• Title/Summary/Keyword: 약리

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The Development of Herbal Medicine Network Analysis System

  • Ho Jang
    • Journal of the Korea Society of Computer and Information
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    • v.28 no.10
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    • pp.113-121
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    • 2023

  • Network pharmacology in traditional Korean and Chinese medicine studies the molecular and biological aspects of herbal medicine using computational methods. Despite variations in databases, techniques, and criteria, most studies follow similar steps: constructing herb-compound networks, compound-target networks, and target interpretation. To ensure efficient and consistent analysis in herbal medicine network pharmacology, we designed and implemented a common analysis pipeline. We showed its reliability with existing databases. The proposed system has a potential to facilitate network pharmacology analysis in traditional medicine, ensuring consistent analysis of various herbal medicines.

  • https://doi.org/10.9708/jksci.2023.28.10.113 인용 PDF HTML

Pharmacological Mechanism of Action of GS283 and GS386 on Human Platelet and Pig Coronary Artery (관상동맥이완과 혈소판응집에 대한 GS283과 GS386의 약리작용기전에 관한 연구)

  • CHANG, Ki Churl;LEE, Hoi Young;LEE, Goun Woo;KOO, Eui Bon;KANG, Young Jin;LEE, Young Soo
    • Biomolecules & Therapeutics
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    • v.5 no.3
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    • pp.239-245
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    • 1997

  • Trimetoquinol (TMQ) and its analogs are known to have thromboxane $A_2$ antagonistic action. We also reported that GS389, chemically similar to TMQ, has competitive antagonistic action in rat aorta and human platelets. In the present study, we investigated the pharmacological characteristics of GS283 and GS 386, analogs of GS389, using vascular smooth muscle, human platelets and rat brain homogenates. In isolated pig coronary artery (PCA), both of GS283 and GS386 relaxed U46619-contracted rings in concentration dependent manner. Pretreatment with several concentrations of GS283 and GS386 shifted the dose-response curves to the right, and reduced of maximum contration dose-dependently. Furthermore, GS283 and GS386 strongly inhibited $Ca^{2+}$ -induced contraction in the PCA. In human platelets, U46619- and A23187-induced platelet aggregation was inhibited by GS283 and GS386, concentration-dependently. Anti-platelet aggregation was related to the compound\`s ability to inhibit ATP release at each stimulation. In rat brain homogenates, receptor-binding assay resulted that both GS283 and GS386 have a relative affinity to $\alpha$-adrenergic receptor. Taken together. we concluded that the mechamism of action of GS283 and GS86 is not related with in TXA$_2$ receptor but concerned with calcium antagonistic action and a-blocking action.n.

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