• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1493-1497
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• 2007

산지 소하천 유역을 대상으로 물순환 과정을 규명하기란 대단히 어려운 실정이다. 1차적으로는 수문자료의 부재가 제일 크며, 자료가 있다 하더라도 홍수기 중심 및 단기간 자료의 축적에 불과하다. 이중 설마천 시험유역은 한국건설기술연구원의 12년간 운영경험을 바탕으로 비교적 장기간의 수문자료를 축적하고 있다. 최근 7년간은 신뢰할 만한 양질의 수문자료를 구축하였으며, 현재는 신뢰도의 완성을 높이는 연구가 활발히 진행 중에 있다. 설마천 시험유역의 유역의 물순환 구조는 자연계의 유입과 유출이 지배적이며, 이들의 수문성분을 규명하기 위해서는 각각의 수문성분들의 관측 및 해석이 필요하며, 각 수문성분들의 물수지 분석을 통하여 정량적인 합의 결과를 가시적으로 확보함이 매우 중요하다. 신뢰도와 정확성에 근거한 관측자료를 이용한 물수지 분석결과는 수문성분들의 총체적 표현이라 할 수 있는 모형(model)의 중요 입력자료이며, 모형의 분석결과를 검증할 수 있는 중요한 기준이 된다. 모형의 결과와의 비교 검토를 통해 산지 소하천 유역의 물순환 관계를 규명하는 기반을 확보하게 될 것이다. 본 연구에서는 신뢰성 있는 수문관측 자료를 이용하여 물수지 분석을 수행하였다. 물수지 분석의 대상유역인 설마천 시험유역의 신뢰할 만한 관측자료에는 강우량, 유출량, 지하수이용량이며, 증발산량 산정을 위한 기상관측 및 대형증발계를 통한 실제 증발량 관측은 이루어지나 유역을 대표하는 증발산량의 관측이 연속적으로 이루어지지 못하는 실정이다. 그러나, 설마천 시험유역은 소규모이며, 대체로 동질성 있는 유역이라고 가정하여 1개 기상관측소에서 운영하는 기상자료를 이용하여 증발산량을 산정하고 물수지에 적용하였다. 또한, 그 동안 관측하지 못했던 지하수위 관측을 실시함으로써 정확한 물순환 해석을 할 수 있는 기반을 확보 하였으며, 가용한 장 단기간의 관측자료와 물수지 분석 연산식의 추정치를 바탕으로 관측자료에 의한 물수지 분석을 수행하였다. 분석 결과로 산지 소하천 유역인 설마천 시험유역의 각 수문요소의 물이동간의 정량적인 값을 알 수가 있었으며, 앞으로 추가적이고 지속적인 수문모니터링이 운영되고 물순환 해석 모형에 의한 검증이 수행된다면 정량적인 물순환 관계를 규명할 수 있을 뿐만 아니라 이와 관련된 수문요소기술을 확보할 수 있을 것이다.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.32 no.3
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• pp.218-228
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• 2010

Components of dental resin-based restorative materials are reported to leach from the filling materials even after polymerization. Hydroquinone (HQ) is one of the major monomers used in the dental resin and is known as a carcinogen. Thus, carcinogenic risk of HQ leaching from the dental resin becomes a public health concern. The present study attempted to examine the carcinogenic potentials of HQ on the human epithelial cell, which is the target cell origin of the most of oral cancers. Cytotoxicity of HQ was observed above 50${\mu}M$ as measured by LDH assay, indicating a relatively low toxicity of this substance in human epithelial cells. The parameters of neoplastic cellular transformation such as cell saturation density, soft agar colony formation and cell aggregation were analyzed to examine the carcinogenic potential of HQ. The study showed that 2-week exposure of HQ showed the tendency of increase in the saturation density and the significant enhancement of soft agar colony formation at the highest dose, 50 ${\mu}M$ only. It is suggested that HQ has a weak potential of carcinogenicity. When cells were treated with HQ and TPA, a well-known tumor promoter, the parameters of neoplastic cellular transformation was significantly increased. This result indicates that the potential risk of carcinogenicity from HQ is largely dependent upon the presence of promoter. Exposure of 50 ${\mu}M$ HQ increased the time-dependent apoptosis as measured by the ELISA kit. This concentration coincides with a dose of neoplastic transformation, indicating a possible link between apoptosis and HQ-induced cellular transformation. Hydroquinone generated Reactive Oxygen Species (ROS) which was evidenced by the treatment of antioxidants such as trolox and N-acetyl cysteine and the GSH depleting agent, BSO. Antioxidants blocked the generation of ROS and the GSH depleting agent, BSO dramatically increased the ROS production. Since HQ is known to increase ROS production thru activation of transcriptional factor such as c-Myb and Pim-1, it is speculated that ROS generation by HQ plays a role in the activation of oncogene, which may lead to neoplastic transformation. In addition, ROS is involved in the alteration of signal transduction, which regulates the apoptosis in many cellular systems. Thus, ROS-mediated apoptosis may be involved in the HQ-induced carcinogenic processes. Protein kinase C (PKC) is known to play pivotal roles in neoplastic transformation of cells and its high expression is often found in a variety of types of tumors including oral cancer. PKC translocation of PKC-${\alpha}$ was observed following HQ exposure. Altered signaling system may also play a role in the transformation process. Taken together, HQ leached from the dental resin does not pose a significant threat as a cancer causing agent, but its carcinogenic potential can be significantly elevated in the presence of promoter. The mechanism of HQ-induced carcinogenesis involved ROS generation, apoptosis and altered signaling pathway. The present study will provide a valuable data to estimate the potential risk of HQ as a carcinogen and understand mechanism of HQ-induced carcinogenesis in human epithelial cells.

