• Clinical and Experimental Pediatrics
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• v.46 no.7
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• pp.687-694
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• 2003

Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth $factor-{\beta}$($TGF-{\beta}$), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury. Methods : Sera and kidney tissue samples(whole kidney, cortex, outer medullae and inner medullae) were obtained before and after one, three, five and seven days of 40 minutes bilateral renal pedicle clamping. Acute renal failure was assessed by measuring the concentration of serum creatinine. Serum IGF-I level was measured by radioimmunoassay. The mRNA expression in kidney was measured by RT-PCR. The distribution of IGF-I and CTGF was detected by immunohistochemistry. Resuts : Serum IGF-I concentration after one day following acute ischemic renal injury was significantly decreased compared to preischemic value. The mRNA levels of IGF-I, IGF-II, $TGF-{\beta}1$ and VEGF in whole kidney were temporally decreased on day one of ischemic injury. IGF-I and IGF-II expressions in outer medullae were significantly decreased on day one after ischemic injury. $TGF-{\beta}1$, CTGF and VEGF expressions were markedly decreased in medullae after one day of ischemic injury compared to other kidney sections. IGF-I was markedly decreased in cortical tubules on day one of uremic rat. CTGF was markedly increased on tubule within three days of ischemic injury. Conclusion : These findings suggest that IGFs, $TGF-{\beta}1$ and CTGF may involve in the pathogenesis or the recovery from acute ischemic renal injury.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.1
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• pp.133-138
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• 2012

Human body such as hands, foots and face are related with five organs. Particularly, foots are called 'second cardiac'. In this paper, we should like to analyze changes of facial color according to stimulation kidney associated foot acupressure point. To this end, we collected facial image of before and after of kidney associated foot acupressure point to normal kidney 20s male in 10 then we measured K of CMYK color system with L of Lab color system in JIGAK area associated kidney of facial area. As a result of us experiment, after stimulation of kidney associated foot acupressure point, L is increased and K is decreased in 90% of subjects. Finally, the effectiveness of this paper is demonstrated with several experiments.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.1426-1429
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• 2010

삶이 윤택해지면서 선진국에서는 건강에 대한 관심도가 높아 질병이 발생되기 전에 조기에 진단하여 예방하는 대체의학이 관심을 받고 있으며 이러한 대체의학 중 귀에 침을 자입을 하여 치료를 하는 이침(耳針)요법이 있다. 이침 요법은 부작용이 적고 자가 진단을 통해 응급처치가 가능한 것으로 실생활에서 손쉽게 이용하고 있다. 따라서 본 논문에서는 신장에 해당하는 이(耳)혈 상응점을 자극하여 신장과 관련된 지각(地閣)의 색 변화를 측정하였다. 이를 위해 동일한 조건에서 시행되는 신장 상응점을 자극하기 전과 후의 영상을 기반으로 이목구비 추출 및 색상 분석 프로그램을 이용하여 CMYK 중 검정 색상값을 의미하는 K값의 변화율을 적용하여 비교, 분석하였다. 결과적으로 신장 상응점 자극에 의해 K값이 낮아져 신장에 해당하는 혈(穴)을 자극할 시에 신장이 안정화 되었다는 결론을 도출하였다.

• Journal of the Korea Convergence Society
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• v.9 no.10
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• pp.467-475
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• 2018

The purpose of this study was to describe self-management related to diabetic nephropathy(DN) patients and analyze instrument for measurement of self-management. Literature search was conducted using computerized databases such as Pubmed, CINAHL, Embase, and Cochrane. The search term of this study were "Diabetes Mellitus", "Self-care", "Kidney Disease". A total of 8 articles were collected and 8 measurement instruments used in the study. But, included studies were assessing the self-management for DN using non-DN specific instruments. Thus, DN specific instrument for measuring the self-care should be developed in future study.

