• Title/Summary/Keyword: 안전성 강화

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Biochemical Assessment of Deer Velvet Antler Extract and its Cytotoxic Effect including Acute Oral Toxicity using an ICR Mice Model (ICR 마우스 모델을 이용한 녹용 추출물의 생화학적 평가 및 급성 경구 독성을 포함한 세포 독성 효과)

  • Ramakrishna Chilakala;Hyeon Jeong Moon;Hwan Lee;Dong-Sung Lee;Sun Hee Cheong
    • Journal of Food Hygiene and Safety
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    • v.38 no.6
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    • pp.430-441
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    • 2023
  • Velvet antler is widely used as a traditional medicine, and numerous studies have demonstrated its tremendous nutritional and medicinal values including immunity-enhancing effects. This study aimed to investigate different deer velvet extracts (Sample 1: raw extract, Sample 2: dried extract, and Sample 3: freeze-dried extract) for proximate composition, uronic acid, sulfated glycosaminoglycan, sialic acid, collagen levels, and chemical components using ultra-performance liquid chromatography-quadrupole-time-of-light mass spectrometry. In addition, we evaluated the cytotoxic effect of the deer velvet extracts on BV2 microglia, HT22 hippocampal cells, HaCaT keratinocytes, and RAW264.7 macrophages using the cell viability MTT assay. Furthermore, we evaluated acute toxicity of the deer velvet extracts at different doses (0, 500, 1000, and 2000 mg/kg) administered orally to both male and female ICR mice for 14 d (five mice per group). After treatment, we evaluated general toxicity, survival rate, body weight changes, mortality, clinical signs, and necropsy findings in the experimental mice based on OECD guidelines. The results suggested that in vitro treatment with the evaluated extracts had no cytotoxic effect in HaCaT keratinocytes cells, whereas Sample-2 had a cytotoxic effect at 500 and 1000 ㎍/mL on HT22 hippocampal cells and RAW264.7 macrophages. Sample 3 was also cytotoxic at concentrations of 500 and 1000 ㎍/mL to RAW264.7 and BV2 microglial cells. However, the mice treated in vivo with the velvet extracts at doses of 500-2000 mg/kg BW showed no clinical signs, mortality, or necropsy findings, indicating that the LD50 is higher than this dosage. These findings indicate that there were no toxicological abnormalities connected with the deer velvet extract treatment in mice. However, further human and animal studies are needed before sufficient safety information is available to justify its use in humans.

A Survey on the Consumer's Recognition of Food Labeling in Seoul Area (서울지역 소비자들의 식품표시에 대한 인식도 조사)

  • Choi, Mi-Hee;Youn, Su-Jin;Ahn, Yeong-Sun;Seo, Kab-Jong;Park, Ki-Hwan;Kim, Gun-Hee
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.39 no.10
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    • pp.1555-1564
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    • 2010
  • This study investigated consumer's recognition of food labeling in order to contribute to the development of food labels which are more informative to consumers. The questionnaires had been collected from 120 male and female customers living in Seoul with the age between 10's and 60's from November 2nd to November 7th 2009. For checking the food label at the time of purchase, 58.3% of the consumers checked the food label and the main reason for checking the food label was to confirm sell-by date (60.1%). Sixty percent of the consumers were satisfied with the current food labeling. Among those who are not satisfied, 30.6% complained about difficult terms to understand and 25.8% were dissatisfied with insufficient information. In every age group, most people were not satisfied with labeling on food ingredient and additives, followed by date of manufacture and sell-by date. 53.1% of consumers demanded to label date of manufacture and sell-by date together. For more clear information, consumers wanted use-by date (47.5%) rather than sell-by date (23.3%). 56.7% of consumers was dissatisfied with warning information such as allergic warning and the reasons for dissatisfaction were poor visibility (37.5%) and insufficient information (33.4%). Moreover most consumers (90.0%) showed little knowledge on irradiation. To improve of the food labeling standards into consumer-oriented standards, both amendment of the food labeling standards and consumer education will be necessary.

