• Journal of Dairy Science and Biotechnology
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• v.34 no.2
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• pp.117-135
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• 2016

The present study was performed to develop a functional raw food material from hydrolyzed whey protein powder (23%-GNANA) medication containing sialic acid as a marker compound that is naturally occurring at 7% concentration in GMP (glycomacropeptide). GMP is used worldwide in foodstuffs for babies and infants and is obtained from the milk protein as safe food. While the purpose of our detailed evaluation was aimed to assess preliminary NOAEL values for and above 2,000 mg/kg/day, a clinical dose allowance for 23%-GNANA (as per characteristic of a functional health product, a highly refined test substance of 23% (v/v) sialic acid combined in GMP), at the same time we also wanted to assess the safety of GMP hydrolyzate lacking sialic acid but with identical properties as GMP. Animal safety evaluation was conducted using 23%-GNANA as the test substance, produced from hydrolyzed whey protein powder (product name: HELICOBACTROL-23; provided by Medinutrol Inc. [Korea]; composed of 23% sialic acid and GMP protein) after isolating the sialic acid using enzymes approved as food additives, with GMP as a raw material, and subsequently increasing the content of xx up to 23% through 80% (v/v) ethanol soaking and concentrating, in accordance with GLP Guideline. The animal safety evaluation mentioned above was made on the basis of toxicity in SPF Sprague-Dawley female and male rats dosed with 10 mL of the test substance diluted to 0, 1,250, 2,500, and 5,000 mg/kg directly into their stomachs for 90 d. This was determined in terms of the general symptoms and animal viability, weight and amount of feed intake, eye examination, uracrasia tests, hematological and blood biochemical disorder tests, blood coagulation test, abnormal intestine weight, abnormalities during postmortem and histopathological examinations. Statistical significance was set at P<0.05. Based on the toxicity determination, a certain minor effect associated with the test substance was observed in male rats with no major effects of the tested substance, in comparison with the control group dosed with sterilized water. Nevertheless, the NOAEL value, evaluated as per toxicity criteria, was verified as 5,000 mg/kg/day (P<0.05). Similarly, for female rats, a certain minor effect associated with the test substance was observed in 5,000 mg/kg/day dosed group, with no major effect, yet the NOAEL value (as assessed as per toxicity criteria) was determined to be 5,000 mg/kg/day (P<0.05), which was the same as for male rats. Accordingly, the NOAEL values of the test substances for all female and male rats were finally verified as 5,000 mg/kg/day (P<0.05). In conclusion, it was determined that the 23%-GNANA test substance exceeds 2,000 mg/kg/day, the clinical allowance characteristic for functional health food, and was finally evaluated to cause no safety concerns when used as a raw material in functional health food production, which was the ultimate goal of the present study.

• The Journal of Engineering Geology
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• v.3 no.3
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• pp.279-293
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• 1993

In recent yeaes, the collapses of man made structures have been encountered from time to time due to the deformation of the ground in korea. Furthermore, the possibilities of casasters from the ground deformation suCh as landslide and active fault are atrracting our attention to the deformation monitoring. In this study, two-coordinate tilt which was monitored during six months in order to develop tediniques for prevention of disasters from the ground deformation. The two-coordinate tilt which was detected by a tilt-sensor installed in shallow depth on the slope with the sensitivity of 0.0001 arc.sec in every 10 minutes was recorded continously to PC through the interface with 200-m line coonection. The observed digital tilt data. together with the relevant meteorological data were analyzed in reference to engineering application. During the whole observation period of six months, the net tilt is 10.06 arc.sec to the west and 73.88 arc.sec to the south. Consequently the ground has a tilt of 74.56 arc.sec to the direction of $S7.75^{\circ}W$ with average tilting of 0.02 arc.sec/hour. In spite of such fast and large tilting, it is interpreted in view of engineering aspects that the site is much safe from danger, since both East-West and North-South components of tilt converge as time goes by. Two categories of deformational events are recognized ; one is toward the direction of surface slope and the other is to the direction of increased pore pressure. Tiks are acenain to have a close relation with precipitation of rain. The daily variation of two-coordinate tilt is delayed 4.3 hours in average after the variation of atmospheric temperature. A certain correlation between atmospheric pressure and deformation might be revealed.

