm leader RNA and a leader peptide have been reported as the elements that control expression. (omitted)

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