• Journal of Life Science
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• v.14 no.2
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• pp.275-279
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• 2004

Gene polymorphisms of cytokines and their receptors are attractive candidates as genetic factors in the pathogenesis of immune-mediated diseases and have been reported to be associated with disease susceptibility to autoimmune, inflammatory and infectious diseases. IL-29 is one of important candidate genes for complex trait of genetic diseases but there is no published survey of single nucleotide polymorphisms (SNPs) in this gene. In this study, for the first time, we have examined the full genomic sequence of IL-29 including the promoter regions to identify SNPs. We examined the frequencies of genotypes and alleles at the SNP site of IL-29 in allergic rhinitis patients and non-allergic rhinitis controls using the direct sequencing method to determine whether this IL-29 SNP is associated with allergic rhinitis in Korean population. We identified one novel SNP (1184C＞A) in the intron 2 and one novel variation site (-1842_-1841dupGA) in the promoter region of human IL-29 gene. The P values of SNP or variation site were not significant between the healthy controls and allergic rhinitis patients. Our results suggest that the 1184C＞A polymorphism and -1842_-1841dupGA variation site in human IL-29 gene were not associated to allergic rhinitis.

• Korean Journal of Adult Nursing
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• v.27 no.4
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• pp.438-448
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• 2015

Purpose: The purpose of this study was to identify the effects of using aroma essential oils on allergic symptoms, eosinophils and quality of life related to rhinitis for university students with allergic rhinitis. Methods: A randomized controlled experimental design was used. There were 37 participants in the experimental group, and 30 in the control group. The experimental group applied the essential oils four times a day in the nasal area as well as using inhalation of the oils each night for four weeks. Rhinoconjunctivitis quality of life questionnaire was composed of 28 questions regarding seven areas associated with allergic reactions. The data were analyzed with SPSS/WIN 21.0 program. Results: Rhinitis symptom index, nose itching (p<.001), sneezing (p<.001), watery rhinorrhea (p<.001), and nose congestion (p<.001) all had significant difference for the participants in the treatment group. Further there were significant differences in eosinophils both for measured time and interaction (p<.001). For the quality of life related to rhinitis, the results showed significant difference (p<.001). Conclusion: Using aroma therapy by applying essential oils turned out to be an effective nursing intervention that can be utilized in the easing of allergic symptom and the decrease of eosinophils, causing improvement in the quality of life related to rhinitis.

• Journal of Korean Academy of Nursing
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• v.46 no.5
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• pp.675-686
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• 2016

Purpose: The purpose of this study was to develop an Allergic Rhinitis-Specific Quality of Life (ARSQOL) scale and verify its validity and reliability. Methods: ARSQOL was developed in 5 steps. Items for the preliminary instrument of ARSQOL were developed through a literature review and deep interviews with allergic rhinitis patients. Face validity with Content Validity Index (CVI), construct validity using factor analysis, and known group comparison, criterion validity test using correlation between ARSQOL and total nasal symptoms score (TNSS) were conducted to evaluate the validity of ARSQOL. Cronbach's ${\alpha}$ was used to evaluate the reliability of ARSQOL. Results: CVI for the items in the final ARSQOL were. 92. Five factors including discomfort associated with nasal symptoms (4 items), physical function (7 items), mental function (5 items), sleep disorder and social function (4 items), and problems of daily life (6 items) were identified through factor analysis and these five factors explained 66.6% of the total variance. The correlation coefficient between TNSS and the total score of life quality was -.69. In the group comparison, the persistent allergic rhinitis group showed lower ARSQOL scores than the intermittent patient group, and moderate to the severe allergic rhinitis patient group presented poorer ARSQOL than the mild symptom patient group. The Cronbach's ${\alpha}$ reliability coefficient was .95. Conclusion: Results show that the ARSQOL has good reliability and validity and thus ARSQOL is a useful scale for clinical practices and research as a measure of quality of life in adults with allergicr hinitis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.494-502
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• 2019

Various international reports have shown strong proof that socioeconomic and sociodemographic variables are correlated with allergic diseases, yet little is known about how these variables affect Korean adolescents. This study was conducted to identify the socioeconomic and sociodemographic risk factors for allergic diseases of Korean adolescents, and to provide information for preventing and managing such conditions. Data from the 2018 Korean Youth Risk Behavior Survey (KYRBS) of 60,040 adolescents was used for this study. An anonymously administered online survey was conducted to collect information on the dependent variables. The independent variables were asthma, allergic rhinitis and atopic dermatitis. Multivariate logistic regression analysis was performed to analyze the correlations between the dependent variables and the independent variables. Low economic status, living with mother, high education level of parents, high school record, obesity, drinking and smoking were the risk factors for asthma. Low economic status, the place of residence, living with mother, high education level of the parents, gender, high school record, obesity, drinking and smoking were the risk factors for allergic rhinitis. Low economic status, living with mother, high education level of parents, genderhigh school record, obesity and drinking were the risk factors for atopic dermatitis. We found that low socioeconomic status and unhealthy behavior were the risk factor for allergic diseases of Korean adolescents. Balanced economic growth in the community and controlling unhealthy behavior can help reduce the prevalence of allergic diseases.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.33 no.4
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• pp.8-11
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• 2004

최근 황사, 새집증후군(SHS), 조류독감 등과 같은 인간의 건강을 위협하는 요인들의 증가 및 대기오염에 의한 실내공기질의 악화는 비염, 천식과 같은 호흡기 질환과 아토피 같은 각종 알레르기 질환 관련 환자들의 증가로 실내의 공기를 건강한 공기로 전환시켜 이러한 질환들을 예방 또는 완화시키는 방법으로서 공기청정기에 대해 설명하고자 한다.(중략)

