• Journal of Hospice and Palliative Care
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• v.18 no.4
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• pp.322-328
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• 2015

Purpose: The aging of society has rapidly progressed, especially in Korea. Therefore, the necessity of research on end-of-life (EOL) care in elderly patients has increased. However, there are few studies on EOL care intensity for non-cancer patients. This study was designed to compare the EOL care intensity between cancer and non-cancer patients. Methods: We retrospectively analyzed the EOL care intensity based on medical records of decedents of Kyung Hee University Medical Center, a tertiary referral hospital from December 2014 through March 2015. And we compared EOL care intensity between cancer patients and non-cancer patients using statistical analysis of the frequency of invasive procedures and logistic regression analysis for factors that affect the EOL care intensity. Results: Statistical analysis showed invasive procedures, such as intensive care unit admission, endotracheal intubation followed by mechanical ventilation and emergency dialysis, were performed more frequently in non-cancer patients than cancer patients (29.3% vs. 72.4%, P<0.001). And age (P=0.038) and morbidity of cancer (P<0.001) influenced the invasive procedural decision when analyzed by logistic regression analysis. Conclusion: The EOL care was more intensive in non-cancer patients, and age and morbidity of cancer were major factors for the treatment intensity.

• Korean Journal of Head & Neck Oncology
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• v.29 no.2
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• pp.93-96
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• 2013

원격 전이된 비인두암 환자에서 주요한 치료 방법은 고식적 항암화학치료에 국한되어왔다. 그러나 적극적인 항암화학치료로 비인두암 환자 중 많은 환자에서 치료 반응을 보이며, 치료 반응을 보인 환자군에서는 국소 제어가 중요한 문제가 된다. 본 저자들은 원격 전이 된 환자 1예를 보고하고자 한다. 환자는 큰 크기의 다발성 전이가 있었으나 항암화학요법으로 관해 상태를 보였다. 이후 공고화 항암화학방사선요법을 추가하였고 현재 30개월 간 무병상태이다. 원격전이된 비인두암에서 공고화 항암화학방사선 요법의 역할에 대하여 문헌 고찰을 통해 논의하고자 한다.

• Journal of Korean Traditional Oncology
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• v.10 no.1
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• pp.1-45
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• 2005

많은 암 환자들이 보완대체의학(CAM)의 치료법을 이용한다. 의사들은 보완대체의학 치료법에 대한 권위 있는 정보들을 이를 찾는 환자들에게 책임 있는 조언을 줄 수 있기 위해 필요로 한다. 이 글은 암 환자에게 일반적으로 사용되는 선택된 보완대체의학 치료법의 효과와 안정성에 대한 최근의 증거를 요약했다. 식이요법과 보조식품, 한약 및 기타 생약제재, 침, 마사지, 운동, 심리 및 심신의학 등의 주요 카테고리가 포함되었다. 효과의 증거에 대한 '가능한 질병진행과 생존율에 대한 효과' 및 '가능한 완화효과'의 두 가지 범주가 고려되었다. 안전성의 증거를 평가하는데 있어 '직적접인 부작용의 위험'과 '통상적 치료법과의 상호작용에 의한 위험'의 두 가지 위험 요소가 고려되었다. 각각의 치료에 있어 효용성과 안정성에 대한 현재의 균형은 이 치료법이 적절히 권고가 되고 수용되어지거나(예를 들어 유방암과 전립선암을 가진 영양 섭취가 충분한 환자의 식이지방 감소) 억제되는 것을(예를 들어 과량의 비타민 A 보조제) 제시한다. 이러한 전략은 보완대체의학의 치료법을 찾는 암환자들에게 책임 있고 근거중심적이고 환자중심적인 조언을 제공하는 것을 발전시킬 수 있다.

• Radiation Oncology Journal
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• v.29 no.1
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• pp.1-10
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• 2011

Due to improved life spans, cancer incidence has increased with more aged patients presenting with cancer. Elderly cancer patients could have compromised organ function and/or comorbidities. Due to poor social support or lack of early diagnosis, treatment outcomes for elderly cancer patients are poor in general. However, with aggressive support during cancer management as well as careful selection, most elderly cancer patients can tolerate standard radiation therapy with good results based on published articles. Here, we reviewed existing articles regarding compliance and treatment results in elderly cancer patients based on tumor site.

• KIPS Transactions on Software and Data Engineering
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• v.10 no.12
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• pp.547-554
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• 2021

Cancer patients can have different kinds of cancer driver genes, and identification of these patient-specific cancer driver genes is an important step in the development of personalized cancer treatment and drug development. Several bioinformatic methods have been proposed for this purpose, but there is room for improvement in terms of accuracy. In this paper, we propose NPD (Network based Patient-specific Driver gene identification) for identifying patient-specific cancer driver genes. NPD consists of three steps, constructing a patient-specific gene network, applying the modified PageRank algorithm to assign scores to genes, and identifying cancer driver genes through a score comparison method. We applied NPD on six cancer types of TCGA data, and found that NPD showed generally higher F1 score compared to existing patient-specific cancer driver gene identification methods.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1991.06a
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• pp.29-29
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• 1991

