• Title/Summary/Keyword: 약물 전달 시스템

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키토산 나노 입자를 이용한 약물전달시스템

  • 권익찬;김광명;김성원;정혜선;정서영
    • Polymer Science and Technology
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    • v.15 no.4
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    • pp.396-401
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    • 2004
  • 약물전달시스템 (DDS, drug delivery system)이란 기존 약물의 부작용을 최소화하고 약물이 가지고 있는 효능 및 효과를 최적화시켜 질병치유에 필요한 최소의 약물을 효과적으로 전달하기 위한 제형으로 정의될 수 있다. DDS 분야는 저비용과 짧은 개발기간으로 기존 약물의 새로운 제형개발을 가능하게 함으로써 차세대 바이오산업의 핵심으로 인식되고 있다.(중략)

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약물전달계로서 바이오 세라믹의 연구개발 동향

  • 김영희;김경자;최의석;김수룡
    • Ceramist
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    • v.7 no.1
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    • pp.5-10
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    • 2004
  • 약물 전달 시스템(Drug Delivery System; DDS)이란 기존 의약품의 부작용을 최소화하고 효능 및 효과를 최대화 시켜 약물을 효율적으로 전달하도록 제형을 설계하고 약물치료를 최적화하는 기술을 말한다. 약물전달은 전달경로, 약물의 종류 및 전달기술의 형태에 따라 구분될 수 있으며 지금까지의 약물전달소재는 유기소재로서 생체 분해성과 친화성을 갖는 천연 또는 합성고분자를 전달체로 하여 경구형, 경피투여형, 흡입형 그리고서방형 주사제 등이 이용되고 있다.(중략)

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Drug Delivery System Using Electrospun Nanofiber Mats (전기방사된 나노파이버 매트를 이용한 약물전달시스템에 관한 연구)

  • Yoon, Hyeon;Park, Yoon-Kyung;Kim, Geun-Hyung
    • Polymer(Korea)
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    • v.33 no.3
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    • pp.219-223
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    • 2009
  • The nanofibers fabricated by using an electrohydrodynamic process has been used as various applications, such as nano-device, filtering system, protective clothes, wound dressing, and drug delivery system (DDS). Of these applications, the DDS should be needed to minimize side effects of drugs, maximize the properties of medicine, and efficiently deliver the required amount of drugs to the diseased area. In this paper, by using the electro spinning process, which is one of electrohydrodynamic processes, two different types, polycarprolactone and poly(ethylene oxide)/Rhodamine B, of electrospun mats were fabricated layer by layer and the release behavior of Rhodamine B was characterized with time. In addition, to show the feasibility of DDS of this type, we tested release behavior of a peptide of the nanofiber system, a PCL/(Peptide+PEO)/PCL nanofiber mat. The released peptide did not loss biological activities. From these results, we believe that the layered nanofiber mat as a DDS has enough function of a new drug delivery system.

Manufacturing and in vitro Characterization of Composite Drug Delivery System (DDS) (복합재 약물전달 시스템의 제작 및 체외 환경 특성 평가)

  • Chu, Won-Shik;Jeong, Suk-Yong;Park, Jeong-Bin;Ahn, Sung-Hoon;Lee, Jae-Hoon;Chi, Sang-Chul
    • Composites Research
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    • v.21 no.3
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    • pp.18-23
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    • 2008
  • The Rapid Prototyping (RP) technology has advanced in many application areas. In this research, implantable Drug Delivery System (DDS) was fabricated by an RP system, Nano Composite Deposition System (NCDS). The DDS composite consists of 5-fluorouracil (5-FU), as drug particles, and PLGA85/15 as biodegradable polymer matrix. To have larger surface area, the DDS was fabricated in a scaffold shape, and its degradation was tested in vitro environment. Biocompatible Hydroxyapatite (HA) powders were added to the drug-polymer composite in order to control drug release. Test results showed a possibility of controlled release of scaffold DDS over 50 days.

Painless Microjet Injector Using Laser Pulse Energy (레이저 펄스 에너지를 이용한 무통증 마이크로젯 약물전달시스템)

  • Yoh, Jai-Ick;Han, Tae-Hee;Hah, Jung-Moo
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.35 no.5
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    • pp.547-550
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    • 2011
  • We have developed a laser-based needle-free liquid drug-injection device. A laser beam is focused inside the liquid contained in the rubber chamber of a micro-scale. The focused laser beam causes explosive bubble growth, and the sudden volume increase in a sealed chamber drives a microjet of liquid drug through the micronozzle. The exit diameter of a nozzle is less than 100 ${\mu}m$, and we verify that the injected microjet is fast enough to penetrate soft human tissue. In the experiment, the microjet penetrated a 5% gelatin-water solution that replicates the human thrombus and pork-fat tissue.

Hospital Medicine Delivery System Design applied RFID (전자태그(RFID)를 적용한 병원 약물전달 시스템 설계(HMDS))

  • Lim Keun;Ju Jin-Sun;Lee Hye-Sun
    • Proceedings of the Korea Information Processing Society Conference
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    • 2006.05a
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    • pp.581-584
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    • 2006
  • 병원에서는 RFID를 적용하여 병원종사자의 동선관리 및 의료 장비 등의 활용성을 개선함으로서 의료환경에 많은 변화가 일어나고 있으며 의료 서비스 향상에 크게 기여하고 있다. 그러나 의료 서비스에 앞서 더욱 중요한 의료 안전분야 에서는 여러 문제점 등이 내재되어 있다. 감염된 혈액의 수혈사고, 수술환자의 이동사고, 약물전달사고 등이 있다. 이러한 문제는 의료서비스 향상에도 불구하고, 의료 안전에 대한 부분이 상대적으로 배재되기 때문에 나타나는 것으로 판단된다. 본 논문에서는 특히 약물전달에 RFID를 적용하여 약물 전달사고를 최소화 하고자 한다.

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Design of swelling gastroretentive drug delivery system for sustained release of metformin (메트포르민의 서방출을 위한 팽윤성 위체류 약물전달시스템 설계)

  • Weon, Kwon Yeon;Kim, Se Gie
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.3
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    • pp.215-222
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    • 2020
  • Metformin is a recommended first-line therapy drug for type 2 diabetes patients. However, compared to other oral antidiabetic drugs (OAD), metformin has a large unit dosage, with bioavailability of 40-60%. This limiting bioavailability is because metformin is absorbed only in the upper gastrointestinal tract as a BCS class 3 drug. Hence, we propose that applying the Gastroretentive Drug Delivery System (GRDDS) and extending drug release time in the stomach will result in improved bioavailability. We selected the swelling type delivery system, as it is considered the most stable gastroretention technology compared to other GRDDSs. We modified the swelling excipient by using a natural swelling excipient to form a swelling tablet made of carrageenan and hydroxypropyl methylcellulose (HPMC). Our results indicate that the swelling complex tablet made of carrageenan and HPMC has a good swelling ability and shows required sustained release in a dissolution pattern. In addition, the carrageenan complex has a better swelling ability than the marketed metformin tablet, as determined by the ratio, (swelling ability)/(excipient weight). Taken together, our results indicate that the carrageenan complex can be developed as a good swelling excipient. Further optimizations are required for the commercialization of the carrageenan complex.