• Parasites, Hosts and Diseases
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• v.21 no.2
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• pp.241-245
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• 1983

PraziquantEI ($Distocide^{\circledR}$), the KcrEan product, was tEstEd for its safety and Efficacy in treatmEnt of Clonorchis sinensiJ infccticn during the period from April to SeptembEr, 1983 in Korea. A total of 55 egg positive cases were selected and treated with the regimen of 25 mg/kg t.i.d. for 1 day (total 75 mg/kg). The follow-up stool examination was done in 47 cases by cellophane thir;k smear and Stoll's egg counting techniques. The 8 uncured cases were treated again with the same regimen. The laboratory tests for blood picture and liver function were done in 27 cases and compared before and after the treatment. The results obtainEd are as follows: 1. After single course treatment, the cure and egg reduction rates were 83.0 and 99.1% respectively. With the second treatment, excellent results of 100% in both rates were obtained. 2. Several kinds of side effects such as dizziness, headache, etc. were complained by 29 cases (61.7 %), however, those were so mild and transient that no special treatment was necessary. 3. No significant change in laboratory findings was recognizable before and after the treatment. From the above results, it is concluded that $Distocide^{\circledR}$ is as effective and safe as $Biltricide^{\circledR}$ and highly recommendable in treatment of C. sinensis infection.

• Tuberculosis and Respiratory Diseases
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• v.42 no.2
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• pp.206-217
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• 1995

Background: In patients with obstructive sleep apnea syndrome(OSAS), there are several factors increasing upper airway resistance and there is a predisposition to compromised respiratory function during waking and sleep related to constitutional factors including a tendency to obesity. Several recent studies have suggested a possible relationship between sleep apnea(SA) and systemic hypertension. But the possible pathophysiologic link between SA and hypertension is still unclear. In this study, we have examined the relationship among age, body mass index(BMI), pulmonary function parameters and polysomnographic data in patients with OSAS. And also we tried to know the difference among these parameters between hypertensive OSAS and normotensive OSAS patients. Methods: Patients underwent a full night of polysomnography and measured pulmonary function during waking. OSAS was diagnosed if patients had more than 5 apneas per hour(apnea index, AI). A careful history of previously known or present hypertension was obtained from each patient, and patients with systolic blood pressure $\geq$ 160mmHg and/or diastolic blood pressure $\geq$ 95mmHg were classified as hypertensives. Results: The noctural nadir of arterial oxygen saturation($SaO_2$ nadir) was negatively related to AI and respiratory disturbance index(RDI), and the degree of noctural oxygen desaturation(DOD) was positively related to AI and RDI. BMI contributed to AI, RDI, $SaO_2$ nadir and DOD values. And also BMI contributed to $FEV_1,\;FEV_1/FVC$ and DLco values. There was a correlation between airway resistance(Raw) and AI, and there was a inverse correlation between DLco and DOD. But there was no difference among these parameters between hypertensive OSAS and normotensive OSAS patients. Conclusion: The obesity contributed to the compromised respiratory function and the severity of OSAS. AI and RDI were important factors in the severity of hypoxia during sleep. The measurement of pulmonary function parameters including Raw and DLco may be helpful in the prediction and assessment of OSAS patients. But we could not find clear difference between hypertensive and normotensive OSAS patients.

