• Proceedings of the KOR-BRONCHOESO Conference
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• 1993.05a
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• pp.110-110
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• 1993

Necrotizing lymphadenitis, or Kikuchi's disease, a newly recognized disease of unknown origin, occurred usually in young woman and mostly resolved spontaneously without treatment within a few months. Clinically, characteristic symptoms and sings were local lymph node enlargement, sometimes accompanied by tenderness, fever, weightless, leukopenia, and elevated erythrocyte sedimentation rate, and so necrotizing lymphadenitis can be confused with malignant lymphoma and tuberculosis. The histologic features of necrotizing lymphadenitis are distinctive. : lymph node biopsy reveals areas with frank cellular necrosis, karyorrhexis, and absence of plasma cell. We present nineteen cases of necrotizing lymphadenitis during from March 1990 to January 1993 and discuss their exact diagnosis and proper treatment.

• 건강소식
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• v.26 no.4 s.281
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• pp.6-13
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• 2002

우리 몸은 적절한 운동을 함으로써 각각의 기능이 정상으로 적응하도록 되어있으며 적절한 운동을 하지 않으면 신체의 기능은 점점 약화되어 건강에 나쁜 영향을 주게 된다. 우리 주위의 많은 사람들은 이러한 사실을 알고 있어도, 시간이 없다는 핑계로, 다른 할 일이 많다는 핑계로 운동 부족을 자초하고 있다. 우리나라의 사망원인 순위를 보면 위기 암(악성신생물), 위가 뇌혈관 질환, 3위가 심장질환으로 식생활, 운동부족 등 잘못된 생활습관이나 스트레스등으로 인한 만성질환이다. 특히 운동부족은 심장병, 암, 당뇨병, 근골격계 질환(골다공증) 등의 위험요인이 되는데 운동부족과 밀접한 관계가 있는 허혈성 심질환의 경우 사망률이 1985년 인구 10만명당 3.8명에서 2000년 21.5명으로 5배 이상 증가하였으며 당뇨병의 경우 1985년 인구 10만명당 6.8명에서 2000년 22.6명으로 3배 이상 증가하였나(통계청, 200년 조사), 우리나라 성인들의 운동 실천율은 매우 낮은 편으로 규칙적으로 운동하는 사람의 비율이 0.8%에 머물러 운동부족의 심각성을 보여주고 있다(한국보건사회연구원 1998) 세계보건기구(WHO)와 보건복지부는 2002년 4월 7일 세계 보건의 날을 맞아 ‘Move for health'라는 구호로 운동의 중요성 및 생활 속의 활기찬 움직임에 대한 중요성을 일깨우기 위해 보건의 날 올해의 주제로 선정하였다. 4월의 이달의 건강 길라잡이에서는 생활 속에서 쉽게 실천할 수 있는 운동, 나에게 맞는 운동에 대하여 알아본다.

• Investigative Magnetic Resonance Imaging
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• v.14 no.1
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• pp.41-46
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• 2010

Purpose : To evaluate the role of magnetic resonance imaging (MRI) in the diagnosis of papillary lesions of the breast. Materials and methods : Among 45 papillary lesions diagnosed at ultrasonography-guided core biopsy (USCB), 27 benign papillary lesions in 22 patients who underwent breast MRI were reviewed. The excsional biopsy was performed in 1-10 days after MRI was done. In MRI findings, lesions were considered suspicious if they show irregular, rim enhancement, or linear enhancement in morphologic evaluation, or washout enhancement pattern of delayed phase in dynamic enhancement characteristics. Diffusionweighted images were analyzed according to visibility of lesions. MRI findings were correlated with pathologic results at excisional biopsy. Results : At excisional biopsy, two lesions (9%) were diagnosed malignant in 22 benign papillary lesions without atypia by USCB and 4 (80%) were malignant in 5 benign papillary lesions with atypia by USCB. Among 18 lesions detected on MRI, 16 lesions showed suspicious findings on MRI, 11 lesions (69%) were diagnosed as benign and 5 (31%) were malignant. Among 12 lesions detected on diffusion weighted imaging, 10 lesions were diagnosed as benign and 2 were malignant. MRI findings were not significantly correlated with pathologic results at excisional biopsy. Conclusion : MRI findings were not useful to predict malignancy in benign papillary lesions diagnosed at USCB, because MRI findings of these were mostly suspicious (88.9%, 16/18). The benign papillary lesion should be included in the false positive lesion on breast MRI.