Analysis of Issues on Underground Space between Central and Local Governments Utilizing Social Media Data (소셜미디어 데이터를 활용한 중앙정부와 지방정부 간 지하공간의 주요 이슈 고찰)

  • Choi, Hae-Ok;Baek, Sung-Joon
    • Journal of Cadastre & Land InformatiX
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    • v.46 no.1
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    • pp.75-86
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    • 2016
  • This study examines the social issues between the central and local governments related with the underground space after happenings of sinkholes in Jamsil area in July, 2014. In this study, we consider the keyword network of the social network analysis as a research methodology. The social issues regarding the underground space have been dealt with through the analysis of the centrality and group density to know the attributes of the network. The results show that the government has been steadily helpful to the local governments for establishing the socialized law for the underground space. This research suggests that the laws and technologies as to the underground space issues cooperate each other in the future. It also shows that the government should enact the policies and the national plans for the development of the underground.

Location Optimization in Heterogeneous Sensor Network Configuration for Security Monitoring (보안 모니터링을 위한 이종 센서 네트워크 구성에서 입지 최적화 접근)

  • Kim, Kam-Young
    • Journal of the Korean Geographical Society
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    • v.43 no.2
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    • pp.220-234
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    • 2008
  • In many security monitoring contexts, the performance or efficiency of surveillance sensors/networks based on a single sensor type may be limited by environmental conditions, like illumination change. It is well known that different modes of sensors can be complementary, compensating for failures or limitations of individual sensor types. From a location analysis and modeling perspective, a challenge is how to locate different modes of sensors to support security monitoring. A coverage-based optimization model is proposed as a way to simultaneously site k different sensor types. This model considers common coverage among different sensor types as well as overlapping coverage for individual sensor types. The developed model is used to site sensors in an urban area. Computational results show that common and overlapping coverage can be modeled simultaneously, and a rich set of solutions exists reflecting the tradeoff between common and overlapping coverage.

Design of Delegation Signature Protocols for Strong Non-Repudiation (강화된 부인방지를 위한 대리서명 프로토콜의 설계)

  • 이용준;이근왕;김희숙;오해석
    • Convergence Security Journal
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    • v.4 no.2
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    • pp.35-41
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    • 2004
  • Proxy signature scheme based on delegation of warrant is studied in these days. Proxy signature Is a signature scheme that the original signer delegates his signing warrant to the proxy signer, and the proxy signer creates a signature on behalf of the original signer. For using this scheme, the security for protecting from the forgeability or misuse is necessary. There are several security requirements for using the proxy signature schemes. In this paper we suggest the proxy-register protocol scheme that original signer registers to the verifier about the proxy related information. In our scheme, verifier verifies the signature that original signer creates about the proxy information and sets the warrant of proxy signer, validity period for proxy signature and some limitation. Finally, we will show the advantages of our suggestion by comparing with the previous proxy signature schemes.

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Institutional Approach to Healthcare Information Exchange: Focused on Medical Law (의료법상 진료정보교류를 위한 법제도적 고찰)

  • Kim, Soomin;Park, Jong Son
    • The Journal of the Korea Contents Association
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    • v.17 no.10
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    • pp.483-491
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    • 2017
  • Compared to penetration of Electronic Medical Record(EMR) system, Healthcare Information Exchange(HIE) has been less active in South Korea. The aim of this study is to explore medical law newly legislated to introduce HIE through the nation. The important insights are that the medical institutions exchange the patient's healthcare information based on the consent of the patient, and it is expected to be set up and managed the medical record exchange support system by the government and a consignment organization. In addition, the certification program for standardization and interoperability on the EMR system would be conducted. Nevertheless, continued policy developments and researches for the promotion of HIE will be urgently needed such as the education for the vendors and developers, developments of the certification programs and the incentive payment programs and the public relations.

