• Journal of Nutrition and Health
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• v.41 no.8
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• pp.733-741
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• 2008

In the present study, we comprehensively examined the associations of plasma levels of total adiponectin and high molecular weight (HMW) adiponectin with the features of cardiometabolic risks including body fat distribution, dyslipidemia, insulin resistance and inflammatory markers in a cross-sectional study of 110 treated hypertensive patients. Blood lipid profiles, high sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA- IR) derived from fasting glucose and insulin concentrations were determined. Plasma levels of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) were analyzed using ELISA. The results showed that plasma levels of HMW-adiponectin were negatively associated with body mass index (BMI, r = - 0.203, p < 0.05) and waist circumference (r = -0.307, p < 0.01), which was not shown in total adiponectin. Plasma levels of HMW-adiponectin were negatively associated with triglyceride (r = -0.223, p < 0.05) and positively associated with HDL-cholesterol (r = 0.228, p < 0.05). Plasma levels of adiponectin were positively associated with HDL-cholesterol (r = 0.224, p < 0.05). Plasma levels of HMW-adiponectin were negatively associated with hsCRP (r = -0.276, p < 0.01) and IL-6 (r = -0.272, p < 0.01). In addition, there were weak associations between plasma levels of HMWadiponectin and TNF-${\alpha}$ (r = -0.163, p = 0.07) and ICAM-1 (r = -0.158, p = 0.09). However, there were no significant associations of total adiponectin with inflammatory markers except hsCRP (r = -0.203, p < 0.05). Stepwise multiple linear regression analysis showed that only plasma levels of HMW-adiponectin was an independent factor influencing serum levels of hsCRP, a marker of systemic low grade inflammation, after adjusting for age, gender, BMI, waist circumference, alcohol intake, smoking status, blood lipids, total adiponectin and drug use (p < 0.01). These results suggest that HMW-adiponectin, rather than total adiponectin, is likely to be closely associated with the features of cardiometabolic risks in treated hypertensive patients and might be effective biomarker for the prediction of cardiovascular disease.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38B no.9
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• pp.722-727
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• 2013

Medical treatment for animals is very difficult as the opinions of pets' masters take priority over treatment regardless of the seriousness of pets' disease or the needs of medical treatment. In case that a pet has heart disease, especially, it is difficult to get the direct answer from the pet's master on the decision or confirmation of treatment. For those reasons, it is almost impossible to predict and treat the pet before an emergency like the heart failure or an unexpected death happens. Using stethoscope can be the first diagnosis method to check the heart or any kinds of disease inside the body. High-tech equipments like CT, X-ray or Ultrasound can be used, but they can only be used as a second choice of diagnosis method since it requires professional skills and its high price. That's why stethoscope is still the best diagnostic tool when one makes the first diagnosis. In this study, we give a detailed account of digital diagnosis system in which veterinarians can analyze the sound from stethoscope without bringing it to their ears and make a diagnosis wherever they are. And we suggest a new concept of diagnosis system surrounding, which shows the relativeness of disease through Level Crossing Rate(LCR) and energy level from the stethoscope sound made in this system.

• The Journal of the Acoustical Society of Korea
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• v.20 no.5
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• pp.21-27
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• 2001

Impulsive sound and vibration signals in gear system are often associated with their faults. Thus these impulsive sound and vibration signals can be used as indicators in condition monitoring of gear system. The traditional continuous wavelet transform has been used for detection of impulsive signals. However, it is often difficult for the continuous wavelet transform to identify spikes at high frequency and meshing frequencies at low frequency simultaneously since the continuous wavelet transform is to apply the linear scaling (a-dilation) to the mother wavelet. In this paper, the spike wavelet transform is developed to extract these impulsive sound and vibration signals. Since the spike wavelet transform is to apply the non-linear scaling, it has better time resolution at high frequency and frequency resolution at low frequency than that of the continuous wavelet transform respectively. The spike wavelet transform can be, therefore, used to detect fault position clearly without the loss of information for the damage of a gear system. The spike wavelet transform is successfully is applied to detection of the gear fault with tip breakage.