• The Korean Journal of Nuclear Medicine
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• v.29 no.3
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• pp.319-327
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• 1995

$^{131}I$-metaiodobenzylguanidine(MIBG) has been used for the diagnosis and treatment of neural crest tumors. We report our experience with this agent in 8 patients[1 multiple endocrine neoplasia(MEN) type IIb; 2 malignant pheochromocytoma; 5 medullary thyroid carcinoma(MTC)]. The therapeutic procedure consisted of 30-200 mCi of $^{131}I-MIBG$ administered by slow I.V. infusion, given at 3-6 months intervals. Commutative activity ranged from 150 mCi to 410 mCi, in 1 to 4 courses. $^{131}I-MIBG$ therapy resulted in significant disease free interval in 1 malignant pheochromocytoma(no measurable lesion) after surgery; complete hormonal and tumoral response in 2 MTC(1 MEN IIb): stable disease in 1 recurred pheochromocytoma(MEN IIb): stable disease but symptomatic improvement in 1 MTC, progressive disease in 1 malignant pheochromocytoma and 2 MTC. The patients who showed progression appeared to have large inoperable tumors or postoperative remnant tumors.

• Journal of the Korea Society of Computer and Information
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• v.26 no.8
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• pp.197-207
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• 2021

Relationship between bone mineral density (BMD) and type 2 diabetes is still inconsistent. Recently, many epidemiologic data show that fracture risk is increased in type 2 diabetic patients regardless of BMD status. In this study, we used nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) to analyze the BMD status in patients with type 2 diabetes compared to non-diabetics. We included subjects aged 50 years or older in men (N=2,959, 2,430 without diabetes, 529 with type 2 diabetes) and postmenopausal women (N=2,902, 2,479 without diabetes, 423 with type 2 diabetes). Subjects with history of medication for osteoporosis or with illness or malignancy affecting bone metabolism were excluded. Data of anthropometric measurements and demographic characteristics were collected by trained examiner. Serum was separated from peripheral venous blood samples obtained after 8 hours of fasting. BMD was measured at lumbar spine and femur using dual-energy X-ray absorptiometry (DXA). There was a significant positive association between lumbar spine BMD and type 2 diabetes after adjusting age, gender, body mass index, monthly house income, education level, physical activity, daily calcium intake and vitamin D concentration by multiple regression analysis in all subjects. In the subgroup analysis by gender, this association was maintained both in male and female after adjusting those confounding factors. However, femur BMD was not different between type 2 diabetic and non-diabetic subjects. In conclusion, lumbar spine BMD was significantly higher in type 2 diabetic patients aged 50 years or more in men and postmenopausal women compared to non-diabetic subjects.

• Journal of the Korean Society of Radiology
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• v.17 no.6
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• pp.919-927
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• 2023

Elastography utilizes the fact that the tissue of a malignant tumor is harder than that of a benign tumor and increases the specificity of diagnosis according to the elastic modulus of the tumor, helping to reduce unnecessary biopsies. However, the reliability of elastography can be influenced by the equipment used and the examiner's skills. In this study, the researchers analyzed the reproducibility of elastography by evaluating phantom images when measuring the elasticity values repeatedly. Phantoms were created using silicone and gelatin with different levels of stiffness, and they were inserted at varying depths from the surface. The elasticity values were measured using shear wave elastography. The study aimed to determine whether the reproducibility of elasticity values remains consistent depending on the stiffness and depth of the lesions. The experimental results showed that there was no statistically significant correlation between the elasticity values obtained through shear wave elastography and the depth or stiffness of the lesions. However, in the lesions with the lowest stiffness, the elasticity values were statistically significant (p<0.001) and showed a high correlation with the depth of the lesions. Although there were variations in the measured elasticity values based on the differences in lesion stiffness and depth, these differences did not significantly impact the diagnosis. Therefore, shear wave elastography remains a reliable diagnostic method, and it is suggested that it can be helpful in the diagnosis of breast lesions.

• Journal of Yeungnam Medical Science
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• v.27 no.2
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• pp.98-104
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• 2010

Primary anterior mediastinal neoplasms comprise a diverse group of tumors and account for 50% of all mediastinal masses. Thymic epithelial neoplasm are most common and classified into thymoma, invasive thymoma, and thymic carcinoma. Neuroendocrine differentiation of thymic epithelial neoplasm are rare malignancies. Germ cell tumor (GCT) is second most common anterior mediastinal tumor and most of them are mature cystic teratoma. Malignant mediastinal GCT are rare than benign. Primary thoracic lymphoma is rare than thoracic involvement of systemic lymphoma and most common location of primary thoracic lymphoma is anterior mediastinum. The clinical and radiologic appearance of the most common masses are reviewed.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.187-187
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• 1994

