• Title/Summary/Keyword: 안전성 지표

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Aprotinin Therapy for Cardiac Operation in Adult -Full dose regimen- (개심술에서 아프로티닌의 효과 (고용량 요법))

  • 장운하;오태윤;김미혜
    • Journal of Chest Surgery
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    • v.32 no.4
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    • pp.358-363
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    • 1999
  • Background: Recently, many cardiac centers have been using aprotinin to reduce operative bleeding in cardiac operations using cardiopulmonary bypass. A variety of reports have confirmed the effectiveness of the drug in cardiac operations. In addition to the operations which could be considered to cause severe operative bleeding such as redo operation, long cardiopulmonary bypass operation and etc, the use of aprotinin is increasing in the field of primary cardiac operations. Varying doses of regimen have been introduced since the first report by Royston et al, and also various opinions on the effectiveness and safeness of the each regimen have been reported. We reviewed our own experience of the full dose aprotinin regimen(Hammersmith regimen) retrospectively. Material and Method: From October 1994 to February 1998, 40 cases of cardiac operative patients were randomized into two groups: aprotinin group(20 patients) which received a full dose aprotinin regimen and control group(20 patients) which did not receive aprotinin. To evaluate the degree of bleeding decrease, we analysed and compared the amount of postoperative 6 hours and 24 hours bleeding in the each group. To confirm the renal dysfunction, we measured the postoperative creatinine level. Result: In the amount of postoperative 6 hours bleeding, a statistically significant bleeding decrease was demonstrated in the aprotinin group compared to the control group(aprotinin group: 186${\pm}$40cc, control group:409${\pm}$69cc, P=0.010). Similar result was observed in the postoperative 24 hours(aprotinin group:317${\pm}$53cc, control group: 671${\pm}$133cc, P=0.024). Conclusion: We concluded that full dose regimen of aprotinin can remarkably reduce postoperative bleeding in cardiac operations without significant renal dysfunctions.

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Monitoring of Restaurant Beef Labeling System (음식점 식육 원산지 표시 모니터링)

  • Hong, Jin;Leem, Dong-Gil;Kim, Mi-Gyeong;Park, Kyoung-Sik;Yoon, Tae-Hyung;No, Ki-Mi;Jeong, Ja-Young
    • Journal of Food Hygiene and Safety
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    • v.25 no.2
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    • pp.162-169
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    • 2010
  • The compulsory beef labelling system has launched from January 1st 2007 by the amended Food Hygiene Law, we were checked the actual conditions of beef origin with a nationwide scale by the Hanwoo differentiation specific test method which was developed by Korea FDA using 90 SNP biomarkers. The test method is useful tool to differentiate the beef origin carrying out the mission of KFDA's annual food safety management guidance. Also we have technically transferred the Hanwoo differentiation specific test method to other institutes as well regional KFDA and established the training program as a regular course in Korea Human Resource Development Institute for Health and Welfare. The beef used in this study were collected according to the 2009 Food safety guidance in roast beef restaurants where business site area greater than 100 $m^2$. Total 216 samples were consisted of 48 samples of the Seoul area and 168 of the region. The monitoring result from restaurants in all the region of Korea showed that 3 of 216 Hanwoo-labelled beefs were found out as a non-Hanwoo (1.3%). This results are gradually deceasing trend compared with 34.0% in 2005, 30.1% in 2006, 3.2% in 2007 and 5.14% in 2008. From these data, the Hanwoo differentiation specific test method on the settlement of the compulsory beef labelling system has an important role. As a outcome of this project, we might be considered the early settlement of the compulsory beef labelling system, technically transferred to other institutes and the establishment of regular training program of the test method.

