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Safety of Nano-sized Bee Pollen in both In-vitro and In-vivo Models (생체 외 및 생체 내 실험조건에서 나노화 벌 화분의 안전성 규명)

  • Pyeon, Hae-In;So, Soojeong;Bak, Jia;Lee, Seunghyun;Lee, Seungmin;Suh, Hwa-Jin;Lim, Je-Oh;Kim, Jung-Woo;Kim, Sun Youn;Lee, Se Ra;Lee, Yong Hyun;Chung, Il Kyung;Choi, Yun-Sik
    • Journal of Life Science
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    • v.28 no.5
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    • pp.605-614
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    • 2018
  • Bee pollen has an outer wall which is resistant to both acidic and basic solutions and even the digestive enzymes in the gastrointestinal tract. Therefore, the oral bioavailability of bee pollen is only 10-15%. A previous study reported on wet-grinding technology which increased the extraction of active ingredients from bee pollen by 11 times. This study was designed to investigate the safety of wet-ground bee pollen. First, a single dose of wet-ground bee pollen was tested in both rats and beagle dogs at dosages of 5, 10, and 20 g/kg and 1.5, 3, and 6 g/kg, respectively. In rats, compound-colored stools were found in those administered 10 g/kg or more of wet-ground bee pollen. In beagle dogs, 6 g/kg of wet-ground bee pollen induced diarrhea in one male for four hours. However, no obvious clinical signs were found through the end of the experiment in rats and beagle dogs. In addition, no histological abnormality was found in all animals. The data indicates that a single dose of up to 20 g/kg of wet-ground bee pollen is safe. Next, the genetic toxicity of nano-sized bee pollen was tested. This study employed a bacterial reverse mutation test, a micronucleus assay, and a chromosomal aberration assay. In the micronucleus assay, there was no genetic toxicity up to the dosage of 2 g/kg. There was also no genetic toxicity in the bacterial reverse mutation test and chromosomal aberration assay. This data provides important information in developing nano-sized bee pollen into more advanced functional foods and herbal medicines.

A study on applications of the natural ventilation pressure(NVP) in local tunnels (터널내 자연환기력(NVP) 적용방안 연구)

  • Kim, Hyo-Gyu;Yoo, Ji-Oh;Lee, Chang-Woo
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.16 no.3
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    • pp.269-285
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    • 2014
  • In spite of the importance of the natural ventilation pressure(NVP) in tunnels for the optimal design of the ventilation system, there have been only few studies on the NVP because its measurement and quantitative analysis are not straightforward. This study aims at quantifying the amount of the NVP with the terrain and meteorological data for the local major tunnels. And ultimately this will lead to developing the guidelines for quantifying and applying NVP for the optimal design of tunnel ventilation system. 22 local tunnels in the major routes are studied for the NVP quantification. NVP derived from the meteorological data is in the range of 20~140 Pa, while NVP estimated from the terrain data ranges from 20 to 200 Pa. Since the jet fan pressure is about 10~15 Pa per unit, the minimum level of NVP expected in the local tunnels is larger than the pressure rise by one unit of the ordinary jet fan. This implies that NVP in local tunnels should be quantified and be taken into consideration for the economic and safe ventilation design. The barometric pressure difference between tunnel portals is found to be the most influential factor, accounting for 61% of the NVP, while the wind pressure acting on the portals and the chimney effects occupy 22% and 17%, respectively.

Development of Intelligent Database Program for PSI/ISI Data Management of Nuclear Power Plant (원자력발전소 PSI/ISI 데이터 관리를 위한 지능형 데이터 베이스 프로그램 개발)

  • Park, Un-Su;Park, Ik-Keun;Um, Byong-Guk;Park, Yun-Won;Kang, Suk-Chul
    • Journal of the Korean Society for Nondestructive Testing
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    • v.18 no.5
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    • pp.389-397
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    • 1998
  • For an effective and efficient management of large amounts of preservice/inservice inspection(PSI/ISI) data in nuclear power plants, an intellegent Windows 95-based data management program was developed. This program enables the prompt extraction of previously conducted PSI/ISI conditions and results so that the time-consuming data management, painstaking data processing and analysis in the past are avoided. The program extracts, and the associated remedies. Furthermore, additional inspection data and comments can be easily added or deleted for subsequent PSI/ISI operation. Although the initial version of the program was applied to Kori nuclear power plant, this program can be equally applied to other nuclear power plant. And also this program can be used to offer the fundamental data for application of evaluation data related to fracture mechanics analysis(FMA), probabilistic reliability assessment(PRA) of PSI/ISI results, performance demonstration initiative(PDI) and risk-informed ISI based on probability of detection(POD) information of ultrasonic examination. Besides, the program can be further developed as a unique PSI/ISI data management expert system that can be apart of PSI/ISI data management expert system that can be a part of PSI/ISI Total Support System(TSS) for Korean nuclear power plants.