선경인더스트리 연구소에서 개발된 100 여종의 새로운 백금착체 항암제 중 그 동안의 전임상연구를 통해 항암효과가 우수하고 안정성이 확인된 항암제인 SKI 2053R의 인체내 최대내약용량을 결정하고 부작용 및 항암효과를 평가하고 약제의 인체내 약동학적 특성을 검토하기 위해 각종 악성종양 환자들을 대상으로 제 1상 임상연구를 시행하였다. 약제의 투여는 500m1의 5% 포도당용액에 용해하여 1시간에 걸쳐 정주하였으며 병의 악화나 심한 독성이 없으면 치료를 매 4주마다 반복하였다. SKI 2053R의 초기용량은 생쥐에서의 LD$_{10}$의 1/10에 해당하는 40 mg/$m^2$로 하였고, 용량의 단계별 증가는 modified Fibonacci법에 따랐다. 각 단계별로 3명이상의 환자를 치료하여 WHO 기준상 3도 이상의 부작용이 2/6 이상에서 나타날 때의 용량을 최대내약용량으로 설정하였다.

• The Korean Nurse
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• v.16 no.4 s.90
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• pp.52-54
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• 1977

현대 공업화의 발전과 공학의 진보로 우리국민은 비교적 풍부하고 조용한 번영의 시기를 30 여년간 향유할 수 있었다. 생활수준이 높아졌고 질병의 주요 원인이 급성 전염병에서 뇌졸중병, 악성종양사고 및 심장병 같은 만성상태로 변했다. 일반적으로 사람들에게 정보가 잘 들어가고 있으며 건강한 생활을 유지하는데 유용한 많은 자원을 발견하고 있다. 우리가 살고 있고 유용한 전문인으로서 인류에게 봉사하고 있는 문화속에서 우리는 건강한 생활을 유지하는 민속법을 무시해서는 안 된다. 사회는 간호전문직에게 건강관리를 맡겼다. 따라서 우리는 책임수행에 있어서 하나라도 남겨 놓은게 있어서는 안 된다. 우리의 가까운 주위를 관찰하고 들어 봄으로써 우리는 타인의 건강욕구에 좀더 민감하고 세심해질 수 있다. 우리가 서양의 과학원칙을 간호실제에 적용시키고 있지만, 동양의 보다 더 내향적이고 완전한 생활방법도 역시 우리의 유용한 전문직의 가능성을 풍부하게 하고 확장시키는데 적용될 수 있다. 새로운 것과 오래된 것의 연속성이 계속 되야 하며, 고객을 도와주면서, 우리는 현재의 새로운 농작물을 경작하여 미래의 유용한 성숙된 농작물로 키울 수 있다. 우리의 전문적인 생활과 고객의 생활을 풍부하게 해줄 수 있는 유용한 자원이 많이 있으며, 우리의 문화적 환경에서 성취할 수 있는 귀중한 자원을 그냥 지나칠 순 없다. 우리는 지금 여기서 행동해야 한다.

• The Journal of the Korean bone and joint tumor society
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• v.14 no.1
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• pp.33-43
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• 2008

Purpose: To evaluate the clinical usability of reconstructive methods, and how to select flap after wide excision of malignant soft tissue tumor in ankle and foot. Materials and Methods: The 15 cases shown in the 14 patients (In case of a male patient, reconstruction was performed two times due to local recurrence.) with malignant soft tissue tumor in ankle and foot, who underwent reconstruction after wide excision from March 2000 until March 2007. Oncologic, surgical and functional results were evaluated. Results: The method of reconstruction used were anterolateral thigh perforator flap (5cases), Reversed superficial sural artery flap (4 cases), dorsalis pedis flap (3 cases), local flap (3cases). The defect, mean size was $5.5{\times}5.7\;cm$, was reconstructed with rotation flap or free flap, mean size was $5.9{\times}6.0\;cm$, skin graft for remnant. The mean operation time was 310 minutes (120~540 minutes); it took 256 minutes to reconstruct by rotation flap, and 420 minutes by free flap. As oncologic results, 7 patients were no evidence of disease, 6 patients were alive with disease and 1 patient was expired by pulmonary metastasis at the time of the last follow-up. 4 patients had local recurrence and 4 pateints had distant metastases. As functional results, 14 patients were evaluated with average score of 68.8% using the system of the Musculoskeletal Tumor Society. Conclusion: The dorsalis pedis and reverse superficial sural artery rotation flap which is easy procedure, has less complication and takes short operation time, can be primarily considered to reconstruct a small defect. And the anterolateral thigh perforator flap is suitable for coverage of a large defects after wide excision of malignant soft tissue tumor in ankle and foot.