The Informativeness of Cash Flows and Earnings (현금흐름과 이익의 정보성)

  • Pyo, Young-In
    • Korean Business Review
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    • v.11
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    • pp.241-253
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    • 1998
  • One form of the anomalies of stock price changes as reaction to earnings information is believed to be caused by the so-called earnings fixation, which is the overreaction of stock prices to earnings. According to the Sloan (1996) study, stock price changes are positively associated with earnings at the time of earnings releases, but the association becomes negative after that, as the early overreaction is corrected. However, the problem in his study is to use cash flows computed by adjusting earnings with appropriate income statement and balance sheet items. As Bahnson et al. (1996) show, these cash flows substantially deviate from SFAS No. 95 cash flows and the sample used in this study is found to be subject to this substantial measurement error. Therefore, the result of Sloan might be driven by this error and the reexamination of earnings fixation is warranted. The results are generally consistent with those in Sloan. First, earnings is positively associated with stock price changes at the time of earnings releases, but the association becomes negative after that. Second, cash flows show a weak association with stock price changes at the time of earnings releases, but the association become stronger thereafter. Third, when seperated from cash flows, accruals have an incremental explanation about stock price changes beyond that of cash flows, accruals have a negative association later on. This finding is consistent with stock price overreaction to accruals, even when more cleaner cash flow data are used.

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Preservation of Subvalvular Apparatus During Mitral Valve Replacement (판막하부 구조물을 보존하는 인공 승모판막 치환술)

  • 임창영;임정철
    • Journal of Chest Surgery
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    • v.29 no.12
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    • pp.1329-1336
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    • 1996
  • From January, 1994 to January. 1996, mitral valve replacement was performed in 27 patients. Among these, 17 patients underwent mitral valve replacement(MVR) with preservation of the annulo-papillary continuity(PAPCMVR) (-Group I), and 10 patients underwent conventional methods of excision of all the chordae(Group II). The operative technique for PAPCM VR consists of the division of the anterior leaflet into anterior and posterior segments, shifting and reattachment of the divided segments to the mitral ring of the respective commissural areas. This retrospective study has been designed to evalute the postoperative left ventricular function in the two groups. In the group 1, LVEF(Left Vnetricular Ejection Fraction : %) was 52 $\pm$ 3 preoperatively And 50$\pm$3 postoperatively, LVESI Vent icular End Systolic Volume Index/mL/m2) wIns 59 :6 and 51 $\pm$ 7, LVEDI Ventricular End Diastolic Volume Index/mL/m2) was 124$\pm$ 11 and 91 :8. In the group II, LVEF was 56$\pm$1 and 47:), LVESVI 62$\pm$12 and 61$\pm$15, LVEDVI 133$\pm$27 and 104$\pm$17. : the variation of the LVEF in these two group was statistically different(p(0.05). A comparison of left ventricular function data between Group I(n: 17) and Group II(n: 10) revealed better results in echocardiographic LVEF(p<0.05), LVEDVI(p<0.01) in the former group. The mean functional class(UYHA) was 2.6 preoperative and improved to 1.0 postoperatively In group 1, and 2.8 and to 1.0 in group II. We conclude that maintenance of continuity between the mitral annulus and papillary muscles is expected to have a beneficial effect on postoperative left ventricular performance.

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An Automated OpenGIS-based Tool Development for Flood Inundation Mapping and its Applications in Jeju Hancheon (OpenGIS 기반 홍수범람지도 작성 자동화 툴 개발 및 제주 한천 적용 연구)

  • Kim, Kyungdong;Kim, Taeeun;Kim, Dongsu;Yang, Sungkee
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.39 no.6
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    • pp.691-702
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    • 2019
  • Flood inundation map has various important roles in terms of municipal planning, timely dam operation, economic levee design, and building flood forecasting systems. Considering that the riparian areas adjacent to national rivers with high potential flood vulnerability conventionally imposed special cares to justify applications of recently available two- or three-dimensional flood inundation numerical models on top of digital elevation models of dense spatial resolution such as LiDAR irrespective of their high costs. On the contrary, local streams usually could not have benefits from recent technological advances, instead they inevitably have relied upon time-consuming manual drawings or have accepted DEMs with poor resolutions or inaccurate 1D numerical models for producing inundation maps due mainly to limited budgets and suitable techniques. In order to efficiently and cost-effectively provide a series of flood inundation maps dedicatedly for the local streams, this study proposed an OpenGIS-based flood mapping tool named Open Flood Mapper (OFM). The spatial accuracy of flood inundation map derived from the OFM was validated throughout comparison with an inundation trace map acquired after typhoon Nari in Hancheon basin located in Jeju Island. Also, a series of inundation maps from the OFM were comprehensively investigated to track the burst of flood in the extreme flood events.

