• Title/Summary/Keyword: 알카인

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Synthesis of Aminofuroxan Derivatives for the Alkyne Formation on Solid Surface and e-Beam Mediated Fragmentation in Gas Phase (고체상 표면에서 알카인 생성을 위한 아미노퓨록산 유도체의 합성과 전자빔에 의한 기체상 분해반응)

  • Heo, Jeong-Mu;Kim, Gi-Young;Hwang, Kwang-Jin
    • Journal of the Korean Chemical Society
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    • v.51 no.2
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    • pp.160-164
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    • 2007
  • Aminofuroxan derivatives 3 and 4 were prepared by the reaction of chlorofuroxan 2 with butyl and benzyl amines, respectively. E-beam mediated fragmentation of aminofuroxans 3, 4 in mass spectrometer was analyzed in a view of the corresponding alkyne formation.

Benign Transient Hyperphosphatasemia of Infancy and Childhood (소아기 일과성 고포스파타아제혈증 (Hyperphosphatasemia)에 대한 임상고찰)

  • Kwon, Jung Hyun;Park, Ji Hye;Kim, Hae Soon;Lee, Seung Joo;Lee, Mi Ae
    • Clinical and Experimental Pediatrics
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    • v.48 no.3
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    • pp.306-309
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    • 2005
  • Purpose : The aim of study is to investigate the clinical manifestations and the etiology of markedly-elevated serum alkaline phosphatase(ALP) levels in children without accompanying liver or bone disease. Methods : The serum ALP and other biochemical laboratory data of 4,989 patients attending the pediatric department of Ewha Womans University Mokdong Hospital between January 2002 to December 2002 were studied. The subjects' ages ranged from 4 months to 14 years. Among them, serum ALP levels were markedly elevated over 1,000 IU/L in 114 children. Among those 114 children, 97 children without liver or bone disease were reviewed retrospectively. Results : Of the 114 children with serum ALP activity of over 1,000 IU/L, 97(85.8 percent) children had neither liver or bone disease. The average ALP activity level was $1,539{\pm}948IU/L$. The male : female ratio was 1 : 0.7. Forty-four children(45.3 percent) were between 4 months to 1-year-old, 19 children(19.3 percent) were between 1- to 2-year-old. We observed a seasonal clustering of cases in during October with 10 cases(10.2 percent) and in during December with 11 cases(11.3 percent). The most common clinical presentation was respiratory tract infection in 25 cases(26.9 percent), and acute gastroenteritis in 17 cases(17.5 percent). Forty-four cases had follow-up ALP activity level, 1 month later and the activity decreased under 1,000 IU/L in 37 cases(84 percent). Conclusion : Hyperphosphatasemia is a benign and transient phenomenon. If there are no clinical and laboratory abnormalities of liver and bone, we suggest monitoring monitor the high serum ALP level 1 month later. If decreased, it seems that it is not necessary for specific examinations to exclude other diseases of malignant condition.

Color Stability of Alkasite Restorative Material: in vitro Studies (알카자이트 수복재의 색안정성 : 실험실적 연구)

  • Jihye, Ahn;Sangho, Lee;Nanyoung, Lee; Hyewon, Shin;Myeongkwan, Jih
    • Journal of the korean academy of Pediatric Dentistry
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    • v.49 no.4
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    • pp.428-441
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    • 2022
  • The purpose of this study is was to compare the color stability of alkasite and other restorative materials commonly used in the field of pediatric dentistry and to study a color change in response to various beverages. Test specimens of glass ionomer, resin modified glass ionomer, alkasite restorative material, and composite resin were prepared, and the color stability was measured after thermocycling. Each specimen was also subdivided into 5 groups and submerged in PBS, coffee, green tea, coke, and orange juice to analyze the color change from the original CIE L*a*b* values after 7, 14, 21, and 28 days. Composite resin showed the best color stability after thermocycling, followed by alkasite restorative material, glass ionomer, and resin modified glass ionomer. Submerging in various beverages for 7 days resulted in color change in all test specimens, with alkasite restorative material showing less color change than glass ionomer but greater change than composite resin. Alkasite restorative material showed the greatest color change in coffee, followed by green tea and orange juice, but almost no change in coke and PBS even after 28 days of submersion.

알카로이드독을 이용한 약물

  • 박종희
    • Journal of Life Science
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    • v.3 no.1
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    • pp.18-24
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    • 1993
  • 毒에는 비소, 수은처럼 無機毒과 식물, 동물성의 有機毒이 있으며, 有機毒에는 알카로이드, 배당체, 단백毒 등이 있다. 식물의 알카로이드毒을 중심으로 이것이 어떻게 藥物로서 이용되어 왔는지에 관해 다루었다. Morphine의 발견을 계기로 여러 종류의 식물 알카로이드가 계속 분리되었으며, 藥의 탐구의 새로운 길을 열었다. Morphine은 우수한 진통의 효과를 가졌지만, 흡수억제 및 습관성의 결점을 가지고 있다. 또, Areca catechu L. 의 종자(빈낭자)에는arecoline, arecaidine 등의 piperidine系의 알카로이드를 함유하고 있다. Arecoline은 副交感神經 흥분작용이 있고, 침분비 촉진, 比瀉 등으로 사용되어 왔지만, 지금은 그 용도가 적어졌다. 그리고 화살독이 되는 毒을 약물로 사용한 것은 Acontium屬 식물이 유일한 것이다. 중국에서는 이를 身體四肢關節의 마비, 疼痛의 회복, 대사기능실조의 회복 등의 목적으로 사용해 왔다.