• Journal of radiological science and technology
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• v.40 no.2
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• pp.219-228
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• 2017

Postmenopausal women are at increased risk for osteoporosis and obesity due to changes in hormones. The relationship between osteoporosis and body weight is known, and its relation with body fat mass is discussed. The purpose of this study was to evaluate the bone mineral density(BMD) changes of epicardial adipose tissue(EAT) and abdominal subcutaneous fat. The subjects of this study were 160 postmenopausal women who underwent BMD and echocardiography. The thickness of the epicardial adipose tissue was measured in three sections and the BMD were meassured according to the diagnostic criteria. The results of this study that age increase the risk of osteoporosis increases, and as the weight and BMI decrease, the risk of osteoporosis increases(p<0.05). The relationship between changes in bone mineral density and adipose tissue in postmenopausal women, increased epicardial adipose tissue was negatively correlated with the bone mineral density(p<0.05). conversely, increased abdominal subcutaneous fat thickness was positively correlated with bone mineral density(p<0.05). In other words, the effect of bone mineral density on the location of adipose tissue was different. If Echocardiography is used to periodically examine changes in the thickness of the epicardial adipose tissue, it may be prevented before proceeding to osteoporosis.

• Journal of Life Science
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• v.18 no.11
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• pp.1493-1498
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• 2008

We defined factors affecting the postoperative outcome in adult cardiac surgery with cardiopulmonary bypass (CPB). Thirty-two adult patients scheduled for elective cardiac surgery participated in this study. Levels of leukocyte, glutamic oxaloacetic transaminase (GOT), troponin-I (cTNI), interleukin-6 (IL-6), D-dimer and neuron-specific enolase (NSE) were significantly elevated, whereas platelet count declined in cardiac surgery with CPB. GOT and D-dimer levels at CPB-off each had a positive significant correlation significantly with 24 hrs-bleeding, total bleeding, mechanical ventilatory assist time, ICU stay time and length of hospitalization. BUN levels at CPB-off were directly related to total bleeding, mechanical ventilatory assist time, ICU stay time and length of hospitalization. Platelet count at CPB-off was inversely related to mechanical ventilatory assist time, ICU stay time and length of hospitalization. Creatinine concentration at CPB-off interrelated positively with mechanical ventilatory assist time and ICU stay time. NSE levels at CPB-off had a positive relationship with postoperative 24 hrs-bleeding. The length of hospitalization was prolonged proportionally to the elevation of cTNI levels in cardiac surgery. Aortic cross-clamping and total CPB times also related with increase of 24 hrs and total bleeding volumes and the length of hospitalization. IL-6 and ET-1 had no mutual relation with any postoperative outcome. These data suggest that GOT, BUN, creatinine, D-dimer and platelet levels are the most important factors affecting postoperative outcomes and patient's recovery in adult cardiac surgery with CPB.

• Journal of Korean Medical classics
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• v.18 no.4 s.31
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• pp.44-48
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• 2005

소위(所謂) 심풍열증시상화치성이혈조(心風熱證是相火熾盛而血操), 인기음수다(引起飮水多), 습열울체어혈분적결흉병(濕熱鬱滯於血分的結胸病). 인이(因而), 흉중수기불능하강(胸中水氣不能下降), 유차가견류사소양병적결흉증상(由此可見類似少陽病的結胸證象), 이차재체표용역조성잉유부진소산적풍열사(而且在體表容易造成仍有不盡消散的風濕邪). 여차병황하(如此病況下), 심장지열영향소장이출현(心臟之熱影向小腸而出現), 뇨수빈이부창(尿雖頻而不暢), 혹뇨량소이소편불리(或尿量少而小便不利). 종상소술(綜上所述), 여하요약기내용(如下要略其內容). 1. 도적강기탕시적합용어소양인소양병습열결흉(導赤降氣湯是適合用於少陽人少陽病濕熱結胸). 2. 기병증수속어혈분증(其病證雖屬於血分證), 인잉유표증(因仍有表證), 고의겸용발산지제(故宜兼用發散之齊). 3. 여겸유안양등(如兼有眼痒等) 간담병증(肝膽病證), 환령가기타처방. 4. 해방대소화계통허약(該方對消化系統虛弱), 겸유수족냉(兼有手足冷), 훈차(暈車), 전두통(前頭痛), 장염(腸炎) 등적환아(等的患兒), 기효과흠가(其效果欠佳). 5. 유차가지(由此可知), 도적강기탕시침대심유습열(導赤降氣湯是針對心有濕熱), 위야유열(胃也有熱), 잉유표증(仍有表證), 부겸유간담병증적환아료효호(不兼有肝膽病證的患兒療效好). 여유소시호탕증(如有小柴胡湯證), 즉선용시호지제이해제해증(則先用柴胡之劑而解除該證), 연후재변증(然後再辨證), 재산시해치법적원칙(才算是該治法的原則).