• Proceedings of the KSLP Conference
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• 2007.03a
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• pp.15-15
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• 2007

• Journal of Acupuncture Research
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• v.27 no.3
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• pp.127-135
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• 2010

목적 : 이 연구는 알레르기 비염 또는 비부비동염으로 인한 비폐색증에 대한 침치료의 효과를 입증하고, 신혈인 심의혈의 임상적 효과를 알아보고자 시도하였다. 방법 : 2009년 9월 22일부터 11월 3일까지 2회 이상 경희의료원 동서비염클리닉에 내원하여 침 치료를 받은 비염환자를 대상으로, 무작위배정방법에 따라 실험군 또는 대조군으로 배정하였다. 실험군은 routine 혈위인 신회 상성 신정 양두유 양찬죽 양지창에 심의혈을 추가하였고, 대조군은 routine 혈위에 양영향을 추가하였다. 유침 시간은 각 군에서 15분간으로 하였다. 유효성 평가 도구로는 SNOT-20를 사용하여 비염의 전반적 증상 점수 변화를 측정하였고, VAS를 사용 하여 비폐색 완화 효과의 정도를 측정하였다. 평가시기는 치료 전후로 하였고, 통계분석은 치료 전후 SNOT-20 차이의 경우 Wilcoxon Signed Ranks Test로, VAS 비교는 Mann-Whitney Test를 이용하여 검정하였다.

• Journal of Korean Biological Nursing Science
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• v.16 no.4
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• pp.300-308
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• 2014

Purpose: The purpose of this study was to analyze the effects of eucalyptus aroma therapy on relieving allergic rhinitis symptoms, improving learning ability and quality of life among university students. Methods: In this study, a non-equivalent control group repeated measured design was applied. Participants included 48 students (24 participants in the experiment and 24 participants in the control group) who were diagnosed with allergic rhinitis. Data were collected on 3 occasions, before eucalyptus aroma application, 4 weeks after the application, and 8 weeks after the application. Collected data were analyzed using ${\chi}^2$-test, Fishers exact test, independent t-test, repeated measured ANCOVA and paired t-test with SPSS 21.0. Results: There were significant differences in allergic symptoms (F=6.926, p=.002) and quality of life (F=3.793, p=.026) according to the time periods after aroma application. Conclusion: Eucalyptus aroma therapy is effective in reducing the symptoms of allergic rhinitis and enhancing the quality of life of university students. It is recommended that eucalyptus aroma therapy be used for university students with allergic rhinitis to reduce their symptoms, and it is recommended that the application of the therapy be extended over 4 weeks.

• Journal of Korean Biological Nursing Science
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• v.12 no.1
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• pp.16-23
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• 2010

Purpose: The purpose of this study was to examine the effects of aromatherapy on blood pressure, pulse, fatigue and sleep for patients with allergic rhinitis admitted at a hospital specialized in an oriental medicine. Methods: This research was a single-group pretest-posttest design. Data were collected at admission and discharge from May to December, 2009. The patients selected were received an aroma inhalation therapy via nebulizer with a 2% diluted oil mixture of eucalyptus and peppermint with 10 cc of saline solution in the ratio of 1:1 ones a day for 15 min in the period of 2 weeks. The data were analyzed for the descriptive statistics and paired t-test. Results: There was a statistically significant improvement on physical and psychological symptoms of fatigue and sleep with a increase in systolic blood pressure. Conclusion: Eucalyptus and peppermint blended oil aromatherapy as a sleep induction modality is an effective nursing and therapeutic intervention in conjunction with acupuncture and herbal medicine for symptoms of nasal congestion. However, further well designed research is required in evaluating the effectiveness of the types of clinically available essential oil.

• The Journal of Internal Korean Medicine
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• v.26 no.1
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• pp.119-128
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• 2005

모든 알레르기 반응의 중심축이 되는 비만세포는 주로 피부, 위장관 및 호흡기관의 점막에 분포하고 있다. 활성화된 비만세포는 즉각형 알레르기 반응을 일으키는 여러 인자들을 방출시키게 된다. 方藥合編(방약합편)에 따르면 蔘蘇飮(삼소음)은 알레르기 鼻炎(비염), 發熱(발열), 風寒(풍한), 頭痛(두통), 기침에 效能(효능)이 있는 處方(처방)이다. 본 硏究(연구)는 蔘蘇飮(삼소음)의 肥滿細胞(비만세포) 의존성 아나필락시 반응(anaphylactic reaction)에 대한 藥理(약리) 效果(효과)를 조사하기 위한 것이다. 蔘蘇飮(삼소음)은 compound 48/80으로 유발되는 전신성 아나필락시 쇼크(systemic anaphylactic shock)와 耳介(이개) 浮腫(부종) 反應(반응)(ear swelling response)을 농도 의존적으로 억제하였다. 蔘蘇飮(삼소음)을 0.1, 1 mg/ml로 전처리 하였을 때, 흰쥐 복강 肥滿細胞(비만세포)(rat peritoneal mast cells, RPMCs)에서 compound 40/80에 의해 유발되는 히스타민 분비는 감소하는 것으로 나타났다. 또한 蔘蘇飮(삼소음)은 anti-dinitrophenyl IgE에 의해 활성화 된 수동 피부 아나필락시(passive cutaneous anaphylaxis, PCA)를 농도 의존적으로 抑制(억제)하였다. 결론적으로 蔘蘇飮(삼소음)은 肥滿細胞(비만세포) 의존성 즉각형 알레르기 反應(반응)을 抑制(억제)하여, 항 아나필락시 활성(anti-anaphylactic activity)을 가지는 것으로 보여 진다.