A Study on Smart Real-time Atmospheric Dispersion System (지능형 실시간 대기확산 시스템에 관한 연구)

  • Oh, Jeong-Seok;Hyun, Ji-I;Bang, Hyo-Jung
    • Journal of the Korean Institute of Gas
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    • v.16 no.4
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    • pp.44-51
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    • 2012
  • It is more important to realize safety management, medium-large accident prevention and risk prediction as accident of industry facilities can generate enormous physical and human damage because most energy plant might handle toxic substance. Especially, atmospheric dispersion system, which is able to simulate situation, have been used for release accident of toxic substance since the accident can show different of dispersion range and velocity according to release material, storage facility and atmospheric status. However those systems have been used generally in design step of industry facility and are difficult to deal with release accident quickly. Although some researches and cases have been studied for using real-time atmospheric information, there are insufficient system for processing quickly release accident. This paper aims to develop real-time smart atmospheric dispersion system that can deal with release accident quickly by enhancing distinct characteristics and efficiency of energy plant, and select release time and area using intelligent algorithm as accident prevention type.

A Design of SWAD-KNH Scheme for Sensor Network Security (센서 네트워크 보안을 위한 SWAD-KNH 기법 설계)

  • Jeong, Eun-Hee;Lee, Byung-Kwan
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.6
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    • pp.1462-1470
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    • 2013
  • This paper proposes an SWAD-KNH(Sybil & Wormhole Attack Detection using Key, Neighbor list and Hop count) technique which consists of an SWAD(Sybil & Wormhole Attack Detection) module detecting an Worm attack and a KGDC(Key Generation and Distribution based on Cluster) module generating and an sense node key and a Group key by the cluster and distributing them. The KGDC module generates a group key and an sense node key by using an ECDH algorithm, a hash function, and a key-chain technique and distributes them safely. An SWAD module strengthens the detection of an Sybil attack by accomplishing 2-step key acknowledgement procedure and detects a Wormhole attack by using the number of the common neighbor nodes and hop counts of an source and destination node. As the result of the SWAD-KNH technique shows an Sybil attack detection rate is 91.2% and its average FPR 3.82%, a Wormhole attack detection rate is 90%, and its average FPR 4.64%, Sybil and wormhole attack detection rate and its reliability are improved.

LGBTQ's Human Rights and Library Services (LGBTQ의 인권과 도서관서비스)

  • Kim, Seon-Ho
    • Journal of Korean Library and Information Science Society
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    • v.46 no.4
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    • pp.21-44
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    • 2015
  • This study is to propose the directions of LGBTQ Friendly Library policies based on LGBTQ's human rights. To accomplish this purpose, this study comparatively analyzed key concepts from UN UDHR, ALA LBR, and IFLA statements up to scholarly library-articles related to LGBTQ with the inductive approach for qualitative data analysis. The result suggests the 7 directions of the library services policy-making for LGBTQ in practice : 1) Recommendations on the enhancement of the LGBTQ's human rights and library obligations, 2) Enforcement of librarians' education and training on LGBTQ subject matters, 3) Convergency on the various LGBTQ's information needs and the enlargement of library collections, 4) Development of search instruments on LGBTQ, 5) Secure library moods and no-distinctive use of its accommodations, 6) Cooperation system with NGO on LGBTQ, 7) Care and support on children and young adults experienced with LGBTQ.

A Study on the Improvement of the Subway Protective Guards System (지하철보안관제도의 활성화 방안에 관한 연구)

  • Lee, Sol-Ji;Lee, Ju-Lak
    • Korean Security Journal
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    • no.49
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    • pp.133-154
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    • 2016
  • The Seoul subway system has one of the highest transport shares in the city of Seoul. A high number of passengers means that a high level of crimes of all kinds occur on the city's subway system. As such, Seoul Metro, created the Subway Protective Guards System in 2009, in an effort to enhance safety on the subway. But this innovative new system did not resolve problems. In fact, many citizens came to question the effectiveness of the new system, as it did not yield tangible results. This study seeks to deduce the problems and activation strategy of the Subway Protective Guards System. An in-depth study was conducted by interviewing subway protective guards who were squad leaders with five or more years of relevant work experience. Semi-structured interview analysis was utilized to evaluate their responses. Specifically, their responses were deduced to identify the strengths and weaknesses internal to the system and the opportunities and threats posed by the environment external to the system. This study presents measures to improve the system based on the aforementioned analysis. Measures for improvement focused on the following areas: the adoption of an education system in response to terror; recruitment and the possibility of becoming a permanent employee; obtaining partial judicial powers; improvement of work environment; and intensifying the promotion of the system.

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