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.481-483
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• 2014

경제가 성장함에 따라 생활문화의 수준 또한 향상되었고 그로인해 삶의 가치가 건강에 대한 관심으로 변하면서 함께 아웃도어 스포츠도 대중화되고 있다. 평균 수명이 늘어남에 따라 아웃도어 스포츠를 즐기는 인구도 노인층뿐만 아니라 다양한 계층으로 확대됨에 따라 아웃도어를 즐기는 이용자가 증가하고 있고 안전사고 또한 증가하고 있다. 아웃도어 활동 중 발생하는 안전사고 사망자의 대다수가 심장마비사고이다. 본 논문에서는 아웃도어 웨어에 심박센서를 장착하여 스마트폰과 연동되게 하며 심박수를 체크해주어 급작스레 심박수에 큰 폭의 변화를 보이면 스마트폰에 경고음을 크게 울려 주위의 사람들에게 위험상황을 알려 도움을 받을 수 있도록 하며 긴급한 사고가 발생할 경우 GPS를 통해 위치를 알려주며 구조요청 메시지를 보내도록 한다.

• The Korean Journal of Nuclear Medicine
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• v.33 no.1
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• pp.49-56
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• 1999

Purpose: Heart to liver ratio on T1-201 per rectal scintigraphy (shunt index) is known to be useful in the assessment of portal systemic shunt. We assessed T1-201 uptake pattern and early liver/heart uptake rate of T1-201 and correlated with shunt index in patients with chronic active hepatitis (CAH) and liver cirrhosis (LC). Materials and Methods: Fifty eight patients with biopsy-proven chronic liver disease (35 with CAH, 23 with LC) underwent T1-201 per rectum scintigraphy after instillation of 18.5 MBq of T1-201 into the upper rectum. We evaluated hepatic uptake (type 1 : homogeneous, 2: inhomogeneous segmental, 3: inhomogeneous nonsegmental) and extrahepatic uptake of spleen, heart and kidney (grade 0: no uptake, 1: less than liver, 2: equal to liver, 3: greater than liver). We measured the early liver/heart uptake rate (the slope of the liver to heart uptake ratio for 10 min) and shunt index (heart to liver uptake ratio). T1-201 uptake pattern and early liver/heart uptake rate of T1-201 was correlated with the pathologic diagnosis and shunt index. Results: Hepatic uptake patterns of type 1 and 2 were dominant in CAH (CAH: 27/35, LC. 8/23), and type 3 in LC (CAH: 8/35, LC: 15/23)(p<0.005). The grades of extrahepatic uptake were higher in LC than in CAH (spleen: p<0.001, other soft tissue: p<0.005). The early liver/heart uptake rate of CAH ($0.110{\pm}0.111$) was significantly higher than that of LC ($0.014{\pm}0.090$)(p<0.001). The sensitivity and specificity of the early liver/heart uptake rate were 77.7% and 67.7% in differentiating LC from CAH. There was negative correlation between early liver/heart uptake rate and shunt index (r=-0.3347, p<0.01). Conclusion: Hepatic and extrahepatic uptake pattern and early liver/heart uptake rate on T1-201 per rectum scintigraphy are useful in the assessment of portal systemic shunt in patients with chronic liver disease.