• Proceedings of the KOR-KST Conference
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• 1998.10b
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• pp.508-508
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• 1998

위험물 차량사고는 일반차량의 교통사고시 발생하는 인명피해, 재산피해, 교통지체 외에 부가적으로 환경적 영향에 의한 엄청난 인명 및 재산손실을 유발시킬 수 있다. 따라서 이러한 위험물차량사고를 예방하고 피해를 최소로 줄이기 위해서는 위험물수송경로의 신중하고 체계적인 결정이 필수적이라 할 수 있다. 외국의 경우, 위험물의 방출이 미치는 환경적 영향에 대한 인식이 확대되면서 위험물 수송시 응급처리에 관한 연구, 위험물 수송에 따른 위험도 평가에 관한 연구, 위험물 수송시 고려해야할 여러 조건에 관한 연구, 위험물 수송경로 설정에 관한 연구 등이 진행되고 있다. 반면에 우리 나라는 위험물차량관리와 사고처리에 대해 실시간적인 관리를 목표로 하는 국가차원의 계획을 수립하고는 있지만, 현재 이와 관련된 연구는 거의 없는 실정이다. 앞으로 산업발달에 따른 위험물수송량의 증가와 환경의식의 변화에 따라 위험물수송 및 사고처리 등에 관한 연구가 필요할 것이다. 따라서, 본 연구는 위험물차량의 운송경로를 결정할 때 고려해야 할 여러 가지의 기준 및 목표에 따라 위험물수송경로를 설정하는 모형을 제시함으로써 위험물수송에 수반되는 위험을 최소화하면서 위험물차량의 통행시간, 거리, 비용 등을 최적화하여 위험물수송의 안전 및 운영효율성을 향상시키고자 한다. 먼저, 위험물 수송경로의 기준지표로 사용될 위험도를 산정하기 위해 링크 주변노출인구, 밀도 등을 변수로 하는 모형식을 제안하고, 두 번째로 산정된 위험도를 기반으로 최적경로를 결정하는 알고리즘을 제안하였다. 마지막으로 가상 네트웍에 본 연구에서 제안된 모형을 적용하고 현재 일반적으로 사용되는 최단경로와 비교·분석하였다.것은 운송거리와 운송비용이 각각 주요한 변수라는 것이다. 모형의 타당성을 검증하기 위해서는 logilikelihood 값을 구하여 $\rho$^2분석을 시행하였다. 여기서는 각 품목별로 $\rho$^2값이 약 0.15~0.3의 비교적 높은 수치를 보여주고 있으므로 모형의 설명력이 어느 정도 있다는 것이 아울러 증명이 되었다. 상관관계에 대한 분석에서는 영업용 차량간의 상관관계가 높게 나타났으며, 이는 곧 영업용 화물차량을 적재중량별로 구분하는 것이 별 의미가 없음을 의미한다. 다시 말하면 자가용 차량을 보유하고 있지 않은 회사는 다른 운송전문업체에 화물운송을 의뢰하게 되므로 출하중량에 따라 화물차량을 구분하는 것에 대해서 그다지 큰 고려를 하지 않는 것으로 해석할 수가 있다.적합함을 재확인함. 6. 혼잡초기를 제외한 혼잡기간 중 대기행렬길이는 밀도데이터 없이도 혼잡 상류부의 도착교통량과 병목지점 본선통과교통량만을 이용하여 추정이 가능함. 7. 이상에 연구한 결과를 토대로, 고속도로 대기행렬길이를 산정할 수 있는 기초적인 도형을 제시함.벌레를 대상으로 처리한 Phenthoate EC가 96.38%의 방제가로 약효가 가장 우수하였고 3월중순 및 4월중순 월동후 암컷을 대상으로 처리한 Machine oil, Phenthoate EC 및 Trichlorfon WP는 비교적 약효가 낮았다.>$^{\circ}$E/$\leq$30$^{\circ}$NW 단열군이 연구지역 내에서 지하수 유동성이 가장 높은 단열군으로 추정된다. 이러한 사실은 3개 시추공을 대상으로 실시한 시추공 내 물리검층과 정압