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Case Study on the Instability of the Slopes in Unsaturated Residual Soils Considering the Rainfall Characteristics (강우특성을 고려한 불포화 잔적토 비탈면의 붕괴사례 연구)

  • Nam, Samheon;Lee, Younghuy;Oh, Seboong
    • Journal of the Korean GEO-environmental Society
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    • v.16 no.1
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    • pp.45-53
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    • 2015
  • This study has obtained Soil Water Retention Curve (SWRC) of the unsaturated soil from the volumetric pressure plate extractor test and the triaxial compression tests was also conducted. By using the rainfall data measured in the site the seepage analysis of unsteady flow was performed with the program of SEEP/W in Geostudio 2007 and stability of the slope was analyzed with SLOPE/W program. Results of analyses show that shear strength of the unsaturated soil increases with the increase of matric suction. And it was also found that the net volumetric stress and the apparent cohesion increased with the matric suction. The seepage analysis of rainfall represents that the increasing rate of negative pore pressure at the zone of large negative pore pressure is appeared to be high even though lower rainfall intensity, but this tendency declines with ground depth. The stability analysis of slope was carried out for the actual plane of failure with the data representing the field condition. The factor of safety thus calculated was about unity (1.0) or just below, which means that the adopted method of analysis is in good agreement with the field condition.

Study on Dissolution Condition of Monsanto Catalyst (몬산토 촉매의 용해방법에 관한 연구)

  • Choi, Kwang Soon;Lee, Chang Heon;Pyo, Hyung Yeol;Park, Yang Soon;Joe, Kih Soo;Kim, Won Ho
    • Analytical Science and Technology
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    • v.14 no.4
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    • pp.317-323
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    • 2001
  • Dissolution procedures of Monsanto catalyst which has been used to produce acrylronitrile by ammoxidation of propylene have been studied. Optimum dissolution condition of the catalyst supported on silica was obtained by microwave digestion system with mixed of HCl, HF and $H_2O_2$. When a safety device was activated by increased pressure in microwave vessel, Bi, Fe, Mo, Sb and U were not volatilized even though silica was volatilized as $SiF_4$. Quantification results by this method were $SiO_2$ $50.5{\pm}0.4%$, $Sb_2O_3$ $29.6{\pm}0.6%$, $UO_2$ $10.2{\pm}0.1%$, $Fe_2O_3$ $6.1{\pm}0.1%$, $MoO_3$ $0.73{\pm}0.01%$ and $Bi_2O_3$ $0.49{\pm}0.01%$ by ICP-AES and the relative error was within ${\pm}10%$ except bismuth.

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Comparison of emission characteristics between fuel injection systems with echanical cam and electric control type on low speed 2 stroke diesel engine for ship propulsion (선박추진용 기계적 캠 구동식 및 전자제어식 연료분사 시스템을 가진 저속 2행정 디젤엔진의 배기특성 비교)

  • Lee, Sang Deuk;Koh, Dae Kwon;Jung, Suk Ho
    • Journal of Advanced Marine Engineering and Technology
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    • v.37 no.6
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    • pp.611-616
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    • 2013
  • Many researches have been carried out consistently for the green ship owing to its economic increasement, efficiency and convenience. One of them is an electronic controlled marine diesel engine. However, we are suffered from dissemination of above engine, due to its anxiety about safety and reliability. In order to solve these problems in this study, emission characteristics test of main propulsive two-stroke diesel engine, equipped both electronic control and cam drive fuel injection systems, has been performed and evaluated under the various load conditions. From the test results, we have confirmed that exhaust gas emission characteristics of the electronic control system is similar to the cam drive system in eco-mode operation, but NOx in emission mode has been decreased 100ppm or more in full load condition. HC emission from the electronic control system is decreased 10~20ppm at 50% load, and 35~40ppm at 25% load in comparison to cam drive system. In fuel consumption, it is considered that 7g/kWh is decreased than the value of cam drive system at 700bar of injection pressure, which is 200bar higher than cam drive system.

Experimental Study on Fretting Wear of Inconel 690 Under High Temperatures and Pressures (고온 고압 환경에서 인코넬 690 재료의 프레팅 마모 특성에 관한 실험적 연구)

  • Lee, Coon-Yeol;Lee, Ju-Suck;Bae, Joon-Woo
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.36 no.6
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    • pp.637-644
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    • 2012
  • In a nuclear power plant, fretting wear due to impact motion between U-tubes and support structures located in steam generators can cause serious problems. In order to guarantee the reliability of the steam generator, the damage due to fretting wear should be thoroughly investigated. The purpose of this study is to elucidate the fretting wear mechanism qualitatively and quantitatively. Hence, fretting wear simulation is performed for the environments to which the actual steam generators in nuclear power plants are exposed. Initial experimental results are obtained for various experimental parameters, and the effect of the work rate and temperature on fretting wear is evaluated. In water, the wear coefficients for $90^{\circ}C$, $200^{\circ}C$, and $340^{\circ}C$ are found to be $9.051{\times}10^{-16}\;Pa^{-1}$, $3.009{\times}10^{-15}\;Pa^{-1}$, and $2.235{\times}10^{-15}\;Pa^{-1}$, respectively. It is also found that the wear coefficient at room temperature is larger than that at low temperature in water because of the dynamic viscosity of water.