• Journal of Life Science
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• v.20 no.9
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• pp.1299-1305
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• 2010

Cardiac troponin-I (cTnI), creatine kinase-MB (CK-MB), and C-reactive protein (CRP) are routine cardiac markers for the diagnosis of cardiovascular disease. Recently, brain natriuretic peptide (BNP) has garnered attention as a marker of heart failure. This study was retrospectively designed to investigate the relationships between preoperative BNP, other cardiac markers levels and perioperative parameters in seventy-four adult patients that underwent off-pump coronary artery bypass grafting (OPCAB) and to assess its usefulness for predicting postoperative outcomes. Preoperative levels of BNP, cTnI, CK-MB, and CRP had significantly positive or negative correlations with echocadiographic parameters. There were significantly positive relationships between BNP, cTnI, CK-MB, and CRP concentration. Postoperative mechanical ventilation time had a positive correlation to preoperative levels of cTnI, CK-MB, and CRP, while ICU-staying period had a positive correlation with BNP, cTnI and CK-MB. These results reveal that a preoperative level of BNP is a good predictor and that its combination with cTnI, CK-MB, and CRP might be useful for diagnosis and comprehensive risk stratification of patients with coronary heart diseases, as well as prognosis of perioperative outcomes in OPCAB patients.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2000.11a
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• pp.118-126
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• 2000

동양의학에서 인체의 주된 생리 정보는 체질과 맥진에서 얻어질 수 있다 체질은 선천적인 오장 육부 기능에 대한 정보를 제공한다. 체질에 대한 판단은 얼굴형상, 맥진, 사주 등의 방법에 의한다. 반면에 진맥은 현재의 오장육부의 건강 상태를 나타낸다. 오장육부의 생체정보는 인체경락의 전기 전도도를 측정하는 방법에 의해서도 얻어질 수 있으나 본 논문에서는 진맥에의한 방법만을 토론한다. 체질과 진맥 정보는 치병에 있어서 처방의 기간과 강도를 결정 할 수 있는 결정적인 변수이다. 이 두가지 정보 중에서 하나라도 결핍될 경우 병에 대한 효율적인 대응이 어려워진다. 그 이유는 처방의 강약 조절이 어렵고 그 결과 다른 부작용 유발가능성이 크다. 본 논문에서는 진맥이론의 일반적 전개를 위하여 음양오행 성질의 과학적인 정의를 기초로 하였다. 구체적인 맥상의 판단에는 (1) 음의 맥과 양의 맥의 절대적 크기와 상대적 비(즉 음양의 강도와 비), (2) 오행의 성질에 기초한 맥의 형상, 그리고 (3) 맥의 느낌이나 성질등 3가지 정보를 종합한 방법으로 맥상을 파악한다. 이러한 맥진기술 이론은 분류방법이 간단할 뿐만아니라 이론이 일반적이다. 그래서 한의학의 전문가는 물론이고 일반인 모두 쉽게 익혀 덜인의 건강상태를 스스로 파악하는 것이 가능하다. 진맥기 제작의 기년 이론으로서 역할을 할 수 있다. 오행이론에 기초 할 경우 맥상은 5가지 대표적인 맥으로 분류된다. 맥의 이름은 황제내경에 제시된 한의학적인 이름과 함께 맥상을 쉽게 유추 할 수 있는 실생활적인 이름을 병용하였다. 예를 들어 위장이 약할 때 나타나는 홍맥을 진빵같이 부드러운 맥으로, 폐가 나쁠 때 나오는 흩어지는 모맥을 도우너츠형 연기맥으로, 신장이 나쁠 때 나오는 단단한 석맥을 고구마형상의 돌덩어리맥으로, 간이 나쁠 때 나오는 긴장된 현맥을 팽팽한 고무줄맥으로 그리고 심장이 나쁠 때 나오는 작고 연한 구맥을 튀어오르는 물방울맥으로 명명하였다. 이외에 진맥에 의하여 인체의 한열이나 지삭 부침등의 정보가 가능하며, 이러한 정보는 고혈압이나 중풍 확률, 비만 가능성 지수, 골다공증 선행지수 그리고 심장기능 파악(불전맥이나 대맥) 등 다양한 인체 정보를 파악하는 데 응용될 수 있음을 강조한다.