• The Monthly Diabetes
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• s.216
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• pp.10-13
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• 2007

요즈음은 인터넷이나 대중매체를 통해 일반인들도 다양한 질병에 대한 많은 정보를 얻을 수 있다. 이에 속하는 것으로 당뇨병은 대표적 만성질환이며 누구나 한번쯤은 들어 본 적이 있는 질환일 것이다. 현대와 같이 고도로 의학이 발달한 상황에서도 만성질환은 완치되는 것이 아니고 평생 관리를 해야하는 질병이기 때문에 많은 환자들이 살아가는 동안 서서히 지치게 되고 관리를 소홀히 하게 됨으로써 당뇨병성 신경병증, 망막증, 신증, 대혈관병증(뇌졸중, 심혈관질환, 말초혈관질환) 등과 같은 합병증의 발생으로 일상생활에 지장을 받게 된다. 따라서 당뇨병환자는 일생 주기적으로 검사와 함께 자신에게 맞는 약을 복용하고 경우에 따라서는 인슐린 주사까지 맞음으로써 지속적인 혈당관리를 하여 합병증의 발생을 최소화 하는 것이 필요하다. 이상에 언급한 다양한 합병증 중 가장 중요한 사망원인은 심혈관질환으로 40세 이후에 발생한 당뇨병환자에서 전체 사망 원인의 50% 이상을 차지한다. 또한 대부분의 당뇨병성 만성합병증이 적극적인 혈당관리로 효과적인 예방이 가능한 반면 심혈관질환과 같은 대혈관합병증은 혈당조절이 잘 되고 있는 환자에서도 당뇨병 발생 기간과 무관하게 발생하고 또 여러 혈관에 걸쳐 다발적이고 광범위하게 발생하므로 원인이 되는 다른 위험요소들에 대한 관리가 함께 이루어져야 한다.

• Childhood Kidney Diseases
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• v.15 no.1
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• pp.14-21
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• 2011

Although left Left ventricular hypertrophy (LVH) is not only an adaptive response of the heart to increased cardiac workload in hypertension, it surelybut also is the most potent risk factor of overt cardiovascular complications such as coronary heart disease, heart failure, arrhythmia and stroke in the hypertensive population. Also it has become generally accepted that subclinical cardiovascular disease begins in childhood and LVH is the most readily assessed marker for that. As LVH can be seen in children and adolescents with even mild blood pressure elevation with the reported prevalence of 10 to 47%, aggressive antihypertensive treatment is critical in preventing the development of hypertensive heart disease in that those cases.

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.50.3-51
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• 2004

• 대한핵의학회:학술대회논문집
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• 1978.06a
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• pp.64-64
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• 1978

• The Monthly Diabetes
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• s.254
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• pp.34-35
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• 2011

당뇨병을 유발시키는 요인에는 여러 가지가 있다. 그 중에서 비만은 당뇨병 뿐 아니라 심혈관질환 등의 관련된 합병증의 주요 원인으로 악명이 높다. 실제로 2009년 대한 당뇨병학회지에 실린 논문에 의하면 제 2형 당뇨병환자의 80% 이상이 과체중 또는 비만으로 나타났다. 비만은 전신적인 지방의 총 양 이외에도 체내 지방의 분포에 따라서 그 위험도가 달라지는데, 특히 복부에 축적된 지방은 인슐린 저항성을 유발하여 심혈관질환의 위험을 더욱 증가시킨다.

• 대한핵의학회:학술대회논문집
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• 1979.05a
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• pp.8.2-9
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• 1979

• Tuberculosis and Respiratory Diseases
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• v.45 no.2
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• pp.404-415
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• 1998