Application of Water Model for the Evaluation of Pesticide Exposure (농약의 노출 평가를 위한 수계예측모형의 적용)

  • Son, Kyeong-Ae;Kim, Chan-Sub;Gil, Geun-Hwan;Kim, Taek-Kyum;Kwon, Hyeyoung;Kim, Jinbae;Im, Geon-Jae;Ihm, Yang-Bin
    • The Korean Journal of Pesticide Science
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    • v.18 no.4
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    • pp.236-246
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    • 2014
  • Pesticide is used to protect the crops, but also become a cause of polluting the environment. Perform a risk assessment using physical and chemical properties, environmental fate and toxicity data in order to determine the pesticide registration. The aquatic model estimates pesticide concentrations in water bodies that result from pesticide applications to rice paddies and apple orchard. The used models are the PRZM, EXAMS and AGRO shell (PA5), Rice Water Quality Model (RICEWQ) and Screening Concentration In GROund Water (SCI-GROW). The residual concentration of water body was estimated using meteorological data, crop calendar and soil series of Korea. The chosen pesticides were butachlor, carbofuran, iprobenfos and tebuconazole. It has shown the potential that the RICEWQ is possible to predict residue level in water of butachlor and iprobenfos, because the maximum value in water monitoring data is lower than the peak concentration of the model, and the minimum value is lower than the average annual concentration of the model. But RICEWQ was insufficient to predict exposure concentrations in ground water. The estimated exposure concentrations of carbofuran in ground water is very higher than in surface water because of its low soil adsorption coefficient. Although tebuconazole were not detected in the water monitoring that means very low concentration, it is possible that the PA5 can be used to predict residue level in water.

Toxicity Assessment and Establishment Acceptable Daily Intake of Pyrimisulfan (피리미설판(Pyrimisulfan)의 독성평가와 일일섭취허용량 설정)

  • Jeong, Mi-Hye;Park, Kyung-Hun;Park, Jae-Eup;Kwack, Seung-Jon;Kim, Young-Bum;Han, Bum-Seok;Son, Woo-Chen
    • The Korean Journal of Pesticide Science
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    • v.15 no.2
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    • pp.208-217
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    • 2011
  • Pyrimisulfan is a herbicide. In order to register this new pesticide, the series of toxicity data on animal testing were reviewed to evaluate its hazards to consumers and also to determine its acceptable daily intake. Pyrimisulfan was excreted mostly by feces. It has low acute oral toxicity while it has no dermal, ocular irritation and skin sensitization (As the result of subchronic and chronic toxicity and carcinogenicity showed changes of hematology and liver.). Two-generation reproduction toxicity, genotoxicity, carcinogenicity and prenatal development toxicity were not proven. Therefore, the ADI for Pyrimisulfan is 0.1 mg/kg/ bw/day, based on the NOAEL of 10 mg/kg/ bw/day of 90-days repeated dose oral toxicity study in dogs while applying an uncertainty factor of 100.

