• Journal of the Korean Society of Tobacco Science
• /
• v.18 no.1
• /
• pp.60-65
• /
• 1996

Chemicals including antibiotics and bactericides were screened for suppression of streptomycin-resistant Erwinia cmutouom subsp. cmutovom (Ecc) strains in laboratory and field conditions. Oxytetracycline, ethoquinolac and dichlorophen suppressed the growth of streptomycin-resistant Ecc strains in vitro. Fractional inhibitory concentration (FIC) indices of oxytetracycline and ethoquinolac mixed with streptomycin against the Ecc strains were equal to and less than one, respectively. Consequently the efficacy of those chemicals in mixture with sorptomycin were non-antagonistic But that of dichlorophen mixed with streptomycin was more than one, therefore the efficacy of the mixture was antagonistic. Spray of oxyteoucycline, ethoquinolac and agrimycin-100 on the topped burley tobacco plants was efficacious in reducing tobacco hollow stalk at the same level of sorptomycin treatment in three-year field trials, which suggests that those are promising chemicals to be alternative to streptomycin for control of tobacco hollow stalk.

• KOREAN POULTRY JOURNAL
• /
• v.40 no.12
• /
• pp.126-129
• /
• 2008

경부고속도로 천안휴게소에 서면 도로 너머로 화려한 원색의 기다란 건물이 보인다. 장난감을 만드는 회사인가 싶을 정도로 알록달록한 이곳은 외관의 느낌과 달리, 면역체계 증진을 위한 사료첨가제와 AI 예방제, 다약제내성병원체(MDRP)치료제를 개발 판매하고 있으며, 각종 친환경 유기농 제품군을 생산, 판매하고 있는 친환경 바이오 전문 기업 (주)리스나(대표 이종화, 이혁기, 정태호)의 본사이다. 리스나(Liisna)는 'Life is Nature'의 약자로 '삶은 곧 자연이다. 생명의 원천은 자연이다. 생명과 자연은 하나다.' 라는 의미를 포함하고 있다. 리스나의 전신인 구 오보바이오는 2005년 단국대학교 내 창업센터에서 시작해 2007년 지금의 자리로 이전하였다. 그리고 순환적 발전 모델을 추구하고자 2008년 8월 '(주)리스나'로 사명과 CI를 변경했다. 사명과 CI 변경을 통해 '바이셀라 코리엔시스(Weissella koreensis)'를 기반으로 한 바이오 사업 부문과 유기농 사업 부문이 순환적으로 결합되어 친환경 바이오 전문기업으로서의 시너지 효과를 꾀하고 있다. 아울러 '인류의 건강한 행복을 지향하는 기업' 이라는 비전을 이루기 위해 노력하고 있다.

• Pediatric Infection and Vaccine
• /
• v.8 no.2
• /
• pp.229-233
• /
• 2001

The incidence of complications of measles is about 4% and most of the chief complications are in the respiratory system, such as pneumonia, bronchitis. One of other potential dangers of measles is exacerbation of an existing pulmonary tuberculosis. We report a case of exacerbated pulmonary tuberculosis in 15-year old male child after contracting measles during epidemic in year 2001.

• The Korean Journal of Health Service Management
• /
• v.8 no.4
• /
• pp.163-173
• /
• 2014

This study was performed to investigate the current status of isolation precautions of multidrug resistant organisms(MDROs) in general hospitals with more than 200bed. The questionnaires were mailed from 3rd, April 2013 to 30th, April 2013. Methicillin resistant Staphylococcus aureus:(MRSA), vancomycin resistant Staphylococcus aureus:(VRSA), vancomycin resistant Enterococcus(VRE), multidrug-resistant Acinetobacter baumannii, carbapenem-resistant Enterobacteriaceae multidrug-resistant Pseudomonas aeruginosa were enrolled. MRSA(100.0%) and VRE(98.7%) were isolated respectively. VRE(97.3%) and MRSA(64.0%) were regulated strictly respectively. VRE(91.5%) and VRSA(50.7%) were isolated in a single room respectively. Hospital being located in Seoul(p<0.001), and beds(${\geq}600$)(p=0.008) were different significantly. The isolation space limitation(71.1%) was the highest difficulty. The development of refunding the costs of the extra supplies and other hygienic materials for infection control was discovered as the most urgent strategy.

• Proceedings of the Korean Society of Fisheries Technology Conference
• /
• 2000.05a
• /
• pp.457-458
• /
• 2000

Pefloxacine(PFX)은 기존 quinolone계 항균제의 단점을 보완한 fluoroquinolone계열의 합성 항균제로서 그람양성균과 그람음성균에 대해서도 살균효과가 뛰어날 뿐 아니라 내성균 출현 가능성이 비교적 낮은 장점이 있는 항균제로 보고되고 있다. 이러한 약리학적 특성 때문에 우리 나라에서도 양식어류 세균성 질병 치료제로 최근 사용량이 증가하고 있으나 현재까지도 어류를 대상으로 한 체내잔류 PFX의 정량분석방범과 PFX의 흡수, 분포, 해설 등 실제 약제 사용방법 설정에 필수적인 임상동태에 관해서는 연구가 되어 있지 않은 실정이다. 따라서 본 연구는 양식어류에 대한 PFX의 효과적인 사용방법을 확립하기 위하여 고속액체크로마토그라피(HPLC)를 사용하여 실험조건의 특이성 등을 검토하여 어체내 잔류 PFX의 최적 분석조건을 설정하였다. 그리고 주요 양식어류를 대상으로 PFX를 경구 투여한 후 시간경과에 따라 혈액을 채취하여 혈종에서의 약물동태학적 Parameter를 조사하였다. (중략)

• Proceedings of the Korean Nuclear Society Conference
• /
• 1999.05a
• /
• pp.381-381
• /
• 1999

• Korean Journal of Veterinary Service
• /
• v.16 no.2
• /
• pp.150-156
• /
• 1993

The present study was conducted to investigate the biochemical characteristics and anti-biotic resistance of pathogenic Escherichia coli (E. coli) isolated from piglets with diarrhea in Kyongbuk Western Area during the period from February to November 1992. 55 E. coli strains were isolated from 97 piglets with diarrhea and the biochemical and cultural reaction were compared with the classification criteria of Edwards and Ewing. The majority of E. coli were susceptible to amikacln, enrofloxacin and gentamicin. 51 (92.7%) out of 55 drug resistance stains carried R factor (R+) which were transferable to the recipients by conjugation.