Overpressure prediction of the Efomeh field using synthetic data, onshore Niger Delta, Nigeria (합성탄성파 기록을 이용한 나이지리아의 나이저 삼각주 해안 에포메(Efomeh) 지역의 이상고압 예측)

  • Omolaiye, Gabriel Efomeh;Ojo, John Sunday;Oladapo, Michael Ilesanmi;Ayolabi, Elijah A.
    • Geophysics and Geophysical Exploration
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    • v.14 no.1
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    • pp.50-57
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    • 2011
  • For effective and accurate prediction of overpressure in the Efomeh field, located in the Niger delta basin of Nigeria, integrated seismic and borehole analyses were undertaken. Normal and abnormal pore pressure zones were delineated based on the principle of normal and deviation from normal velocity trends. The transition between the two trends signifies the top of overpressure. The overpressure tops were picked at regular intervals from seismic data using interval velocities obtained by applying Dix's approximation. The accuracy of the predicted overpressure zone was confirmed from the sonic velocity data of the Efomeh 01 well. The variation to the depth of overpressure between the predicted and observed values was less than 10mat the Efomeh 01 well location, with confidence of over 99 per cent. The depth map generated shows that the depth distribution to the top of the overpressure zone of the Efomeh field falls within the sub-sea depth range of 2655${\pm}$2m (2550 ms) to 3720${\pm}$2m (2900 ms). This depth conforms to thick marine shales using the Efomeh 01 composite log. The lower part of the Agbada Formation within the Efomeh field is overpressured and the depth of the top of the overpressure does not follow any time-stratigraphic boundary across the field. Prediction of the top of the overpressure zone within the Efomeh field for potential wells that will total depth beyond 2440m sub-sea is very important for safer drilling practice as well as the prevention of lost circulation.

Performance Analysis of TPMS Beamformer According to Variance of Antenna Interelement Spacing (안테나 간격 변화에 대한 TPMS 빔형성기 성능분석)

  • Choi, Byung-Sang;Kim, Seong-Min;Hwang, Suk-Seung
    • The Journal of the Korea institute of electronic communication sciences
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    • v.8 no.6
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    • pp.907-915
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    • 2013
  • Tire Pressure Monitoring System (TPMS) is an auxiliary safety system for recognizing the condition of tires based on the pressure and temperature data transmitted from the sensor unit installed on a tire of the vehicle. Using TPMS, a driver can frequently check the state of tires and it aids to maintain the optimum running condition of the vehicle. Since TPMS must utilize the wireless communication technique to transmit data from a sensor unit to a signal processing unit installed in the vehicle, it suffers from interference signals caused by various external electrical or electronic devices. In order to suppress high-power interference signals, we employ beamforming techniques based on the uniform linear antenna array. As the number of the antennas is increased, the performance of the interference suppression is improved. However, there is the limit of the number of antennas, installed in the center of a vehicle, because of its size. In this paper, we compare and analyze the performance of the beamformer, when reducing the interelement spacing of antennas, to increase the number of the receiving antennas. For the performance analysis of the beamformers, we consider the switching beamformer and minimum-variance distortionless-response (MVDR) beamformer for TPMS, recently proposed.

Gas Explosion Hazard Analysis in Domestic (가정집에서 가스폭발 위험성 분석)

  • Jo Young-Do;Kim Ji-Yun;Kim Sang-sub
    • Journal of the Korean Institute of Gas
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    • v.5 no.2 s.14
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    • pp.36-42
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    • 2001
  • A leak of fuel gas in partially confined area creates a flammable atmosphere and give rise to an explosion, which is one of the most common accident in domestic. Observations from accident in domestic suggest that some explosions are caused by a quantify of fuel significantly less than lower explosion limit(LEL) amount required to fill the room, which is attributed to inhomogeneous mixing of leaked gas. The minimum amount of leaked gas for explosion is highly dependent on the mixing degree in the area. For lighter gas, such as methane, a high concentration tends to build up in the space from ceiling of room. But heavy gas, such as propane, a high concentration tends to build up in the space from bottom of room. This paper presents a method for analysing the explosion hazard in a room with very small amount of leaked gas. Based on explosion limit concentration, the gaussian distribution model is used to estimate the minimum amount of leak which yields a specified explosion pressure. The results demonstrate that catastrophic structural damage can be achieved with a volume of fuel gas which is less than 0.5 percent of the total enclosed volume in domestic. The method will help analyzing hazard to develop new safe device as well as investigating accident.

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