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Synthesis of Dendrimer with PEG Core by Click Chemistry (클릭 화학에 의한 PEG 핵을 갖는 덴드리머의 합성)

  • Han, Seung-Choul;Jin, Sung-Ho;Lee, Jae-Wook
    • Polymer(Korea)
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    • v.36 no.3
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    • pp.295-301
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    • 2012
  • Efficient stitching methods for the synthesis of Fr$\acute{e}$chet-type dendrimers with linear PEG units at a core were elaborated. The synthetic strategy involved an inexpensive 1,3-dipolar cycloaddition reaction between an alkyne and an azide in the presence of Cu(I) species which is known as the best example of click chemistry. The linear core building blocks, two diazido-PEG units, were chosen to serve as the azide functionalities for dendrimer growth via click reactions with the alkyne-dendrons. These two building blocks were employed together with the alkyne-functionalized Fr$\acute{e}$chet-type dendrons in a convergent strategy to synthesize two kinds of Fr$\acute{e}$chet-type dendrimers with different linear core units.

Decentralization from Al-Qaida central among Salafi-jihadist groups, Boko Haram and the Islamic States (살라피 지하디스트의 탈-알카에다 중심화와 보코하람, IS에 대한 분석연구)

  • Kim, Eun-Young
    • Korean Security Journal
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    • no.41
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    • pp.185-212
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    • 2014
  • This research examines the decentralization of al-Qaida and other Salafi-jihadist terrorist groups, which is a subject of intense debate in the West. Especially, this study focused on investigating the status and evolution of al Qa'ida and other two Salafi-jihadist groups, Boko Haram and the Islamic States. These terrorist groups are currently considered as the most active Salafi-jihadist terrorist groups leading today's decentralization from Al-Qaida central terrorism network. This study also aims to examine the contemporary threats posed by the two extremely violent jihadist terrorist groups and these groups's terrorist networks. In order to achieve the purpose of this study, this study conducted content analyses with a wide range of documents reporting about Salafi-jihadist terrorists groups. Also this study utilized GTD data set drwan from START centner to provide descriptive analyses regarding IS and Boko Haram's activities and threats. On the basis of analyses, this study argues that recently the threats posed by core al Qaida has been severely weakened. Further, the broader Salafi-jihadist movement has become more decentralized among four tiers: first, core al Qaida in Pakistan; second, formal al Qa'ida affiliated groups that have sworn allegiance to core al Qaida; a number of Salafi-jihadist groups that have committed to establishing an extremist Islamic emirate without sworn allegiance to al Qaida; third, individual followers and networks inspired by al Qaida and other Salafi-jihadist groups. In concusion and discussion, this study highlights the need for a long-term engagement counter terrorism strategy against Salifi-jihadist terrorists groups on behalf of the peace and security of the world society.

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A Study on the Islamic terrorism in the Southeast Asia: Its Evaluation and perspectives (동남아시아 이슬람 테러리즘 현황 및 전망에 관한 연구)

  • Choi, Jin-Tai
    • Korean Security Journal
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    • no.14
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    • pp.549-567
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    • 2007
  • In the post-Cold war world, the threat of terrorism is emerging as the most formidable challenge. The terrorist attacks including 9.11 World Trade Center attack have proved such challenge. It has become apparent that no country is safe from the scourage of terrorism. The region of the southeast Asia is no exception to this trend. The Bali bombing of 2002, killing about 200 innocent people, demonstrated that the threat environment had significantly altered. Today, local and regional groups such as Jemiah Islamiah can conduct terrorist operations as devastating as those carried out by Al Qaeda. As fighting terrorism is a complex multi-dimensional task, the responsibility for fighting terrorism must not rest with a single government. The burden must be shared by both the local governments and international communities. In addition, To prevent another bombing of the scale of Bali, countries in the region of southeast Asia must respond decisively. The purpose of this study is to examine the current situation on terrorism in the southeast Asia and to provide perspectives on future terrorism in this region. To foster the better understanding, historical survey on the terrorism in the region and local terrorist groups' network with the foreign terrorist organizations including Al Qaeda have been researched. Based on the result of the research, this paper provides a perspectives and evaluation on the future terrorism in the southeast Asia. It also provides an implications for our reference in the war against terrorism.

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Assessment of Fluoride Release through Dentin Adhesive in the Alkasite Restorative Material and Giomer (알카자이트 수복재와 자이오머의 상아질 접착제를 투과하는 불소 유리 평가)

  • Kim, Haeni;Park, Howon;Lee, Juhyun;Seo, Hyunwoo
    • Journal of the korean academy of Pediatric Dentistry
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    • v.48 no.4
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    • pp.367-375
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    • 2021
  • This study evaluated the fluoride release of alkasite restorative material (ARM) and giomer penetrating the dentin adhesive layer. Twenty specimens were prepared for each restorative material, and dentin adhesive with uniform thickness was applied to half of them. The prepared specimens were placed in a polyethylene tube containing 2.0 mL of deionized water and deposited in a 37.0℃ water bath for the study duration. The amount of fluoride release was measured on the 1st, 3rd, 7th, 14th, 21st, and 28th days after deposition. The dentin adhesive applied to the ARM and giomer could not completely block the fluoride release; however, it significantly reduced its amount. The cumulative amount of fluoride release of the ARM after 28 days was higher than that of the giomer regardless of the application of dentin adhesive.