• Clinical and Experimental Pediatrics
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• v.51 no.10
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• pp.1090-1095
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• 2008

Purpose : To assess the height growth of children with epilepsy receiving antiepileptic drugs (AEDs) and the related factors. Methods : The subjects were 148 children diagnosed with epilepsy at Pusan National University Hospital between January 1996 and December 2003, who received AEDs for more than 3 y. We measured height at the initiation of AED medication and at the last visit during AED medication. We analyzed the mean height standard deviation score (SDS) according to several factors, including sex, age at initial medication, seizure type, underlying causes of epilepsy, seizure frequency before AED medication, seizure control, number of AEDs, height SDS before medication, and duration of medication. Results : In the total population, height SDS at initial therapy and last follow-up were $-0.06{\pm}1.39$ versus $0.10{\pm}1.12$ (P=0.09). Children with controlled seizures showed a significant increase in height SDS, from $-0.12{\pm}1.39$ to $0.10{\pm}1.09$ (P=0.04), and children on medication for less than 6 y showed a significant increase in height SDS, from $-0.09{\pm}1.54$ to $0.21{\pm}1.07$ (P=0.03). Also, children with negative initial height SDS showed a significant increase in height SDS (P<0.05). No height SDS changes were observed in any of the other groups, regardless of sex, seizure type, underlying causes of epilepsy, or age at initial medication. Conclusion : Neither epilepsy nor AED medication affects long-term height growth. Controlled seizure and short duration of AED medication are positive factors for height growth in children with epilepsy.

• Journal of Veterinary Clinics
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• v.26 no.1
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• pp.29-35
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• 2009

This study was to determine the effects of ascorbic acid and alpha-tocopherol on the attenuation of an ischemia-reperfusion injury (IRI) after renal auto-transplantation in a pig model. In the treatment group, three pigs were subjected to a renal auto-transplantation followed by the administration of ascorbic acid and alpha-tocopherol and the flushing of ascorbic acid plus hepa-saline solution. Otherwise, the control group used only flushing of hepa-saline solution. Blood samples were collected from these pigs for measurement of serum blood urea nitrogen (BUN) and creatinine values on the day before surgery and day 1, 3, 5 and 7 after surgery. The kidneys were taken for histopathological evaluation following euthanasia on day 14 after surgery. Serum creatinine and BUN values showed a significantly difference between control and treatment group on day 1, 3 and 5 (P<0.05). In histopathologic findings, treatment group showed less damage than that of the control group on the basis of renal tubular damage. As a result, this study suggests that the exogenous ascorbic acid and alpha-tocopherol pretreatment therapy with ascorbic acid irrigation-aspiration has a role of attenuation of renal I/R injury and recovery of renal function in a pig transplantation model.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.380-386
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• 2019

Shoulder joint pain is a very common musculoskeletal disorder, in which about 20 percent of adults experience it more than once in their lives. In this study, an objective assessment was made that subacromial space was increased by pectoralis minor stretching exercise, which has a positive effect on impingement syndrome and shoulder pain. Also, This study examined the effects on pectoralis minor length(PML) and acromio-humeral distance(AHD) following pectoralis minor self-stretching exercise in normal adults. In this study, a total of 30 subjects were recruited and randomly divided into a self-stretching exercise group(n=15) and manual stretching exercise group(n=15) to compare the immediate effects of treatment. Studies have shown that both groups have significantly increased both PML and AHD within the group(p<.05). There was no statistically significant difference in the comparison between the groups(p>.05). The results suggest that self-stretching exercise can be recommended as a treatment method for impingement syndrome and prevention of shoulder disease.

• The Korean Journal of Zoology
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• v.6 no.1
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• pp.9-14
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• 1963