센서 네트워크용 초소형 OS

  • Song, Jun-Geun;Ma, Pyeong-Su;Park, Seung-Min
    • Information and Communications Magazine
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    • v.24 no.7
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    • pp.26-35
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    • 2007
  • 최근 몇 년간 유비쿼터스 서비스를 구현하기 위한 핵심 기술 중 하나인 무선 센서 네트워크에 대한 관심이 높아지고 있다. 무선 센서 네트워크 기술은 물류, 유통, 환경 감시, 홈오토메이션, 군사 분야 등 다양한 분야에 적용 될 수 있기 때문에 앞으로 관련 분야의 시장 또한 커질 것으로 예상되고 있다 [1]. 무선 센서 네트워크는 기존 유선 센서 네트워크나 무선 네트워크 환경과는 많은 차이를 가진다. 우선 극도로 제한된 시스템 자원만을 가질 수 있으며, 열악한 환경 속에서 무선매체를 통해 유기적으로 동작하여야 하는 특징을 가지고 있다. 적게는 수십 개에서 많게는 수백, 수천 개의 자율적인 하드웨어 노드들로 구성되는 무선 센서 네트워크에서 제한된 자원을 효과적으로 활용하기 위해서는 센서 노드에 적합한 운영체제가 필수적으로 요구된다. 지난 몇 년간 센서 노드하드웨어의 발달과 더불어 많은 센서 네트워크용 초소형 운영체제가 개발되어왔다. 현재 많이 알려져 있는 센서 네트워크용 OS로는, 가장 활발한 참여를 보이고 있는 TinyOS[3]부터 SOS[4], MANTIS[5], Contiki[6], T-kernel[7] 등이 있으며, 국내 기술로 개발된 Nano-Qplus[8] 등이 존재한다. 본고에서는 우선 센서 네트워크에 대한 배경 지식과 플랫폼 등에 대한 내용을 간단히 다루고, 본론에서 센서 네트워크용 운영체제가 가져야 할 조건과 현재 개발되어 있는 센서 네트워크 OS들의 특징에 대해 간략히 살펴보도록 하겠다. 또한 센서 네트워크 OS와 밀접한 연관성을 가지는 분야에 대해 간단히 살펴보고, 마지막으로 앞으로의 방향에 대해 알아본다.고려해 볼 때 atlas의 장축의 시계방향 회전은 액티베이터의 사용 효과로 생각되며, 이는 차후 II급 부정교합자에서 액티베이터 치료 효과를 판단하는 또 하나의 지표가 될 수 있다고 생각한다.인해 한반도를 포함한 동아시아 대륙이 태평양판 쪽으로 밀려감으로써 섭입하던 태평양판의 각도가 급해져 동아시아 연변에 강력한 흡입력이 발생하였으며, 이 때문에 태평양판의 운동 방향이 북북서에서 서북서방향으로 회전되었을 가능성이 있다. 따라서 약 51 Ma부터 한반도 동남부에는 지판 경계의 강력한 흡입력으로 동서 내지 서북서-동남동의 인장력이 작동되어 B그룹 암맥군이 관입한 것으로 해석된다.Ledge는 세 군 모두에서 나타나지 않았다. 4. 파일 binding 횟수는 MC군이 가장 적고 PT군이 가장 많았다 (p < 0.05). 이상의 결과를 볼 때, Mtwo 전동 파일을 crown-down technique으로 사용하는 것이 single length technique과 유사한 성형 효율을 보이면서도 더 안전할 것으로 추정된다.고 1명(3%)에서 원격전이를 보였다. 치료 중 급성 합병증으로 11명(37%)에서 RTOG grade 1-2의 장염을 보였으며 1명은 대장의 천공이 발생하여 수술로 치유되었다. 12명(40%)에서 RTOG grade 1-2의 급성 방광염을 보였다. 3명(10%)에서 RTOG grade 1-2의 백혈구 감소증이 보였으며 1명에서 심한 백혈구 감소증(RTOG grade 4)이 나타났으나 회복되어 치료를 완료하였다. 만성 합병증으로 5명(15%)에서 RTOG grade 1-2의 만성 장염을 보였으며 별다른 치료 없이 지내고 있으며

Determining Priority of Transport Policies with a Focus on Data Envelopment Analysis with Ranked Voting Data (자료포락분석(DEA)을 이용한 교통정책 우선순위 설정에 관한 연구)

  • 홍석진;오재학;하헌구
    • Journal of Korean Society of Transportation
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    • v.21 no.5
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    • pp.49-58
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    • 2003
  • The Transport policies in Korea have been planned and implemented as a part of a larger economy policy based on the achievement of economic growth. As a result, previous transport policies have been focused mostly on the supply of transport infrastructure. The average annual economic growth of six percent and a twelve percent growth in motor vehicles until the late 90s led to the acceleration of the imbalance between the supply and demand of infrastructure. As such, there is a need to establish an innovative transportation policy in order to increase national competitiveness and provide momentum for national growth in the Twenty one century. This research has developed strategies and policies based on interviews that were carried out with specialists in transport field. Moreover, some transport policies have been established for the year 2020 through the conducting of a survey. The survey was conducted by interviewing respondents on making the priority of transport policies. which was then analyzed using the Data Envelopment Analysis with ranked voting data. The results are as follows. The most urgent matter was considered to be the development of a inter-modal transport system, followed by an integrated service system for public transport, and the need to increase the competitiveness of the transport and logistics industries and to further transport safety. Meanwhile, the provision of transportation for disabled people as well as the elderly was considered to be less important in Korea than in welfare nations. This stems from the belief as further attention needs to be paid to the construction of a public transport system, the establishment of transportation networks construction in preparation for reunification and the North-East Asian era, as well as the privatization of the transport infrastructure.