• Journal of Soil and Groundwater Environment
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• v.9 no.4
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• pp.15-23
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• 2004

Deicer operations provide traffic safety during winter driving conditions in urban areas. Using large quantities of de-icing chemicals (i.e., $CaCl_2$ and NaCl) can cause serious environmental problems and may change behaviors of heavy metals in roadside sediments, resulting in an increase in mobilization of heavy metals due to complexation of heavy metals with chloride ions. To examine effect of de-icing salt concentration on the leaching behaviors and mobility of heavy metals (cadmium, zinc, copper, lead, arsenic, nickel, chromium, cobalt, manganese, and iron), leaching experiments were conducted on roadside sediments collected from Seoul city using de-icing salt solutions having various concentrations (0.01-5.0M). Results indicate that zinc, copper, and manganese in roadside sediments were easily mobilized, whereas chromium and cobalt remain strongly fixed. The zinc, copper and manganese concentrations measured in the leaching experiments were relatively high. De-icing salts can cause a decrease in partitioning between adsorbed (or precipitated) and dissolved metals, resulting in an increase in concentrations of dissolved metals in salt laden snowmelt. As a result, run-off water quality can be degraded. The de-icing salt applied on the road surface also lead to infiltration and contamination of heavy metal to groundwater.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.124-124
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• 2016

하천에서의 분변성대장균은 분변성 오염 정도를 나타내는 지표로서, 이 농도가 높을수록 오염된 하천수와의 접촉을 통한 호흡기, 소화기 및 피부 관련 질병의 발발 확률이 높다고 알려져 있다. 따라서 하천에서의 수영, 수상스키 등과 같은 입수형 친수활동을 할 때, 분변성대장균 농도가 농도 기준 이하인지를 확인하고 이러한 정보를 친수활동에 이용할 필요가 있다. 그러나 분변성대장균의 경우, 현재 자동수질측정망에서 측정되고 있는 다른 수질인자들과는 달리 실시간 측정이 불가능하다고 알려져 있다. 분변성대장균을 측정하는데 있어 최소 18시간 이상이 필요하며, 이러한 분변성대장균 측정 방식은 하천 이용자들이 안전한 친수활동을 영위하는데 있어 적절한 수질 정보를 제공하지 못한다. 그러므로 분변성대장균을 예측하는 모델을 개발하고, 이를 이용하여 실시간 분변성대장균 정보를 생성하여 하천 이용자들에게 제공할 필요가 있다. 본 연구에서는 친수활동이 활발하게 이루어지는 곳 중 하나인 북한강의 대성리 지점에 대해 데이터 기반 모델을 이용하여 분변성대장균을 예측하였다. 데이터 기반 모델은 물리 기반 모델에서 필요한 지형데이터나 비점오염원 등의 초기 오염물의 양에 대한 데이터를 필요로 하지 않고, 대신 독립변수로 사용되는 기상 및 수질데이터를 필요로 한다. 이러한 기상 및 수질데이터는 기존 기상관측소, 수질관측소에서 매일 자동으로 측정되기 때문에 데이터 기반 모델은 물리 기반 모델에 비해 입력데이터를 구성하기가 쉽다는 장점을 지닌다. 이러한 데이터 기반 모델 중 분류 모델은 회귀 모델과 달리 분변성대장균 농도가 일정 수질기준 이상을 넘는지를 바로 예측할 수 있다. 본 연구에서는 분류 모델 중 높은 예측력을 가진다고 알려진 랜덤포레스트(random forest) 기법을 이용하여 분변성대장균 예측 모델을 개발하였다. 분변성대장균 예측 모델은 주어진 기상 및 수질 조건에 대해 분변성대장균이 200 CFU/100ml가 넘는지를 예측하였다. 예측된 분변성대장균이 기준을 넘는 경우를 2등급, 넘지 않는 경우를 1등급으로 명명하였다. 모델을 개발하기 위하여 북한강 대성리 인근 측정소에서 2010년부터 2015년까지 측정된 기상 및 수질데이터를 수집하였다. 수집한 데이터를 훈련 및 검증데이터로 샘플링하였으며, 이 때 샘플링한 데이터가 기존 데이터가 가지고 있던 등급별 비율을 유지하기 위하여 층화샘플링을 하였다. 본 연구에서는 샘플링에 의한 불확실성을 줄이기 위하여 랜덤하게 50번 샘플링된 각각의 훈련데이터에 대해 모델을 개발하였다. 50개의 모델의 검증 결과를 종합한 결과, 전체 예측률은 0.139로 나타났다.