S.M.계인 마우스♂♀를 정상군과 4개의 실험군 즉 양성가속도(5G-50초간과 11G-50초간 매일 각각 폭로) 및 전격(5volt-2초간과 10 volt 2 초간 매일 각각 전격)군으로 나누어 최소한 22일간 순화시킨 후 여지 전지영동법에 의해서 Albumin/Globulin 바와 단백질분할을 측정하고 또한 혈청 전단백질, 혈색소량, Hematocrit 비, 적혈구포약성 및 간, 신장의 중량을 측정하였다. A/G 와 전단백질은 양성가속도의 G-force 증가와 전격적 증가의 각군이 정확군보다 유의하게 현저히 낮은 치를 나타내고 있다. 간장중량, 혈색소량 및 Hematocrit 비는 또한 정상군보다 양성가속도, 전격적 각 조건하에서 낮은 치를 나타내고 있다. 그러나 신장중량은 현저히 증가된 치를 나타낸다. 양성가속도와 전격적조건군의 간장의 조직학적 소견은 혈관적 변화가 나타나고 그리고 양성가속도에서는 또한 액포가 출현하였다. 적혈구 포약성은 거의 변화가 없었다. 이상의 결과로 미루어보아 상기 두 효과로 인해서 주로 간장기능 즉 단백질대사에 이상을 초래하는 것으로 생각된다.

• The Korean Journal of Zoology
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• v.6 no.2
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• pp.1-5
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• 1963

SM계인 마우스 ♂♀를 정상군과 4개의 실험군, 즉 온열적 (33 $^{\circ}C$-60분, 매일 각각 폭로) 및 한냉적인 (5$^{\circ}C$-60분과 $0^{\circ}C$-60분, 매일 각각 폭로) 군으로 나누어 최소한 22일간 순화시킨 후 여지 전기영동에 의해서 Albumin /blobulin 비와 단백질 분할을 측정하고 또한 혈청전단백질량, 혈색소량, Hematocrit 비, 적혈구 포약성 및 간장 신장기관중량을 측정하였다. A/G 비와 전단백질양은 온열적 증가와 한랭적 증가의 각군이 정상군보다 유의하게 현저히 낮은 치를 나타내고 있다. 간장중량, 혈색소량 및 Hematocrit 비는 정상군보다 온열적 한랭적 조건하에서 낮은 치를 또한 나타내고 있다. 그러나 신장중량은 현저하게 증가된 치를 나타내고 있다. 온열적 한냉적 조건군의 간장에서의 조직학적 소견은 현저한 변화는 없고 다만 혈관적 변화만 나타내고 적혈구의 포약성은 거의 변화가 없다. 이와 같은 결과로 미루어 보다 온열적 한랭적의 효과로 인해서 주로 간장기능 즉 단백질대사에 이상을 초래하는 것으로 생각된다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.3
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• pp.369-374
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• 2000

메밀가루를 이용한 빵을 만들기 위하여 밀가루에 메밀가루를 10,20,30%를 혼합한 반죽과 30% 메밀복합분에 글루텐, ascorbic acid 및 HPMC를 혼합한 반죽들의 amylogram, farinogram 및 extensogram의 특성을 측정하였으며 SEM을 이용한 반죽의 구조도 관찰하였다. Amylograph에 의한 호화개시온도, 최고점도 및 최고점도시의 글루텐, ascorbic acid 및 HPMC의 의해 감소하는 경향이었다. Farinograph에 의한 흡수량은 메밀가루의 참가량이 많을수록 약간씩 감소하였고, 글루텐을 첨가하였을 경우에는 증가하였으나 HPMC에 의해서는 오히려 감소하였다. 반죽형성시간은 메밀가루의 혼합비율이 높을수록 점차 짧아졌고 첨가제에 의해서는 증가하였다. Extensograph에 의한 발효특성은 메밀가루의 첨가량이 많을수록 신장도와 신장에 대한 저항도는 감소하였으나 첨가제사용에 의해 증가하였으며 특히 글루템에 의해 신장저항도와 반죽의 강도가 높게 나타났다. 또한 SEM에 으한 반죽의 구조는 메밀가루의 혼합비율이 높아질수록 규칙적인 protein matrix를 형성하지 못하고 구형의 큰 전분입자와 작은 전분입자들이 엉겨서 덩어리진 상태로 혼합되어 있었으며 첨가제에 의해 전분입자와 단백질matrix 상호간에 결합상태가 개선되었으며 특히 첨가제 중 글루템은 밀가루 반죽과 유사하였으므로 빵의 부피 및 제빵성을 향상시켜 줄 것으로 생각된다.