• Journal of KIISE:Computer Systems and Theory
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• v.33 no.4
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• pp.242-255
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• 2006

In the recent years, Popularization of mobile devices such as Smart Phones, PDAs and MP3 Players causes rapid increasing necessity of Power management technology because it is most essential factor of mobile devices. On the other hand, despite low price, hard disk has large capacity and high speed. Even it can be made small enough today, too. So it appropriates mobile devices. but it consumes too much power to embed In mobile devices. Due to these motivations, in this paper we had suggested methods of minimizing Power consumption while playing multimedia data in the disk media for real-time and we evaluated what we had suggested. Strict limitation of power consumption of mobile devices has a big impact on designing both hardware and software. One difference between real-time multimedia streaming data and legacy text based data is requirement about continuity of data supply. This fact is why disk drive must persist in active state for the entire playback duration, from power management point of view; it nay be a great burden. A legacy power management function of mobile disk drive affects quality of multimedia playback negatively because of excessive I/O requests when the disk is in standby state. Therefore, in this paper, we analyze power consumption profile of disk drive in detail, and we develop the algorithm which can play multimedia data effectively using less power. This algorithm calculates number of data block to be read and time duration of active/standby state. From this, the algorithm suggested in this paper does optimal scheduling that is ensuring continual playback of data blocks stored in mobile disk drive. And we implement our algorithms in publicly available MPEG player software. This MPEG player software saves up to 60% of power consumption as compared with full-time active stated disk drive, and 38% of power consumption by comparison with disk drive controlled by native power management method.

• Journal of Yeungnam Medical Science
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• v.19 no.2
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• pp.107-115
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• 2002

Purpose: Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

• Journal of KIISE:Computer Systems and Theory
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• v.35 no.11
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• pp.497-508
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• 2008

Mobile Multimedia File System, MNFS, is a file system which extensively exploits NAND FLASH Memory, Since general Flash file systems does not precisely meet the criteria of mobile devices such as MP3 Player, PMP, Digital Camcorder, MNFS is designed to guarantee the optimal performance of FLASH Memory file system. Among many features MNFS provides, there are three distinguishable characteristics. MNFS guarantees, first, constant response time in sequential write requests of the file system, second, fast file system mounting time, and lastly least memory footprint. MNFS implements four schemes to provide such features, Hybrid mapping scheme to map file system metadata and user data, manipulation of user data allocation to fit allocation unit of file data into allocation unit of NAND FLASH Memory, iBAT (in core only Block Allocation Table) to minimize the metadata, and bottom-up representation of directory. Prototype implementation of MNFS was tested and measured its performance on ARM9 processor and 1Gbit NAND FLASH Memory environment. Its performance was compared with YAFFS, NAND FLASH File system, and FAT file system which use FTL. This enables to observe constant request time for sequential write request. It shows 30 times faster mounting time to YAFFS, and reduces 95% of HEAP memory consumption compared to YAFFS.

• Journal of Satellite, Information and Communications
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• v.9 no.1
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• pp.51-56
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• 2014

High-availability seamless redundancy (HSR) is a protocol for fault-tolerant Ethernet (FTE) networks. It provides two frame copies and each copy is forwarded on a separate physical path, which provides zero fail-over time. Therefore, the HSR is becoming a potential candidate for various real-time FTE applications. However, the generation and circulation of unnecessary frames due to the duplication of every sending frame is inherent drawback of HSR. Such drawback degrades the performance of the network and may deplete its resources. In this paper, we present a new algorithm called port locking (PL) based on the media access control (MAC) address to solve the abovementioned problem in popular connected-rings network. Our approach makes the network gradually learn the locations of the source and the destination nodes without relying on network control frames. It then prunes all the rings that do not contain the destination node by locking corresponding rings' entrance ports. With the PL algorithm, the traffic can be significantly reduced and therefore the network performance will be greatly enhanced specially in a large scale connected-rings network. Analytical results are provided to validate the PL algorithm.

• Journal of Korean Society of Environmental Engineers
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• v.36 no.7
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• pp.483-491
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• 2014

In this study, we developed an M-COS (molit coagulant-dosing optimization system), which enables to apply the optimum coagulant dose determined in real time, in order to satisfy the total phosphorus (TP) regulation (0.5 mg/L), and then tested its field applicability. Field tests were conducted at three different periods in 2014 in a pilot plant where the M-COS was installed. Coagulant reduction rate by the M-COS was 10.4%, 15.3%, and 9.0% for each period (average 11.6%), when comparing with a control where coagulants were applied at a constant rate. Total cost for the M-COS or control was estimated by summing up the coagulant cost and sludge treatment cost, and then the resulting cost increase was predicted. Cost reduction rate by the M-COS was 13.8%, 20.0%, and 11.4% for each period (average 15.0%). This study indicates that the M-COS can be an alternative to a conventional system for TP treatment, with a better cost efficiency.

• Geophysics and Geophysical Exploration
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• v.20 no.1
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• pp.43-48
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• 2017

The applicability of refraction survey has been tested using a wave glider widely used in long-term ocean observations around the world. To record seismic refractions, a single channel streamer with metal weight and a seismic recording system were mounted on the wave glider. We used GPS precise time synchronization signal and radio frequency (RF) communication to synchronize shot and recorder triggers and to control acquired data quality in real time. When the wave glider is positioned close to the set point, a 2,000 J sparker is exploded along the designed track at 2 second intervals. Through the test survey, we were able to successfully acquire refractions from the subsurface.