Background: Sleep apnea syndrome, which occurs in 1~4 % of the adult population, frequently has different cardiovascular complications such as hypertension, ischemic heart disease, cardiac arrythmia as well as sleep-wake disorder such as excessive daytime hypersomnolence or insomnia. Mortality and vascular morbidity are reported to be significantly higher in sleep apnea syndrome patients than in normal population. According to the recent studies, autonomic dysfunction as well as hypoxemia, hypercapneic acidosis, and increased respiratory effort, may playa role in the high prevalence of cardiovascular complications in patients with sleep apnea syndrome. However the cause and mechanism of autonomic neuropathy in patients with sleep apnea syndrome are not well understood. We studied the existence of autonomic neuropathy in patients with sleep apnea syndrome and factors which influence the pathogenesis of autonomic neuropathy. Method: We used the cardiovascular autonomic neuropathy(CAN) test as a method for evaluation of autonomic neuropathy. The subjects of this study were 20 patients who diagnosed sleep apnea syndrome by polysomnography and 15 persons who were normal by polysomnography. Results: Body mass index and resting systolic blood pressure were higher in sleep apnea group than control group. Apnea index(Al), respiratory disturbance index(RDI) and snoring time percentage were significantly higher in sleep apnea group compared with control group. But there were no significant differences in saturation of oxygen and sleep efficiency in two groups. In the cardiac autonomic neuropathy test, the valsalva ratio was significantly low in sleep apnea group compared with control group but other tests had no differences between two groups. The CAN scores and corrected QT(QTc) interval were calculated significantly higher in sleep apnea group, but there were no significant correlations between CAN scores and QTc interval. There were no significant data of polysomnography to correlate to the CAN score. It meant that the autonomic neuropathy in patients with sleep apnea was affected by other multiple factors. Conclusion: The cardiovascular autonomic neuropathy test was a useful method for the evaluation of autonomic neuropathy in patients with sleep apnea syndrome and abnormalities of cardiovascular autonomic neuropathy were observed in patients with sleep apnea syndrome. However, we failed to define the factors that influence the pathogenesis of autonomic neuropathy of sleep apnea syndrome. This study warrants futher investigations in order to define the pathogenesis of autonomic neuropathy in patients with sleep apnea syndrome.

• The Journal of the Korea Contents Association
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• v.18 no.12
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• pp.208-217
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• 2018

The purpose of this study was to provide information on the treatment and management of diabetic patients using all the available data of the Korea National Health and Nutrition Examination Survey (KNHANES, 2013-2015) on the serological and complication patterns of cardiovascular disease (CVD) according to the duration of diabetes mellitus (DM). KNHANES consists of health questionnaires, screenings, and nutrition surveys. The study subjects were 1,316 persons who were aged between 18 and 80 years and who answered the duration of DM. DM was classified as 0-5, 6-10, 11-15, 16-20, and over 20 years according to duration of DM. The longer the duration of DM, the older the BMI, the lower the smoker, the higher the HbA1c and the lower the glomerular filtration rate. Total cholesterol, LDL-C and triglyceride levels were low and HDL-C levels were similar. The proportion of patients receiving insulin and oral hypoglycemic agents increased. The longer the duration of DM, the worse blood glucose control and the increased risk of microvascular and macrovascular complications. To prevent these complications, intensive care and monitoring should be used to control the risk factors.

• The Monthly Diabetes
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• s.257
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• pp.32-33
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• 2011

건강한 치아는 오복(五福) 중의 하나로 여길 만큼 우리 몸에서 중요한 기능을 담당한다. 한 연구결과에 따르면 당뇨병환자가 치주질환이 있으면 헐당조절이 어려워질 뿐 아니라 뇌졸중, 심혈관질환 등 합병증이 조기에 발생할 수 있는 것으로 밝혀졌다. 당뇨병이 있으면 치주질환이 잘 생기는데 제대로 관리하지 않고 방치하면 전선질환까지 발생할 수 있는 것이다.

• The Monthly Diabetes
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• s.192
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• pp.32-35
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• 2005

당뇨병은 노화의 당연한 과정이 아니라 적극적으로 관리하고 치료해야 되는 일종의 질환으로 생각하는 것이 좋다. 당뇨관리를 적극적으로 실천하지 않으면 뇌졸증, 실명, 만성심부전, 심혈관질환 등 삶의 질과 더불어 무엇보다도 소중한 생명을 잃게 될 수도 있는 치명적인 합병증이 발병할 수도 있는 것이다.