• Tuberculosis and Respiratory Diseases
• /
• v.51 no.4
• /
• pp.325-333
• /
• 2001

Background : This study aimed to estimate the clinical outcome and identify the characteristics of a group of patients with pulmonary tuberculosis who completed anti-tuberculosis therapy with the First-line drugs in spite of having positive smear results with negative sputum culture results over the previous six months. Method : A retrospective chart review of 21 patients who fulfilled the above criteria between 1995 and 1999 was performed. The laboratory data as well as the clinical data of the patients with positive smear results and negative culture results over a six months period were reviewed. Results : The negative conversion of sputum culture results was achieved within $1.3{\pm}1.2$ months and the negative conversion of the sputum smear results was accomplished during $9.5{\pm}3.3$ months. Chest X-rays at 5 months following the institution of anti-tuberculosis therapy from all patients revealed improvements. Four out of 21 patients(19%) relapsed during the follow up, $15.2{\pm}13.4$ months after administering anti-tuberculosis therapy for $13.3{\pm}3.1$ months. Relapses were confirmed from between 3 months and 4 months after the treatment completion. Only one of the four relapses had no past history of anti-tuberculosis therapy and the others had prior treatment twice (p<0.01). The period of anti-tuberculosis treatment was extended to a mean of $4.6{\pm}2.6$ months in 12 patients. However, prolongation of anti-tuberculosis therapy had no affect on the relapse rate (odds ratio, 95% CI 0.18, 2.15). Conclusion : Prolongation of therapy with the First-line drugs is not necessary for patients with persistently positive smear results over 6 months and negative culture results. A patient who has had prior anti-tuberculosis therapy more than twice should be paid the closest attention.

• Tuberculosis and Respiratory Diseases
• /
• v.49 no.4
• /
• pp.421-431
• /
• 2000

Background : The length of postoperative drug therapy remains controversial in pulmonary tuberculosis. We analyzed our experiences to determine the postoperative duration of chemotherapy after resection. Method : A retrospective review was performed in 66 of 95 patients that underwent pulmonary resection for pulmonary tuberculosis between January 1993 and December 1998. We compared the relapse rates according to the length of postoperative chemotherapy in each group, classified by the results of sputum AFB culture before the surgery, the number of resistant drugs, the number of prior treatment and the division of anti-TB drugs used postoperatively. Results : Fifty three of 66(80.3%) were men and 13(19.7%) were women with a median age of 33.5 years(range, 16 to 63). The mean lengths of the pre- and post-operative chemotherapies were 4.9 months, and 12.9 months respectively. Five of 66 patients (7.6%) relapsed during the mean period of follow up (39.7 months). In the group less than three times of the prior treatment, there were two relapses (20%) in Ed-the highlight above-rephrase 10 patients that were medicated for 6 months or less, and one relapse in 43 patients (2.3%) that took medicine for more than 6 months (p=0.03). In the group using second-line drugs postoperatively, there was one relapse (25%) in four patients that were medicated for 12 months or less. No patient in a total of 17 that received medicine for more than 12 months relapsed (p=0.03). Conclusion : We recommend that patients with the prior treatment less than three times should be treated for more than 6 months after resection and patients using the second-line drugs postoperatively should be medicated for more than 12 months.

• Tuberculosis and Respiratory Diseases
• /
• v.60 no.2
• /
• pp.228-234
• /
• 2006

Background : Acinetobacter baumannii is an important pathogen associated with nosocomial infections in intensive care units, and is responsible for nosocomial pneumonia, UTI, bacteremia, etc. The main concern is that this pathogen is often resistant to many antimicrobial agents, particularly to carbapenem. This study compared the clinical those of ICU admitted patients with the carbapenem resistant A. baumannii isolated from the sputum with characteristics of patients with carbapenem sensitive A. baumannii. Methods : A total of 49 patients with A. baumannii from a sputum culture who were admitted to the ICU from January to December 2003 were enrolled in this study. This study evaluated the demographic variables, mortality, APACHE II score, comorbidity, antibiotics used, hospital and ICU stay, Clinical Pulmonary Infection Score, and mechanical ventilation. A retrospective analysis was made by a review of the patients' medical records. Results : Carbapenem sensitive and resistant A. baumannii was isolated from 23 patients and 26 patients respectively. Univariate analysis revealed renal disease, the use of carbapenem and aminoglycoside to be statistically significant factors for carbapenem resistance. Multivariate analysis revealed carbapenem use(p=0.024; OR, 8.17; CI 1.32 to 50.68) to be positively associated with carbapenem resistance, and aminoglycoside use(p=0.026; OR, 0.18; CI, 0.04 to 0.82) to be negatively associated with carbapenem resistance. There was no significant difference in mortality between the carbapenem sensitive and resistant group(30 vs 42%. P=0.39). Conclusion : The occurrence of carbapenem resistant A. baumannii is positively associated with carbapenem use and negatively associated with aminoglycoside use. Carbapenem resistance in the sputum culture did not affect the mortality rate.