• Journal of the Korean Geotechnical Society
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• v.38 no.11
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• pp.107-118
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• 2022

The social need for stable hydrogen storage technologies that respond to the increasing demand for hydrogen energy is increasing. Among them, underground hydrogen storage is recognized as the most economical and reasonable storage method because of its vast hydrogen storage capacity. In Korea, low-depth hydrogen storage using artificial protective structures is being considered. Further, establishing corresponding safety standards and ground stability evaluation is becoming essential. This study evaluated the hydro-mechanical behavior of the ground during a hydrogen gas leak from a low-depth underground hydrogen storage facility through the HM coupled analysis model. The predictive reliability of the simulation model was verified through benchmark experiments. A parameter study was performed using a metamodel to analyze the sensitivity of factors affecting the surface uplift caused by the upward infiltration of high-pressure hydrogen gas. Accordingly, it was confirmed that the elastic modulus of the ground was the largest. The simulation results are considered to be valuable primary data for evaluating the complex analysis of hydrogen gas explosions as well as hydrogen gas leaks in the future.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.1
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• pp.79-89
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• 2023

The inventory of many materials requires a large storage space, and the longer the storage period, the higher the potential maintenance cost. When materials are stored on a construction site, there are also concerns about safety due to the reduction of room for movement and working. On the other hand, construction sites that do not store materials have insufficient inventory, making it difficult to respond to demands such as sudden design changes. Ordering materials is then subject to delays and extra costs. Although securing an appropriate amount of inventory is important, in many cases, material management on a construction site depends on the experience of the site manager, so a reasonable material inventory management plan that reflects the construction conditions of a site is required. This study proposes an economical material management method by reflecting variables such as the status of the preceding and following activities, site size, material delivery cost, timing of an order, and quantity of orders. To this end, we set the appropriate inventory amount while adjusting related activities in the activity network, using float time for each activity, the size of the yard, and the order quantity as the main variables, and applied a genetic algorithm to this process to suggest the optimal order timing and order quantity. The material delivery cost derived from the results is set as a fitness index and the efficiency of inventory management was verified through a case application.

• Journal of Venture Innovation
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• v.5 no.1
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• pp.145-154
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• 2022

This study briefly compares the first-cycle certification of nursing hospitals with the second-cycle certification, reviews the changes and achievements of the second-cycle certification and the third-cycle certification, and examples of challenges and solutions in the process of preparing the third-cycle certification. In this study, it is suggested as follows. First, in order to see the practical effect of certification intended by the government, the exhibition is prepared in a short period of time before certification. Second, after the implementation of the nursing hospital certification system, research on the hospital performance of the medical institution certification system is insufficient in terms of quality and quantity. Therefore, in order to see the effect on the certification system, various research support is also required so that research on this can be actively conducted. Third, design certification standard guidelines from a long-term perspective so that the standard guidelines for certification do not change significantly, and certify not only the guidelines but also individual standards and forms that can be used by medical institutions. Fourth, in the four-cycle certification, accurate and realistic guidelines for infection control and quarantine ward operation support should be developed. The importance of managing infectious diseases will be highlighted in the future due to COVID-19. Fifth, medical institutions can improve the quality of medical care in nursing hospitals and have competitiveness if their daily activities, not short-term certification preparation, are carried out in accordance with certification standards, which affects performance. Sixth, when preparing for certification, nursing hospital officials have problems in organizing documents or processing administratively in the short term as in the past. This is also based on the certification criteria for the usual business process.