Cause and Countermeasure of Inundation Damage in Underground Space (우리나라 지하공간 내수침수피해 원인 및 대책)

  • Cho, Jae-Woong;Choi, Woo-Jung
    • Proceedings of the Korea Water Resources Association Conference
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    • 2011.05a
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    • pp.420-420
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    • 2011
  • 도시지역의 내수침수피해는 거의 매년 발생하고 있으며, 반지하와 같은 거주공간이 매우 취약한 상태이다. 특히 최근에는 지하철, 지하상가 등이 대규모 개발되고 복합네트워크화 되어 지하공간의 침수대책과 대피방안 마련이 시급한 상황이다. 일본의 경우 2000년 토카이 호우피해 후 통합유출해석 모형을 개발하였으며, 1999년 및 2003년 후쿠오카 침수피해 발생 후 특정도시하천침수피해대책법을 제정, 1999 후쿠오카, 2004년 하마마츠, 2008년 카누마 피해 후 일본 방재연구소에서는 실시간 1차원 지표범람모형과 모니터링을 통한 실시간 내수침수지도를 개발하였다. 특히 지하공간에 대해서는 "지하공간에 유입하는 범람수가 계단상 보행자게에 주는 위험성에 관한 연구" 등 실험을 바탕으로 각종 지하공간 침수대책 매뉴얼 및 지하시설의 침수시 피난확보계획 지침, 지하공간 침수대책 가이드라인 등 인명피해를 줄이고자하는 노력이 계속되어 오고 있다. 우리나라는 2006년 경기도 고양시 3호선 정발산역이 침수되었으며, 2010년 서울시 지하철 2호선 사당역 및 4호선이 침수되는 등의 지하철 침수피해와 2010년 서울시 광화문 지하상가, 인천시 부평구 우림라이온스 벨리, 우남플라자, 계양구 농협하나로마트, 서원아파트 등의 지하상가와 지하다층의 침수피해가 발생하였다. 특히 2006년 3호선 정발산역 침수는 17시간이나 지하철이 불통되었고 이로 인하여 심각한 교통 체증이 유발 되었다. 본 연구에서는 2010년 집중호우로 인한 서울, 인천지역의 지하공간 침수피해를 중심으로 최근 10년간 지하공간 침수피해사례로부터 대표적인 침수피해 원인 및 특성을 정리하였으며, 그 결과 지하공간 침수의 주요원인은 지상공간의 침수류가 지하공간으로 유입하고, 지하공간의 배수설비 용량부족, 지하공간으로의 유입을 방지하기위한 방지턱, 차수판, 침수시 비상전원 공급, 침수시 지하공간 대피 매뉴얼의 부재 등 다양한 원인이 있는 것으로 나타났다. 특히, 소방방재청에서 고시한 '지하공간 침수방지를 위한 수방기준'에 지하공간 침수 방지를 위한 각종 시설의 설치 및 대피 경로지정 등에 대한 기준이 마련되어 있으나, 지하공간 중 유동인구가 가장 많은 지하철역에서 조차 침수에 대한 행동매뉴얼이나 대피에 대한 가이드라인이 마련되지 않은 것으로 나타났다. 따라서, 지하공간 침수를 방지하기 위하여 센서를 이용한 자동 차수판과 경보기 설치, 지하공간의 사람들이 안전한 대피로를 찾을 수 있도록 지상공간 및 지하공간 출입구를 모니터링 할 수 있는 CCTV의 설치, Dry Area를 두어 비상대피 할 수 있는 공간의 마련 등 시설적인 부분에 대하여 '지하공간 침수방지를 위한 수방기준'을 더욱 강화할 필요가 있으며, 지상공간의 침수 상황을 고려한 지하공간의 대피매뉴얼 또는 가이드라인 등의 수립이 필요하다. 또한 이와 더불어 재산 및 인명피해를 더욱 효율적으로 줄일 수 있도록 실시간 예 경보를 위한 침수해석 모형의 개발이 시급하다.

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