후두암의 치료는 병변의 위치, 크기 등에 따라 치료방법이 다양하고 그 예후 또한 상이하다. 일반적으로 초기 후두암에서는 수술이나 방사선 요법이 비슷한 치료결과를 보이고, 진행된 후두암에서는 수술적 치료가 더 좋은 예후를 나타내는 것으로 알려져 있으나 발성장애를 초래하는 경우가 대부분이다. 저자들은 1986년부터 1990년까지 5년간 강남성모병원에서 후두암치료를 받았던 환자 81명을 대상으로 치료방법에 따른 음성보존 성적을 분석하였다. 1. T1 성대암 환자 18명중 16명 (88.9%)에서 방사선치료 또는 수술로써 음성을 보존할 수 있었다. 2. T2 후두암 환자 11명중 6명은 수술후 음성보존이 가능하였다. 3. 진행암환자 (T3, T4) 50명중 33명에 대해 수술을 시행하였고 이중 16명(48.5%)은 후두부분 또는 근전적출술 및 기관-식도 누공술에 의해 음성기능을 보존할 수 있었다. 4. 진행암환자에서 유도화학요법과 방사선치료의 병용요법만을 받은 17명 모두 6개월 이내에 재발하였고, 수술 혹은 수술과 방사선 치료를 병용한 33명중 27명이 최소한 6개월 이상 평균 2년 이상의 무병상태였다. 5. 후두부분 또는 근전적출술은 총 81명중 28명에서 시행되었고 그중 5명 (17.9%)에서 재발하였다.

• Korean Journal of Psychosomatic Medicine
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• v.7 no.1
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• pp.134-141
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• 1999

Objects : Cancer patients receiving radiotherapy have many psychological problems. Those problems depend on clinical factors of cancer and the characteristics of patients. This study was designed to estimate the morbidity of psychiatric disorder and to investigate the relationship between psychiatric disorders and clinical variables. Methods : The subjects were 47 patients who had been treated by radiotherapy. Psychiatric disorder was diagnosed according to DSM-IV. The authors assessed the relation between psychiatric disorder and demographic features, clinical features of cancer such as site, duration, frequency of recurrence of cancer, and patients' awareness of disease and expectation of outcome of radiotherapy. Results : 21 patients(44.7%) had a psychiatric disorder. The most common psychiatric disorder were adjustment disorder(66.7%), and the next major depressive disorder(23.8%). There was a significant positive relationship between psychiatric disorder and recurrence of cancer, patients' expectation of poor outcome after radiotherapy. Psychiatric morbidity was significantly low in those who had no evidence of recurrence and who considered radiation treatment as curative. However, site and duration of cancer, patients' awareness about serious illness were not related with psychiatric disorder. Conclusion : Psychiatric disorders are common among cancer patients on radiotherapy. Further clinical attention and effective treatment of psychiatric complication in cancer patients are needed not only for reducing symptoms but for better adjustment.

• Proceedings of the KAIS Fall Conference
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• 2012.05a
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• pp.336-339
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• 2012

본 연구는 여성 결장암 환자의 암 진전도에 영향을 미치는 요인을 규명하고자 시도하였다. 자료수집은 2012년 1월 23일부터 2012년 2월 23일까지 서울에 소재한 종합병원 외과에 내원한 결장암 환자 227명을 선정하여 설문조사를 하였다. 연구결과는 첫째, 이전의 결장암 검사여부는 암 검사를 하지 않은 여성은 distant는 61.7%로 localized인 여성은 36.7% 보다 유의하게 높았다($X^2$=26.41, p<.05). 둘째, 교육과 암검진력은 양의 상관관계를 보였다(r=0.27, p<.01). 셋째, 연령이 암 진전도를 23.8%, 과거 결장암 검진여부는 7.5%, 스트레스여부는 4.1%로 각각 설명하였다. 이러한 결과를 토대로 결장암 위험요인에 노출되어 있는 여성들의 결장암 발생을 예방하기 위해서는 조기검진에 대한 적극적인 홍보과 교육이 필요하다고 본다.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.343-346
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• 2009

본 연구는 이미 전 세계적으로 효과가 인정되고 있는 아유르베다 요법을 초기 암 환자들에게 적용하여 이들에게 부작용 없이 효과적인 관리 프로그램을 제공하여 초기 암 환자들에게 도움을 주고자 시행하였다. 연구방법은 아유르베다 요법인 정화요법과 식이요법, 명상요법을 밝히고 바타(공기), 피타(불), 카파(물) 세 가지 체질에 따른 초기 암 환자의 아유르베다 프로그램의 개발을 수행하였다.

• Journal of Hospice and Palliative Care
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• v.2 no.1
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• pp.36-45
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• 1999

Purpose : Cancer, one of the major causes of death in Korea, tends to become chronic due to the rapid development of diagnostic and therapeutic methods. As a result, the number of home-based cancer patients is in the increasing trend. However, on account of the insufficiency of continuous and comprehensive cancer patient management system, a number of cancer patients are left in a defenseless state. This study was designed for need assessment of home-based cancer patient to establish the community-based health care system for the comprehensive and continuous health care service to improve the quality of life of cancer patients and reduce rare burdens of their families. Methods : Through making a survey for needs assessment toward the health care service, the 455 respondents among home-based cancer patients answered the given enquetes to analyze the management status and problems of home-based cancer patients Results : 1) Unsatisfaction rates of pain control is 25.5 percent for mild cases, 46.5 percent for severe cases. 2) According to the needs assessment of home-based cancer patients, most of the respondents want to receive economical support, alleviation for the pain and symptoms, and the information of health care and consultation. So these needs account for the main contents of the home-based cancer patient management plan. 3) In the aspect of the satisfaction rate for basic care need, most items account for $20{\sim}30%$ of satisfaction. And the proportion of need for special case is under 5%, satisfaction rate for special care need is about 50% of satisfaction. So the home-based cancer patients are not being cared sufficiently. Conclusion : According to the result of need assessment, many home-based cancer patients received inadequate pain and symptom management. And Satisfaction rate for basic and special care need is low. So development of comprehensive and continuous health care service to improve the quality of life of cancer patients and reduce care burdens of their families is very necessary.