• Journal of Navigation and Port Research
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• v.47 no.6
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• pp.367-375
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• 2023

This study developed a new distance metric for vessel trajectories, applicable to marine traffic control services in the Korean coastal waters. The proposed metric is designed through the weighted summation of the traditional Hausdorff distance, which measures the similarity between spatiotemporal data and incorporates the differences in the average Speed Over Ground (SOG) and the variance in Course Over Ground (COG) between two trajectories. To validate the effectiveness of this new metric, a comparative analysis was conducted using the actual Automatic Identification System (AIS) trajectory data, in conjunction with an agglomerative clustering algorithm. Data visualizations were used to confirm that the results of trajectory clustering, with the new metric, reflect geographical distances and the distribution of vessel behavioral characteristics more accurately, than conventional metrics such as the Hausdorff distance and Dynamic Time Warping distance. Quantitatively, based on the Davies-Bouldin index, the clustering results were found to be superior or comparable and demonstrated exceptional efficiency in computational distance calculation.

• Tuberculosis and Respiratory Diseases
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• v.42 no.6
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• pp.900-912
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• 1995

Background: Although graded exercise stress tests are widely used for the evaluation of cardiorespiratory performance, normal standards on respiratory gas exchange and ventilatory functions at maximal exercise in Koreans have not been well established. The purpose of this study is to provide reference values on these by sex and age, along with derivation of some of their prediction equations. Method: Symptom-limited maximal exercise test was carried out by Bruce protocol in 1,000 healthy adults consisting of 603 males and 397 females, aged 20~66 years. Among them VC, $FEV_1$ and MVV were also determined in 885 cases. All the subjects were members of a health center, excluding athletes. During the exercise, subjects were allowed to hold on to front hand rail of the treadmill for safety purpose. Results: The $VO_2\;max/m^2$, $VCO_2\;max/m^2$ and $V_E\;max/m^2$ were greater in males than in females and decreased with age. The RR max in men and women was similar but decreased slightly with age. The $V_T$ max was markedly greater in men but showed no significant changes with age in either gender. The mean of $V_T$ max/VC, $V_E$ max/MVV and BR revealed that there were considerable ventilatory reserves at maximal exercise even in older females. The regression equations of the cardinal parameters obtained using exercise time(ET, min), age(A, yr), height(Ht, cm), weight(W, kg), sex(S, 0=male; 1=female), VC(L), $FEV_1$(L) and $V_E$ max(L) as variables are as follows: $VO_2\;max/m^2$(L/min)=1.449+0.073 ET-0.007A+0.010W-0.006Ht-0.209S, $VCO_2\;max/m^2$(L/min)=1.672+0.063ET-0.008A+0.010W-0.005Ht-0.319S, VE max/$m^2$(L/min)=58.161+1.503ET-0.315A-9.871S or VE max/$m^2$(L/min)=47.873+6.548 $FEV_1$-5.715 S, and VT max(L)=1.497+0.223VC-0.493S. Conclusion: Respiratory gas exchange and ventilatory variables at maximal exercise were studied in 1,000 non-athletes by Bruce protocol. During exercise, the subjects were allowed to hold on to hand rail of the treadmill for safety purpose. We feel that our results would provide ideal target values for patients and healthy individuals to be achieved, since our study subjects were members of a health center whose physical fitness levels were presumably higher than ordinary population.